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1. 发明授权

US09745336B2 Fluorescent dye compounds, conjugates and uses thereof 有权
公开(公告)号：US09745336B2
公开(公告)日：2017-08-29
申请号：US14229663
申请日：2014-03-28
申请人： APPLIED BIOSYSTEMS, LLC
发明人： Ronald Graham , Ruiming Zou , Krishna Upadhya , Scott Benson
IPC分类号： C07H19/04 , C07H21/00 , C07D219/06 , C09B15/00 , C09K11/06 , C12Q1/68 , G01N33/58
CPC分类号： C07H21/00 , C07D219/06 , C09B15/00 , C09K11/06 , C09K2211/1011 , C09K2211/1029 , C12Q1/6816 , C12Q1/6869 , G01N33/582 , Y10S436/80 , Y10T436/143333
摘要： The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.

2. 发明申请

US20140303003A1 Fluorescent Dye Compounds, Conjugates and Uses Thereof 有权
标题翻译：荧光染料化合物，共轭物及其用途
公开(公告)号：US20140303003A1
公开(公告)日：2014-10-09
申请号：US14229663
申请日：2014-03-28
申请人： APPLIED BIOSYSTEMS, LLC
发明人： Ronald Graham , Ruiming Zou , Krishna Upadhya , Scott Benson
IPC分类号： G01N33/58 , C12Q1/68
CPC分类号： C07H21/00 , C07D219/06 , C09B15/00 , C09K11/06 , C09K2211/1011 , C09K2211/1029 , C12Q1/6816 , C12Q1/6869 , G01N33/582 , Y10S436/80 , Y10T436/143333
摘要： The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
摘要翻译：本教导通常涉及荧光染料，荧光染料的可连接形式，能量转移染料，用荧光染料标记的试剂及其用途。

3. 发明申请

US20140145115A1 Fluorescent Polymeric Materials Containing Lipid Soluble Rhodamine Dyes 有权
标题翻译：含有脂溶性罗丹明染料的荧光聚合材料
公开(公告)号：US20140145115A1
公开(公告)日：2014-05-29
申请号：US14090554
申请日：2013-11-26
申请人： Applied Biosystems, LLC
发明人： Joe Y.L. LAM , Steven Menchen , Ruiming Zou , Scott Benson
IPC分类号： C09K11/02
CPC分类号： C09K11/025 , C07D311/80 , C09B11/24 , C09B67/0092 , C09B67/0097 , C09B69/103 , C09K11/06 , C09K2211/1088 , C09K2211/1416 , C09K2211/145
摘要： Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed.
摘要翻译：公开了包含聚合物和一种或多种脂溶性罗丹明染料的荧光聚合物材料。这些材料在制备多彩色微粒，特别是多色聚苯乙烯微粒中是特别有用的，用于在单个样品中多个分析物的多重分析。当被光源激发时，材料基于其中染料的性质，浓度和比例发出独特的发射。还公开了制备和使用所述材料的方法。

4. 发明授权

US09493656B2 Phenyl xanthene dyes 有权
公开(公告)号：US09493656B2
公开(公告)日：2016-11-15
申请号：US14741258
申请日：2015-06-16
申请人： APPLIED BIOSYSTEMS, LLC
发明人： Joe Y. L. Lam , Steven M. Menchen , Ruiming Zou , Scott C. Benson
IPC分类号： C07D311/82 , C09B11/06 , C09B11/12 , C09B11/22 , C09B11/24 , C09B11/26 , C09B13/00 , C07D491/14 , C09B57/00 , C09B62/002
CPC分类号： C09B11/24 , C07D311/82 , C07D491/14 , C09B11/06 , C09B11/12 , C09B11/22 , C09B11/26 , C09B13/00 , C09B57/00 , C09B62/0025
摘要： Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes. The phenyl xanthene dyes are useful for a number of purposes, including labels for use in automated DNA sequencing as well the formation of fluorescent “bar codes” for polymeric particles used in the multiplexed analysis of analytes.

5. 发明授权

US09090775B2 Phenyl xanthene dyes 有权
标题翻译：苯基呫吨染料
公开(公告)号：US09090775B2
公开(公告)日：2015-07-28
申请号：US14188309
申请日：2014-02-24
申请人： APPLIED BIOSYSTEMS, LLC
发明人： Joe Y. Lam , Steven Menchen , Ruiming Zou , Scott Benson
IPC分类号： C09B62/002 , C09B57/00 , C09B13/00 , C07D311/82 , C07D491/14 , C09B11/06 , C09B11/24 , C09B11/12 , C09B11/26
CPC分类号： C09B11/24 , C07D311/82 , C07D491/14 , C09B11/06 , C09B11/12 , C09B11/22 , C09B11/26 , C09B13/00 , C09B57/00 , C09B62/0025
摘要： Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes. The phenyl xanthene dyes are useful for a number of purposes, including labels for use in automated DNA sequencing as well the formation of fluorescent “bar codes” for polymeric particles used in the multiplexed analysis of analytes.
摘要翻译：描述了包含任何含有特定C 9苯环的任何荧光素，罗丹明或若丹明的荧光苯基呫吨染料。下C9苯环上的一个或两个邻基被选自烷基，杂烷基，烷氧基，卤素，卤代烷基，氨基，巯基，烷硫基，氰基，异氰基，氰基，巯基氰基，亚硝基，硝基，叠氮基，磺酰亚胺基，亚磺酰基和亚磺酰基。在一个实施方案中，使用卤素和/或羟基。最佳染料含有较低的C 9苯环，其中两个邻基团相同，并且下环表现出相对于从苯环连接点到呫吨染料的其余部分的假想轴的对称性。附件点。苯基呫吨染料可以被活化。此外，苯基呫吨染料可以与一种或多种包括其它染料的物质共轭。苯基呫吨染料可用于许多目的，包括用于自动DNA测序的标记，以及用于分析物复用分析中使用的聚合物颗粒的荧光“条形码”。

6. 发明授权

US09034920B2 Fluorescent polymeric materials containing lipid soluble rhodamine dyes 有权
标题翻译：含有脂溶性罗丹明染料的荧光聚合材料
公开(公告)号：US09034920B2
公开(公告)日：2015-05-19
申请号：US14090554
申请日：2013-11-26
申请人： Applied Biosystems, LLC
发明人： Joe Y. L. Lam , Steven Menchen , Ruiming Zou , Scott Benson
IPC分类号： C07D311/80 , C09K11/02 , C09B67/42 , C09K11/06
CPC分类号： C09K11/025 , C07D311/80 , C09B11/24 , C09B67/0092 , C09B67/0097 , C09B69/103 , C09K11/06 , C09K2211/1088 , C09K2211/1416 , C09K2211/145
摘要： Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes with the following core structure: The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticles, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using the fluorescent polymeric materials are also disclosed.
摘要翻译：公开了包含聚合物和一种或多种具有以下核心结构的脂溶性罗丹明染料的荧光聚合物材料：该材料特别可用于制备多色微粒，特别是多色聚苯乙烯微粒，用于多个分析物的多重分析在一个单一的样品。当被光源激发时，材料基于其中染料的性质，浓度和比例发出独特的发射。还公开了制备和使用荧光聚合物材料的方法。

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