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1. 发明授权

US08252845B1 Pterostilbene as an agonist for the peroxisome proliferator-activated receptor alpha isoform 有权
标题翻译：作为过氧化物酶体增殖物激活受体α亚型的激动剂的P芪烯
公开(公告)号：US08252845B1
公开(公告)日：2012-08-28
申请号：US13363959
申请日：2012-02-01
申请人： Agnes M. Rimando , Dennis R. Feller , Wallace H. Yokoyama
发明人： Agnes M. Rimando , Dennis R. Feller , Wallace H. Yokoyama
IPC分类号： A61K31/075 , A61K38/00 , A01N65/00
CPC分类号： A61K31/704 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/45 , A61K36/87 , A23V2200/3262 , A23V2250/21
摘要： Resveratrol has been reported to have hypolipidemic properties. We investigated whether resveratrol and its analogs: pterostilbene, piceatannol and resveratrol trimethyl ether, would activate the peroxisome proliferator-activated receptor alpha (PPARα) isoform. This nuclear receptor is proposed to mediate the activity of lipid-lowering drugs such as the fibrates. The four stilbenes and ciprofibrate (positive control) were evaluated for the activation of endogenous PPARα in H4IIEC3 cells transfected with a luciferase gene reporter construct. Pterostilbene demonstrated the highest induction of PPARα; the maximal response to pterostilbene was similar to that obtained with the hypolipidemic drug, ciprofibrate.
摘要翻译：据报道，白藜芦醇具有降血脂性质。我们调查了白藜芦醇及其类似物：ter芪烯，白藜芦醇和白藜芦醇三甲基醚是否会激活过氧化物酶体增殖物激活受体α（PPARα）同种型。提议这种核受体介导降脂药物如贝特类药物的活性。评估四种芪和环丙沙星（阳性对照）活化的荧光素酶基因报道构建体转染的H4IIEC3细胞内源性PPARα。 P il烯表现出最高的PPARα诱导; 对ter芪烯的最大反应与用降血脂药物环丙司酮获得的相似。

2. 发明申请

US20110060060A1 Pterostilbene as a New Agonist for the Peroxisome Proliferator-Activated Receptor Alpha Isoform 有权
标题翻译： Pterostilbene作为过氧化物酶体增殖物激活受体α亚型的新激动剂
公开(公告)号：US20110060060A1
公开(公告)日：2011-03-10
申请号：US12911376
申请日：2010-10-25
申请人： Agnes M. Rimando , Dennis R. Feller , Wallace H. Yokoyama
发明人： Agnes M. Rimando , Dennis R. Feller , Wallace H. Yokoyama
IPC分类号： A61K31/09 , A61P3/06 , B65D69/00
CPC分类号： A61K31/704 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/45 , A61K36/87 , A23V2200/3262 , A23V2250/21
摘要： Resveratrol, a stilbenoid antioxidant found in grapes, wine, peanuts and other berries, has been reported to have hypolipidemic properties. Resveratrol and its three analogs (pterostilbene, piceatannol and resveratrol trimethyl ether) were evaluated for their effects on the activation of the peroxisome proliferator-activated receptor alpha (PPARα) isoforms, a receptor shown to mediate the activity of lipid-lowering drugs such as the fibrates. The four stilbenes and ciprofibrate (positive control) were evaluated for the activation of endogenous PPARα in H4IIEC3 cells. Pterostilbene demonstrated the highest induction of PPARα demonstrating increases of 7- and 9-14 fold relative to control. The maximal responses to pterostilbene are similar to those obtained with the hypolipidemic drug, ciprofibrate; that is, pterostilbene acts as a PPARα agonist, like that of the fibrate class, and is a more effective hypolipidemic agent than resveratrol.
摘要翻译：据报道，白藜芦醇是葡萄，葡萄酒，花生和其他浆果中发现的芪类抗氧化剂，具有降血脂特性。评估白藜芦醇及其三种类似物（ter芪二烯，白藜芦醇和白藜芦醇三甲基醚）对过氧化物酶体增殖物激活受体α（PPARα）同工型的活化的影响，所述受体显示为介导降脂药物的活性，例如贝特类。评估了四苯并苯和环丙沙星（阳性对照）在H4IIEC3细胞中内源性PPARα的活化。 Pterostilbene表现出最高的PPARα诱导，显示相对于对照增加7和9-14倍。对ter芪烯的最大反应与使用降血脂药物环丙沙星获得的类似; 也就是说，ter芪烯作为PPARα激动剂，与贝特类相似，是比白藜芦醇更有效的降血脂药。

