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1. 发明授权

US5534520A Spiro compounds containing five-membered rings 失效
标题翻译：含五元环的螺环化合物
公开(公告)号：US5534520A
公开(公告)日：1996-07-09
申请号：US94855
申请日：1993-07-20
申请人： Abraham Fisher , Yishai Karton , Daniele Marciano , Dov Barak , Haim Meshulam
发明人： Abraham Fisher , Yishai Karton , Daniele Marciano , Dov Barak , Haim Meshulam
IPC分类号： C07D487/10 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/438 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/28 , C07D453/02 , C07D471/10 , C07D471/20 , C07D491/10 , C07D497/10 , C07D498/10 , C07D498/20 , C07D513/10 , A61K31/445 , C07D221/20 , C07D491/20
CPC分类号： C07D471/10 , C07D491/10 , C07D497/10 , C07D513/10
摘要： Compounds useful for treating diseases of the central or peripheral nervous system in mammals have formulae I-XIII: ##STR1## wherein ring A or A' together with the spiro-carbon atom constitutes a bridged or unbridged ring containing one or two ring nitrogen atoms; and the other symbols have specified values, subject to certain conditions.
摘要翻译：可用于治疗哺乳动物中枢神经系统或周围神经系统疾病的化合物具有式I-XIII：II III IV V VI AGE> X 其中环A或A'与螺 - 碳原子一起构成含有一个或两个环氮原子的桥连或非桥连环; 其他符号具有指定值，

2. 发明授权

US5852029A Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity 失效
标题翻译：作用于具有毒蕈碱激动剂活性的胆碱能系统的佐氮螺环化合物
公开(公告)号：US5852029A
公开(公告)日：1998-12-22
申请号：US627222
申请日：1996-01-18
申请人： Abraham Fisher , Yishal Karton , Daniele Marciano , Dov Barak , Haim Meshulam
发明人： Abraham Fisher , Yishal Karton , Daniele Marciano , Dov Barak , Haim Meshulam
IPC分类号： C07D471/10 , C07D471/20 , C07D491/10 , C07D497/10 , C07D498/10 , C07D498/20 , C07D513/10 , A61K31/445 , A61K31/46 , C07D491/20
CPC分类号： C07D471/10 , C07D491/10 , C07D497/10 , C07D513/10
摘要： Compounds useful for treating diseases of the central or peripheral nervous system in mammals have formulae I-XII ##STR1## wherein ring A or A' together with the spiro-carbon atom constitutes a bridged or unbridged ring containing one or two ring nitrogen atoms; and the other symbols have specified values, subject to certain conditions.
摘要翻译：可用于治疗哺乳动物中枢神经系统或周围神经系统疾病的化合物具有式I-XII I II III IV V VI VII 其中环A或A'与螺 - 碳原子一起构成含有一个或两个环氮原子的桥连或非桥连环; 并且其他符号具有指定的值，在某些条件下。

3. 发明授权

US5407938A Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines) 失效
标题翻译：某些1-甲基 - 哌啶-4-螺-4' - （1'-3'-恶唑啉）和相应的 - （1'，3'噻唑啉）
公开(公告)号：US5407938A
公开(公告)日：1995-04-18
申请号：US137690
申请日：1993-10-14
申请人： Abraham Fisher , Yoffi Segall , Ezra Shirin , Yishai Karton , Haim Meshulam
发明人： Abraham Fisher , Yoffi Segall , Ezra Shirin , Yishai Karton , Haim Meshulam
IPC分类号： C07D471/10 , C07D471/20 , C07D491/10 , C07D497/10 , C07D498/10 , C07D498/20 , C07D513/10 , A61K31/44 , C07D491/20 , C07D495/20 , C07D497/20
CPC分类号： C07D471/10 , C07D491/10 , C07D497/10 , C07D513/10
摘要： The invention relates to compounds (I) for treating diseases of the central and peripheral nervous system, including enantiomers, racemates and acid addition and quaternary salts, ##STR1## wherein Q is selected from two H atoms, (CH.sub.2).sub.m and C(CH.sub.3).sub.2 where m is 1, 2 or 3 and n and p are; each independently 0, 1, 2 or 3, provided that n+p=1-3, and R.sup.0 is H, methyl or OH; the moiety ##STR2## R is selected from H, NH.sub.2, NH-C.sub.1-6 -alkyl, N(C.sub.1-6 -alkyl).sub.2, C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl, C.sub.2-6 -alkynyl, C.sub.3-7 - cycloalkyl, C.sub.1-6 -alkyl substituted by 1-6 halogen atoms, hydroxy- C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.1-6 -alkylthio, C.sub.1-6 -alkoxy-C.sub.1-6 -alkyl, carboxy-C.sub.1-6 -alkyl, (C.sub.1-6 -alkoxy)carbonyl-C.sub.1-6 -alkyl, amino-C.sub.1-6 -alkyl, mono-(C.sub.1-6 -alkyl)amino-C.sub.1-6 -alkyl, di-(C.sub.1-6 -alkyl)amino-C.sub.1-6 -alkyl, 2-oxo-pyrrolidin-1-yl-methyl, aryl, diarylmethylol, and C.sub.1-6 -alkyl substituted by one or two aryl groups; R' is independently selected from the group from which R is selected and C.sub.1-6 -alkanoyl and arylcarbonyl; and aryl denotes unsubstituted phenyl or phenyl substituted by 1-3 substituents selected from halogen, C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy and CF.sub.3, subject to certain provisos.
摘要翻译：本发明涉及用于治疗中枢和周围神经系统疾病的化合物（I），包括对映体，外消旋体和酸加成和季盐。其中Q选自两个H原子，（CH 2）m和 C（CH 3）2，其中m为1,2或3，n和p为每个独立地为0,1,2或3，条件是n + p = 1-3，R 0为H，甲基或OH; R 1选自H，NH 2，NH-C 1-6 - 烷基，N（C 1-6 - 烷基）2，C 1-6 - 烷基，C 2-6 - 烯基，C 2-6 - 炔基，C 3 -7-环烷基，被1-6个卤素原子取代的C 1-6 - 烷基，羟基-C 1-6 - 烷基，C 1-6 - 烷氧基，C 1-6 - 烷硫基，C 1-6 - 烷氧基-C 1-6 - 烷基，羧基-C 1-6 - 烷基，（C 1-6 - 烷氧基）羰基-C 1-6 - 烷基，氨基-C 1-6 - 烷基，单 - （C 1-6 - 烷基）氨基-C 1-6 - 烷基，（C 1-6 - 烷基）氨基-C 1-6 - 烷基，2-氧代 - 吡咯烷-1-基 - 甲基，芳基，二芳基羟甲基和被一个或两个芳基取代的C 1-6 - 烷基; R'独立地选自选自R的基团和C 1-6 - 烷酰基和芳基羰基; 并且芳基表示未取代的苯基或被1-3个选自卤素，C 1-6 - 烷基，C 1-6 - 烷氧基和CF 3的取代基取代的苯基，具有一定条件。

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