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    • 3. 发明申请
    • Treating Xerophthalmia With Compounds Increasing Meibomian Gland Secretion
    • 用化合物治疗弥漫性睑板腺分泌物的Xerophthalmia
    • US20110294897A1
    • 2011-12-01
    • US12956386
    • 2010-11-30
    • A.K. Gunnar AbergVincent B. Ciofalo
    • A.K. Gunnar AbergVincent B. Ciofalo
    • A61K31/137A61P27/04
    • A61K31/137A61K9/0019A61K9/0048A61K9/06A61K47/10
    • Methods for the treatment of patients suffering from dry eyes, by using adrenergic beta-receptor agonists, particularly salbutamol and in particular the optically pure or substantially pure R-enantiomer thereof. The embodiments disclosed herein include methods of increasing the Meibomian lipid secretion and thereby reducing or eliminating xerophthalmia symptoms by the administration of formulations containing therapeutically effective amounts of an adrenergic beta-receptor agonist to said patients. In particular, certain embodiments disclosed herein concern compositions that contain R-salbutamol as the active beta-receptor stimulating ingredient. In certain embodiments, the formulations are administered to the ocular surface of the eye and/or to the eyelid (the underside of the eyelid and/or the top of the eyelid) of a patient in need thereof.
    • 通过使用肾上腺素能β受体激动剂,特别是沙丁胺醇,特别是光学纯的或基本上纯的R-对映体,治疗患有干眼症的患者的方法。 本文公开的实施方案包括通过向所述患者施用含有治疗有效量的肾上腺素能β受体激动剂的制剂来增加睑板腺脂质分泌并从而减少或消除干眼症状的方法。 特别地,本文公开的某些实施方案涉及含有R-沙丁胺醇作为活性β-受体刺激成分的组合物。 在某些实施方案中,将制剂施用于眼睛的眼表面和/或施用于有需要的患者的眼睑(眼睑的下侧和/或眼睑的顶部)。