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1. 发明授权

US08574642B2 Antiviral Morinda citrifolia L. based formulations and methods of administration 失效
标题翻译：抗病毒药物Morinda citrifolia L.的制剂和给药方法
公开(公告)号：US08574642B2
公开(公告)日：2013-11-05
申请号：US11562224
申请日：2006-11-21
申请人： Afa Kehaati Palu , Chen Su , Bing-Nan Zhou , Brett West , Claude Jarake Jensen , Stephen Story
发明人： Afa Kehaati Palu , Chen Su , Bing-Nan Zhou , Brett West , Claude Jarake Jensen , Stephen Story
IPC分类号： A61K36/00
CPC分类号： A61K36/746 , A23L33/105 , A23V2002/00 , A61K8/97 , A61K2800/782 , A61Q19/00 , A23V2250/21 , A23V2200/308 , A23V2200/318 , A23V2200/322 , A23V2200/306 , A23V2200/324
摘要： The present invention relates to methods and formulations directed to the management of Cathepsin G, Cathepsin S, Cathepsin B, Cathepsin L, Butyryl Cholinesterase, Peptidase HIV-1, and NF-kB enzymes comprising the administration of processed Morinda citrifolia based formulations.
摘要翻译：本发明涉及用于管理组织蛋白酶G，组织蛋白酶S，组织蛋白酶B，组织蛋白酶L，丁酰胆碱酯酶，肽酶HIV-1和包含施用加工的海巴戟天基配方的NF-kB酶的方法和制剂。

2. 发明申请

US20090053341A1 Preventative and Treatment Effects of Morinda Citrifolia as an Aromatase Inhibitor 审中-公开
标题翻译： Morinda Citrifolia作为芳香酶抑制剂的预防和治疗效果
公开(公告)号：US20090053341A1
公开(公告)日：2009-02-26
申请号：US11842503
申请日：2007-08-21
申请人： Afa Kehaati Palu , Brett West , Claude Jarake Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
发明人： Afa Kehaati Palu , Brett West , Claude Jarake Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
IPC分类号： A61K36/746 , A61P35/00
CPC分类号： A61K36/746
摘要： The present invention is directed to methods of inhibiting Aromatase or Aromatase enzymes that function to convert androgens to estrogens, inhibiting receptors from binding with estrogen, and reducing and/or regulating estrogen production, as well as reducing the amount of estrogen produced within the body and regulating such production. The present invention methods and compositions effectively function to treat estrogen-dependent cancers, and particularly inhibit, destroy, and reverse the effects of estrogen-dependent cancerous tumors through the introduction into the body (e.g. ingesting) a safe, pre-determined dosage of a naturaceutical composition formulated with or comprising one or more processed Morinda citrifolia products for a safe, pre-determined duration.
摘要翻译：本发明涉及抑制作用于将雄激素转化成雌激素，抑制受体与雌激素结合，减少和/或调节雌激素产生以及减少体内产生的雌激素的量的芳香酶或芳香酶的方法，调节这种生产。本发明的方法和组合物有效地用于治疗雌激素依赖性癌症，特别是抑制，破坏和逆转雌激素依赖性癌性肿瘤通过引入体内的作用（例如摄取）安全的预定剂量的配制或包含一种或多种加工的Morinda citrifolia产品的保健组合物用于安全的预定持续时间。

3. 发明申请

US20090022830A1 MORINDA CITRIFOLIA LEAF EXTRACT COMPOSITIONS AND METHODS OF OBTAINING THE SAME 审中-公开
标题翻译： MORINDA CITRIFOLIA LEAF萃取组合物及其获得方法
公开(公告)号：US20090022830A1
公开(公告)日：2009-01-22
申请号：US11778723
申请日：2007-07-17
申请人： Afa Kehaati Palu , Chen Su , Bing-Nan Zhou , Stephen Story , Claude Jarake Jensen
发明人： Afa Kehaati Palu , Chen Su , Bing-Nan Zhou , Stephen Story , Claude Jarake Jensen
IPC分类号： A61K36/00
CPC分类号： A61K36/746
摘要： Methods and compositions relating to leaf extracts obtained from removing liquids from relatively dry Morinda citrifolia leaves. Methods and compositions relating to a leaf serum created from combining leaf extract and fruit juice from the Morinda citrifolia L. plant. Methods and compositions relating to leaf extract compositions comprising one or more of the leaf extracts and leaf serums.
摘要翻译：与通过从相对干燥的Morinda citrifolia叶中除去液体获得的叶提取物相关的方法和组合物。与叶片提取物和来自Morinda citrifolia L.植物的果汁组合的叶片血清相关的方法和组合物。涉及包含一种或多种叶提取物和叶血清的叶提取物组合物的方法和组合物。

