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1. 发明授权

US11160931B2 Method of assembling and filling a drug delivery device 有权
公开(公告)号：US11160931B2
公开(公告)日：2021-11-02
申请号：US16401471
申请日：2019-05-02
申请人： AMGEN INC.
发明人： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC分类号： B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/31 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/142
摘要： An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

2. 发明授权

US11058821B2 Injector and method of assembly 有权
公开(公告)号：US11058821B2
公开(公告)日：2021-07-13
申请号：US16687254
申请日：2019-11-18
申请人： AMGEN INC.
发明人： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC分类号： A61M5/31 , B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/142
摘要： An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

3. 发明授权

US10537681B2 Injector and method of assembly 有权
公开(公告)号：US10537681B2
公开(公告)日：2020-01-21
申请号：US15040308
申请日：2016-02-10
申请人： AMGEN INC.
发明人： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC分类号： A61M5/31 , B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/142
摘要： An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

4. 发明申请

US20180256821A1 INJECTOR AND METHOD OF ASSEMBLY 审中-公开
公开(公告)号：US20180256821A1
公开(公告)日：2018-09-13
申请号：US15974354
申请日：2018-05-08
申请人： AMGEN INC.
发明人： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC分类号： A61M5/31 , B65B55/10 , B65B55/08 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/162 , B65B7/28 , B65B3/00 , A61M5/24 , A61M5/172 , A61M5/142
摘要： An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

5. 发明申请

US20160199583A1 METHOD OF ASSEMBLING AND FILLING A DRUG DELIVERY DEVICE 审中-公开
标题翻译：装配和填充药物递送装置的方法
公开(公告)号：US20160199583A1
公开(公告)日：2016-07-14
申请号：US15047815
申请日：2016-02-19
申请人： AMGEN INC.
发明人： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Son C. Tran , Sheldon Moberg , Mark D. Holt
IPC分类号： A61M5/31 , B65B55/10 , B65B55/08 , B65B3/00 , B65B7/28
摘要： An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
摘要翻译：注射器可以包括具有带有内表面的壁和具有内表面的密封组件的容器，壁的内表面和密封组件限定了填充有药物产品的封闭的无菌容器，其包括粒细胞集落刺激因子（G-CSF）。注射器还可以包括流体输送系统，该流体输送系统包括清洁的，未被加热的刚性容器针，其具有仅在部分地通过密封组件处于储存状态的点，并且设置成通过密封组件的内表面输送到无菌容器中州。此外，注射可以包括适于将容器针从储存状态移动到输送状态的致动器。

6. 发明申请

US20160199578A1 INJECTOR AND METHOD OF ASSEMBLY 审中-公开
标题翻译：注射器和组装方法
公开(公告)号：US20160199578A1
公开(公告)日：2016-07-14
申请号：US15040308
申请日：2016-02-10
申请人： AMGEN INC.
发明人： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC分类号： A61M5/24 , A61M5/172
摘要： An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
摘要翻译：注射器可以包括具有内表面的壁和具有内表面的密封组件的容器，壁的内表面和密封组件限定了充满药物的封闭的无菌容器。注射器还可以包括流体输送系统，该流体输送系统包括清洁的，未被加热的刚性容器针，其具有仅在部分地通过密封组件处于储存状态的点，并且设置成通过密封组件的内表面输送到无菌容器中州。此外，注射可以包括适于将容器针从储存状态移动到输送状态的致动器。

7. 发明申请

US20160166765A1 INJECTOR AND METHOD OF ASSEMBLY 审中-公开
标题翻译：注射器和组装方法
公开(公告)号：US20160166765A1
公开(公告)日：2016-06-16
申请号：US15047792
申请日：2016-02-19
申请人： AMGEN INC.
发明人： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC分类号： A61M5/162 , A61M5/148 , A61M5/158 , A61M5/145
摘要： An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
摘要翻译：注射器可以包括具有带有内表面的壁和具有内表面的密封组件的容器，壁的内表面和密封组件限定了填充有药物产品的封闭的无菌容器，其包括粒细胞集落刺激因子（G-CSF）。注射器还可以包括流体输送系统，该流体输送系统包括清洁的，未被加热的刚性容器针，其具有仅在部分地通过密封组件处于储存状态的点，并且设置成通过密封组件的内表面输送到无菌容器中州。此外，注射可以包括适于将容器针从储存状态移动到输送状态的致动器。

8. 发明授权

US11110225B2 Injector and method of assembly 有权
公开(公告)号：US11110225B2
公开(公告)日：2021-09-07
申请号：US15974354
申请日：2018-05-08
申请人： AMGEN INC.
发明人： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC分类号： A61M5/31 , B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/142
摘要： An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

9. 发明申请

US20200179609A1 INJECTOR AND METHOD OF ASSEMBLY 审中-公开
公开(公告)号：US20200179609A1
公开(公告)日：2020-06-11
申请号：US16687254
申请日：2019-11-18
申请人： AMGEN INC.
发明人： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC分类号： A61M5/31 , A61M5/162 , A61M5/158 , A61M5/148 , A61M5/145 , A61M5/172 , A61M5/24 , B65B55/10 , B65B55/08 , B65B7/28 , B65B3/00
摘要： An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

10. 发明授权

US10537682B2 Injector and method of assembly 有权
公开(公告)号：US10537682B2
公开(公告)日：2020-01-21
申请号：US15047792
申请日：2016-02-19
申请人： AMGEN INC.
发明人： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC分类号： A61M5/31 , B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/142
摘要： An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

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