3. 发明授权

US08133917B2 Pterostilbene as an agonist for the peroxisome proliferator-activated receptor alpha isoform 有权
标题翻译：作为过氧化物酶体增殖物激活受体α亚型的激动剂的P芪烯
公开(公告)号：US08133917B2
公开(公告)日：2012-03-13
申请号：US12911376
申请日：2010-10-25
申请人： Agnes M. Rimando , Dennis R. Feller , Wallace H. Yokoyama
发明人： Agnes M. Rimando , Dennis R. Feller , Wallace H. Yokoyama
IPC分类号： A61K31/075 , A61K38/00 , A01N65/00
CPC分类号： A61K31/704 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/45 , A61K36/87 , A23V2200/3262 , A23V2250/21
摘要： Resveratrol, a stilbenoid antioxidant found in grapes, wine, peanuts and other berries, has been reported to have hypolipidemic properties. Resveratrol and its three analogs (pterostilbene, piceatannol and resveratrol trimethyl ether) were evaluated for their effects on the activation of the peroxisome proliferator-activated receptor alpha (PPARα) isoforms, a receptor shown to mediate the activity of lipid-lowering drugs such as the fibrates. The four stilbenes and ciprofibrate (positive control) were evaluated for the activation of endogenous PPARα in H4IIEC3 cells. Pterostilbene demonstrated the highest induction of PPARα demonstrating increases of 7- and 9-14 fold relative to control. The maximal responses to pterostilbene are similar to those obtained with the hypolipidemic drug, ciprofibrate; that is, pterostilbene acts as a PPARα agonist, like that of the fibrate class, and is a more effective hypolipidemic agent than resveratrol.
摘要翻译：据报道，白藜芦醇是葡萄，葡萄酒，花生和其他浆果中发现的芪类抗氧化剂，具有降血脂性质。评估白藜芦醇及其三种类似物（ter芪二烯，白藜芦醇和白藜芦醇三甲基醚）对过氧化物酶体增殖物激活受体α（PPARα）同工型的活化的影响，所述受体显示为介导降脂药物的活性，例如贝特类。评估了四苯并苯和环丙沙星（阳性对照）在H4IIEC3细胞中内源性PPARα的活化。 Pterostilbene表现出最高的PPARα诱导，显示相对于对照增加7和9-14倍。对ter芪烯的最大反应与用降血脂药物环丙沙星获得的相似; 也就是说，ter芪烯作为PPARα激动剂，与贝特类相似，是比白藜芦醇更有效的降血脂药。

4. 发明申请

US20120129804A1 METHODS OF REDUCING ABSORPTION OF TRANS FATTY ACIDS USING WATER-INSOLUBLE CELLULOSE DERIVATIVES 审中-公开
标题翻译：使用水不溶性纤维素衍生物减少转运脂肪酸的吸收方法
公开(公告)号：US20120129804A1
公开(公告)日：2012-05-24
申请号：US13124533
申请日：2009-10-16
申请人： Kerr W.H. Anderson , David R. Albers , Scott A. Young , Wallace H. Yokoyama
发明人： Kerr W.H. Anderson , David R. Albers , Scott A. Young , Wallace H. Yokoyama
IPC分类号： A61K31/717 , A61P3/00
CPC分类号： A23L33/24 , A23L29/262
摘要： Provided are food products comprising at least 0.5 g of trans fatty acid per serving and one or more water-insoluble cellulose derivatives in an amount sufficient to reduce absorption of the trans fatty acid by a mammal consuming the food product, methods of ameliorating the harmful effects of trans fatty acids on a mammal that has consumed trans fatty acids, and methods of reducing the amount of trans fatty acids capable of being absorbed by a mammal ingesting a trans fatty acid containing food product.
摘要翻译：提供的是每份含有至少0.5g反式脂肪酸的食品和一种或多种水不溶性纤维素衍生物，其量足以减少消耗食品的哺乳动物吸收反式脂肪酸，改善有害影响的方法反式脂肪酸对已经消耗反式脂肪酸的哺乳动物的反式脂肪酸的量，以及减少能够被摄入含反式脂肪酸的食品的哺乳动物吸收的反式脂肪酸的量的方法。

