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1. 发明申请

US20130084336A1 ENHANCED NITRIC OXIDE DELIVERY AND USES THEREOF 审中-公开
公开(公告)号：US20130084336A1
公开(公告)日：2013-04-04
申请号：US13533025
申请日：2012-06-26
申请人： Adam Friedman , Joel Friedman , Joshua Nosanchuk , Parimala Nacharaju , Karin Blecher , Chaim Tuckman-Vernon
发明人： Adam Friedman , Joel Friedman , Joshua Nosanchuk , Parimala Nacharaju , Karin Blecher , Chaim Tuckman-Vernon
IPC分类号： A61K33/00 , A61K9/48
CPC分类号： A61K33/00 , A61K9/14 , A61K9/48 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5161 , A61K38/063 , A61K47/183 , A61K47/20 , B82Y5/00 , Y02A50/473 , A61K2300/00
摘要： Methods and compositions are disclosed that enhance delivery of nitric oxide (NO) by combining nitric oxide releasing nanoparticles (NO-np) with exogenous glutathione (GSH), as well as therapeutic uses of the methods and compositions.

2. 发明申请

US20140220138A1 ENHANCED NITRIC OXIDE DELIVERY AND USES THEREOF 审中-公开
标题翻译：增强氧化氮输送及其用途
公开(公告)号：US20140220138A1
公开(公告)日：2014-08-07
申请号：US14250099
申请日：2014-04-10
申请人： Adam Friedman , Joel Friedman , Joshua Nosanchuk , Parimala Nacharaju , Karin Blecher , Chaim Tuckman-Vernon
发明人： Adam Friedman , Joel Friedman , Joshua Nosanchuk , Parimala Nacharaju , Karin Blecher , Chaim Tuckman-Vernon
IPC分类号： A61K33/00 , A61K47/18 , A61K9/14
CPC分类号： A61K33/00 , A61K9/14 , A61K9/48 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5161 , A61K38/063 , A61K47/183 , A61K47/20 , B82Y5/00 , Y02A50/473 , A61K2300/00
摘要： Methods and compositions are disclosed that enhance delivery of nitric oxide (NO) by combining nitric oxide releasing nanoparticles (NO-np) with exogenous glutathione (GSH), as well as therapeutic uses of the methods and compositions.
摘要翻译：公开了通过将一氧化氮释放纳米颗粒（NO-np）与外源性谷胱甘肽（GSH）组合来增强一氧化氮（NO）的递送的方法和组合物，以及该方法和组合物的治疗用途。

3. 发明申请

US20150313935A1 ENHANCED NITRIC OXIDE DELIVERY AND USES THEREOF 审中-公开
公开(公告)号：US20150313935A1
公开(公告)日：2015-11-05
申请号：US14800415
申请日：2015-07-15
申请人： Adam Friedman , Joel Friedman , Joshua Nosanchuk , Parimala Nacharaju , Karin Blecher , Chaim Tuckman-Vernon
发明人： Adam Friedman , Joel Friedman , Joshua Nosanchuk , Parimala Nacharaju , Karin Blecher , Chaim Tuckman-Vernon
IPC分类号： A61K33/00 , A61K9/51 , A61K47/20
CPC分类号： A61K33/00 , A61K9/14 , A61K9/48 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5161 , A61K38/063 , A61K47/183 , A61K47/20 , B82Y5/00 , Y02A50/473 , A61K2300/00
摘要： Methods and compositions are disclosed that enhance delivery of nitric oxide (NO) by combining nitric oxide releasing nanoparticles (NO-np) with exogenous glutathione (GSH), as well as therapeutic uses of the methods and compositions.

