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1. 发明授权

US06287756B1 Methods for determining presence of cancer in a sample by determining expression of an SSX gene 失效
标题翻译：通过确定SSX基因表达来确定样品中癌症存在的方法
公开(公告)号：US06287756B1
公开(公告)日：2001-09-11
申请号：US09105839
申请日：1998-06-26
申请人： Özlem Türeci , Yao-Tseng Chen , Ugur Sahin , Ali O. Gure , Lloyd J. Old , Michael Pfreundschuh
发明人： Özlem Türeci , Yao-Tseng Chen , Ugur Sahin , Ali O. Gure , Lloyd J. Old , Michael Pfreundschuh
IPC分类号： G01N3353
CPC分类号： C07K14/82 , A61K38/00 , G01N33/57484 , G01N2333/82
摘要： The invention relates to members of the SSX family of genes, as well as to their uses.
摘要翻译：本发明涉及SSX家族基因的成员以及它们的用途

2. 发明授权

US06291658B1 Isolated nucleic acid molecules encoding SSX family members and thereof 失效
标题翻译：编码SSX家族成员及其分离的核酸分子
公开(公告)号：US06291658B1
公开(公告)日：2001-09-18
申请号：US08851138
申请日：1997-05-05
申请人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
发明人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
IPC分类号： C07H2102
CPC分类号： C07K14/47
摘要： The invention relates to members of the SSX family of genes, as well as their uses.
摘要翻译：本发明涉及SSX家族基因的成员及其用途

3. 发明授权

US06339140B1 SSX family proteins 有权
标题翻译： SSX家族蛋白
公开(公告)号：US06339140B1
公开(公告)日：2002-01-15
申请号：US09796780
申请日：2001-03-01
申请人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
发明人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
IPC分类号： C07K100
CPC分类号： C07K14/47
摘要： The invention relates to members of the SSX family of genes, as well as their uses.
摘要翻译：本发明涉及SSX家族基因的成员及其用途

4. 发明授权

US06338947B1 Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith 有权
标题翻译：通过测定与其相关的多种抗原来确定乳腺癌和黑素瘤的方法
公开(公告)号：US06338947B1
公开(公告)日：2002-01-15
申请号：US09578378
申请日：2000-05-25
申请人： Ugur Sahin , Özlem Türeci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
发明人： Ugur Sahin , Özlem Türeci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
IPC分类号： G01N3353
CPC分类号： G01N33/57415 , C07K14/4748 , C12Q1/6886 , C12Q2600/106
摘要： The invention relates to assays for determining breast cancer or melanoma. It has been found that the accuracy of such assays can be improved by assaying samples for three or more known tumor rejection antigen precursors. For breast cancer, the tumor rejection antigen precursors known as SCP-1, NY-ESO-1, and SSX-2 are assayed. For melanoma, SSX-2, NY-ESO-1, and MAGE-3 are assayed. Additional known tumor rejection antigen precursors can also be determined to confirm the assays. It is preferred to carry these out via polymerase chain reactions.
摘要翻译：本发明涉及用于确定乳腺癌或黑素瘤的测定法。已经发现，通过测定三种或更多种已知的肿瘤排斥抗原前体的样品，可以提高这些测定的准确性。对于乳腺癌，测定称为SCP-1，NY-ESO-1和SSX-2的肿瘤排斥抗原前体。对于黑素瘤，测定SSX-2，NY-ESO-1和MAGE-3。还可以确定另外已知的肿瘤排斥抗原前体以确认测定。优选通过聚合酶链反应进行这些操作。

5. 发明授权

US6140050A Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith 失效
公开(公告)号：US6140050A
公开(公告)日：2000-10-31
申请号：US105907
申请日：1998-06-26
申请人： Ugur Sahin , Ozlem Tureci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
发明人： Ugur Sahin , Ozlem Tureci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
IPC分类号： C07K14/47 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P19/34
CPC分类号： G01N33/57415 , C07K14/4748 , C12Q1/6886 , C12Q2600/106
摘要： The invention relates to assays for determining breast cancer or melanoma. It has been found that the accuracy of such assays can be improved by assaying samples for three or more known tumor rejection antigen precursors. For breast cancer, the tumor rejection antigen precursors known as SCP-1, NY-ESO-1, and SSX-2 are assayed. For melanoma, SSX-2, NY-ESO-1, and MAGE-3 are assayed. Additional known tumor rejection antigen precursors can also be determined to confirm the assays. It is preferred to carry these out via polymerase chain reactions.

