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1. 发明授权

US09382537B2 Methods and compositions involving miRNA and miRNA inhibitor molecules 有权
公开(公告)号：US09382537B2
公开(公告)日：2016-07-05
申请号：US14459182
申请日：2014-08-13
申请人： Asuragen, Inc.
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/11 , C12N15/113 , A61K31/7105 , A61K45/06 , A61N5/10 , C12Q1/68 , A61K9/127 , A61K31/7088 , A61K31/713
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.

2. 发明申请

US20150004221A1 METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES 有权
公开(公告)号：US20150004221A1
公开(公告)日：2015-01-01
申请号：US14459182
申请日：2014-08-13
申请人： ASURAGEN, INC.
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.

3. 发明授权

US09506061B2 Methods and compositions involving miRNA and miRNA inhibitor molecules 有权
公开(公告)号：US09506061B2
公开(公告)日：2016-11-29
申请号：US14712591
申请日：2015-05-14
申请人： Asuragen, Inc.
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/11 , C12N15/113 , A61K31/7105 , A61K45/06 , A61N5/10 , C12Q1/68 , A61K9/127 , A61K31/7088 , A61K31/713
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.

4. 发明授权

US09068219B2 Methods and compositions involving miRNA and miRNA inhibitor molecules 有权
公开(公告)号：US09068219B2
公开(公告)日：2015-06-30
申请号：US14459074
申请日：2014-08-13
申请人： Asuragen, Inc.
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/11 , C12Q1/68 , C12N15/113 , A61K9/127 , A61K31/7088
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.

5. 发明申请

US20140348908A1 METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES 审中-公开
公开(公告)号：US20140348908A1
公开(公告)日：2014-11-27
申请号：US14459192
申请日：2014-08-13
申请人： ASURAGEN, INC.
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.

6. 发明申请

US20140348907A1 METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES 审中-公开
公开(公告)号：US20140348907A1
公开(公告)日：2014-11-27
申请号：US14459119
申请日：2014-08-13
申请人： ASURAGEN, INC.
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.

7. 发明申请

US20140274791A1 miRNA BIOMARKERS OF LUNG DISEASE 审中-公开
标题翻译：肺病的miRNA生物标志物
公开(公告)号：US20140274791A1
公开(公告)日：2014-09-18
申请号：US14251156
申请日：2014-04-11
申请人： Asuragen, Inc.
发明人： Elizabeth Mambo , David Brown , Alex T. Adai , Tiffany Sanford , Stephanie Volz , Ashish Choudhary
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing lung disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as lung cancer.
摘要翻译：该应用描述了可用作血清或血浆生物标志物的miRNA，用于表征患者的肺部疾病。这些miRNA生物标志物可以单独使用或与其他标志物组合使用，用于诊断，预后或监测诸如肺癌的疾病。

8. 发明申请

US20140228228A1 Methods and Compositions Involving MicroRNA 审中-公开
标题翻译：涉及MicroRNA的方法和组成
公开(公告)号：US20140228228A1
公开(公告)日：2014-08-14
申请号：US14062612
申请日：2013-10-24
申请人： ASURAGEN, INC.
发明人： David Brown , Rick Conrad , Eric Devroe , Marianna Goldrick , Kerri Keiger , Emmanuel Labourier , Ivonne Moon , Patricia Powers , Jeffrey Shelton , Jaclyn Shingara
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12N15/111 , C12N2310/14 , C12N2310/3517 , C12N2310/3519 , C12N2320/10 , C12P19/34 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Q2565/501 , C12Q2525/207
摘要： The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.
摘要翻译：本发明涉及用于分离，富集和/或标记miRNA分子以及制备和使用阵列或其他用于miRNA分析的检测技术的方法和组合物。此外，本发明涉及用于产生miRNA谱并用于治疗，诊断和预后应用的这种分布的方法和组合物。

9. 发明申请

US20140141423A1 miRNAs Differentially Expressed in Lymph Nodes from Cancer Patients 审中-公开
标题翻译： miRNA在癌症患者淋巴结中差异表达
公开(公告)号：US20140141423A1
公开(公告)日：2014-05-22
申请号：US14051354
申请日：2013-10-10
申请人： ASURAGEN, INC.
发明人： Sylvie Beaudenon , Laura Elizondo , Martina Doleshal , David Brown , Emmanuel Labourier
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12N15/111 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12Q2600/112 , C12Q2600/178
摘要： The present invention provides diagnostics and/or prognostic methods by identifying miRNAs that are differentially expressed or mis-regulated in various states of diseased, normal, cancerous, and/or abnormal tissues, including but not limited to cervix, skin, colon, breast, bladder, esophagus, liver, ovary, prostate, lung, pancreas, thyroid, kidney, stomach, testicle, uterus, spleen, tongue, brain, thymus, trachea and/or small intestine. In certain aspects, differential miRNA expression is initially determined by comparing miRNA expression between a normal tissue and cancer negative lymph node (LNneg), a normal tissue and a cancer positive lymph node (LNpos), a cancerous tissue and LNneg and/or LNpos, LNneg and LNpos. The methods of the invention are used to identify the presence or absence of non-lymphoid cells from other organs or tissues, and/or metastatic cancer cells present in lymph nodes.
摘要翻译：本发明通过鉴定在患病，正常，癌性和/或异常组织的各种状态中差异表达或错误调节的miRNA来提供诊断和/或预后方法，包括但不限于子宫颈，皮肤，结肠，乳房，膀胱，食管，肝，卵巢，前列腺，肺，胰腺，甲状腺，肾，胃，睾丸，子宫，脾，舌，脑，胸腺，气管和/或小肠。在某些方面，差异miRNA表达最初通过比较正常组织和癌阴性淋巴结（LNneg），正常组织和癌淋巴结（LNpos），癌组织和LNneg和/或LNpos之间的miRNA表达来确定， LNneg和LNpos。本发明的方法用于鉴定存在于淋巴结中的其它器官或组织和/或转移性癌细胞的非淋巴细胞的存在或不存在。

10. 发明申请

US20130303591A1 METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES 审中-公开
公开(公告)号：US20130303591A1
公开(公告)日：2013-11-14
申请号：US13887008
申请日：2013-05-03
申请人： Asuragen, Inc.
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitry Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.

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