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1. 发明授权

US6089228A Apparatus and methods for dispersing dry powder medicaments 失效
公开(公告)号：US6089228A
公开(公告)日：2000-07-18
申请号：US4558
申请日：1998-01-08
申请人： Adrian E. Smith , John D. Burr , Jeffrey W. Etter , George S. Axford , Jack M. Anthony
发明人： Adrian E. Smith , John D. Burr , Jeffrey W. Etter , George S. Axford , Jack M. Anthony
IPC分类号： B65D83/06 , A61M20060101 , A61M15/00 , A61M16/00 , B05B7/14 , B05D7/14
CPC分类号： A61M15/0045 , A61M15/0036 , A61M15/0041 , A61M15/0051 , A61M15/0055 , A61M2202/064 , A61M2205/0233 , A61M2205/073
摘要： A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube with a penetration in a receptacle containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprise the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be in the form of a cartridge containing a plurality of receptacles formed in a continuous web. The cartridge may be reciprocated relative to the feed tube and a separate piercing mechanism in order to sequentially piercing the receptacle and thereafter couple the feed tube through the resulting penetration for extracting the powder. Alternatively, penetration(s) through the receptacle may be formed as the feed tube is coupled, or some penetrations formed prior to coupling with other penetrations formed at the time of coupling.

2. 外观设计

USD390651S Medicament inhaler housing 失效
公开(公告)号：USD390651S
公开(公告)日：1998-02-10
申请号：US63668
申请日：1996-12-12
申请人： Adrian E. Smith , John D. Burr , Jeffrey W. Etter , George S. Axford
设计人： Adrian E. Smith , John D. Burr , Jeffrey W. Etter , George S. Axford

3. 发明授权

US06543448B1 Apparatus and methods for dispersing dry powder medicaments 失效
标题翻译：用于分散干粉药物的装置和方法
公开(公告)号：US06543448B1
公开(公告)日：2003-04-08
申请号：US09583300
申请日：2000-05-30
申请人： Adrian E. Smith , John D. Burr , Jeffrey W. Etter , George S. Axford , Jack M. Anthony
发明人： Adrian E. Smith , John D. Burr , Jeffrey W. Etter , George S. Axford , Jack M. Anthony
IPC分类号： A61M1500
CPC分类号： A61M15/0045 , A61M15/0036 , A61M15/0041 , A61M15/0051 , A61M15/0055 , A61M2202/064 , A61M2205/0233 , A61M2205/073
摘要： A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube with a penetration in a receptacle containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprise the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be in the form of a cartridge containing a plurality of receptacles formed in a continuous web. The cartridge may be reciprocated relative to the feed tube and a separate piercing mechanism in order to sequentially piercing the receptacle and thereafter couple the feed tube through the resulting penetration for extracting the powder. Alternatively, penetration(s) through the receptacle may be formed as the feed tube is coupled, or some penetrations formed prior to coupling with other penetrations formed at the time of coupling.
摘要翻译：用于雾化粉末状药物的方法包括将进料管的粉末入口端与容纳粉末的容器中的穿透物接合。粉末通过管向上拉，并分散在流过进料管的一部分的高压气流中。设备包括安装在靠近用于一个或多个插座的保持器的基座外壳内的进料管，其可以是包含形成在连续卷材中的多个容器的盒形式。盒可以相对于进料管和单独的穿孔机构往复运动，以便顺序地刺穿容器，然后将进料管通过所得到的渗透物抽出粉末。或者，穿过容器的穿透可以在进料管被联接时形成，或者在与联接之前形成的其它穿透件结合之前形成一些穿透。

4. 发明授权

US5740794A Apparatus and methods for dispersing dry powder medicaments 失效
公开(公告)号：US5740794A
公开(公告)日：1998-04-21
申请号：US487184
申请日：1995-06-07
申请人： Adrian E. Smith , John D. Burr , Jeffrey W. Etter , George S. Axford , Jack M. Anthony
发明人： Adrian E. Smith , John D. Burr , Jeffrey W. Etter , George S. Axford , Jack M. Anthony
IPC分类号： B65D83/06 , A61M15/00 , B05B7/14 , A61M16/00 , B05D7/14
CPC分类号： A61M15/0045 , A61M15/0036 , A61M15/004 , A61M15/0041 , A61M15/0051 , A61M15/0055 , A61M15/0086 , A61M2202/064 , A61M2205/0233 , A61M2205/073 , A61M2205/6045
摘要： A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube with a penetration in a receptacle containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprise the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be in the form of a cartridge containing a plurality of receptacles formed in a continuous web. The cartridge may be reciprocated relative to the feed tube and a separate piercing mechanism in order to sequentially piercing the receptacle and thereafter couple the feed tube through the resulting penetration for extracting the powder. Alternatively, penetration(s) through the receptacle may be formed as the feed tube is coupled, or some penetrations formed prior to coupling with other penetrations formed at the time of coupling.

