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1. 发明授权

US07670627B2 pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients 失效
标题翻译： pH触发用于递送药物活性成分的靶向控制释放系统
公开(公告)号：US07670627B2
公开(公告)日：2010-03-02
申请号：US10315801
申请日：2002-12-09
申请人： Adi Shefer , Samuel David Shefer
发明人： Adi Shefer , Samuel David Shefer
IPC分类号： A61K9/14
CPC分类号： A61K9/5138 , A61K9/1635 , A61K9/2077 , A61K9/5084 , A61K49/0404 , A61K49/0485 , B82Y5/00
摘要： The present invention relates to a novel pH triggered, targeted controlled release system. The controlled delivery system of the present invention is substantially a free-flowing powder formed of solid hydrophobic nano-spheres comprising pharmaceutical active ingredients that are encapsulated in a pH sensitive micro-spheres. The invention also relates to the processes for preparing the compositions and processes for using same. The controlled release system can be used to target and control the release of pharmaceutical active ingredients onto certain regions of the gastrointestinal tract including the stomach and the small intestine. The invention further pertains to pharmaceutical products comprising the controlled release system of the present invention.
摘要翻译：本发明涉及一种新的pH触发的靶向控制释放系统。本发明的受控递送系统基本上是由固体疏水性纳米球形成的自由流动的粉末，其包含被包封在pH敏感的微球中的药物活性成分。本发明还涉及制备组合物的方法及其使用方法。控制释放系统可用于靶向和控制药物活性成分在包括胃和小肠的胃肠道的某些区域的释放。本发明还涉及包含本发明的控制释放系统的药物产品。

2. 发明授权

US06979440B2 Compositions and method for targeted controlled delivery of active ingredients and sensory markers onto hair, skin, and fabric 失效
标题翻译：将有效成分和感官标记物靶向控制递送到毛发，皮肤和织物上的组合物和方法
公开(公告)号：US06979440B2
公开(公告)日：2005-12-27
申请号：US10222054
申请日：2002-08-16
申请人： Adi Shefer , Samuel David Shefer
发明人： Adi Shefer , Samuel David Shefer
IPC分类号： A61K8/00 , A61K8/04 , A61K8/11 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/67 , A61K8/81 , A61K8/84 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/97 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q13/00 , C11D1/62 , C11D3/00 , C11D3/37 , C11D17/00 , A61K31/74
CPC分类号： B82Y5/00 , A61K8/0204 , A61K8/11 , A61K8/34 , A61K8/416 , A61K8/671 , A61K8/8111 , A61K8/84 , A61K2800/244 , A61K2800/413 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q13/00 , C11D1/62 , C11D3/001 , C11D3/3719 , C11D3/3723 , C11D17/0039
摘要： The present invention is a controlled delivery system that can be incorporated in hair, skin, and fabric care products such as shampoos, conditioners, hair styling products, lotions, creams, liquid laundry detergents, fabric softener, and other hair, skin, and fabric care products to effectively deliver a broad range of active agents and sensory markers onto the hair, skin, and fabric. The system also prolongs the release rate of the active agents or sensory markers over an extended period of time, or provides heat triggered release of the active agents and yields a high impact fragrance “burst” upon blow drying the hair, ironing the fabric, or other types of heat treatment. The controlled delivery system of the present invention is a nano-sphere, having an average sphere diameter of from about 0.01 microns to about 10 microns. The nano-sphere comprises hydrophobic materials, cationic conditioning agent or, cationic conditioning agent in conjunction with a cationic charge booster to assist in adhering the spheres onto hair, skin, and fabric. The invention further relates to a controlled delivery system where the release rate of the active ingredients is synchronized with that of a sensory marker to convey to the consumer the product performance.
摘要翻译：本发明是可以并入头发，皮肤和织物护理产品如洗发剂，调理剂，发型产品，洗剂，霜剂，液体衣物洗涤剂，织物柔软剂和其它头发，皮肤和织物中的受控递送系统。护理产品以有效地将广泛的活性剂和感官标记物递送到头发，皮肤和织物上。该系统还可延长活性剂或感官标记物在延长的时间段内的释放速率，或者提供活性剂的热触发释放，并且在吹干头发，熨烫织物时产生高冲击性香味“爆裂” 其他类型的热处理。本发明的受控递送系统是纳米球体，平均球体直径为约0.01微米至约10微米。纳米球包括疏水性材料，阳离子调理剂或阳离子调理剂，与阳离子电荷增强剂结合以帮助将球体粘附到毛发，皮肤和织物上。本发明还涉及一种受控递送系统，其中活性成分的释放速率与感官标记物的释放速率同步，以向消费者传达产品性能。

