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    • 2. 发明授权
      US08022178B2 Modified self-assembling peptides 有权
    • Modified self-assembling peptides
    • 改良的自组装肽
    • US08022178B2
    • 2011-09-20
    • US11904278
    • 2007-09-26
    • Akihiro Horii , Shuguang Zhang , Xiumei Wang , Fabrizio Gelain
    • Akihiro Horii , Shuguang Zhang , Xiumei Wang , Fabrizio Gelain
    • C07K14/00
    • C07K14/001 , A61K47/66 , A61L27/227 , A61L27/54 , A61L2300/25 , A61L2300/414 , B82Y5/00 , C07K14/78
    • The present invention provides a self-assembling peptide comprising: (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not mediate self-assembly in isolated form, wherein the second amino acid domain comprises at least one minimal biologically active sequence. Such self-assembling peptides are described herein as “modified self-assemblingpeptides.” The present invention also provides pharmaceutical compositions, kits and matrices comprising a modified self-assembling peptide, and methods of using and making such compositions, kits and matrices.
    • 本发明提供了一种自组装肽，其包含：（a）介导自组装的第一氨基酸结构域，其中所述结构域包含互补和结构相容的交替疏水和亲水氨基酸，并且自组装成宏观结构，当 以未经修改的形式出现; 和（b）不以分离形式介导自组装的第二氨基酸结构域，其中第二氨基酸结构域包含至少一个最小生物活性序列。 这种自组装肽在本文中被描述为“修饰的自组装肽”。本发明还提供了包含修饰的自组装肽的药物组合物，试剂盒和基质，以及使用和制备这种组合物，试剂盒和基质的方法。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 4. 发明申请
      US20100311640A1 SELF-ASSEMBLING PEPTIDE INCORPORATING MODIFICATIONS AND METHODS OF USE THEREOF 有权
    • SELF-ASSEMBLING PEPTIDE INCORPORATING MODIFICATIONS AND METHODS OF USE THEREOF
    • 自组装肽的修改及其使用方法
    • US20100311640A1
    • 2010-12-09
    • US12724153
    • 2010-03-15
    • Elsa Genove , Shuguang Zhang , Carlos Semino
    • Elsa Genove , Shuguang Zhang , Carlos Semino
    • A61K38/02 , C07K2/00 , C07K14/00 , C12N5/00 , A61P35/00 , A61P13/12 , C07K7/08 , C07K7/06 , C07K5/10 , C07K5/08
    • C07K7/08 , A61K38/00 , C07K7/06 , C07K14/78 , C07K2319/735
    • The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule. In certain embodiments of the invention the naturally occurring protein is a component of the extracellular matrix, e.g., a component of the basement membrane. The invention further provides scaffolds comprising the self-assembling peptides and methods of using the scaffolds including for cell culture, tissue engineering, and tissue repair.
    • 本发明提供一种自组装肽，其包含（a）介导自组装的第一氨基酸结构域，其中所述结构域包含互补和结构相容的交替的疏水性和亲水性氨基酸，并且当存在于 未经修改的形式; 和（b）不以分离形式自组装的第二个氨基酸结构域。 在本发明的某些实施方案中，第二氨基酸结构域包含生物活性肽基序，例如在天然存在的蛋白质中发现的肽基序，或与生物分子相互作用的靶位点。 在本发明的某些实施方案中，天然存在的蛋白质是细胞外基质的组分，例如基底膜的组分。 本发明还提供了包含自组装肽的支架和使用支架的方法，包括用于细胞培养，组织工程和组织修复。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 6. 发明申请
      US20070190603A1 Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor 审中-公开
    • Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
    • 通过两亲肽的自组装形成稳定的宏观膜并用于其
    • US20070190603A1
    • 2007-08-16
    • US11512753
    • 2006-08-29
    • Todd Holmes , Shuguang Zhang , Alexander Rich , C. DiPersio , Curtis Lockshin
    • Todd Holmes , Shuguang Zhang , Alexander Rich , C. DiPersio , Curtis Lockshin
    • C12P21/06 , C07H21/04 , C12N5/08 , C07K14/47
    • C07K7/08 , A61K9/009 , C07K5/0815 , C07K7/06 , C07K14/001 , C07K14/395 , C12N5/0068 , C12N2533/30 , C12N2533/50
    • Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.
    • 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2 N自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 9. 发明授权
      US06548630B1 Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor 失效
    • Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
    • 通过两亲肽的自组装形成稳定的宏观膜并用于其
    • US06548630B1
    • 2003-04-15
    • US08898300
    • 1997-07-22
    • Shuguang Zhang , Curtis Lockshin , Alexander Rich , Todd Holmes
    • Shuguang Zhang , Curtis Lockshin , Alexander Rich , Todd Holmes
    • C07K700
    • C07K7/08 , A61K9/009 , C07K14/001 , C07K14/395 , C12N5/0068 , C12N2533/30 , C12N2533/50
    • Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)2 (ARARADAD)2, were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.
    • 这里描述的是将两亲肽，即具有交替疏水和亲水残基的肽自组装成宏观膜。 成膜肽长度大于12个氨基酸，优选至少16个氨基酸是互补的并且在结构上相容。 具体来说，显示两种肽（AEAEAKAK）2（ARARADAD）2自组装成宏观膜。 还描述了肽自组装成宏观膜的条件和制备膜的方法。 肉眼膜具有几个有趣的性质：它们在水溶液，血清和乙醇中稳定，对热，碱性和酸性pH，化学变性剂和蛋白水解消化具有高度抗性，并且是非细胞毒性的。 该膜可用于生物材料应用，如慢扩散药物递送系统，人造皮肤和分离基质，以及阿尔茨海默病和瘙痒病感染的实验模型。 肽EAK16的序列衍生自称为佐酮的来自酵母的推定的Z-DNA结合蛋白。 还描述了ZUO1基因的克隆和表征。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
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