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1. 发明申请

US20070154582A1 Preventative and Treatment Effects of Morinda Citrifolia as an Aromatase Inhibitor 审中-公开
标题翻译： Morinda Citrifolia作为芳香酶抑制剂的预防和治疗效果
公开(公告)号：US20070154582A1
公开(公告)日：2007-07-05
申请号：US11668035
申请日：2007-01-29
申请人： Afa Palu , Brett West , Claude Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
发明人： Afa Palu , Brett West , Claude Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
IPC分类号： A61K36/746
CPC分类号： A61K36/746 , A23L33/105 , A61K31/353
摘要： The present invention is directed to methods of inhibiting Aromatase or Aromatase enzymes that function to convert androgens to estrogens, inhibiting receptors from binding with estrogen, and reducing and/or regulating estrogen production, as well as reducing the amount of estrogen produced within the body and regulating such production. The present invention methods and compositions effectively function to treat estrogen-dependent cancers, and particularly inhibit, destroy, and reverse the effects of of estrogen-dependent cancerous tumors through the introduction into the body (e.g. ingesting) a safe, pre-determined dosage of a naturaceutical composition formulated with or comprising one or more processed Morinda citrifolia products for a safe, pre-determined duration.
摘要翻译：本发明涉及抑制作用于将雄激素转化成雌激素，抑制受体与雌激素结合，减少和/或调节雌激素产生以及减少体内产生的雌激素的量的芳香酶或芳香酶的方法，调节这种生产。本发明的方法和组合物有效地用于治疗雌激素依赖性癌症，特别是抑制，破坏和逆转雌激素依赖性癌性肿瘤的作用，通过引入体内（例如摄取）安全的预定剂量配制或包含一种或多种加工的Morinda citrifolia产品的保健组合物用于安全的预定持续时间。

2. 发明申请

US20070286910A1 Method and Composition for Administering Bioactive Compounds Derived from Morinda Citrifolia 有权
标题翻译：用于管理来自海巴戟天的生物活性化合物的方法和组合物
公开(公告)号：US20070286910A1
公开(公告)日：2007-12-13
申请号：US11746798
申请日：2007-05-10
申请人： Bing-Nan Zhou , Chen Su , Afa Palu , Brett West , Shixin Dong , Claude Jensen , Stephen Story
发明人： Bing-Nan Zhou , Chen Su , Afa Palu , Brett West , Shixin Dong , Claude Jensen , Stephen Story
IPC分类号： A61K36/00 , A61P43/00
CPC分类号： A61K36/746
摘要： This invention relates to a method and composition for providing in various health benefits by administering various bioactive compounds derived from the plant Morinda cirtrifolia to individuals. This invention relates to using one or more of the following: Noni Leaf Extract; Noni Leaf Juice; and/or Roast Leaf. More particularly this invention relates to administering one or more of the following: Pyro-phorbide a, Pheophorbide a, Purpin 7, and/or Pheophorbide all which may be derived from Noni leaf extract, Noni leaf juice, and/or Roast leaf. Moreover, the foregoing formulations result in alleviating pain and inflammation.
摘要翻译：本发明涉及通过向个体施用衍生自植物Morinda cirtrifolia的各种生物活性化合物来提供各种健康益处的方法和组合物。本发明涉及使用以下一种或多种：非叶提取物; 诺丽叶汁和/或烤叶。更具体地说，本发明涉及施用一种或多种以下物质：可以衍生自Noni叶提取物，Noni叶汁和/或Rost叶的Pyro-Phorbide a，Pheophorbide a，Purpin 7和/或Pheororbide all。此外，上述制剂导致减轻疼痛和炎症。

3. 发明申请

US20070184137A1 Morinda Citrifolia L. Based Formulations for Inhibiting Matrix Metalloproteinase Enzymes 审中-公开
标题翻译：用于抑制基质金属蛋白酶酶的Morinda Citrifolia L.制剂
公开(公告)号：US20070184137A1
公开(公告)日：2007-08-09
申请号：US11564166
申请日：2006-11-28
申请人： Afa Palu , Johannes Westendorf , Brett West , Bing-Nan Zhou , Claude Jensen , Stephen Story
发明人： Afa Palu , Johannes Westendorf , Brett West , Bing-Nan Zhou , Claude Jensen , Stephen Story
IPC分类号： A61K36/746
CPC分类号： A61K36/746
摘要： The present invention relates to methods and formulations directed to the management of various Matrix Metalloproteinases enzymes comprising the administration of processed Morinda citrifolia based formulations.
摘要翻译：本发明涉及用于管理各种基质金属蛋白酶的方法和制剂，所述基质金属蛋白酶包括施用经加工的基于Morinda citrifolia的制剂。

