专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08552205B2 Derivatives of 6,7-dihydro-5H-imidazo[1,2-alpha]imidazole-3-carboxylic acid amides 有权
标题翻译： 6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-羧酸酰胺的衍生物
公开(公告)号：US08552205B2
公开(公告)日：2013-10-08
申请号：US12745439
申请日：2008-11-20
申请人： Antonio Jose del Moral Barbosa, Jr. , Joerg Martin Bentzien , Steven Richard Brunette , Zhidong Chen , Derek Cogan , Donghong A. Gao , Alexander Heim-Riether , Joshua Courtney Horan , Jennifer A. Kowalski , Michael David Lawlor , Rene Marc Lemieux , Weimin Liu , Bryan McKibben , Craig Andrew Miller , Neil Moss , Matt Aaron Tschantz , Zhaoming Xiong , Hui Yu , Yang Yu
发明人： Antonio Jose del Moral Barbosa, Jr. , Joerg Martin Bentzien , Steven Richard Brunette , Zhidong Chen , Derek Cogan , Donghong A. Gao , Alexander Heim-Riether , Joshua Courtney Horan , Jennifer A. Kowalski , Michael David Lawlor , Rene Marc Lemieux , Weimin Liu , Bryan McKibben , Craig Andrew Miller , Neil Moss , Matt Aaron Tschantz , Zhaoming Xiong , Hui Yu , Yang Yu
IPC分类号： A61K31/4188 , C07D403/14 , C07D403/12 , C07D401/12 , C07D401/14
CPC分类号： C07D487/04
摘要： Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要翻译： 6,7-二氢-5H-咪唑并[1,2-α]咪唑-3-羧酸酰胺的衍生物对CAM和白血球素蛋白的相互作用表现出良好的抑制作用，因此可用于治疗炎性疾病。

2. 发明申请

US20120295896A1 OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION 有权
标题翻译：氧氟沙星生产的氧化氮抑制剂
公开(公告)号：US20120295896A1
公开(公告)日：2012-11-22
申请号：US13237112
申请日：2011-09-20
申请人： Alessandra BARTOLOZZI , Todd BOSANAC , Zhidong CHEN , Stephane DE LOMBAERT , Jonathon Alan DINES , John D. HUBER , Weimin W. LIU , Pui Leng LOKE , Tina Marie MORWICK , Alan OLAGUE , Doris RIETHER , Heather TYE , Lifen WU , Renee M. ZINDELL
发明人： Alessandra BARTOLOZZI , Todd BOSANAC , Zhidong CHEN , Stephane DE LOMBAERT , Jonathon Alan DINES , John D. HUBER , Weimin W. LIU , Pui Leng LOKE , Tina Marie MORWICK , Alan OLAGUE , Doris RIETHER , Heather TYE , Lifen WU , Renee M. ZINDELL
IPC分类号： A61K31/506 , C07D417/14 , C07D487/04 , A61K31/519 , A61K31/541 , A61K31/5377 , A61K31/497 , A61K31/444 , A61P9/00 , A61P29/00 , A61P37/08 , A61P11/00 , A61P13/12 , A61P35/00 , A61P9/10 , C07D413/14
CPC分类号： C07D413/14
摘要： The present invention relates to compounds of formula (I) and (IA): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）和（IA）化合物及其药学上可接受的盐，其中R 1 -R 5如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

3. 发明申请

US20120245162A1 OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION 有权
标题翻译：氧氟沙星生产的氧化氮抑制剂
公开(公告)号：US20120245162A1
公开(公告)日：2012-09-27
申请号：US13237106
申请日：2011-09-20
申请人： Alessandra BARTOLOZZI , Todd BOSANAC , Zhidong CHEN , Stephane DE LOMBAERT , John D. HUBER , Weimin LIU , Ho Yin LO , Pui Leng LOKE , Doris RIETHER , Heather TYE , Lifen WU , Renee M. ZINDELL
发明人： Alessandra BARTOLOZZI , Todd BOSANAC , Zhidong CHEN , Stephane DE LOMBAERT , John D. HUBER , Weimin LIU , Ho Yin LO , Pui Leng LOKE , Doris RIETHER , Heather TYE , Lifen WU , Renee M. ZINDELL
IPC分类号： A61K31/506 , A61P29/00 , A61P37/08 , A61P11/00 , A61P13/12 , A61P35/00 , A61P9/10 , C07D413/14 , A61K31/444 , A61K31/5377 , C07D498/04 , A61K31/5383 , C07D487/04 , A61K31/519 , A61K31/4985 , A61P9/00
CPC分类号： C07D413/14
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体