4. 发明申请

US20050201988A1 Universal red blood cells, methods of preparing same, and uses thereof 失效
标题翻译：通用红细胞，其制备方法及其应用
公开(公告)号：US20050201988A1
公开(公告)日：2005-09-15
申请号：US11004052
申请日：2004-12-03
申请人： Seetharama Acharya , Parimala Nacharaju , Belur Manjula
发明人： Seetharama Acharya , Parimala Nacharaju , Belur Manjula
IPC分类号： C12N5/078 , C12N5/08
CPC分类号： C12N5/0641 , C12N5/0006
摘要： The present invention is directed to pegylated red blood cells comprising a polyethylene glycol (PEG) attached to a thiolated amino group on a membrane protein, and to compositions comprising the pegylated red blood cells. The invention also provides methods of preparing pegylated red blood cells comprising reacting red blood cells with a compound that produces a thiolated amino group on a red blood cell membrane protein, and reacting the thiolated red blood cell with a PEG. The invention further provides methods of treatment using pegylated red blood cells.
摘要翻译：本发明涉及包含与膜蛋白上的硫醇化氨基连接的聚乙二醇（PEG）的聚乙二醇化红细胞以及包含聚乙二醇化红细胞的组合物。本发明还提供了制备聚乙二醇化红细胞的方法，包括使红细胞与在红细胞膜蛋白上产生硫醇化氨基的化合物反应，并将硫醇化的红细胞与PEG反应。本发明进一步提供了使用聚乙二醇化红细胞的治疗方法。

5. 发明申请

US20130231287A1 PEGYLATED ALBUMIN POLYMERS AND USES THEREOF 审中-公开
标题翻译：聚对苯二甲酸乙二醇酯聚合物及其用途
公开(公告)号：US20130231287A1
公开(公告)日：2013-09-05
申请号：US13578684
申请日：2011-02-22
申请人： Parimala Nacharaju , Marcos Intaglietta
发明人： Parimala Nacharaju , Marcos Intaglietta
IPC分类号： C07K14/76
CPC分类号： C07K14/76 , A61K47/60 , A61K47/643 , C07K14/765 , Y10T428/2982
摘要： The present invention provides an albumin polymer and a process of making an albumin polymer, the process comprising breaking instrinsic disulfide bridges in albumin with a reducing agent and crosslinking inter- and intra-molecular disulfide bridges so as to form the polymer. The present invention also provides PEGylated albumin polymers and methods of making PEGylated albumin polymers, the methods comprising polymerizing albumin by crosslinking inter- and intra-molecular disulfide bridges, and PEGylating the albumin polymer. The present invention further provides a pharmaceutical composition useful as a blood plasma expander, blood substitute or for drug delivery, and methods of treating blood loss in a subject and of delivering drugs to a subject's tissue, the pharmaceutical composition comprising a therapeutically effective amount of the PEGylated albumin polymer.
摘要翻译：本发明提供白蛋白聚合物和制备白蛋白聚合物的方法，该方法包括用还原剂和交联的分子内和分子内二硫键桥接白蛋白中的固有二硫键，以形成聚合物。本发明还提供聚乙二醇化白蛋白聚合物和制备聚乙二醇化白蛋白聚合物的方法，所述方法包括通过交联分子内和分子内二硫键聚合白蛋白，以及聚乙二醇化白蛋白聚合物。本发明还提供了可用作血浆扩张剂，血液代用品或用于药物递送的药物组合物，以及治疗受试者的失血量和向药物组织递送药物的方法，所述药物组合物包含治疗有效量的聚乙二醇化白蛋白聚合物。

6. 发明授权

US07521174B2 Universal red blood cells, methods of preparing same, and uses thereof 失效
标题翻译：通用红细胞，其制备方法及其应用
公开(公告)号：US07521174B2
公开(公告)日：2009-04-21
申请号：US11004052
申请日：2004-12-03
申请人： Seetharama A. Acharya , Parimala Nacharaju , Belur N. Manjula
发明人： Seetharama A. Acharya , Parimala Nacharaju , Belur N. Manjula
IPC分类号： A01N1/02
CPC分类号： C12N5/0641 , C12N5/0006
摘要： The present invention is directed to pegylated red blood cells comprising a polyethylene glycol (PEG) attached to a thiolated amino group on a membrane protein, and to compositions comprising the pegylated red blood cells. The invention also provides methods of preparing pegylated red blood cells comprising reacting red blood cells with a compound that produces a thiolated amino group on a red blood cell membrane protein, and reacting the thiolated red blood cell with a PEG. The invention further provides methods of treatment using pegylated red blood cells.
摘要翻译：本发明涉及包含与膜蛋白上的硫醇化氨基连接的聚乙二醇（PEG）的聚乙二醇化红细胞以及包含聚乙二醇化红细胞的组合物。本发明还提供了制备聚乙二醇化红细胞的方法，包括使红细胞与在红细胞膜蛋白上产生硫醇化氨基的化合物反应，并将硫醇化的红细胞与PEG反应。本发明进一步提供了使用聚乙二醇化红细胞的治疗方法。

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