5. 发明申请

US20080230058A1 Dry powder dispersing apparatus and methods for their use 失效
公开(公告)号：US20080230058A1
公开(公告)日：2008-09-25
申请号：US12077877
申请日：2008-03-21
申请人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herm Snyder , Carlos A. Schuler , George S. Axford , Charles Ray
发明人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herm Snyder , Carlos A. Schuler , George S. Axford , Charles Ray
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.

6. 发明授权

US07422013B2 Dry powder dispersing apparatus and methods for their use 失效
标题翻译：干粉分散装置及其使用方法
公开(公告)号：US07422013B2
公开(公告)日：2008-09-09
申请号：US11076418
申请日：2005-03-09
申请人： John D. Burr , Adrian E. Smith , George S. Axford
发明人： John D. Burr , Adrian E. Smith , George S. Axford
IPC分类号： A61M11/00 , A61M15/00
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.
摘要翻译：本发明提供了用于使粉末状药物雾化的各种装置和方法。在一个示例性实施例中，一种装置包括加压缸和可在气缸内滑动以对气体加压的活塞。手柄联接到活塞并且可以在延伸位置和原始位置之间移动以对气体加压。包括雾化机构，并且被配置为使来自气缸的加压气体保持在容器内的粉末状药物雾化。包括支架组件以接收容器并将容器连接到雾化机构。第一和第二互锁可操作地与托架组件接合以防止容器与雾化机构的联接。第一互锁被释放以允许滑架在手柄移动到延伸位置时移动。如果容器仅部分地插入到滑架组件中，则第二互锁保持接合。

7. 发明授权

US06257233B1 Dry powder dispersing apparatus and methods for their use 有权
标题翻译：干粉分散装置及其使用方法
公开(公告)号：US06257233B1
公开(公告)日：2001-07-10
申请号：US09312434
申请日：1999-05-14
申请人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
发明人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.
摘要翻译：本发明提供了用于使粉末状药物雾化的各种装置和方法。在一个示例性实施例中，一种装置包括加压缸和可在气缸内滑动以对气体加压的活塞。手柄联接到活塞并且可以在延伸位置和原始位置之间移动以对气体加压。包括雾化机构，并且被配置为使来自气缸的加压气体保持在容器内的粉末状药物雾化。包括支架组件以接收容器并将容器连接到雾化机构。第一和第二互锁可操作地与托架组件接合以防止容器与雾化机构的联接。第一互锁被释放以允许滑架在手柄移动到延伸位置时移动。如果容器仅部分地插入到滑架组件中，则第二互锁保持接合。

8. 发明授权

US08161969B2 Dry powder dispersing apparatus and methods for their use 失效
标题翻译：干粉分散装置及其使用方法
公开(公告)号：US08161969B2
公开(公告)日：2012-04-24
申请号：US12077877
申请日：2008-03-21
申请人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herm Snyder , Carlos A. Schuler , George S. Axford , Charles Ray
发明人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herm Snyder , Carlos A. Schuler , George S. Axford , Charles Ray
IPC分类号： A61M15/00 , A61M16/00
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.
摘要翻译：本发明提供了用于使粉末状药物雾化的各种装置和方法。在一个示例性实施例中，一种装置包括加压缸和可在气缸内滑动以对气体加压的活塞。手柄联接到活塞并且可以在延伸位置和原始位置之间移动以对气体加压。包括雾化机构，并且被配置为使来自气缸的加压气体保持在容器内的粉末状药物雾化。包括支架组件以接收容器并将容器连接到雾化机构。第一和第二互锁可操作地与托架组件接合以防止容器与雾化机构的联接。第一互锁被释放以允许滑架在手柄移动到延伸位置时移动。如果容器仅部分地插入到滑架组件中，则第二互锁保持接合。

9. 发明授权

US06901929B2 Dry powder dispersing apparatus and methods for their use 失效
标题翻译：干粉分散装置及其使用方法
公开(公告)号：US06901929B2
公开(公告)日：2005-06-07
申请号：US10327633
申请日：2002-12-19
申请人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
发明人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
IPC分类号： A61K31/505 , A61M15/00 , B05B11/06 , C07D239/70 , C07D487/12
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.
摘要翻译：本发明提供了用于使粉末状药物雾化的各种装置和方法。在一个示例性实施例中，一种装置包括加压缸和可在气缸内滑动以对气体加压的活塞。手柄联接到活塞并且可以在延伸位置和原始位置之间移动以对气体加压。包括雾化机构，并且被配置为使来自气缸的加压气体保持在容器内的粉末状药物雾化。包括支架组件以接收容器并将容器连接到雾化机构。第一和第二互锁可操作地与托架组件接合以防止容器与雾化机构的联接。第一互锁被释放以允许滑架在手柄移动到延伸位置时移动。如果容器仅部分地插入到滑架组件中，则第二互锁保持接合。

10. 发明授权

US06546929B2 Dry powder dispersing apparatus and methods for their use 失效
公开(公告)号：US06546929B2
公开(公告)日：2003-04-15
申请号：US09873946
申请日：2001-06-04
申请人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
发明人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.

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