4. 发明授权

US07395702B2 Step-adjustable tire pressure monitoring sensor signal housing assembly 有权
标题翻译：步进可调轮胎压力监测传感器信号壳体组件
公开(公告)号：US07395702B2
公开(公告)日：2008-07-08
申请号：US11796833
申请日：2007-04-30
申请人： Zhenfang Qiu , Jiansong Huang , Zhidong Chen
发明人： Zhenfang Qiu , Jiansong Huang , Zhidong Chen
IPC分类号： G01M17/02
CPC分类号： B60C23/0494 , Y10T137/36
摘要： This present invention discloses a step-adjustable tire pressure monitoring sensor signal housing assembly including a valve and a valve core fixed on a rim, a sensor signal housing which consists of a housing holder and a connecting part, the connecting part has a curve connecting face where a Slot 1 is provided, and a Slot 3 is provided on the housing holder under the connecting part; a D block, which is in D shape and has a flat part and a cylinder part, a Slot 2 is provided in the center of the cylinder part perpendicular to the flat part, some ratchet teeth are provided longitudinally in the cylinder part by the side of a mounting hole; a U-pawl and a spring, which are installed in the Slot 3, the spring is in the bottom of the U-pawl and the top of the U-pawl is corresponding to the ratchet teeth on the D block; and a connector which fixes the sensor signal housing and the D block onto the tire valve through the Slot 1 in the signal housing and the Slot 2 on the D block. This present invention is applicable for all the rims of 5˜35°, and therefore is widely applicable and easy to install.
摘要翻译：本发明公开了一种步进可调轮胎压力监测传感器信号壳体组件，其包括固定在轮辋上的阀和阀芯，由壳体保持器和连接部分组成的传感器信号壳体，连接部分具有曲线连接面其中设置有插槽1，并且插槽3设置在连接部下的壳体保持器上; D形块，其形状为D形，具有平坦部分和圆筒部分，在垂直于平坦部分的圆筒部分的中心设置有槽2，一些棘轮齿沿缸体部分纵向设置在侧面的安装孔; U形棘爪和弹簧，其安装在槽3中，弹簧位于U形棘爪的底部，U形棘爪的顶部对应于D块上的棘齿; 以及通过信号外壳中的插槽1和D块上的插槽2将传感器信号外壳和D块固定到轮胎气门上的连接器。本发明适用于5〜35°的所有轮辋，因此应用广泛，安装方便。

5. 发明申请

US20080127724A1 STEP-ADJUSTABLE TIRE PRESSURE MONITORING SENSOR SIGNAL HOUSING ASSEMBLY 有权
标题翻译：步进可调轮胎压力监测传感器信号壳体组件
公开(公告)号：US20080127724A1
公开(公告)日：2008-06-05
申请号：US11796833
申请日：2007-04-30
申请人： Zhenfang Qiu , Jiansong Huang , Zhidong Chen
发明人： Zhenfang Qiu , Jiansong Huang , Zhidong Chen
IPC分类号： B60C23/02
CPC分类号： B60C23/0494 , Y10T137/36
摘要： This present invention discloses a step-adjustable tire pressure monitoring sensor signal housing assembly including a valve and a valve core fixed on a rim, a sensor signal housing which consists of a housing holder and a connecting part, the connecting part has a curve connecting face where a Slot 1 is provided, and a Slot 3 is provided on the housing holder under the connecting part; a D block, which is in D shape and has a flat part and a cylinder part, a Slot 2 is provided in the center of the cylinder part perpendicular to the flat part, some ratchet teeth are provided longitudinally in the cylinder part by the side of a mounting hole; a U-pawl and a spring, which are installed in the Slot 3, the spring is in the bottom of the U-pawl and the top of the U-pawl is corresponding to the ratchet teeth on the D block; and a connector which fixes the sensor signal housing and the D block onto the tire valve through the Slot 1 in the signal housing and the Slot 2 on the D block. This present invention is applicable for all the rims of 5˜35°, and therefore is widely applicable and easy to install.
摘要翻译：本发明公开了一种步进可调轮胎压力监测传感器信号壳体组件，其包括固定在轮辋上的阀和阀芯，由壳体保持器和连接部分组成的传感器信号壳体，连接部分具有曲线连接面其中设置有插槽1，并且插槽3设置在连接部下的壳体保持器上; D形块，其形状为D形，具有平坦部分和圆筒部分，在垂直于平坦部分的圆筒部分的中心设置有槽2，一些棘轮齿沿缸体部分纵向设置在侧面的安装孔; U形棘爪和弹簧，其安装在槽3中，弹簧位于U形棘爪的底部，U形棘爪的顶部对应于D块上的棘齿; 以及通过信号外壳中的插槽1和D块上的插槽2将传感器信号外壳和D块固定到轮胎气门上的连接器。本发明适用于5〜35°的所有轮辋，因此应用广泛，安装方便。