4. 发明申请

US20070166417A1 Formulation and Methods for Use of Morinda Citrifolia Seed Oil 审中-公开
标题翻译：海伦达柠檬油种子油的配方和使用方法
公开(公告)号：US20070166417A1
公开(公告)日：2007-07-19
申请号：US11561987
申请日：2006-11-21
申请人： Afa Palu , Bing-Nan Zhou , Brett West , Claude Jensen , Stephen Story
发明人： Afa Palu , Bing-Nan Zhou , Brett West , Claude Jensen , Stephen Story
IPC分类号： A61K36/746 , A61K31/7048 , A61K31/353 , A61K31/202
CPC分类号： A61K36/746 , A61K31/202 , A61K31/353 , A61K31/7048 , A61K36/45 , A61K36/73 , A61K36/87 , A61K2300/00
摘要： The present invention relates to nutraceutical formulations and methods for use of fetid oil derived from Morinda citrifolia seeds. Research supporting this invention indicates that processed Morinda citrifolia seed products may be used for weight management and health promotion. The present invention is supported by research findings related to the nutritional benefits of fetid oil extracted from the seeds contained within Morinda citrifolia fruit. This oil has been found to include high concentrations of linoleic acid, which is known to increase metabolic rate, help prevent cancer, protect the liver, and help prevent the build up of artery plaque. These observations are consistent with the concept that noni, can positively affect the regulation of excess body weight and promote overall good health.
摘要翻译：本发明涉及营养药物制剂和使用源自海巴戟天种子的无精油的方法。支持本发明的研究表明，加工的Morinda citrifolia种子产品可用于体重管理和健康促进。本发明得到了与从含有海参的果实中提取的种子提取的蓖麻油的营养益处有关的研究结果。已经发现这种油包括高浓度的亚油酸，已知其增加代谢率，有助于预防癌症，保护肝脏，并有助于防止动脉斑块的积聚。这些观察结果与noni的概念一致，可以积极地影响体重过重的调节，促进身体健康。

5. 发明申请

US20070154580A1 Antiviral Morinda Citrifolia L. Based Formulations and Methods of Administration 失效
标题翻译： Antiviral Morinda Citrifolia L. based Formulations and Methods of Administration
公开(公告)号：US20070154580A1
公开(公告)日：2007-07-05
申请号：US11562224
申请日：2006-11-21
申请人： Afa Palu , Chen Su , Bing-Nan Zhou , Brett West , Claude Jensen , Stephen Story
发明人： Afa Palu , Chen Su , Bing-Nan Zhou , Brett West , Claude Jensen , Stephen Story
IPC分类号： A61K36/746
CPC分类号： A61K36/746 , A23L33/105 , A23V2002/00 , A61K8/97 , A61K2800/782 , A61Q19/00 , A23V2250/21 , A23V2200/308 , A23V2200/318 , A23V2200/322 , A23V2200/306 , A23V2200/324
摘要： The present invention relates to methods and formulations directed to the management of Cathepsin G, Cathepsin S, Cathepsin B, Cathepsin L, Butyryl Cholinesterase, Peptidase HIV-1, and NF-kB enzymes comprising the administration of processed Morinda citrifolia based formulations.
摘要翻译：本发明涉及针对组织蛋白酶G，组织蛋白酶S，组织蛋白酶B，组织蛋白酶L，丁酰胆碱酯酶，肽酶HIV-1和包含施用加入的基于柠檬酸的加入的柠檬酸假单胞菌制剂的NF-kB酶的方法和制剂。

6. 发明申请

US20070281903A1 Morinda Citrifolia-Based Formulation 5-LOX And 15-LOX 审中-公开
标题翻译： Morinda Citrifolia-based配方5-LOX和15-LOX
公开(公告)号：US20070281903A1
公开(公告)日：2007-12-06
申请号：US11842247
申请日：2007-08-21
申请人： Afa Palu , Brett West , Claude Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
发明人： Afa Palu , Brett West , Claude Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
IPC分类号： A61K31/7016 , A61K31/352 , A61P29/00 , C07D311/30
CPC分类号： A61K31/352 , A61K31/7016 , A61K36/746
摘要： The present invention is directed to methods and formulations for inhibiting Lipoxygenase enzymes that function to biosynthesize or metabolize arachidonic acid into its intermediate Leukotriene constituents, as well as a method and formulation for treating and preventing diseases, including inflammatory diseases, and the symptoms associated with such diseases. The present invention methods and formulations effectively function as such through the introduction into the body (e.g. ingesting) a safe, pre-determined dosage of a naturaceutical composition formulated with or comprising one or more processed Morinda citrifolia products for a safe, pre-determined duration, wherein the processed Morinda citrifolia product may comprise one or more isolated active ingredients.
摘要翻译：本发明涉及用于抑制作用于将花生四烯酸生物合成或代谢为其中间白细胞三烯成分的脂氧合酶的方法和制剂，以及用于治疗和预防包括炎性疾病在内的疾病的方法和制剂，以及与之相关的症状疾病本发明的方法和制剂通过引入身体（例如摄取）有效地起作用，以安全，预定的剂量与由一种或多种加工的Morinda citrifolia产品配制或包含一种或多种加工的Morinda citrifolia产品的安全，预定的持续时间，其中所述加工的Morinda citrifolia产品可以包含一种或多种分离的活性成分。

