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1. 发明授权

US06635483B1 Compound and methods of inhibiting or stimulating presenilin 1 and related pharmaceuticals and diagnostic agents 失效
标题翻译：化合物和抑制或刺激早老素1及相关药物和诊断剂的方法
公开(公告)号：US06635483B1
公开(公告)日：2003-10-21
申请号：US09382396
申请日：1999-08-25
申请人： Adam Telerman , Robert Amson
发明人： Adam Telerman , Robert Amson
IPC分类号： C12N1588
CPC分类号： C12N15/113 , A61K38/00 , C07K14/4711 , C07K16/18
摘要： A compound that inhibits the cellular expression of a nucleotide sequence corresponding to all or part of the presenilin 1 gene, the compound comprising an antisense molecule comprising the antisense of a polynucleotide sequence selected from the group consisting of the entire polynucleotide sequence of the presenilin 1 gene, a fragment of the sequence of the presenilin 1 gene, the promoter or other regulatory sequence of the presenilin 1 gene and a polynucleotide sequence that is at least 90% homologous to the polynucleotide sequence of the presenilin 1 gene is described. Pharmaceuticals containing and methods of inhibiting the presenilin 1 gene using such compound are also described. A compound and method of inhibiting the expression product of the presenilin 1 gene also is described. A method of treating a patient having a condition characterized by excessive cell growth also is described. A method of diagnosing cancer also is described. A method of screening drugs that inhibit the presenilin 1 gene also is described. A compound and pharmaceutical that activates the presenilin 1 gene also is described as is a method of treating diseases associated with cell death.
摘要翻译：抑制对应于早老素1基因全部或部分的核苷酸序列的细胞表达的化合物，所述化合物包含反义分子，所述反义分子包含选自早老素1基因的整个多核苷酸序列的多核苷酸序列的反义描述了早老素1基因序列的片段，早老素1基因的启动子或其他调控序列以及与早老素1基因的多核苷酸序列至少90％同源的多核苷酸序列。还描述了含有药物和使用这种化合物抑制早老素1基因的方法。还描述了抑制早老素1基因表达产物的化合物和方法。还描述了治疗患有特征在于过度细胞生长的病症的患者的方法。还描述了诊断癌症的方法。还描述了筛选抑制早老素1基因的药物的方法。激活早老素1基因的化合物和药物也被描述为治疗与细胞死亡有关的疾病的方法。

2. 发明授权

US06956110B1 Genes involved in the molecular paths of tumor suppression and/or resistance to viruses 失效
标题翻译：涉及肿瘤抑制和/或抗病毒的分子途径的基因
公开(公告)号：US06956110B1
公开(公告)日：2005-10-18
申请号：US09762249
申请日：1999-06-18
申请人： Robert Amson , Adam Telerman
发明人： Robert Amson , Adam Telerman
IPC分类号： G01N33/50 , A61K35/76 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/12 , A61P35/00 , C07K14/47 , C07K14/82 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577 , C07H21/02 , C12N5/00 , C12N15/63
CPC分类号： C07K14/82 , A61K38/00 , C07K14/4747 , C12N2799/022 , C12N2799/023 , C12N2799/027 , C12N2799/028
摘要： The invention concerns genes involved in the molecular paths for tumor suppression and/or resistance to viruses, and whereof the cell expression is in particular induced or inhibited during apoptosis and/or tumor suppression.
摘要翻译：本发明涉及涉及用于肿瘤抑制和/或对病毒的抗性的分子途径的基因，并且其细胞表达特别是在凋亡和/或肿瘤抑制期间诱导或抑制。

3. 发明授权

US06921845B1 Use of animal model deficient in p53 and having memory deficiency and/or behavioral disorders for therapeutic purposes 失效
标题翻译：使用缺乏p53的动物模型，并具有记忆缺陷和/或行为障碍用于治疗目的
公开(公告)号：US06921845B1
公开(公告)日：2005-07-26
申请号：US09762248
申请日：1999-07-26
申请人： Robert Amson , Jean-Michel Lassalle , Adam Telerman
发明人： Robert Amson , Jean-Michel Lassalle , Adam Telerman
IPC分类号： A01K67/027 , C07K14/47 , C12N15/85 , G01N33/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , C07K14/4746
摘要： Mice that are deficient in p53 are found to have memory disorders and/or behavioral disorders such as increased anxiety. A method of using p53-deficient mice to screen compounds for memory restoring activity and/or anti-anxiety activity is described.
摘要翻译：发现缺乏p53的小鼠具有记忆障碍和/或行为障碍，例如焦虑增加。描述了使用p53缺陷小鼠筛选化合物用于记忆恢复活性和/或抗焦虑活性的方法。

