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1. 发明授权

US08652101B2 Implantation device for metabolite sensors 有权
标题翻译：用于代谢物传感器的植入装置
公开(公告)号：US08652101B2
公开(公告)日：2014-02-18
申请号：US13122110
申请日：2009-10-02
申请人： Achim Müller , Peter Herbrechtsmeier
发明人： Achim Müller , Peter Herbrechtsmeier
IPC分类号： A61M37/00
CPC分类号： A61B17/3468 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B2017/00535 , A61B2017/00539 , A61B2017/3447
摘要： The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.
摘要翻译：本发明涉及一种用于植入用于检测体液或身体组织中的至少一种分析物的传感器元件的植入装置。植入装置包括用于刺穿患者皮肤表面的至少一个套管。插管具有用于保持传感器元件的至少一个保持区域。植入装置还具有连接到套管的用于保持液压流体和至少一个压力产生装置的至少一个液压容器。压力产生装置被设计成对液压流体施加压力，其中传感器元件可以使用液压流体从插管转移到身体组织中。

2. 发明申请

US20110230835A1 Implantation Device For Metabolite Sensors 有权
标题翻译：代谢传感器植入装置
公开(公告)号：US20110230835A1
公开(公告)日：2011-09-22
申请号：US13122110
申请日：2009-10-02
申请人： Achim Müller , Peter Herbrechtsmeier
发明人： Achim Müller , Peter Herbrechtsmeier
IPC分类号： A61M37/00
CPC分类号： A61B17/3468 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B2017/00535 , A61B2017/00539 , A61B2017/3447
摘要： The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.
摘要翻译：本发明涉及一种用于植入用于检测体液或身体组织中的至少一种分析物的传感器元件的植入装置。植入装置包括用于刺穿患者皮肤表面的至少一个套管。插管具有用于保持传感器元件的至少一个保持区域。植入装置还具有连接到套管的用于保持液压流体和至少一个压力产生装置的至少一个液压容器。压力产生装置被设计成对液压流体施加压力，其中传感器元件可以使用液压流体从插管转移到身体组织中。

3. 发明申请

US20100063371A1 DEVICE FOR MEASURING AN ANALYTE IN AN EYE FLUID 有权
标题翻译：用于测量眼液中分析物的装置
公开(公告)号：US20100063371A1
公开(公告)日：2010-03-11
申请号：US12374866
申请日：2007-07-23
申请人： Achim Müller , Peter Herbrechtsmeier , Klaus Haberstroh
发明人： Achim Müller , Peter Herbrechtsmeier , Klaus Haberstroh
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0223
摘要： The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. Furthermore, the handheld measuring appliance comprises a calibration system (128), wherein the calibration system (128) is set up to perform a comparison measurement of at least one analyte concentration in a body fluid and/or to adopt measurement data from a comparison measurement performed using a separate measuring appliance and to take them into account when determining the concentration of the at least one analyte.
摘要翻译：本发明提出了一种手动测量仪器（112）和分析测量系统（110），其可用于测量眼睛（114）的眼睛液体中的至少一种分析物。手持式测量仪器（112）包括测量系统（120）和定位系统（122）。测量系统（120）可以测量眼液中至少一种分析物的至少一种性质和/或至少一种分析物依赖的至少一种眼睛传感器（116）的性质变化，并且这可以用于推测眼液中分析物的浓度。定位系统（122）被设置为测量空间定位，其中空间定位包括眼睛（114）中的至少一个测量位置与手持式测量仪器（112）之间的距离，此外还包括至少一个另外的定位坐标。此外，手持式测量仪器包括校准系统（128），其中设置校准系统（128）以对体液中的至少一种分析物浓度进行比较测量和/或采用来自比较测量的测量数据使用单独的测量仪器执行，并在确定至少一种分析物的浓度时考虑它们。