4. 发明申请

US20090022828A1 METHODS AND COMPOSITIONS FOR INHIBITING ANGIOTENSIN CONVERTING AND CHYMASE ENZYMES 审中-公开
标题翻译：抑制血管紧张素转化酶和胆固醇酶的方法和组合物
公开(公告)号：US20090022828A1
公开(公告)日：2009-01-22
申请号：US11778432
申请日：2007-07-16
申请人： Afa Kehaati Palu , Chen Su , Bing-Nan Zhou , Stephen Story , Claude Jarake Jensen
发明人： Afa Kehaati Palu , Chen Su , Bing-Nan Zhou , Stephen Story , Claude Jarake Jensen
IPC分类号： A61K36/746 , A61P9/00 , A61P9/10 , A61P9/12
CPC分类号： A61K36/746
摘要： The present invention relates to medicinal products, as well as to health and wellness food products, and particularly to a medicinal product or a health and wellness food product for inhibiting Angiotensin Converting Enzyme and Chymase enzyme pathways.
摘要翻译：本发明涉及医药产品，以及健康和保健食品，特别涉及用于抑制血管紧张素转化酶和糜酶酶途径的药用产品或健康和保健食品。

5. 发明申请

US20080206376A1 METHODS AND COMPOSITIONS FOR INHIBITING ANGIOTENSIN CONVERTING AND CHYMASE ENZYMES 审中-公开
标题翻译：抑制血管紧张素转化酶和胆固醇酶的方法和组合物
公开(公告)号：US20080206376A1
公开(公告)日：2008-08-28
申请号：US11677722
申请日：2007-02-22
申请人： Afa Kehaati Palu , Chen Su , Bing-Nan Zhou , Claude Jarakae Jensen , Stephen Story
发明人： Afa Kehaati Palu , Chen Su , Bing-Nan Zhou , Claude Jarakae Jensen , Stephen Story
IPC分类号： A61K36/746 , A61P9/12
CPC分类号： A61K36/746
摘要： The present invention relates to medicinal products, as well as to health and wellness food products, and particularly to a medicinal product or a health and wellness food product for inhibiting Angiotensin Converting Enzyme and Chymase enzyme pathways.
摘要翻译：本发明涉及医药产品，以及健康和保健食品，特别涉及用于抑制血管紧张素转化酶和糜酶酶途径的药用产品或健康和保健食品。

6. 发明授权

US08025910B2 Method and composition for administering bioactive compounds derived from Morinda citrifolia 有权
标题翻译：用于施用源自海巴戟天的生物活性化合物的方法和组合物
公开(公告)号：US08025910B2
公开(公告)日：2011-09-27
申请号：US11746798
申请日：2007-05-10
申请人： Bing-Nan Zhou , Chen Su , Afa K. Palu , Brett J. West , Shixin Dong , Claude Jarake Jensen , Stephen Story
发明人： Bing-Nan Zhou , Chen Su , Afa K. Palu , Brett J. West , Shixin Dong , Claude Jarake Jensen , Stephen Story
IPC分类号： A61K36/746 , A61K36/00
CPC分类号： A61K36/746
摘要： This invention relates to a method and composition for providing in various health benefits by administering various bioactive compounds derived from the plant Morinda cirtrifolia to individuals. This invention relates to using one or more of the following: Noni Leaf Extract; Noni Leaf Juice; and/or Roast Leaf. More particularly this invention relates to administering one or more of the following: Pyro-phorbide a, Pheophorbide a, Purpin 7, and/or Pheophorbide all which may be derived from Noni leaf extract, Noni leaf juice, and/or Roast leaf. Moreover, the foregoing formulations result in alleviating pain and inflammation.
摘要翻译：本发明涉及通过向个体施用衍生自植物Morinda cirtrifolia的各种生物活性化合物来提供各种健康益处的方法和组合物。本发明涉及使用以下一种或多种：非叶提取物; 诺丽叶汁和/或烤叶。更具体地说，本发明涉及施用一种或多种以下物质：可以衍生自Noni叶提取物，Noni叶汁和/或Rost叶的Pyro-Phorbide a，Pheophorbide a，Purpin 7和/或Pheororbide all。此外，上述制剂导致减轻疼痛和炎症。

