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1. 发明授权

US08323327B2 Stent delivery catheter system and method of implanting a self-expanding stent with embolic protection 有权
标题翻译：支架输送导管系统和植入具有栓塞保护的自扩张支架的方法
公开(公告)号：US08323327B2
公开(公告)日：2012-12-04
申请号：US12857467
申请日：2010-08-16
申请人： Nianjiong Joan Bei , Keif Fitzgerald , Patrick C. Saxton , Zhicheng Lin , Steven A. Tyler , Joanna Lubas
发明人： Nianjiong Joan Bei , Keif Fitzgerald , Patrick C. Saxton , Zhicheng Lin , Steven A. Tyler , Joanna Lubas
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2002/9583 , A61F2230/0006 , A61F2230/008
摘要： A catheter system for implanting an endoprosthesis at a treatment site in a patient's body lumen. The catheter includes an elongated shaft outer member and a stent sheath distal portion and a self-expanding stent radially restrained in a collapsed configuration within the stent sheath distal portion. A balloon catheter dimensioned for relative axial movement within the shaft outer member has an elongated shaft having an inflation lumen and a device receiving lumen. A stent stop secured to the balloon catheter is reversibly radially expandable to deploy from a collapsed to a radially expanded configuration. In the expanded configuration, the stent stop prevents longitudinal displacement of the stent. A balloon is located on a distal shaft section is releasably locked with respect to the shaft outer member and slidably disposed therein in an unlocked configuration.
摘要翻译：一种用于在患者体腔内的治疗部位植入内假体的导管系统。导管包括细长轴外部构件和支架护套远端部分以及在扩张器护套远端部分中以收缩构型径向约束的自扩张支架。用于在轴外部构件内进行相对轴向移动的气囊导管具有细长轴，该细长轴具有充气腔和容纳腔的装置。固定到气囊导管的支架止动器可逆地径向展开，从展开状态展开到径向展开的构型。在扩张结构中，支架止动件防止支架的纵向位移。位于远侧轴部上的气囊相对于轴外部构件可释放地锁定并且以可解锁的构造可滑动地设置在其中。

2. 发明申请

US20080269868A1 STENT DELIVERY CATHETER SYSTEM AND METHOD OF IMPLANTING A SELF-EXPANDING STENT WITH EMBOLIC PROTECTION 有权
标题翻译： STENT传送导管系统及其自动伸展手柄的嵌入式保护方法
公开(公告)号：US20080269868A1
公开(公告)日：2008-10-30
申请号：US11739743
申请日：2007-04-25
申请人： Nianjiong Joan Bei , Keif Fitzgerald , Patrick C. Saxton , Zhicheng Lin , Steven A. Tyler , Joanna Lubas
发明人： Nianjiong Joan Bei , Keif Fitzgerald , Patrick C. Saxton , Zhicheng Lin , Steven A. Tyler , Joanna Lubas
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2002/9583 , A61F2230/0006 , A61F2230/008
摘要： A catheter system and method for implanting an i such as a stent at a treatment site in a patient's body lumen. The catheter provides a complete system for stent delivery, dilatation, and delivery and/or recovery of an expandable device, such as an embolic protection device, adjacent to the treatment site in the body lumen.
摘要翻译：用于在患者体腔内的治疗部位植入诸如支架的i的导管系统和方法。该导管提供了用于支架输送，扩张，以及邻近体腔内治疗部位的可扩张装置（例如栓塞保护装置）的递送和/或回收的完整系统。

3. 发明授权

US08992761B2 Methods for passivating metallic implantable medical devices including radiopaque markers 有权
标题翻译：用于钝化包括不透射线标记的金属可植入医疗装置的方法
公开(公告)号：US08992761B2
公开(公告)日：2015-03-31
申请号：US13548908
申请日：2012-07-13
申请人： Zhicheng Lin
发明人： Zhicheng Lin
IPC分类号： C25F3/16 , A61F2/86
CPC分类号： A61L31/18 , A61F2/86 , A61F2210/0076 , A61F2240/001 , A61F2250/0054 , A61F2250/0098 , A61L31/022 , C25F3/16 , F04C2270/041
摘要： The present disclosure is directed to methods of manufacturing and passivating stents and other implantable medical devices including one or more attached radiopaque markers. In one embodiment, the method includes providing a metallic implantable medical device body without any radiopaque marker(s) attached thereto, primary electropolishing the device body without any markers attached thereto, attaching one or more radiopaque markers to the device body, and lightly electropolishing the device including device body and attached radiopaque markers. Light electropolishing removes no more than about 5 percent by weight of the device (i.e., the device body and attached marker(s)). Light electropolishing passivates the exposed surfaces of the device body and markers, while also providing electropolishing to the region of any welds where the radiopaque marker(s) attach to the device body.
摘要翻译：本公开涉及制造和钝化支架和其它可植入医疗装置的方法，包括一个或多个附接的不透射线标记物。在一个实施例中，该方法包括提供金属可植入医疗装置主体，而没有附接到其上的任何不透射线的标记，初次电抛光装置主体而没有附接到其上的任何标记，将一个或多个不透射线的标记附接到装置主体，以及轻轻电解抛光装置包括装置主体和附接的不透射线标记。轻质电解抛光消除不超过装置重量的约5％（即，装置主体和附着的标记）。光电抛光钝化了器件主体和标记的暴露表面，同时还向不透射线标记附着到器件主体的任何焊缝的区域提供电抛光。