4. 发明授权

US09826926B2 Implantable sensor element 有权
公开(公告)号：US09826926B2
公开(公告)日：2017-11-28
申请号：US13122087
申请日：2009-10-02
申请人： Achim Müller , Peter Herbrechtsmeier
发明人： Achim Müller , Peter Herbrechtsmeier
IPC分类号： A61B5/1455 , A61B5/1459 , A61B5/1473 , B29C39/00 , B29C39/02 , B29C39/10 , A61B5/145 , A61B5/00 , B29C39/24
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/14546 , A61B5/14735 , A61B5/685 , A61B2562/0238 , A61B2562/12 , B29C39/006 , B29C39/021 , B29C39/023 , B29C39/025 , B29C39/028 , B29C39/10 , B29C39/24
摘要： The invention relates to a sensor element for detecting at least one analyte in a body fluid or in a body tissue, particularly for determining at least one metabolite concentration in a body fluid. The sensor element comprises an implantable, one-piece shaped body, which comprises a sensor end and a coupling end. The shaped body comprises, in the area of the sensor end, at least one sensor area, which comprises at least one sensor material. The sensor material changes at least one optically measurable property in the presence of the analyte. The shaped body also has at least one optically transparent coupling part, which is designed to transmit electromagnetic radiation in at least one spectral range between the sensor area and the coupling end. In the sensor area, the shaped body has at least one optically transparent matrix material, and the analyte can at least partially diffuse through the matrix material to the sensor material. The sensor material is embedded in the matrix material. The coupling part is formed at least partially by the matrix material.

5. 发明授权

US08057041B2 Apparatus for measuring an analyte in an eye fluid 有权
标题翻译：用于测量眼液中分析物的装置
公开(公告)号：US08057041B2
公开(公告)日：2011-11-15
申请号：US12374772
申请日：2007-07-23
申请人： Achim Müller , Peter Herbrechtsmeier , Klaus Haberstroh , Roman Gruler
发明人： Achim Müller , Peter Herbrechtsmeier , Klaus Haberstroh , Roman Gruler
IPC分类号： A61B3/00 , A61B3/10
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0223
摘要： The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. The positioning system (122) comprises at least one of the following systems: a camera system, particularly a monocular or binocular camera system, having at least one camera (410; 910); an image recognition system; a triangulation system; a propagation time measuring system, particularly for 1-, 2- or 3-dimensional propagation time measurement, particularly using at least one laser and/or at least one phase mix detector (PMD); a 1-, 2- or 3-dimensional intensity measuring system for at least one signal; a 2- or 3-dimensional magnetoresistive measuring system.
摘要翻译：本发明提出了一种手动测量仪器（112）和分析测量系统（110），其可用于测量眼睛（114）的眼睛液体中的至少一种分析物。手持式测量仪器（112）包括测量系统（120）和定位系统（122）。测量系统（120）可以测量眼液中至少一种分析物的至少一种性质和/或至少一种分析物依赖的至少一种眼睛传感器（116）的性质变化，并且这可以用于推测眼液中分析物的浓度。定位系统（122）被设置为测量空间定位，其中空间定位包括眼睛（114）中的至少一个测量位置与手持式测量仪器（112）之间的距离，此外还包括至少一个另外的定位坐标。定位系统（122）包括以下系统中的至少一个：具有至少一个照相机（410; 910）的相机系统，特别是单目或双目相机系统。图像识别系统; 三角测量系统; 传播时间测量系统，特别是对于1或2维或3维传播时间测量，特别是使用至少一个激光和/或至少一个相位混合检测器（PMD）; 用于至少一个信号的1，2或3维强度测量系统; 2或3维磁阻测量系统。

6. 发明申请

US20110224514A1 Implantable Sensor Element 有权
标题翻译：可植入传感器元件
公开(公告)号：US20110224514A1
公开(公告)日：2011-09-15
申请号：US13122087
申请日：2009-10-02
申请人： Achim Müller , Peter Herbrechtsmeier
发明人： Achim Müller , Peter Herbrechtsmeier
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/14546 , A61B5/14735 , A61B5/685 , A61B2562/0238 , A61B2562/12 , B29C39/006 , B29C39/021 , B29C39/023 , B29C39/025 , B29C39/028 , B29C39/10 , B29C39/24
摘要： The invention relates to a sensor element (110) for detecting at least one analyte in a body fluid or in a body tissue (130), particularly for determining at least one metabolite concentration in a body fluid. The sensor element (110) comprises an implantable, one-piece shaped body (112), which comprises a sensor end (114) and a coupling end (116). The shaped body (112) comprises, in the area of the sensor end (114), at least one sensor area (118), which comprises at least one sensor material (122). The sensor material (122) changes at least one optically measurable property in the presence of the analyte. The shaped body (112) also has at least one optically transparent coupling part (120), which is designed to transmit electromagnetic radiation in at least one spectral range between the sensor area (118) and the coupling end (116). In the sensor area (118), the shaped body (112) has at least one optically transparent matrix material (124), and the analyte can at least partially diffuse through the matrix material (124) to the sensor material (122). The sensor material (122) is embedded in the matrix material (124). The coupling part (120) is formed at least partially by the matrix material (124).
摘要翻译：本发明涉及用于检测体液或身体组织（130）中的至少一种分析物的传感器元件（110），特别是用于确定体液中的至少一种代谢物浓度。传感器元件（110）包括可植入的一件式的主体（112），其包括传感器端（114）和联接端（116）。成形体（112）在传感器端（114）的区域中包括至少一个传感器区域（118），其包括至少一个传感器材料（122）。在分析物的存在下，传感器材料（122）改变至少一种可光学测量的性质。成形体（112）还具有至少一个光学透明的耦合部分（120），其被设计成在传感器区域（118）和耦合端（116）之间的至少一个光谱范围内传输电磁辐射。在传感器区域（118）中，成形体（112）具有至少一个光学透明基质材料（124），并且分析物可以至少部分地通过基质材料（124）扩散到传感器材料（122）。传感器材料（122）嵌入在基体材料（124）中。所述联接部件（120）至少部分地由所述基体材料（124）形成。