3. 发明授权

US06740631B2 Multi component controlled delivery system for fabric care products 失效
标题翻译：用于织物护理产品的多组分控制递送系统
公开(公告)号：US06740631B2
公开(公告)日：2004-05-25
申请号：US10133833
申请日：2002-04-26
申请人： Adi Shefer , Samuel David Shefer
发明人： Adi Shefer , Samuel David Shefer
IPC分类号： A61K951
CPC分类号： C11D17/0039 , C11D1/62 , C11D3/505 , C11D9/00 , C11D9/26 , C11D9/36
摘要： The present invention relates to an improved controlled delivery system that can be incorporated in dry granular, or powder, fabric care products, such as laundry detergents, tumble dryer sheets, rinse added products, and other fabric care products, to enhance fragrance performance. The controlled delivery system of the present invention comprises substantially free-flowing, powder formed of solid hydrophobic, positively charged, nano-spheres of encapsulated active ingredients, such as a fragrance, that are encapsulated in a moisture sensitive micro-spheres, solid spheres. The high cationic charge density of the nano-sphere improves fragrance deposition onto the laundered fabric. The high cationic charge density on the nano-sphere surface is created by incorporating a cationic fabric conditioning agent into the solid hydrophobic matrix of the nano-spheres, by incorporating a cationic charge “booster” in the water sensitive micro-sphere matrix, or by using a cationic fabric conditioning agent in the nano-sphere matrix in conjunction with a cationic charge “booster” in the micro-sphere matrix. The fragrance carrier system also provides controlled release or prolonged fragrance release from the dry laundered fabric over an extended period of time, or yields a high impact fragrance “burst” upon ironing the fabric. The invention also pertains to fabric care products comprising the controlled release system of the present invention.
摘要翻译：本发明涉及一种改进的受控递送系统，其可并入干燥颗粒状或粉末状织物护理产品，例如衣物洗涤剂，滚筒干燥片，漂洗添加产品和其它织物护理产品中，以增强香味性能。本发明的受控递送系统包括基本上自由流动的粉末，其由包封的活性成分（例如香料）的固体疏水性，带正电荷的纳米球形成，其被包封在湿气敏感的微球体，固体球体中。纳米球的高阳离子电荷密度改善了洗涤织物上的香味沉积。纳米球表面上的高阳离子电荷密度是通过将阳离子织物调理剂掺入到纳米球的固体疏水性基质中，通过在水敏微孔基质中掺入阳离子电荷“助剂”或通过在纳米球基质中使用阳离子织物调理剂与微球基质中的阳离子电荷“增强剂”相结合。香料载体系统还在延长的时间内提供受控释放或长时间从干洗织物释放的香料，或在熨烫织物时产生高冲击性的香料“爆裂”。本发明还涉及包含本发明的控制释放系统的织物护理产品。

4. 发明授权

US07119060B2 Controlled delivery system for fabric care products 有权
公开(公告)号：US07119060B2
公开(公告)日：2006-10-10
申请号：US10342672
申请日：2003-01-15
申请人： Adi Shefer , Samuel David Shefer
发明人： Adi Shefer , Samuel David Shefer
IPC分类号： C11D3/37
CPC分类号： C11D3/505 , C11D1/62 , C11D3/37 , C11D3/373
摘要： The present invention relates to a controlled delivery system that can be incorporated in liquid, as well as, dry granular, or powder, fabric care products, such as fabric softeners, laundry detergents, rinse added products, and other fabric care products, to enhance fragrance performance. The controlled delivery system of the present invention is a solid, substantially spherical particle comprising hydrophobic cationic charge enhancing agents in conjunction with cationic fabric softening agents that assist in adhering the particles onto fabric. The particles can also include a fragrance. The particle can have an average particle diameter of from about 1 micron to about 500 microns. The controlled delivery system of the present invention can be utilized to deliver a broad range of fragrance ingredients onto fabric and prolong fragrance release from the dry laundered fabric over an extended period of time, or yield a high impact fragrance “burst” upon ironing the fabric. The invention also pertains to fabric care products comprising the controlled release system of the present invention.

5. 发明授权

US07067152B2 Multi component moisture triggered controlled release system that imparts long lasting cooling sensation on the target site and/or provides high impact fragrance or flavor burst 失效
公开(公告)号：US07067152B2
公开(公告)日：2006-06-27
申请号：US10211727
申请日：2002-08-02
申请人： Adi Shefer , Samuel David Shefer
发明人： Adi Shefer , Samuel David Shefer
IPC分类号： A61K6/00 , A61K9/16
CPC分类号： A61K8/11 , A61K8/0204 , A61K31/045 , A61K38/00 , A61K2800/244 , A61K2800/31 , A61K2800/413 , A61Q1/04 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/001 , B82Y5/00
摘要： The present invention relates to cosmetic formulations comprising a multi component controlled release system that imparts long lasting cooling sensation and/or provides high odor or flavor intensity (i.e., high impact fragrance or flavor burst) in response to moisture. The controlled delivery system of the present invention is substantially free-flowing powder formed of solid hydrophobic nano-spheres that are encapsulated in a moisture sensitive micro-spheres.

