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1. 发明申请

US20150170776A1 METHOD AND APPARATUS FOR THE PRODUCTION OF LEAD 212 FOR MEDICAL USE 有权
标题翻译：用于生产用于医疗用途的引线212的方法和装置
公开(公告)号：US20150170776A1
公开(公告)日：2015-06-18
申请号：US14402325
申请日：2013-05-23
申请人： AREVA MED SAS
发明人： Julien Torgue , Patrick Maquaire , John Young , Gilbert Andreoletti , Patrick Bourdet
IPC分类号： G21G1/00 , C22B13/06 , C22B13/02 , A61K51/12 , C22C11/00
CPC分类号： G21G1/0005 , A61K51/12 , C22B13/02 , C22B13/06 , C22C11/00 , G21G4/08 , G21G2001/0094
摘要： The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterised in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.
摘要翻译：本发明涉及一种用于制备用于医疗用途的铅（212）的方法。该方法包括在包括固体介质的发生器中通过镭（224）的衰变产生铅（212），镭（224）结合到该固体介质上，随后在发生器中从引线（212）中提取铅水溶液A1的形式，其特征在于，通过柱上的液相色谱法，包含在水溶液A1中的铅（212）从也含在所述水溶液中的放射性和化学杂质中纯化。本发明还涉及专门设计用于所述方法的封闭系统中的自动化实施的装置。它还涉及通过该方法和该装置产生的引线（212）。应用：在人类和动物中制造基于铅（212）的放射性药物，用于治疗癌症，特别是放射免疫疗法或用于医学成像的核医学。

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