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1. 发明授权

US09840495B2 Oxindole derivatives carrying a piperidyl-substituted azetidinyl substituent and use thereof for treating vasopressine-related diseases 有权
公开(公告)号：US09840495B2
公开(公告)日：2017-12-12
申请号：US15106670
申请日：2014-12-19
申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： Hervé Geneste , Wilfried Hornberger , Charles W. Hutchins , Katja Jantos , Andreas Kling , Loic Laplanche , Marcel Van Gaalen
IPC分类号： A01N43/00 , A61K31/00 , C07D401/14 , C07D401/04 , C07B59/00 , C07D405/14 , C07D491/107
CPC分类号： C07D401/14 , C07B59/002 , C07B2200/05 , C07D401/04 , C07D405/14 , C07D491/107
摘要： The present invention relates to novel substituted oxindole derivatives of formula (I) wherein the variables are as defined in the claims and description; to pharmaceutical compositions comprising them, and to their use for treatment of vasopressin-related disorders.

2. 发明授权

US09862704B2 Oxindole derivatives carrying an amine-substituted piperidyl-acetidinyl substituent and use thereof for treating vasopressine-related diseases 有权
公开(公告)号：US09862704B2
公开(公告)日：2018-01-09
申请号：US15106662
申请日：2014-12-19
申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： Hervé Geneste , Wilfried Hornberger , Charles W. Hutchins , Katja Jantos , Andreas Kling , Loic Laplanche , Marcel Van Gaalen
IPC分类号： C07D401/14
CPC分类号： C07D401/14
摘要： The present invention relates to novel substituted oxindole derivatives of formula (I) wherein the variables are as defined in the claims and description; to pharmaceutical compositions comprising them, and to their use for the treatment of vasopressin-related disorders.

3. 发明授权

US09688678B2 Oxindole compounds carrying a nitrogen-bound spiro substituent and use thereof for treating vasopressin-related diseases 有权
公开(公告)号：US09688678B2
公开(公告)日：2017-06-27
申请号：US14713909
申请日：2015-05-15
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： Hervé Geneste , Wilfried Hornberger , Katja Jantos , Andreas Kling , Marcel Van Gaalen
IPC分类号： C07D471/10 , C07D487/10 , C07D295/135 , C07D305/08
CPC分类号： C07D471/10 , C07D295/135 , C07D305/08 , C07D487/10
摘要： The present invention relates to novel substituted oxindole derivatives of the formula I wherein A is a ring selected from phenyl and 6-membered hetaryl containing 1 or 2 nitrogen atoms as ring members, where ring A carries one substituent R6 and optionally one substituent R7; B is a ring selected from phenyl and a monocyclic or bicyclic heteroaromatic ring containing 1, 2 or 3 heteroatoms selected from O, N and S as ring members, where ring B may carry 1, 2 or 3 substituents R8; X1, X2, X3 and X4, independently of each other, are selected from —CH2—, —O—, —S(O)c—, —NH—, —C(O)—, —CH2CH2—, —CH2O—, —OCH2—, —S(O)cCH2—, —CH2S(O)c—, CH2NH—, —NHCH2—, —CH2C(O)— and C(O)CH2—; X5 is NH, CH2 or O; and wherein c, R1, R2, (R3)a, (R4)b, R5, R6, R7, and R8 are as defined in the claims. The present invention also relates to pharmaceutical compositions comprising the novel substituted oxindole derivatives of the formula I, and to their use for the treatment of vasopressin-related disorders.

4. 发明申请

US20150344489A1 OXINDOLE COMPOUNDS CARRYING A CO-BOUND SPIRO SUBSTITUENT AND USE THEREOF FOR TREATING VASOPRESSIN-RELATED DISEASES 有权
标题翻译：携带共轭螺旋体替代物的氧化物化合物及其用于治疗相关疾病的用途
公开(公告)号：US20150344489A1
公开(公告)日：2015-12-03
申请号：US14713824
申请日：2015-05-15
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： Wilfried Braje , Hervé Geneste , Wilfried Hornberger , Katja Jantos , Andreas Kling , Claudia Krack , Marcel Van Gaalen
IPC分类号： C07D487/10 , C07D401/14 , C07D471/10
CPC分类号： C07D487/10 , C07D209/40 , C07D213/64 , C07D295/135 , C07D305/08 , C07D401/14 , C07D471/10
摘要： The present invention relates to novel substituted oxindole derivatives of formula I wherein the variables are as defined in the claims and the description. The invention further relates to pharmaceutical compositions comprising compounds I and their use for the treatment of vasopressin-related disorders.
摘要翻译：本发明涉及式I的新的取代的羟基吲哚衍生物，其中变量如权利要求和说明书所定义。本发明还涉及包含化合物I及其用于治疗加压素相关病症的用途的药物组合物。