7. 发明申请

US20060269630A1 Morinda citrifolia as a 5-Lipoxygenase inhibitor 审中-公开
标题翻译：海巴戟天作为5-脂氧合酶抑制剂
公开(公告)号：US20060269630A1
公开(公告)日：2006-11-30
申请号：US11500728
申请日：2006-08-08
申请人： Afa Palu , Brett West , Claude Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
发明人： Afa Palu , Brett West , Claude Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
IPC分类号： A61K36/746
CPC分类号： A61K36/746
摘要： The present invention is directed to methods and formulations for inhibiting Lipoxygenase or Lipoxygenase enzymes that function to biosynthesize or metabolize arachidonic acid into its intermediate Leukotriene constituents, as well as a method and formulation for treating and preventing inflammatory diseases and the symptoms associated with such diseases. The present invention methods and formulations effectively function as such through the introduction into the body (e.g. ingesting) a safe, pre-determined dosage of a naturaceutical composition formulated with or comprising one or more processed Morinda citrifolia products for a safe, pre-determined duration, wherein the processed Morinda citrifolia product may comprise one or more isolated active ingredients.
摘要翻译：本发明涉及用于抑制作用于将花生四烯酸生物合成或代谢为其中间体白三烯组分的脂氧合酶或脂氧合酶的方法和制剂，以及用于治疗和预防炎性疾病和与此类疾病相关的症状的方法和制剂。本发明的方法和制剂通过引入身体（例如摄取）有效地起作用，以安全，预定的剂量与由一种或多种加工的Morinda citrifolia产品配制或包含一种或多种加工的Morinda citrifolia产品的安全，预定的持续时间，其中所述加工的Morinda citrifolia产品可以包含一种或多种分离的活性成分。

8. 发明申请

US20060204601A1 Formulations and methods for preventing and treating substance abuse and addiction 审中-公开
标题翻译：预防和治疗药物滥用和成瘾的制剂和方法
公开(公告)号：US20060204601A1
公开(公告)日：2006-09-14
申请号：US11076992
申请日：2005-03-09
申请人： Afa Palu , Bing-Nan Zhou , Brett West , Claude Jensen , Stephen Story
发明人： Afa Palu , Bing-Nan Zhou , Brett West , Claude Jensen , Stephen Story
IPC分类号： A61K36/746
CPC分类号： A61K36/746 , A23L33/105 , A61K2300/00
摘要： The invention relates to formulations and methods for preventing and/or treating substance abuse, addiction, withdrawal symptoms, and anticipation associated with substance abuse. In particular the invention relates to formulations comprising at least one processed Morinda citrifolia L. product, and methods comprising the administration of at least one processed Morinda citrifolia L product to prevent and/or treat substance abuse, addiction, withdrawal symptoms, and anticipation associated with substance abuse in living organisms. Embodiments of the invention further comprise Morinda citrifolia based nutraceuticals and administration thereof to affect regulation of dopamine levels, inhibition of opioid receptors, inhibition of mu opioid receptors, inhibition of kappa opioid receptors, inhibition of delta opioid receptors, acting as NMDA antagonist, inhibition of sensitization of NMDA receptors, and/or acting as opiate antagonists.
摘要翻译：本发明涉及用于预防和/或治疗药物滥用，成瘾，戒断症状以及与药物滥用有关的预期的制剂和方法。特别地，本发明涉及包含至少一种经加工的Morinda citrifolia L.产品的制剂，以及包括施用至少一种加工的Morinda citrifolia L产品以防止和/或治疗药物滥用，成瘾，戒断症状和与生物体内药物滥用。本发明的实施方案还包括基于海巴戟天的营养药物和其施用以影响多巴胺水平的调节，阿片样物质受体的抑制，μ阿片受体的抑制，κ阿片受体的抑制，作为NMDA拮抗剂的δ阿片受体的抑制，抑制 NMDA受体的敏化和/或起鸦片拮抗作用。