6. 发明授权

US07314721B2 Small cell lung cancer associated antigens and uses therefor 有权
标题翻译：小细胞肺癌相关抗原及其用途
公开(公告)号：US07314721B2
公开(公告)日：2008-01-01
申请号：US10761169
申请日：2004-01-20
申请人： Ali O. Gure , Elisabeth Stockert , Matthew J. Scanlan , Dirk Jager , Lloyd J. Old , Yao-Tseng Chen
发明人： Ali O. Gure , Elisabeth Stockert , Matthew J. Scanlan , Dirk Jager , Lloyd J. Old , Yao-Tseng Chen
IPC分类号： G01N33/53 , C07K1/00 , C07K16/00
CPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , C07K14/4748 , G01N33/57423
摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in small cell lung cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with small cell lung cancer. The invention provides, among other things, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.
摘要翻译：已经通过使用来自癌症患者的抗血清的小细胞肺癌细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。本发明涉及在患有小细胞肺癌的患者中表达的癌症相关抗原的核酸和编码多肽。本发明尤其提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。还提供了前述的片段，包括功能片段和变体。另外提供了含有上述分子的试剂盒。本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

7. 发明授权

US06403373B1 Isolated nucleic acid molecules associated with colon, renal, and stomach cancer and methods of using these 失效
标题翻译：与结肠，肾和胃癌相关的分离的核酸分子及其使用方法
公开(公告)号：US06403373B1
公开(公告)日：2002-06-11
申请号：US09102322
申请日：1998-06-22
申请人： Matthew J. Scanlan , Yao-Tseng Chen , Elisabeth Stockert , Lloyd J. Old
发明人： Matthew J. Scanlan , Yao-Tseng Chen , Elisabeth Stockert , Lloyd J. Old
IPC分类号： C12N510
CPC分类号： G01N33/56977 , A61K38/00 , C07K14/4748 , C12Q1/6886 , C12Q2600/158 , G01N33/5748
摘要： Various molecules associated with cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules.
摘要翻译：公开了与癌症相关的各种分子。本发明还公开了基于这些分子的诊断和治疗方法。

8. 发明授权

US06440663B1 Renal cancer associated antigens and uses therefor 有权
标题翻译：肾癌相关抗原及其用途
公开(公告)号：US06440663B1
公开(公告)日：2002-08-27
申请号：US09166350
申请日：1998-10-05
申请人： Matthew J. Scanlan , Elisabeth Stockert , Yao-Tseng Chen , Lloyd J. Old , Elke Jager , Alex Knuth
发明人： Matthew J. Scanlan , Elisabeth Stockert , Yao-Tseng Chen , Lloyd J. Old , Elke Jager , Alex Knuth
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K35/00 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/11 , C12Q1/6886 , C12Q2600/158 , G01N33/57488 , G01N33/57492
摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in renal cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with renal cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.
摘要翻译：已经通过使用来自癌症患者的抗血清的肾癌细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。本发明涉及在患有肾癌的患者中表达的癌症相关抗原的核酸和编码多肽。本发明尤其提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。还提供了前述的片段，包括功能片段和变体。另外提供了含有上述分子的试剂盒。本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

9. 发明授权

US07009035B2 Isolated peptides which bind to HLA-C molecules and uses thereof 失效
公开(公告)号：US07009035B2
公开(公告)日：2006-03-07
申请号：US10274017
申请日：2002-10-18
申请人： Sacha Gnjatic , Lloyd J. Old , Yasuhiro Nagata , Elke Jager , Yao-Tseng Chen , Alexander Knuth
发明人： Sacha Gnjatic , Lloyd J. Old , Yasuhiro Nagata , Elke Jager , Yao-Tseng Chen , Alexander Knuth
IPC分类号： C07K7/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5158
摘要： The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.

10. 发明授权

US5843448A Tumor rejection antigen precursor 失效
标题翻译：肿瘤排斥抗原前体
公开(公告)号：US5843448A
公开(公告)日：1998-12-01
申请号：US560024
申请日：1995-11-17
申请人： Yao-Tseng Chen , Elisabeth Stockert , Yachi Chen , Pilar Garin-Chesa , Wolfgang J. Rettig , Lloyd J. Old
发明人： Yao-Tseng Chen , Elisabeth Stockert , Yachi Chen , Pilar Garin-Chesa , Wolfgang J. Rettig , Lloyd J. Old
IPC分类号： C12N15/02 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , C07H21/04 , C07K20060101 , C07K7/08 , C07K14/47 , C07K14/705 , C07K16/30 , C12N5/10 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/574 , A61K38/10 , C07K14/82
CPC分类号： C07K14/4748 , C07K16/30 , A61K38/00 , A61K39/00
摘要： The invention relates to monoclonal antibodies which specifically bind to the tumor rejection antigen precursor molecule MAGE-1, hybridomas which produce these monoclonal antibodies, and their use. Also described is a recombinant form of MAGE-1, peptides which are useful as immunogens, and immunogenic compositions containing the peptides and an adjuvant.
摘要翻译：本发明涉及与肿瘤排斥抗原前体分子MAGE-1特异性结合的单克隆抗体，产生这些单克隆抗体的杂交瘤及其应用。还描述了重组形式的MAGE-1，可用作免疫原的肽和含有肽和佐剂的免疫原性组合物。

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