4. 发明授权

US08658006B2 System and method for electropolising devices 有权
标题翻译：电解抛光装置的系统和方法
公开(公告)号：US08658006B2
公开(公告)日：2014-02-25
申请号：US12758485
申请日：2010-04-12
申请人： Michael R. Bialas , David P. Strauss , Robert Barbier , Duane M. DeMore , Alan Gene Tahran , Zhicheng Lin , Sophia Wong
发明人： Michael R. Bialas , David P. Strauss , Robert Barbier , Duane M. DeMore , Alan Gene Tahran , Zhicheng Lin , Sophia Wong
IPC分类号： C25F7/00
CPC分类号： C25F3/16 , C25F7/00
摘要： A system and method is described for electropolishing tubular metallic prostheses. In one aspect, the system provides a continuously changing set of points of contact between anode and prosthesis. In another aspect, the cathode is given a conical shape to correct for current concentrations that would otherwise exist and unevenly affect the amount of electropolishing over the length of the prosthesis.
摘要翻译：描述了用于电抛光管状金属假体的系统和方法。在一个方面，系统提供阳极和假体之间连续变化的接触点组。在另一方面，阴极被给予圆锥形形状以校正否则将存在的电流浓度并且不均匀地影响假体长度上的电解抛光量。

5. 发明申请

US20090165898A1 FATIGUE-RESISTANT NICKEL-TITANIUM ALLOYS AND MEDICAL DEVICES USING SAME 有权
标题翻译：耐疲劳镍 - 钛合金和使用相同的医疗器械
公开(公告)号：US20090165898A1
公开(公告)日：2009-07-02
申请号：US12324732
申请日：2008-11-26
申请人： SOPHIA L. WONG , ZHICHENG LIN , ALAN G. TAHRAN, JR.
发明人： SOPHIA L. WONG , ZHICHENG LIN , ALAN G. TAHRAN, JR.
IPC分类号： C22C19/00 , C22C30/00 , A61F2/94
CPC分类号： B23P17/00 , A61L31/022 , A61L31/14 , A61L2400/16 , C08L2201/12 , C22C14/00 , C22C19/007 , C22C19/03 , C22F1/10 , Y10T29/49863
摘要： Superelastic and/or shape memory nickel-titanium alloys having an increased fatigue life that is superior to known nickel-titanium alloys are disclosed. The nickel-titanium alloys have a minimum fatigue life that may be at least about 10 million strain cycles at a strain of at least about 0.75. The minimum fatigue life may be due, at least in part, to the nickel-titanium alloy having at least one of an oxygen concentration of less than about 200 ppm, a carbon concentration of less than about 200 ppm, the absence of oxide-based and/or carbide-based inclusions having a size greater than about 5 microns (μm), the presence of an R-phase, or combinations of the foregoing. Articles manufactured from such fatigue-resistant nickel-titanium alloys can be more durable because they are more resistant to repetitive strain and crack propagation.
摘要翻译：公开了具有优于已知镍 - 钛合金的疲劳寿命增加的超弹性和/或形状记忆镍钛合金。镍钛合金具有最小的疲劳寿命，其在至少约0.75的应变下可能为至少约1000万个应变循环。最小的疲劳寿命可能至少部分地归因于具有小于约200ppm的氧浓度，小于约200ppm的碳浓度，低于约200ppm的氧浓度的氧 - 和/或具有大于约5微米（mum）的尺寸的碳化物基夹杂物，R相的存在或前述的组合。由这种耐疲劳镍钛合金制成的制品可以更耐用，因为它们更能抵抗重复的应变和裂纹扩展。