6. 发明授权

US07214382B2 Self-warming or self-heating cosmetic and dermatological compositions and method of use 有权
标题翻译：自暖或自加热化妆品和皮肤病学成分及使用方法
公开(公告)号：US07214382B2
公开(公告)日：2007-05-08
申请号：US10454915
申请日：2003-06-05
申请人： Adi Shefer , Samuel David Shefer
发明人： Adi Shefer , Samuel David Shefer
IPC分类号： A61Q19/00
CPC分类号： A61Q1/02 , A61K8/0208 , A61K8/0229 , A61K8/817 , A61K8/84 , A61K2800/242 , A61K2800/31 , A61Q9/02 , A61Q19/00
摘要： This invention relates to cosmetic applications for topical applications to the human skin. In particular, it relates to anhydrous cosmetic and dermatological compositions, with the capacity for self-warming or self-heating upon application. The self-warming or self-heating cosmetic compositions of the present invention comprise: (i) from about 0.1 to about 99% by weight of an anhydrous skin care preparation; and (ii) from about 0.01 to about 99% by weight of a heating agent selected from polyvinyl amine, polyalkyleneamine or polyalkyleneimine.
摘要翻译：本发明涉及用于人皮肤局部应用的化妆品应用。特别涉及无水化妆品和皮肤病学组合物，其具有在使用时自热或自加热的能力。本发明的自加热或自加热化妆品组合物包含：（i）约0.1至约99重量％的无水护肤制剂; 和（ii）约0.01至约99重量％的选自聚乙烯胺，聚亚烷基胺或聚亚烷基亚胺的加热剂。

7. 发明授权

US06887493B2 Multi component controlled release system for oral care, food products, nutraceutical, and beverages 有权
标题翻译：用于口腔护理，食品，营养保健品和饮料的多成分控释系统
公开(公告)号：US06887493B2
公开(公告)日：2005-05-03
申请号：US10387907
申请日：2003-03-13
申请人： Adi Shefer , Samuel David Shefer
发明人： Adi Shefer , Samuel David Shefer
IPC分类号： A23G1/00 , A23G1/54 , A23L1/22 , A23L2/39 , A61F2/00 , A61F13/00 , A61K8/02 , A61K8/04 , A61K8/11 , A61K8/34 , A61K8/49 , A61K8/92 , A61K9/00 , A61K9/127 , A61K9/14 , A61K9/16 , A61K9/50 , A61K9/51 , A61Q11/00
CPC分类号： A23G1/54 , A23L2/39 , A23L27/72 , A23V2002/00 , A61K8/0241 , A61K8/11 , A61K8/347 , A61K8/4926 , A61K8/92 , A61K8/922 , A61K9/006 , A61K9/0063 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/5123 , A61K2800/412 , A61K2800/413 , A61K2800/56 , A61Q11/00 , A23V2200/25
摘要： The present invention relates to an improved controlled release system that can encapsulate different flavors, sensory markers, and active ingredients, or combinations of flavors, sensory markers and various active ingredients and release multiple active ingredients in a consecutive manner, one after the other. The controlled delivery system of the present invention is substantially free-flowing powder formed of solid hydrophobic nanospheres that are encapsulated in a moisture sensitive microspheres. The flavors, and active ingredients encapsulated in the hydrophobic nanospheres, in the water sensitive microsphere, or in both the nano and the microsphere. The flavors and active ingredients encapsulated in the nanospheres can be the same or different from those encapsulated in the microspheres. The encapsulation of different flavors or active agents in the various components of the system, such as nanospheres and microspheres, provides flavor transition (change in flavor character) during the use of the products. The controlled release system of the present invention enhances the stability and bioavailability of wide range of flavors, sensory markers, and other active ingredients, prolong their residence time in the oral cavity, control their release characteristics, and prolong the sensation of flavors and other sensory markers in the mouth to provide long lasting organoleptic perception or long lasting mouthfeel. The invention further relates oral care, food products, and beverages comprising the controlled release system of the present invention.
摘要翻译：本发明涉及一种改进的控制释放系统，其可以将不同口味，感官标记物和活性成分，或风味剂，感官标记物和各种活性成分的组合包封，并以连续的方式一个接一个地释放多种活性成分。本发明的受控递送系统是固体疏水性纳米球形成的基本自由流动的粉末，其被包封在湿敏微球体中。包封在疏水性纳米球中的香料和活性成分，在水敏感性微球中，或纳米和微球中。包封在纳米球中的风味剂和活性成分可以与包封在微球体中的那些相同或不同。不同风味剂或活性剂在系统的各种组分（例如纳米球和微球体）中的包封在产品使用期间提供风味转变（风味特征的变化）。本发明的控制释放系统增强了各种风味，感官标记物和其它活性成分的稳定性和生物利用度，延长了它们在口腔中的停留时间，控制了它们的释放特性，并延长了口味和其他感觉的感觉口中的标记提供持久的感官感觉或持久的口感。本发明还涉及包含本发明的控制释放系统的口腔护理，食品和饮料。

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