5. 发明授权

US09527856B2 Oxindole compounds carrying a CO-bound spiro substituent and use thereof for treating vasopressin-related diseases 有权
标题翻译：携带CO键螺旋取代基的羟吲哚化合物及其用于治疗加压素相关疾病的用途
公开(公告)号：US09527856B2
公开(公告)日：2016-12-27
申请号：US14713824
申请日：2015-05-15
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： Wilfried Braje , Hervé Geneste , Wilfried Hornberger , Katja Jantos , Andreas Kling , Claudia Krack , Marcel Van Gaalen
IPC分类号： C07D471/10 , C07D295/135 , C07D305/08 , C07D401/14 , C07D487/10 , C07D209/40 , C07D213/64
CPC分类号： C07D487/10 , C07D209/40 , C07D213/64 , C07D295/135 , C07D305/08 , C07D401/14 , C07D471/10
摘要： The present invention relates to novel substituted oxindole derivatives of formula I wherein the variables are as defined in the claims and the description. The invention further relates to pharmaceutical compositions comprising compounds I and their use for the treatment of vasopressin-related disorders.
摘要翻译：本发明涉及式I的新的取代的羟基吲哚衍生物，其中变量如权利要求和说明书所定义。本发明还涉及包含化合物I及其用于治疗加压素相关病症的用途的药物组合物。

6. 发明申请

US20150329551A1 OXINDOLE COMPOUNDS CARRYING A NITROGEN-BOUND SPIRO SUBSTITUENT AND USE THEREOF FOR TREATING VASOPRESSIN-RELATED DISEASES 有权
标题翻译：携带氮离子螺旋体替代物的氧化合物及其用于治疗相关疾病的用途
公开(公告)号：US20150329551A1
公开(公告)日：2015-11-19
申请号：US14713909
申请日：2015-05-15
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： Hervé Geneste , Wilfried Hornberger , Katja Jantos , Andreas Kling , Marcel Van Gaalen
IPC分类号： C07D487/10
CPC分类号： C07D471/10 , C07D295/135 , C07D305/08 , C07D487/10
摘要： The present invention relates to novel substituted oxindole derivatives of the formula I wherein A is a ring selected from phenyl and 6-membered hetaryl containing 1 or 2 nitrogen atoms as ring members, where ring A carries one substituent R6 and optionally one substituent R7; B is a ring selected from phenyl and a monocyclic or bicyclic heteroaromatic ring containing 1, 2 or 3 heteroatoms selected from O, N and S as ring members, where ring B may carry 1, 2 or 3 substituents R8; X1, X2, X3 and X4, independently of each other, are selected from —CH2—, —O—, —S(O)c—, —NH—, —C(O)—, —CH2CH2—, —CH2O—, —OCH2—, —S(O)cCH2—, —CH2S(O)c—, CH2NH—, —NHCH2—, —CH2C(O)— and C(O)CH2—; X5 is NH, CH2 or O; and wherein c, R1, R2, (R3)a, (R4)b, R5, R6, R7, and R8 are as defined in the claims. The present invention also relates to pharmaceutical compositions comprising the novel substituted oxindole derivatives of the formula I, and to their use for the treatment of vasopressin-related disorders
摘要翻译：本发明涉及式I的新的取代羟吲哚衍生物，其中A是选自苯基和含有1或2个氮原子作为环成员的6元杂芳基的环，其中环A携带一个取代基R6和任选的一个取代基R7; B是选自苯基和含有1,2或3个选自O，N和S的环成员的单环或双环杂芳族环的环，其中环B可以带有1,2或3个取代基R8; X1，X2，X3和X4彼此独立地选自-CH 2 - ， - O - ， - S（O）c - ， - NH - ， - C（O） - ， - CH 2 CH 2 - ，-OCH 2 - ， - S（O）cCH 2 - ， - CH 2 S（O）c - ，CH 2 NH - ， - NHCH 2 - ， - CH 2 C（O） - 和C（O） X 5是NH，CH 2或O; 并且其中c，R 1，R 2，（R 3）a，（R 4）b，R 5，R 6，R 7和R 8如权利要求中所定义。本发明还涉及包含式I的新型取代的羟吲哚衍生物的药物组合物及其用于治疗加压素相关疾病的用途

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