6. 发明申请

US20080121032A1 Stepless-adjustable tire pressure monitoring sensor housing assembly 审中-公开
标题翻译：无级调节轮胎压力监测传感器外壳组件
公开(公告)号：US20080121032A1
公开(公告)日：2008-05-29
申请号：US11796834
申请日：2007-04-30
申请人： Zhenfang Qiu , Jiansong Huang , Zhidong Chen
发明人： Zhenfang Qiu , Jiansong Huang , Zhidong Chen
IPC分类号： B60C23/04
CPC分类号： B60C23/0408 , B60C23/0494
摘要： The present invention discloses a stepless adjustable tire pressure monitoring sensor signal housing assembly, which consists of a sensor signal housing with a housing holder and a connecting part on the center of the holder. The connecting part has a curve connecting face where a Slot 1 is provided. It also includes a D block which has a flat part and a cylinder part. On the cylinder part, a Slot 2 is provided longitudinally. Two mounting holes are provided on the wall of the deep side of the Slot 2, two springs and two needle rollers are installed in the two holes respectively. A through hole is also provided in the center of the cylinder part perpendicular to the flat part. It still contains a connector which fixes the sensor signal housing and the D block onto the tire valve through the Slot 1 in the signal housing and the Slot 2 in the D block. The TPMS signal housing of the stepless adjustable tire pressure monitoring sensor signal housing assembly of the present invention is connected to the tire valve in a movable way, which is not only convenient for installation and debugging, but also applicable for rims of various sizes.
摘要翻译：本发明公开了一种无级可调轮胎压力监测传感器信号壳体组件，其包括具有壳体保持器的传感器信号壳体和在保持器的中心上的连接部件。连接部分具有设置插槽1的曲线连接面。它还包括具有平坦部分和圆柱体部分的D块。在圆筒部分上，纵向设置插槽2。在槽2的深侧的壁上设置两个安装孔，两个孔中分别安装两个弹簧和两个滚针。在垂直于平坦部分的圆筒部分的中心处还设有通孔。它仍然包含连接器，通过信号外壳中的插槽1和D块中的插槽2将传感器信号外壳和D块固定到轮胎气门上。本发明的无级可调轮胎压力监测传感器信号壳体组件的TPMS信号壳体以可移动的方式连接到轮胎阀，这不仅方便安装和调试，而且适用于各种尺寸的轮辋。

7. 发明授权

US07119102B2 Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses 有权
标题翻译：取代的3-氨基 - 噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法及其用途
公开(公告)号：US07119102B2
公开(公告)日：2006-10-10
申请号：US11002828
申请日：2004-12-02
申请人： Zhidong Chen , Pier Francesco Cirillo , Darren DiSalvo , Weimin Liu , Daniel Richard Marshall , Lifen Wu , Erick Richard Roush Young
发明人： Zhidong Chen , Pier Francesco Cirillo , Darren DiSalvo , Weimin Liu , Daniel Richard Marshall , Lifen Wu , Erick Richard Roush Young
IPC分类号： A61K31/4365 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D409/14
CPC分类号： C07D495/04
摘要： Disclosed are compounds of formula (I): wherein the variables R1, R2, R3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译：公开了式（I）的化合物：其中本文描述了可变的R 1，R 2，R 3和Z，它们是有用的作为IkappaB激酶（IKK）复合物的激酶活性的抑制剂。因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫疾病炎性疾病和癌症。还公开了包含这些化合物的药物组合物和制备这些化合物的方法。