9. 发明申请

US20070202206A1 Morinda Citrifolia Leaf Juice And Leaf Extract Based Formulations 审中-公开
标题翻译： Morinda Citrifolia叶汁和叶提取物制剂
公开(公告)号：US20070202206A1
公开(公告)日：2007-08-30
申请号：US11560407
申请日：2006-11-16
申请人： Afa Palu , Bing-Nan Zhou , Chen Su , Claude Jensen , Brett West , Stephen Story
发明人： Afa Palu , Bing-Nan Zhou , Chen Su , Claude Jensen , Brett West , Stephen Story
IPC分类号： A61K36/746
CPC分类号： A61K36/746
摘要： A method and composition for inhibiting certain enzymes, where such inhibition results in various health benefits is provided. More particularly, a method and composition using one or more of the following: Noni Leaf Extract; Noni Leaf Juice; and/or Roast Leaf to inhibit the following: HMG-CoA Reductase; Phosphodiesterases (3 and 4) PDE3 and PDE4; 5-Lipoxygenase (LOX) and 15-LOX; Xanthine Oxidase (XO); Gamma Amino Butyric Acid (GABA) and the growth of the second most common human skin cancer cell line, is provided. Moreover, the foregoing enzymatic inhibitions result in: alleviating pain and inflammation; treating prostate cancers; lowering cholesterol levels; counteracting Diabetes Type II; maintaining the highest possible integrity of cellular interactions in the brain resulting in an undisturbed neural function, (i.e., neuroprotection); ameliorating the effects of asthma and allergies; improving energy; improving insulin secretion; decreasing kidney stone accumulation; alleviating the effects of gout; minimizing convulsions related to epilepsy and other seizure disorders; and providing palliative effects to those addicted to drugs.
摘要翻译：用于抑制某些酶的方法和组合物，其中这种抑制作用产生各种健康益处。更具体地，使用以下一种或多种的方法和组合：非叶提取物; 诺丽叶汁和/或烤叶抑制以下物质：HMG-CoA还原酶; 磷酸二酯酶（3和4）PDE3和PDE4; 5-脂氧合酶（LOX）和15-LOX; 黄嘌呤氧化酶（XO）; 提供γ-氨基丁酸（GABA）和第二常见的人类皮肤癌细胞系的生长。此外，上述酶抑制导致：缓解疼痛和炎症; 治疗前列腺癌; 降低胆固醇水平; 抵制糖尿病II型; 保持脑中细胞相互作用的最高可能完整性，导致不受干扰的神经功能（即神经保护）; 改善哮喘和过敏的作用; 改善能源; 改善胰岛素分泌; 减少肾结石积累; 减轻痛风的影响; 减少与癫痫和其他癫痫发作相关的惊厥; 并为吸毒成瘾者提供姑息治疗。

10. 发明申请

US20070166416A1 Formulations and Methods for Preventing and Treating Substance Abuse and Addiction 审中-公开
标题翻译：预防和治疗药物滥用和成瘾的制剂和方法
公开(公告)号：US20070166416A1
公开(公告)日：2007-07-19
申请号：US11686451
申请日：2007-03-15
申请人： Afa Palu , Bing-Nan Zhou , Brett West , Claude Jensen , Stephen Story
发明人： Afa Palu , Bing-Nan Zhou , Brett West , Claude Jensen , Stephen Story
IPC分类号： A61K36/746 , A61K31/7048 , A61K31/56 , A61K31/375
CPC分类号： A61K36/746 , A23L33/105 , A61K2300/00
摘要： The invention relates to formulations and methods for preventing and/or treating substance abuse, addiction, withdrawal symptoms, and anticipation associated with substance abuse. In particular the invention relates to formulations comprising at least one processed Morinda citrifolia L. product, and methods comprising the administration of at least one processed Morinda citrifolia L product to prevent and/or treat substance abuse, addiction, withdrawal symptoms, and anticipation associated with substance abuse in living organisms. Embodiments of the invention further comprise Morinda citrifolia based nutraceuticals and administration thereof to affect regulation of dopamine levels, inhibition of opioid receptors, inhibition of mu opioid receptors, inhibition of kappa opioid receptors, inhibition of delta opioid receptors, acting as NMDA antagonist, inhibition of sensitization of NMDA receptors, and/or acting as opiate antagonists.
摘要翻译：本发明涉及用于预防和/或治疗药物滥用，成瘾，戒断症状以及与药物滥用有关的预期的制剂和方法。特别地，本发明涉及包含至少一种经加工的Morinda citrifolia L.产品的制剂，以及包括施用至少一种加工的Morinda citrifolia L产品以防止和/或治疗药物滥用，成瘾，戒断症状和与生物体内药物滥用。本发明的实施方案还包括基于海巴戟天的营养药物和其施用以影响多巴胺水平的调节，阿片样物质受体的抑制，μ阿片受体的抑制，κ阿片受体的抑制，作为NMDA拮抗剂的δ阿片受体的抑制，抑制 NMDA受体的敏化和/或起鸦片拮抗作用。

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