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1. 发明授权

US08431149B2 Coated medical devices for abluminal drug delivery 有权
标题翻译：用于外用药物输送的涂层医疗器械
公开(公告)号：US08431149B2
公开(公告)日：2013-04-30
申请号：US12072672
申请日：2008-02-27
申请人： David McMorrow , Barry Heaney , Anthony Malone , Aiden Flanagan , Tim O'Connor
发明人： David McMorrow , Barry Heaney , Anthony Malone , Aiden Flanagan , Tim O'Connor
IPC分类号： A61K9/00 , A61P7/00 , A61P9/10
CPC分类号： A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0036 , A61F2250/0068 , B33Y80/00
摘要： The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable stent, such as an intravascular stent, having a coating comprising an inorganic or ceramic oxide, metal or inert carbon and a plurality of reservoirs in such material that contain a therapeutic agent.
摘要翻译：本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置，以及用于制造这种医疗装置的方法。特别地，本发明涉及可植入支架，例如血管内支架，其具有包含无机或陶瓷氧化物，金属或惰性碳的涂层以及含有治疗剂的这种材料中的多个储存器。

2. 发明授权

US08070797B2 Medical device with a porous surface for delivery of a therapeutic agent 有权
标题翻译：具有用于递送治疗剂的多孔表面的医疗装置
公开(公告)号：US08070797B2
公开(公告)日：2011-12-06
申请号：US12072666
申请日：2008-02-27
申请人： Aiden Flanagan , David McMorrow , Anthony Malone , Tim O'Connor
发明人： Aiden Flanagan , David McMorrow , Anthony Malone , Tim O'Connor
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61L31/082 , A61L31/146 , A61L31/16 , A61L2300/416
摘要： The present invention is generally directed to implantable medical devices for delivering therapeutic agents to the body tissue of a patient and methods for making such medical devices. In particular, the present invention is directed to implantable medical devices, such as intravascular stents, having a surface that includes a plurality of cavities and a plurality of pores and a composition disposed in the pores and/or cavities, as well as, implantable medical devices, such as intravascular stents, having a surface that has a coating composition disposed on the surface, wherein the coating composition includes a plurality of cavities and a plurality of pores and another coating composition disposed in the pores and/or cavities.
摘要翻译：本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置和用于制造这种医疗装置的方法。特别地，本发明涉及可植入医疗装置，例如血管内支架，其具有包括多个空腔的表面和多个孔以及设置在孔和/或空腔中的组合物，以及植入式医疗装置，例如血管内支架，其具有设置在表面上的涂层组合物的表面，其中所述涂层组合物包括多个空腔和多个孔以及设置在孔和/或空腔中的另一涂层组合物。

3. 发明申请

US20080241218A1 Coated medical devices for abluminal drug delivery 有权
标题翻译：用于外用药物输送的涂层医疗器械
公开(公告)号：US20080241218A1
公开(公告)日：2008-10-02
申请号：US12072672
申请日：2008-02-27
申请人： David McMorrow , Barry Heaney , Anthony Malone , Aiden Flanagan , Tim O'Connor
发明人： David McMorrow , Barry Heaney , Anthony Malone , Aiden Flanagan , Tim O'Connor
IPC分类号： A61K9/00 , A61P7/00 , A61P9/10
CPC分类号： A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0036 , A61F2250/0068 , B33Y80/00
摘要： The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable stent, such as an intravascular stent, having a coating comprising an inorganic or ceramic oxide, metal or inert carbon and a plurality of reservoirs in such material that contain a therapeutic agent.
摘要翻译：本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置，以及用于制造这种医疗装置的方法。特别地，本发明涉及可植入支架，例如血管内支架，其具有包含无机或陶瓷氧化物，金属或惰性碳的涂层以及包含治疗剂的这种材料中的多个储存器。

4. 发明申请

US20080243231A1 Medical device with a porous surface for delivery of a therapeutic agent 有权
标题翻译：具有用于递送治疗剂的多孔表面的医疗装置
公开(公告)号：US20080243231A1
公开(公告)日：2008-10-02
申请号：US12072666
申请日：2008-02-27
申请人： Aiden Flanagan , David McMorrow , Anthony Malone , Tim O'Connor
发明人： Aiden Flanagan , David McMorrow , Anthony Malone , Tim O'Connor
IPC分类号： B05D3/12 , A61F2/06
CPC分类号： A61F2/06 , A61L31/082 , A61L31/146 , A61L31/16 , A61L2300/416
摘要： The present invention is generally directed to implantable medical devices for delivering therapeutic agents to the body tissue of a patient and methods for making such medical devices. In particular, the present invention is directed to implantable medical devices, such as intravascular stents, having a surface that includes a plurality of cavities and a plurality of pores and a composition disposed in the pores and/or cavities, as well as, implantable medical devices, such as intravascular stents, having a surface that has a coating composition disposed on the surface, wherein the coating composition includes a plurality of cavities and a plurality of pores and another coating composition disposed in the pores and/or cavities.
摘要翻译：本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置和用于制造这种医疗装置的方法。特别地，本发明涉及可植入医疗装置，例如血管内支架，其具有包括多个空腔的表面和多个孔以及设置在孔和/或空腔中的组合物，以及植入式医疗装置，例如血管内支架，其具有设置在表面上的涂层组合物的表面，其中所述涂层组合物包括多个空腔和多个孔以及设置在孔和/或空腔中的另一涂层组合物。

