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1. 发明申请

US20150353552A1 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA 有权
标题翻译：人类磷脂酰肌醇三激酶三磷酸抑制剂
公开(公告)号：US20150353552A1
公开(公告)日：2015-12-10
申请号：US14443294
申请日：2013-11-15
申请人： Abdelghani Abe ACHAB , Michael D. ALTMAN , Yongqi DENG , Timothy GUZI , Solomon KATTAR , Jason D. KATZ , Joey L. METHOT , Hua ZHOU , Meredeth MCGOWAN , Matthew P. CHRISTOPHER , Yudith GARCIA , Neville John THONY , Francesc Xavier FRADERA LLINAS , Changwei MU , Sixing ZHANG , Rong ZHANG , Kin Chiu FONG , Xiansheng LENG , MERCK SHARP & DOHME CORP.
发明人： Abdelghani Abe Achab , Michael D. Altman , Yongqi Deng , Timothy Guzi , Solomon Kattar , Jason D. Katz , Joey L. Methot , Hua Zhou , Meredeth McGowan , Matthew P. Christopher , Yudith Garcia , Neville John Anthony , Francesc Xavier Fradera Llinas , Kin Chiu Fong , Xiansheng Leng , Changwei Mu , Sixing Zhang , Rong Zhang
IPC分类号： C07D473/30 , A61K31/5377 , A61K31/52
CPC分类号： A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/00 , C07D473/06 , C07D473/30 , C07D473/38 , C07D519/00 , A61K2300/00
摘要： The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.
摘要翻译：本发明提供了作为PI3K-δ抑制剂的式I化合物，因此可用于治疗PI3K-δ介导的疾病如炎症，哮喘，COPD和癌症。

2. 发明授权

US09938281B2 Purine inhibitors of human phosphatidylinositol 3-kinase delta 有权
公开(公告)号：US09938281B2
公开(公告)日：2018-04-10
申请号：US14443314
申请日：2013-11-15
申请人： Merck Sharp & Dohme Corp.
发明人： Abdelghani Abe Achab , Michael D. Altman , Yongqi Deng , Solomon Kattar , Jason D. Katz , Joey L. Methot , Hua Zhou , Meredeth McGowan , Matthew P. Christopher , Yudith Garcia , Neville John Anthony , Francesc Xavier Fradera Llinas , Liping Yang , Changwei Mu , Xiaona Wang , Feng Shi , Baijun Ye , Sixing Zhang , Xiaoli Zhao , Rong Zhang , Kin Chiu Fong , Xiansheng Leng
IPC分类号： A61K31/52 , A61K31/535 , C07D473/00 , C07D403/00 , C07D487/04 , C07D473/34 , A61K45/06 , A61K31/5377 , A61K31/55 , C07D519/00
CPC分类号： C07D487/04 , A61K31/52 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D473/34 , C07D519/00 , A61K2300/00
摘要： The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.

3. 发明授权

US09730940B2 Purine inhibitors of human phosphatidylinositol 3-kinase delta 有权
公开(公告)号：US09730940B2
公开(公告)日：2017-08-15
申请号：US14443294
申请日：2013-11-15
申请人： Merck Sharp & Dohme Corp.
发明人： Abdelghani Abe Achab , Michael D. Altman , Yongqi Deng , Timothy Guzi , Solomon Kattar , Jason D. Katz , Joey L. Methot , Hua Zhou , Meredeth McGowan , Matthew P. Christopher , Yudith Garcia , Neville John Anthony , Francesc Xavier Fradera Llinas , Kin Chiu Fong , Xiansheng Leng , Changwei Mu , Sixing Zhang , Rong Zhang
IPC分类号： A61K31/52 , C07D473/00 , C07D473/06 , C07D473/30 , C07D473/38 , C07D519/00 , A61K31/5377 , A61K45/06
CPC分类号： A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/00 , C07D473/06 , C07D473/30 , C07D473/38 , C07D519/00 , A61K2300/00
摘要： The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.