7. 发明授权

US07048952B2 Formulation for inhibiting fungal and microbial growth comprising morinda citrifolia puree juice 有权
标题翻译：用于抑制真菌和微生物生长的制剂，其包含烟酸柠檬酸果泥汁
公开(公告)号：US07048952B2
公开(公告)日：2006-05-23
申请号：US10439596
申请日：2003-05-16
申请人： Scott Gerson , Afa Kehaati Palu , Bing-Nan Zhou , Chen Su , Claude Jarakae Jensen , Stephen P. Story , Robert V. Ogden
发明人： Scott Gerson , Afa Kehaati Palu , Bing-Nan Zhou , Chen Su , Claude Jarakae Jensen , Stephen P. Story , Robert V. Ogden
IPC分类号： A61K35/78
CPC分类号： A61K36/746
摘要： The present invention relates to antifungal and antibacterial activity of processed Morinda citrifolia products, as well as from various fractions of extracts from these processed products and the Morinda citrifolia L. plant, and related methods to determine mean inhibitory concentrations. In particular, the present invention relates to ethanol, methanol and ethyl acetate extracts from Morinda citrifolia L. and their inhibitory activities on common fungi and bacteria and the identification of mean inhibitory concentrations.
摘要翻译：本发明涉及加工的海巴戟天产品的抗真菌和抗菌活性，以及来自这些加工产品的提取物和Morinda citrifolia L.植物的各种级分，以及确定平均抑制浓度的相关方法。特别地，本发明涉及来自海巴戟天的乙醇，甲醇和乙酸乙酯提取物及其对常见真菌和细菌的抑制活性以及平均抑制浓度的鉴定。

8. 发明申请

US20070202206A1 Morinda Citrifolia Leaf Juice And Leaf Extract Based Formulations 审中-公开
标题翻译： Morinda Citrifolia叶汁和叶提取物制剂
公开(公告)号：US20070202206A1
公开(公告)日：2007-08-30
申请号：US11560407
申请日：2006-11-16
申请人： Afa Palu , Bing-Nan Zhou , Chen Su , Claude Jensen , Brett West , Stephen Story
发明人： Afa Palu , Bing-Nan Zhou , Chen Su , Claude Jensen , Brett West , Stephen Story
IPC分类号： A61K36/746
CPC分类号： A61K36/746
摘要： A method and composition for inhibiting certain enzymes, where such inhibition results in various health benefits is provided. More particularly, a method and composition using one or more of the following: Noni Leaf Extract; Noni Leaf Juice; and/or Roast Leaf to inhibit the following: HMG-CoA Reductase; Phosphodiesterases (3 and 4) PDE3 and PDE4; 5-Lipoxygenase (LOX) and 15-LOX; Xanthine Oxidase (XO); Gamma Amino Butyric Acid (GABA) and the growth of the second most common human skin cancer cell line, is provided. Moreover, the foregoing enzymatic inhibitions result in: alleviating pain and inflammation; treating prostate cancers; lowering cholesterol levels; counteracting Diabetes Type II; maintaining the highest possible integrity of cellular interactions in the brain resulting in an undisturbed neural function, (i.e., neuroprotection); ameliorating the effects of asthma and allergies; improving energy; improving insulin secretion; decreasing kidney stone accumulation; alleviating the effects of gout; minimizing convulsions related to epilepsy and other seizure disorders; and providing palliative effects to those addicted to drugs.
摘要翻译：用于抑制某些酶的方法和组合物，其中这种抑制作用产生各种健康益处。更具体地，使用以下一种或多种的方法和组合：非叶提取物; 诺丽叶汁和/或烤叶抑制以下物质：HMG-CoA还原酶; 磷酸二酯酶（3和4）PDE3和PDE4; 5-脂氧合酶（LOX）和15-LOX; 黄嘌呤氧化酶（XO）; 提供γ-氨基丁酸（GABA）和第二常见的人类皮肤癌细胞系的生长。此外，上述酶抑制导致：缓解疼痛和炎症; 治疗前列腺癌; 降低胆固醇水平; 抵制糖尿病II型; 保持脑中细胞相互作用的最高可能完整性，导致不受干扰的神经功能（即神经保护）; 改善哮喘和过敏的作用; 改善能源; 改善胰岛素分泌; 减少肾结石积累; 减轻痛风的影响; 减少与癫痫和其他癫痫发作相关的惊厥; 并为吸毒成瘾者提供姑息治疗。