5. 发明申请

US20130066257A1 Design of Interventional Cutting Balloon with Enhanced API Delivery Capability 审中-公开
标题翻译：具有增强的API传送能力的介入切割气球的设计
公开(公告)号：US20130066257A1
公开(公告)日：2013-03-14
申请号：US13608237
申请日：2012-09-10
申请人： Martyn Folan , John Clarke , Aiden Flanagan , Anthony Malone , Tim O'Connor
发明人： Martyn Folan , John Clarke , Aiden Flanagan , Anthony Malone , Tim O'Connor
IPC分类号： A61B17/22 , A61M37/00
CPC分类号： A61M25/104 , A61B17/320725 , A61B2017/22061 , A61M25/1002 , A61M2025/1004 , A61M2025/105 , A61M2025/1059 , A61M2025/1086
摘要： A medical balloon assembly including an inflatable balloon and at least one cutting element extending from the balloon is disclosed. The inflatable balloon includes an outer wall facing outward and an inner wall facing outward. The cutting element comprises a plurality of openings therein including a first opening and a second opening. The first opening is closed off by a portion of the outer wall. The cutting element further includes a passageway extending from the first opening to the second opening. The passageway is defined by the cutting element and the portion of the outer wall which closes off the passageway. The passageway may contain a therapeutic agent.
摘要翻译：公开了一种医用气囊组件，其包括可充气球囊和从球囊延伸的至少一个切割元件。充气气囊包括面向外的外壁和面向外的内壁。切割元件包括多个开口，其中包括第一开口和第二开口。第一开口被外壁的一部分封闭。切割元件还包括从第一开口延伸到第二开口的通道。通道由切割元件和封闭通道的外壁部分限定。通道可以含有治疗剂。

6. 发明申请

US20080097569A1 REDUCTION OF BURST RELEASE FROM THERAPEUTICALLY TREATED MEDICAL DEVICES 审中-公开
标题翻译：从治疗医疗器械减少爆发
公开(公告)号：US20080097569A1
公开(公告)日：2008-04-24
申请号：US11857849
申请日：2007-09-19
申请人： Tim O'Connor , Aiden Flanagan , Dave McMorrow , Anthony Malone
发明人： Tim O'Connor , Aiden Flanagan , Dave McMorrow , Anthony Malone
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2250/0067 , A61L31/08 , A61L2300/602
摘要： The present invention generally relates to the conditioning of coated medical devices such as stents. More specifically, the present invention relates to methods for positioning a medical device within an elution media for a predetermined time period to eliminate a burst release from the coating. Under methods and processes of the invention, a medical device target surface may be identified and coated with therapeutic. The coated surface of the medical device may then be positioned within an elution media for a predetermined period of time to release a predetermined amount of coating.
摘要翻译：本发明一般涉及诸如支架之类的涂覆的医疗装置的调理。更具体地，本发明涉及用于将洗涤介质中的医疗装置定位在预定时间段内以消除从涂层中爆发释放的方法。在本发明的方法和方法下，可以鉴定医疗器械靶表面并用治疗剂涂覆。然后可以将医疗装置的涂覆表面定位在洗脱介质中预定的时间段以释放预定量的涂层。

7. 发明申请

US20080281409A1 STENTS WITH DRUG ELUTING COATINGS 审中-公开
标题翻译：带药液涂层的手套
公开(公告)号：US20080281409A1
公开(公告)日：2008-11-13
申请号：US11933517
申请日：2007-11-01
申请人： Anthony Malone , Tim O'Connor , Dave McMorrow , Aiden Flanagan
发明人： Anthony Malone , Tim O'Connor , Dave McMorrow , Aiden Flanagan
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/622
摘要： Provided is a coated medical device (e.g., a stent) comprising one or more surfaces having dispersed thereon a plurality of microparticles comprising an active pharmaceutical ingredient (API) and a polymer. Specifically, the microparticles are disposed on a device surface in a microparticulate phase coating, i.e., as discrete microparticles in the absence of a continuous phase coating. The medical device effectively adheres one or more APIs to its surface, and allows controlled release of the APIs from the device surface to a desired treatment area by using a minimal amount of polymer. The medical device is suitable for insertion or implantation into a subject, preferably a human. Also provided are methods for preparing and using the coated medical device.
摘要翻译：提供了包含一个或多个在其上分散有多个包含活性药物成分（API）和聚合物的微粒的表面的涂覆医疗装置（例如支架）。具体地，微粒在微粒相涂层中的器件表面上，即在不存在连续相涂覆的情况下作为离散微粒布置。医疗设备有效地将一个或多个API粘附到其表面，并且允许通过使用最少量的聚合物将API从设备表面控制释放到期望的治疗区域。医疗装置适于插入或植入受试者，优选人。还提供了制备和使用涂覆的医疗装置的方法。