5. 发明申请

US20110130360A1 PREVENTING OR REDUCING OXIDATIVE STRESS OR OXIDATIVE CELL INJURY 审中-公开
标题翻译：预防或减少氧化应激或氧化性细胞损伤
公开(公告)号：US20110130360A1
公开(公告)日：2011-06-02
申请号：US12446362
申请日：2007-10-18
申请人： Stephanie K. Lynch , Wallace H. Yokoyama , Maciej Turowski
发明人： Stephanie K. Lynch , Wallace H. Yokoyama , Maciej Turowski
IPC分类号： A61K31/717 , C08B11/04 , A61P39/06
CPC分类号： A61K31/717
摘要： A water-insoluble cellulose derivative, such as ethyl cellulose is useful for preventing or reducing oxidative stress or oxidative cell injury in tissues of an animal and in particular for influencing the level Stearoyl-CoA Desaturase-1 (SCD1) gene expression or ATP synthase mitochondrial F1 complex assembly factor 1 (ATPAF1) gene expression in non-adipose tissues of the animal.
摘要翻译：水不溶性纤维素衍生物如乙基纤维素可用于预防或减少动物组织中的氧化应激或氧化性细胞损伤，特别是用于影响硬脂酰辅酶A去饱和酶-1（SCD1）基因表达或ATP合成酶线粒体的水平 F1复合装配因子1（ATPAF1）基因在动物非脂肪组织中的表达。

6. 发明申请

US20100331278A1 USES OF CATIONIC HYDROXYETHYLCELLULOSE IN ORAL INGESTION FORMS, AND PREVENTION AND TREATMENT OF METABOLIC DISORDERS 审中-公开
标题翻译：口服羟丙基纤维素在口腔吸收形式中的应用及预防和治疗代谢障碍
公开(公告)号：US20100331278A1
公开(公告)日：2010-12-30
申请号：US12775180
申请日：2010-05-06
申请人： W. H. Kerr Anderson , Shao-Ching Hung , William T. Stott , Maciej Turowski , Wallace H. Yokoyama , Scott A. Young
发明人： W. H. Kerr Anderson , Shao-Ching Hung , William T. Stott , Maciej Turowski , Wallace H. Yokoyama , Scott A. Young
IPC分类号： A61K31/717 , C08B11/08 , A61P3/04 , A61P3/00 , A61P3/06 , A61P3/10
CPC分类号： A61K31/717 , A23L2/52 , A23L33/24 , A23V2002/00 , A23V2200/326 , A23V2200/332 , A23V2200/322 , A23V2250/5108
摘要： Described are an oral ingestion form comprising cationic hydroxyethylcellulose, and methods of using the same in prevention and treatment of metabolic disorders.
摘要翻译：描述了包含阳离子羟乙基纤维素的口服摄取形式，及其用于预防和治疗代谢紊乱的方法。

7. 发明申请

US20100112122A1 METHOD OF PREFERENTIALLY REDUCING ABSORBABILITY OF SATURATED FATTY ACIDS 审中-公开
标题翻译：优选降低饱和脂肪酸的吸收性的方法
公开(公告)号：US20100112122A1
公开(公告)日：2010-05-06
申请号：US12112775
申请日：2008-04-30
申请人： Yun-Jeong Hong , Scott A. Young , Maciej Turowski , Wallace H. Yokoyama , Marsha L. Langhorst , David R. Albers
发明人： Yun-Jeong Hong , Scott A. Young , Maciej Turowski , Wallace H. Yokoyama , Marsha L. Langhorst , David R. Albers
IPC分类号： A23K1/16 , A23D9/00 , A23D7/00 , A23L1/39 , G01N33/03
CPC分类号： A23D9/007 , A23L29/262 , A23L33/20 , A23L33/24
摘要： A method of reducing the amount of saturated fatty acids capable of being absorbed by an animal body relative to the amount of unsaturated fatty acids capable of being absorbed by an animal body in or from a fat-containing food product comprises the steps of i) identifying a food product comprising one or more saturated fatty acids and one or more unsaturated fatty acids, and ii) incorporating one or more water-soluble cellulose derivatives in the food product or administering one or more water-soluble cellulose derivatives before, during or after the consumption of the food product.
摘要翻译：相对于能够被含脂肪的食品中的动物身体吸收的不饱和脂肪酸的量，减少能够被动物身体吸收的饱和脂肪酸的量的方法包括以下步骤：i）鉴定包含一种或多种饱和脂肪酸和一种或多种不饱和脂肪酸的食品，以及ii）将一种或多种水溶性纤维素衍生物掺入食品中或在所述食品中之前，期间或之后施用一种或多种水溶性纤维素衍生物消费食品。