7. 发明授权

US09244064B2 Use of hydrogels for biosensors having elevated sensitivity 有权
标题翻译：水凝胶对敏感性升高的生物传感器的使用
公开(公告)号：US09244064B2
公开(公告)日：2016-01-26
申请号：US13994071
申请日：2011-12-13
申请人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
发明人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
IPC分类号： G01N33/53 , G01N33/66
CPC分类号： G01N33/5308 , G01N33/66
摘要： The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.
摘要翻译：本发明涉及用于测定葡萄糖和基于葡萄糖代谢受损的疾病诊断的措施。特别地，本发明涉及由至少一种水溶性聚合物组成的聚合物基水凝胶在传感器中用于富集溶解的葡萄糖结合蛋白的用途，其中所述至少一种水溶性聚合物能够与葡萄糖结合蛋白，并且其中所述葡萄糖结合蛋白存在于与配体的络合物中。

8. 发明授权

US08647271B2 Hydrogel implant for sensing metabolites in body tissue 有权
标题翻译：水凝胶植入物用于感测身体组织中的代谢物
公开(公告)号：US08647271B2
公开(公告)日：2014-02-11
申请号：US12601524
申请日：2008-05-23
申请人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
发明人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14532 , G01N21/77 , G01N2021/773 , G01N2021/7786
摘要： An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).
摘要翻译：提出了用于检测体液中的至少一种分析物（126）的植入物（110），特别是眼液。植入物（110）设计成植入患者眼睛的组织层和/或腔室中，植入物（110）具有至少一种水凝胶（114）的水凝胶基体（110）。植入物（110）还具有分散在水凝胶基质（110）中的传感器颗粒（116），传感器颗粒（116）具有至少一个具有传感器基体材料（122）的传感器矩阵（120）和至少一个传感器材料（124）。

9. 发明申请

US20120258551A1 STABILIZATION OF BIO-SENSORS FOR IN VIVO APPLICATIONS 有权
标题翻译：生物传感器在生活应用中的稳定性
公开(公告)号：US20120258551A1
公开(公告)日：2012-10-11
申请号：US13503599
申请日：2010-10-25
申请人： Peter Herbrechtsmeier , Achim Müller , Monika Knuth , Katharina Nikolaus
发明人： Peter Herbrechtsmeier , Achim Müller , Monika Knuth , Katharina Nikolaus
IPC分类号： G01N33/53
CPC分类号： C07K14/42 , C07K14/4726 , G01N33/66 , Y10S436/827
摘要： The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.
摘要翻译：本发明涉及用于稳定分离的蛋白质的制剂的用途。特别地，公开了在生物化学传感器中使用这种用于稳定受体的制剂。本发明还涉及含有这种制剂的生化传感器。

10. 发明申请

US20140024060A1 USE OF HYDROGELS FOR BIOSENSORS HAVING ELEVATED SENSITIVITY 有权
标题翻译：对具有高灵敏度的生物传感器的水凝胶的使用
公开(公告)号：US20140024060A1
公开(公告)日：2014-01-23
申请号：US13994071
申请日：2011-12-13
申请人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
发明人： Achim Müller , Peter Herbrechtsmeier , Monika Knuth , Katharina Nikolaus
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/66
摘要： The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.
摘要翻译：本发明涉及用于测定葡萄糖和基于葡萄糖代谢受损的疾病诊断的措施。特别地，本发明涉及由至少一种水溶性聚合物组成的聚合物基水凝胶在传感器中用于富集溶解的葡萄糖结合蛋白的用途，其中所述至少一种水溶性聚合物能够与葡萄糖结合蛋白，并且其中所述葡萄糖结合蛋白存在于与配体的络合物中。

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