4. 发明申请

US20160207926A1 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA 有权
标题翻译：人类磷脂酰肌醇三激酶三磷酸抑制剂
公开(公告)号：US20160207926A1
公开(公告)日：2016-07-21
申请号：US14443314
申请日：2013-11-15
申请人： Merck Sharp & Dohme Corp.
发明人： Abdelghani Abe Achab , Michael D. Altman , Yongqi Deng , Solomon Kattar , Jason D. Katz , Joey L. Methot , Hua Zhou , Meredeth McGowan , Matthew P. Christopher , Yudith Garcia , Neville John Anthony , Francesc Xavier Fradera Llinas , Liping Yang , Changwei Mu , Xiaona Wang , Feng Shi , Baijun Ye , Sixing Zhang , Xiaoli Zhao , Rong Zhang , Kin Chiu Fong , Xiansheng Leng
IPC分类号： C07D487/04 , A61K31/55 , A61K31/5377 , A61K31/52 , C07D519/00
CPC分类号： C07D487/04 , A61K31/52 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D473/34 , C07D519/00 , A61K2300/00
摘要： The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflamation, asthma, COPD and cancer.
摘要翻译：本发明提供了作为PI3K-δ抑制剂的式I化合物，因此可用于治疗PI3K-δ介导的疾病如炎症，哮喘，COPD和癌症。

5. 外观设计

USD1032620S1 USB device 有权
公开(公告)号：USD1032620S1
公开(公告)日：2024-06-25
申请号：US29832627
申请日：2022-03-29
申请人： Rong Zhang
设计人： Rong Zhang
摘要： FIG. 1 is a front, left and top perspective view of a USB device showing my new design;
FIG. 2 is a rear, right and bottom perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines in the figures illustrate portions of the USB device that form no part of the claimed design.

6. 发明授权

US09564677B2 Mobile terminal 有权
标题翻译：移动终端
公开(公告)号：US09564677B2
公开(公告)日：2017-02-07
申请号：US13518931
申请日：2010-12-16
申请人： Shoudong Tian , Gang Yan , Shaolian Liu , Rong Zhang , Zhijun Gao
发明人： Shoudong Tian , Gang Yan , Shaolian Liu , Rong Zhang , Zhijun Gao
IPC分类号： H01Q1/24 , H01Q1/40 , H01Q1/42 , H01Q9/42 , H01Q5/00 , H01Q5/364 , H04M1/02
CPC分类号： H01Q1/243 , H01Q1/40 , H01Q1/42 , H01Q5/364 , H01Q9/42 , H04M1/0249
摘要： A mobile terminal and an antenna thereof are provided. The mobile terminal includes a housing, a main board arranged within said housing, and an antenna arranged on the outer surface of said housing such that the antenna is connected with said main board. The height of the mobile phone antenna can be effectively increased and, thus the performance of the antenna is improved.
摘要翻译：提供了一种移动终端及其天线。移动终端包括壳体，布置在所述壳体内的主板和布置在所述壳体的外表面上的天线，使得天线与所述主板连接。可以有效地提高移动电话天线的高度，从而提高天线的性能。

7. 发明授权

US09171372B2 Depth estimation based on global motion 有权
标题翻译：基于全局运动的深度估计
公开(公告)号：US09171372B2
公开(公告)日：2015-10-27
申请号：US13301225
申请日：2011-11-21
申请人： Rong Zhang , Ying Chen , Marta Karczewicz
发明人： Rong Zhang , Ying Chen , Marta Karczewicz
IPC分类号： H04N13/02 , G06T7/00
CPC分类号： G06T7/0071 , G06T7/579
摘要： This disclosure describes techniques for estimating a depth of image objects for a two-dimensional (2D) view of a video presentation. For example, a plurality of feature points may be determined for a 2D view. The plurality of feature points may be used to estimate global motion, e.g., motion of an observer (e.g., camera), of the 2D view. For example, the plurality of feature points may be used to generate a global motion frame difference. The global motion frame difference may be used to create a depth map for the 2D view, which may be used to generate an alternative view of the video presentation that may be used to display a three-dimensional (3D) video presentation.
摘要翻译：本公开描述了用于估计视频呈现的二维（2D）视图的图像对象的深度的技术。例如，可以为2D视图确定多个特征点。多个特征点可以用于估计2D视图的全局运动，例如观察者（例如，照相机）的运动。例如，可以使用多个特征点来产生全局运动帧差。全局运动帧差可以用于创建2D视图的深度图，其可以用于生成可用于显示三维（3D）视频呈现的视频呈现的替代视图。