8. 发明授权

US06620597B1 Method for in vitro amplification of circular DNA 失效
标题翻译：环状DNA的体外扩增方法
公开(公告)号：US06620597B1
公开(公告)日：2003-09-16
申请号：US09582906
申请日：2000-07-06
申请人： Zhidong Chen , Duane E. Ruffner
发明人： Zhidong Chen , Duane E. Ruffner
IPC分类号： C12Q168
CPC分类号： C12Q1/686 , C12Q1/6846 , C12Q2531/125 , C12Q2521/501 , C12Q2525/307
摘要： A method for generating and amplifying closed circular DNA having a specific sequence in vitro in a cell-free system is disclosed. Prior to the invention of this method, closed circular DNA could only be amplified in vivo in appropriate host cells. The essence of the method is the inclusion of a thermostable DNA ligase in a PCR reaction. This procedure is referred to as ligation-during-amplification (LDA), in which the fully extended DNA strands are ligated by the DNA ligase and used as templates for subsequent amplification. Closed circular DNA having a specific sequence can be selectively amplified exponentially by the use of two sequence-specific primers in the LDA reaction. In addition, one or more site-specific mutations can be introduced into a closed circular DNA by the use of one or more mutagenic primers in the LDA reaction. Various thermostable DNA polymerases and thermostable ligases can be used for LDA amplification. Any primer position and orientation, either inward or outward, can be used in LDA amplification, as long as there is at least one primer complementary to each strand of the circular DNA. This method has applications in the areas of mutagenesis, cloning, DNA detection, DNA modification, gene hunting, gene therapy, and cell-free DNA production.
摘要翻译：公开了一种在无细胞体系中产生和扩增体外具有特定序列的封闭环状DNA的方法。在该方法发明之前，封闭的环状DNA只能在合适的宿主细胞中体内扩增。该方法的本质是在PCR反应中包含热稳定的DNA连接酶。此过程称为连接扩增期（LDA），其中完全延伸的DNA链通过DNA连接酶连接并用作随后扩增的模板。通过在LDA反应中使用两个序列特异性引物，可以选择性地扩增具有特定序列的封闭环状DNA。此外，通过在LDA反应中使用一种或多种诱变引物，可以将一个或多个位点特异性突变引入封闭的环状DNA。各种耐热DNA聚合酶和热稳定连接酶可用于LDA扩增。任何引物位置和方向，向内或向外均可用于LDA扩增，只要至少有一个与环状DNA的每条链互补的引物即可。该方法具有诱变，克隆，DNA检测，DNA修饰，基因寻找，基因治疗和无细胞DNA生产等领域的应用。

9. 发明授权

US08575201B2 Oxadiazole inhibitors of leukotriene production 有权
标题翻译：恶二唑抑制剂生产白三烯
公开(公告)号：US08575201B2
公开(公告)日：2013-11-05
申请号：US13237112
申请日：2011-09-20
申请人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin W. Liu , Pui Leng Loke , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin W. Liu , Pui Leng Loke , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
IPC分类号： A01N43/40 , A61K31/44
CPC分类号： C07D413/14
摘要： The present invention relates to compounds of formula (I) and (IA): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）和（IA）化合物及其药学上可接受的盐，其中R 1 -R 5如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

10. 发明授权

US08420655B2 Benzimidazole inhibitors of leukotriene production 有权
标题翻译：苯并咪唑抑制剂白三烯生产
公开(公告)号：US08420655B2
公开(公告)日：2013-04-16
申请号：US12957766
申请日：2010-12-01
申请人： Zhidong Chen , Ming-Hong Hao , Weimin Liu , Ho-Yin Lo , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Hidenori Takahashi , Heather Tye , Lifen Wu
发明人： Zhidong Chen , Ming-Hong Hao , Weimin Liu , Ho-Yin Lo , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Hidenori Takahashi , Heather Tye , Lifen Wu
IPC分类号： A61K31/506 , C07D403/14
CPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 7如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式