9. 发明申请

US20070281903A1 Morinda Citrifolia-Based Formulation 5-LOX And 15-LOX 审中-公开
标题翻译： Morinda Citrifolia-based配方5-LOX和15-LOX
公开(公告)号：US20070281903A1
公开(公告)日：2007-12-06
申请号：US11842247
申请日：2007-08-21
申请人： Afa Palu , Brett West , Claude Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
发明人： Afa Palu , Brett West , Claude Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
IPC分类号： A61K31/7016 , A61K31/352 , A61P29/00 , C07D311/30
CPC分类号： A61K31/352 , A61K31/7016 , A61K36/746
摘要： The present invention is directed to methods and formulations for inhibiting Lipoxygenase enzymes that function to biosynthesize or metabolize arachidonic acid into its intermediate Leukotriene constituents, as well as a method and formulation for treating and preventing diseases, including inflammatory diseases, and the symptoms associated with such diseases. The present invention methods and formulations effectively function as such through the introduction into the body (e.g. ingesting) a safe, pre-determined dosage of a naturaceutical composition formulated with or comprising one or more processed Morinda citrifolia products for a safe, pre-determined duration, wherein the processed Morinda citrifolia product may comprise one or more isolated active ingredients.
摘要翻译：本发明涉及用于抑制作用于将花生四烯酸生物合成或代谢为其中间白细胞三烯成分的脂氧合酶的方法和制剂，以及用于治疗和预防包括炎性疾病在内的疾病的方法和制剂，以及与之相关的症状疾病本发明的方法和制剂通过引入身体（例如摄取）有效地起作用，以安全，预定的剂量与由一种或多种加工的Morinda citrifolia产品配制或包含一种或多种加工的Morinda citrifolia产品的安全，预定的持续时间，其中所述加工的Morinda citrifolia产品可以包含一种或多种分离的活性成分。

10. 发明申请

US20060269630A1 Morinda citrifolia as a 5-Lipoxygenase inhibitor 审中-公开
标题翻译：海巴戟天作为5-脂氧合酶抑制剂
公开(公告)号：US20060269630A1
公开(公告)日：2006-11-30
申请号：US11500728
申请日：2006-08-08
申请人： Afa Palu , Brett West , Claude Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
发明人： Afa Palu , Brett West , Claude Jensen , Chen Su , Bing-Nan Zhou , Stephen Story
IPC分类号： A61K36/746
CPC分类号： A61K36/746
摘要： The present invention is directed to methods and formulations for inhibiting Lipoxygenase or Lipoxygenase enzymes that function to biosynthesize or metabolize arachidonic acid into its intermediate Leukotriene constituents, as well as a method and formulation for treating and preventing inflammatory diseases and the symptoms associated with such diseases. The present invention methods and formulations effectively function as such through the introduction into the body (e.g. ingesting) a safe, pre-determined dosage of a naturaceutical composition formulated with or comprising one or more processed Morinda citrifolia products for a safe, pre-determined duration, wherein the processed Morinda citrifolia product may comprise one or more isolated active ingredients.
摘要翻译：本发明涉及用于抑制作用于将花生四烯酸生物合成或代谢为其中间体白三烯组分的脂氧合酶或脂氧合酶的方法和制剂，以及用于治疗和预防炎性疾病和与此类疾病相关的症状的方法和制剂。本发明的方法和制剂通过引入身体（例如摄取）有效地起作用，以安全，预定的剂量与由一种或多种加工的Morinda citrifolia产品配制或包含一种或多种加工的Morinda citrifolia产品的安全，预定的持续时间，其中所述加工的Morinda citrifolia产品可以包含一种或多种分离的活性成分。

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