8. 发明授权

US08968453B2 Anthrapyridone sulfonic acid compounds and their preparation methods and applications 有权
标题翻译：蒽吡啶酮磺酸化合物及其制备方法和应用
公开(公告)号：US08968453B2
公开(公告)日：2015-03-03
申请号：US13583282
申请日：2011-01-14
申请人： Xiaojun Peng , Tao Liu , Jinhe Wu , Rong Zhang , Jingyue Wang , Feng Wang , Shaolei Li , Jianzhou Zhang , Zhengru Yang
发明人： Xiaojun Peng , Tao Liu , Jinhe Wu , Rong Zhang , Jingyue Wang , Feng Wang , Shaolei Li , Jianzhou Zhang , Zhengru Yang
IPC分类号： C09D11/02 , C09B5/14 , C09D11/328 , C09D11/037 , C09B62/04 , C09B62/465 , C09B62/503
CPC分类号： C09D11/328 , C09B5/14 , C09B62/04 , C09B62/465 , C09B62/503 , C09D11/037
摘要： The present invention relates to a class of compounds of general formula (I) or their salts of general formula (II): In formula (I)-(II), the substituents (A)p and (SO3H)n on the benzene ring are at the ortho, meta or para position, n is 0-2, and p is 0-3; M is selected from Li+, Na+, K+, NH4+ or organic ammonium salt N+R1R2R3R4, where R1, R2, R3, R4 are the same or different H, C1-18 alkyl groups, cyclohexyl groups, CH2CH2OH, CH(CH3)CH2OH or benzyl groups; where p>0, A stands for the same or different groups selected from: H, CN, NO2, NH2, F, Cl, Br, C1-18 alkyl group, cyclohexyl group, phenyl group, benzyl group, phenoxy group, C1-18 alkoxy group, C1-18 alkylthio group, SO2CH═CH2, SO2CH2CH2A1, NR6COR5 or NR6SO2R5.
摘要翻译：本发明涉及一类通式（I）的化合物或其通式（Ⅱ）的盐：在式（I） - （II）中，苯环上的取代基（A）p和（SO 3 H）n 在邻位，间位或对位，n为0-2，p为0-3; M选自Li +，Na +，K +，NH4 +或有机铵盐N + R1R2R3R4，其中R1，R2，R3，R4是相同或不同的H，C1-18烷基，环己基，CH2CH2OH，CH（CH3）CH2OH 或苄基; 其中p> 0，A代表选自以下的相同或不同的基团：H，CN，NO 2，NH 2，F，Cl，Br，C 1-18烷基，环己基，苯基，苄基，苯氧基， 18烷氧基，C1-18烷硫基，SO2CH = CH2，SO2CH2CH2A1，NR6COR5或NR6SO2R5。