8. 发明申请

US20110230439A1 METHODS OF REDUCING ABSORPTION OF TRANS FATTY ACIDS USING WATER-SOLUBLE CELLULOSE DERIVATIVES 审中-公开
标题翻译：使用水溶性纤维素衍生物减少转运脂肪酸的吸收方法
公开(公告)号：US20110230439A1
公开(公告)日：2011-09-22
申请号：US13124537
申请日：2009-10-16
申请人： Kerr Anderson , David R. Albers , Scott A. Young , Wallace H. Yokoyama
发明人： Kerr Anderson , David R. Albers , Scott A. Young , Wallace H. Yokoyama
IPC分类号： A61K31/717 , A61P3/06
CPC分类号： A23L33/24 , A23L29/262 , A23L33/12
摘要： Provided are food products comprising at least 0.5 g of trans fatty acid per serving and at least 1.33 weight percent of one or more water-soluble cellulose derivatives, based on the total weight of the food product, methods of ameliorating the harmful effects of trans fatty acids on a mammal that has consumed trans fatty acids, and methods of reducing the amount of trans fatty acids capable of being absorbed by a mammal ingesting a trans fatty acid containing food product.
摘要翻译：提供的食品包含每份至少0.5g的反式脂肪酸和至少1.33％（重量）的一种或多种水溶性纤维素衍生物，基于食品的总重量，改善反式脂肪的有害作用的方法已经消耗反式脂肪酸的哺乳动物上的酸，以及减少能够被哺乳动物摄入含反式脂肪酸的食品吸收的反式脂肪酸的量的方法。

9. 发明申请

US20090176735A1 PREVENTING OR REDUCING OXIDATIVE STRESS OR OXIDATIVE CELL INJURY 审中-公开
标题翻译：预防或减少氧化应激或氧化性细胞损伤
公开(公告)号：US20090176735A1
公开(公告)日：2009-07-09
申请号：US12051283
申请日：2008-03-19
申请人： Wallace H. Yokoyama , Qiming Shao , Maciej Turowski , Stephanie K. Lynch
发明人： Wallace H. Yokoyama , Qiming Shao , Maciej Turowski , Stephanie K. Lynch
IPC分类号： A61K31/717 , A61P39/06
CPC分类号： A61K31/717
摘要： A water-soluble cellulose derivative is useful for preventing or reducing oxidative stress or oxidative cell injury in tissues of an animal and in particular for regulating Stearoyl-CoA Desaturase-1 gene expression and/or ATPF1 gene expression in non-adipose tissues of the animal.
摘要翻译：水溶性纤维素衍生物可用于预防或减少动物组织中的氧化应激或氧化细胞损伤，特别是用于在动物的非脂肪组织中调节硬脂酰辅酶A脱氢酶-1基因表达和/或ATPF1基因表达。

10. 发明申请

US20080280854A1 PREVENTING OR REDUCING OXIDATIVE STRESS OR OXIDATIVE CELL INJURY 审中-公开
标题翻译：预防或减少氧化应激或氧化性细胞损伤
公开(公告)号：US20080280854A1
公开(公告)日：2008-11-13
申请号：US12051249
申请日：2008-03-19
申请人： Wallace H. Yokoyama , Qiming Shao , Maciej Turowski , Stephanie K. Lynch
发明人： Wallace H. Yokoyama , Qiming Shao , Maciej Turowski , Stephanie K. Lynch
IPC分类号： A61K31/717 , A61P43/00
CPC分类号： A61K31/717
摘要： A water-soluble cellulose derivative is useful for preventing or reducing oxidative stress or oxidative cell injury in tissues of an animal and in particular for regulating Stearoyl-CoA Desaturase-1 gene expression and/or ATPF1 gene expression in non-adipose tissues of the animal.
摘要翻译：水溶性纤维素衍生物可用于预防或减少动物组织中的氧化应激或氧化细胞损伤，特别是用于在动物的非脂肪组织中调节硬脂酰辅酶A脱氢酶-1基因表达和/或ATPF1基因表达。

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