4. 发明申请

US20060140970A1 Proteic binding partners of TCTP and methods of modulating tumor reversion or cell apoptosis 审中-公开
标题翻译： TCTP的蛋白结合配偶体和调节肿瘤反转或细胞凋亡的方法
公开(公告)号：US20060140970A1
公开(公告)日：2006-06-29
申请号：US11187891
申请日：2005-07-25
申请人： Adam Telerman , Robert Amson , Christophe Cans , Vanessa Nancy-Portebois , Brent Passer
发明人： Adam Telerman , Robert Amson , Christophe Cans , Vanessa Nancy-Portebois , Brent Passer
IPC分类号： A61K38/17 , A61K39/00 , A61K38/44 , A61K38/47 , A61K38/18 , A61K38/19
CPC分类号： A61K38/46 , A61K38/1709 , G01N33/57484
摘要： This invention encompasses proteic binding partners of Translationally Controlled Tumor Protein (TCTP), which can modulate tumor reversion or cell apoptosis. Methods of screening for compounds useful for treating, preventing or managing cancer, an inflammatory disorder, or a neurodegenerative disorder and use of these compounds are also encompassed.
摘要翻译：本发明包括可以调节肿瘤逆转或细胞凋亡的翻译控制的肿瘤蛋白（TCTP）的蛋白结合配偶体。还包括筛选用于治疗，预防或控制癌症，炎症性疾病或神经变性疾病和这些化合物的用途的化合物的方法。

5. 发明申请

US20050221303A1 Sequences involved in phenomena of tumour suppression, tumour reversion, apoptosis and/or virus resistance and their use as medicines 审中-公开
标题翻译：涉及肿瘤抑制，肿瘤反转，凋亡和/或病毒抗性现象的序列及其作为药物的用途
公开(公告)号：US20050221303A1
公开(公告)日：2005-10-06
申请号：US10467851
申请日：2002-02-13
申请人： Adam Telerman , Robert Amson , Marius Tuijnder , Laurent Susini
发明人： Adam Telerman , Robert Amson , Marius Tuijnder , Laurent Susini
IPC分类号： A01K67/027 , A61K31/7088 , A61K38/00 , A61K39/395 , A61P25/00 , A61P31/12 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C07H21/04 , C12N9/99
CPC分类号： C07K14/47 , A01K2217/05 , C12N2799/021
摘要： This invention is directed to sequences that are involved in the molecular pathways of tumor suppression, tumor revision, apoptosis and/or virus resistance. The use of the compounds having these sequences, or encoded by them, in treating cancer, neurodegenerative diseases or viral diseases, and screening methods for compounds having such therapeutic properties are also encompassed.
摘要翻译：本发明涉及涉及肿瘤抑制，肿瘤修复，凋亡和/或病毒抗性的分子途径的序列。还包括使用具有这些序列或由它们编码的化合物治疗癌症，神经变性疾病或病毒性疾病以及具有这种治疗性质的化合物的筛选方法。

6. 发明申请

US20050058999A1 Gene involved in apoptosis regulation 审中-公开
标题翻译：基因参与凋亡调控
公开(公告)号：US20050058999A1
公开(公告)日：2005-03-17
申请号：US10451862
申请日：2001-12-26
申请人： Robert Amson , Adam Telerman , Brent Passer , Jean-Pierre Roperch
发明人： Robert Amson , Adam Telerman , Brent Passer , Jean-Pierre Roperch
IPC分类号： A01K67/027 , A61K35/76 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/00 , A61P25/28 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/577 , C07H21/04 , C12N9/02
CPC分类号： C07K14/4747 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： This invention encompasses sequences of nucleic acids and polypeptides that are involved in the regulation of tumor suppression and apoptosis and methods of using the sequences. Methods of identification for compounds that are effective in treating disorders such as cancer and neurodegenerative disease are also disclosed.
摘要翻译：本发明包括参与调节肿瘤抑制和凋亡的核酸和多肽的序列以及使用该序列的方法。还公开了有效治疗疾病如癌症和神经变性疾病的化合物的鉴定方法。

7. 发明授权

US06503502B1 Nucleotide sequences, proteins, drugs and diagnostic agents of use in treating cancer 失效
标题翻译：用于治疗癌症的核苷酸序列，蛋白质，药物和诊断剂
公开(公告)号：US06503502B1
公开(公告)日：2003-01-07
申请号：US09544618
申请日：2000-04-06
申请人： Adam Telerman , Robert Amson , Daniel Cohen
发明人： Adam Telerman , Robert Amson , Daniel Cohen
IPC分类号： A01N6300
CPC分类号： C08J5/18 , A61K38/00 , C07K14/4702 , C07K14/4747 , C07K14/82 , C08J2333/20 , C12N2799/022 , C12N2799/023 , C12N2799/027 , C12N2799/028
摘要： Tumor Suppressor Activated Pathway (TSAP) genes and nucleotide sequences therefore as well as vectors and cells containing such nucleotide sequences and various uses therefore are described. The mechanism by which TSAP 3 activates apoptosis also is described. Pharmaceutical compositions and methods for preventing tumorigenesis also is described.
摘要翻译：因此，描述了肿瘤抑制因子活化途径（TSAP）基因和核苷酸序列以及含有这种核苷酸序列和各种用途的载体和细胞。还描述了TSAP 3激活凋亡的机制。还描述了用于预防肿瘤发生的药物组合物和方法。

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