9. 发明申请

US20140303683A1 METHOD FOR THE TREATMENT OF AUTISM 审中-公开
标题翻译：治疗恶性肿瘤的方法
公开(公告)号：US20140303683A1
公开(公告)日：2014-10-09
申请号：US13821221
申请日：2011-09-06
申请人： Jisheng Han , Rong Zhang , Songping Han , Meixiang Jia , Jishui Zhang , Xiuting Zhang
发明人： Jisheng Han , Rong Zhang , Songping Han , Meixiang Jia , Jishui Zhang , Xiuting Zhang
IPC分类号： A61N1/36
CPC分类号： A61N1/36025 , A61H39/002 , A61H2201/5005 , A61M21/00 , A61M2021/0072 , A61N1/36014
摘要： The present invention provides a method for treating autism. The method comprises following steps: step 1, applying a first electrical current stimulation of 30 minutes in the vicinity of the Hegu acupuncture point and the Nei guan acupuncture point at one side of the patient, wherein the first electrical current stimulation has a first slow-quick waveform, and the maximum current of the first electrical current stimulation is 3-10 mA; and step 2, applying a second electrical current stimulation of 30 minutes in the vicinity of the Zusanli acupuncture point, and the Sanyinjiao acupuncture point at opposite side of the patient, wherein the second electrical current stimulation has a second slow-quick waveform, and the maximum current of the second electrical current stimulation is 4-15 mA. The above-mentioned method may actually aim at the etiology in the biological and medical aspects, and results in actual therapeutic significance. In the course of treatment, the above-mentioned method is not found to have any side effects, so it can be used for a long time. The present method of the present application is non-invasive and painless, and it is acceptable for children, and suitable for family use. The method can obviously improve the symptoms of autism. The clinical manifestations is an increase of passive and active language, an improvement of social interaction-ability, emotion becoming stable, a better sleep (sleep quickly, a long time). In addition, the method is simple and do not need an acupuncturist.
摘要翻译：本发明提供一种治疗自闭症的方法。该方法包括以下步骤：步骤1，在患者的一侧的Hegu针刺点和内关穴穴附近施加30分钟的第一电流刺激，其中，第一电流刺激具有第一慢速刺激，快速波形，第一次电流刺激的最大电流为3-10mA; 步骤2，在祖山里针穴附近施加30分钟的第二电流刺激，在患者对侧的三一角穴位，其中第二电流刺激具有第二慢速波形，第二次电流刺激的最大电流为4-15mA。上述方法实际上可以针对生物和医学方面的病因，并产生实际的治疗意义。在治疗过程中，没有发现上述方法具有任何副作用，因此可长时间使用。本申请的本方法是非侵入性和无痛性的，并且对于儿童是可接受的，并且适合于家庭使用。该方法可以明显改善自闭症的症状。临床表现是被动和主动语言的增加，社会互动能力的提高，情绪变得稳定，睡眠更好（睡眠很快，长时间）。此外，该方法简单，不需要针灸师。

10. 发明授权

US08487080B2 Fluorine-labeled compounds 失效
标题翻译：氟标记化合物
公开(公告)号：US08487080B2
公开(公告)日：2013-07-16
申请号：US13032099
申请日：2011-02-22
申请人： Omayra Liz Padilla de Jesus , Faisal Ahmed Syud , Rong Zhang , Ernest William Kovacs
发明人： Omayra Liz Padilla de Jesus , Faisal Ahmed Syud , Rong Zhang , Ernest William Kovacs
IPC分类号： A61K38/00 , C07K1/00
CPC分类号： C07K1/13 , A61K51/08 , C07B59/008 , C07K5/0817 , C07K5/1019
摘要： Methods for introducing fluorine atom onto a polypeptide are provided. Also provided are linkers, bioconjugates, and bifunctional compound agents made using the methods, linkers, and bioconjugates. The methods comprise: (i) providing a linker comprising a thiol-reactive terminus and an aldehyde-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a polypeptide comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the aldehyde-reactive terminus of the linker with a fluorine-substituted aldehyde.
摘要翻译：提供了将氟原子引入到多肽上的方法。还提供了使用方法，接头和生物缀合物制备的接头，生物缀合物和双功能化合物试剂。所述方法包括：（i）提供包含硫醇反应性末端和醛反应性末端的连接体; （ii）使接头的硫醇反应性末端与包含至少一个硫醇基团或其反应性衍生物的多肽反应; 和（iii）随后使接头的醛反应性末端与氟取代的醛反应。

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