8. 发明申请

US20080071351A1 ENDOPROSTHESIS WITH ADJUSTABLE SURFACE FEATURES 有权
标题翻译：具有可调节表面特征的内窥镜
公开(公告)号：US20080071351A1
公开(公告)日：2008-03-20
申请号：US11855541
申请日：2007-09-14
申请人： Aiden Flanagan , Dave McMorrow , Anthony Malone , Tim O'Connor , Barry Heaney
发明人： Aiden Flanagan , Dave McMorrow , Anthony Malone , Tim O'Connor , Barry Heaney
IPC分类号： A61F2/06
CPC分类号： A61L31/146 , A61F2/82 , A61F2/91 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/626
摘要： Endoprostheses (e.g., stents) containing adjustable surfaces are disclosed.
摘要翻译：公开了包含可调表面的内假体（例如，支架）。

9. 发明授权

US08182859B2 Using magnetism to prepare a medical device 失效
标题翻译：用磁性制备医疗器械
公开(公告)号：US08182859B2
公开(公告)日：2012-05-22
申请号：US12057135
申请日：2008-03-27
申请人： Liliana Atanasoska , Aiden Flanagan , Timothy O'Connor , David McMorrow , Robert Nolan , Anthony Malone , Jan Weber
发明人： Liliana Atanasoska , Aiden Flanagan , Timothy O'Connor , David McMorrow , Robert Nolan , Anthony Malone , Jan Weber
IPC分类号： A61L33/00
CPC分类号： B05B5/00 , A61F2/91 , A61F2210/009 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/60 , A61L2300/62 , B05C3/09 , B05D1/18 , B05D1/32 , B05D3/207 , B05D2401/32
摘要： The present invention is directed to methods, processes, and systems for delivering therapeutic agent to a medical device. Under some methods, processes, and systems of the invention, particles including a magnetic material and a therapeutic agent may be directed towards a medical device via magnetic attraction. In another embodiment particles including a magnetic material may force a therapeutic agent/solvent solution into porous matrix by using a magnetic attraction. In still another embodiment, a medical device having at least a portion thereof including a magnetic material is used to attract and adhere particles comprising magnetic material and therapeutic agent to a target surface of the medical device, wherein the particles are fused to the target surface.
摘要翻译：本发明涉及将治疗剂递送到医疗装置的方法，过程和系统。在一些方法下，本发明的方法和系统，包括磁性材料和治疗剂的颗粒可以通过磁吸引而引向医疗装置。在另一个实施方案中，包括磁性材料的颗粒可以通过使用磁吸引剂将治疗剂/溶剂溶液强制成多孔基质。在另一个实施例中，使用包括磁性材料的至少其一部分的医疗装置将包含磁性材料和治疗剂的颗粒吸附并附着到医疗装置的靶表面上，其中所述颗粒与目标表面融合。

10. 发明授权

US07875069B2 Stent with support element 失效
标题翻译：支架与支撑元件
公开(公告)号：US07875069B2
公开(公告)日：2011-01-25
申请号：US11526278
申请日：2006-09-21
申请人： Barry Heaney , Dave McMorrow , Anthony Malone , Aiden Flanagan , Tim O'Connor
发明人： Barry Heaney , Dave McMorrow , Anthony Malone , Aiden Flanagan , Tim O'Connor
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/852 , A61F2/86 , A61F2220/0033 , A61F2220/005 , A61F2220/0058 , A61F2250/0063 , A61F2250/0068
摘要： An implantable stent comprising a first strut having an abluminal surface, and subluminal surface, and at least one side surface; a first depression formed in the abluminal surface; and a first support element at least partially disposed in the first depression; wherein at least a portion of the first support element extends beyond the abluminal surface of the first strut.
摘要翻译：一种可植入支架，其包括具有近端表面的第一支柱和亚锥形表面以及至少一个侧表面; 形成在外侧表面的第一凹陷; 以及至少部分地设置在所述第一凹部中的第一支撑元件; 其中所述第一支撑元件的至少一部分延伸超过所述第一支柱的所述外侧表面。

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