6. 发明申请

US20140014530A1 METHODS FOR PASSIVATING METALLIC IMPLANTABLE MEDICAL DEVICES INCLUDING RADIOPAQUE MARKERS 有权
标题翻译：用于吞入金属可植入医疗器械的方法，包括无线电标记
公开(公告)号：US20140014530A1
公开(公告)日：2014-01-16
申请号：US13548908
申请日：2012-07-13
申请人： Zhicheng Lin
发明人： Zhicheng Lin
IPC分类号： C25F3/16
CPC分类号： A61L31/18 , A61F2/86 , A61F2210/0076 , A61F2240/001 , A61F2250/0054 , A61F2250/0098 , A61L31/022 , C25F3/16 , F04C2270/041
摘要： The present disclosure is directed to methods of manufacturing and passivating stents and other implantable medical devices including one or more attached radiopaque markers. In one embodiment, the method includes providing a metallic implantable medical device body without any radiopaque marker(s) attached thereto, primary electropolishing the device body without any markers attached thereto, attaching one or more radiopaque markers to the device body, and lightly electropolishing the device including device body and attached radiopaque markers. Light electropolishing removes no more than about 5 percent by weight of the device (i.e., the device body and attached marker(s)). Light electropolishing passivates the exposed surfaces of the device body and markers, while also providing electropolishing to the region of any welds where the radiopaque marker(s) attach to the device body.
摘要翻译：本公开涉及制造和钝化支架和其它可植入医疗装置的方法，包括一个或多个附接的不透射线标记物。在一个实施例中，该方法包括提供金属可植入医疗装置主体，而没有附接到其上的任何不透射线的标记，初次电抛光装置主体而没有附接到其上的任何标记，将一个或多个不透射线的标记附接到装置主体，以及轻轻电解抛光装置包括装置主体和附接的不透射线标记。轻质电解抛光消除不超过装置重量的约5％（即，装置主体和附着的标记）。光电抛光钝化了器件主体和标记的暴露表面，同时还向不透射线标记附着到器件主体的任何焊缝的区域提供电抛光。

7. 发明授权

US07776080B2 Stent delivery catheter system and method of implanting a self-expanding stent with embolic protection 有权
标题翻译：支架输送导管系统和植入具有栓塞保护的自扩张支架的方法
公开(公告)号：US07776080B2
公开(公告)日：2010-08-17
申请号：US11739743
申请日：2007-04-25
申请人： Nianjiong Joan Bei , Keif Fitzgerald , Patrick C. Saxton , Zhicheng Lin , Steven A. Tyler , Joanna Lubas
发明人： Nianjiong Joan Bei , Keif Fitzgerald , Patrick C. Saxton , Zhicheng Lin , Steven A. Tyler , Joanna Lubas
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2002/9583 , A61F2230/0006 , A61F2230/008
摘要： A catheter system and method for implanting an endoprosthesis such as a stent at a treatment site in a patient's body lumen. The catheter provides a complete system for stent delivery, dilatation, and delivery and/or recovery of an expandable device, such as an embolic protection device, adjacent to the treatment site in the body lumen.
摘要翻译：用于在患者体腔内的治疗部位植入诸如支架的内假体的导管系统和方法。该导管提供了用于支架输送，扩张，以及邻近体腔内治疗部位的可扩张装置（例如栓塞保护装置）的递送和/或回收的完整系统。

8. 发明授权

US08398789B2 Fatigue-resistant nickel-titanium alloys and medical devices using same 有权
标题翻译：耐疲劳镍钛合金和使用其的医疗器械
公开(公告)号：US08398789B2
公开(公告)日：2013-03-19
申请号：US12324732
申请日：2008-11-26
申请人： Sophia L. Wong , Zhicheng Lin , Alan G. Tahran, Jr.
发明人： Sophia L. Wong , Zhicheng Lin , Alan G. Tahran, Jr.
IPC分类号： A61L27/06 , C22C14/00
CPC分类号： B23P17/00 , A61L31/022 , A61L31/14 , A61L2400/16 , C08L2201/12 , C22C14/00 , C22C19/007 , C22C19/03 , C22F1/10 , Y10T29/49863
摘要： Superelastic and/or shape memory nickel-titanium alloys having an increased fatigue life that is superior to known nickel-titanium alloys are disclosed. The nickel-titanium alloys have a minimum fatigue life that may be at least about 10 million strain cycles at a strain of at least about 0.75. The minimum fatigue life may be due, at least in part, to the nickel-titanium alloy having at least one of an oxygen concentration of less than about 200 ppm, a carbon concentration of less than about 200 ppm, the absence of oxide-based and/or carbide-based inclusions having a size greater than about 5 microns (μm), the presence of an R-phase, or combinations of the foregoing. Articles manufactured from such fatigue-resistant nickel-titanium alloys can be more durable because they are more resistant to repetitive strain and crack propagation.
摘要翻译：公开了具有优于已知镍 - 钛合金的疲劳寿命增加的超弹性和/或形状记忆镍钛合金。镍钛合金具有最小的疲劳寿命，其在至少约0.75的应变下可能为至少约1000万个应变循环。最小的疲劳寿命可能至少部分地归因于具有小于约200ppm的氧浓度，小于约200ppm的碳浓度，低于约200ppm的氧浓度的氧 - 和/或具有大于约5微米（μm）的尺寸的碳化物基夹杂物，R相的存在或前述的组合。由这种耐疲劳镍钛合金制成的制品可以更耐用，因为它们更能抵抗重复的应变和裂纹扩展。

9. 发明申请

US20110247943A1 SYSTEM AND METHOD FOR ELECTROPOLISING DEVICES 有权
标题翻译：用于电镀设备的系统和方法
公开(公告)号：US20110247943A1
公开(公告)日：2011-10-13
申请号：US12758485
申请日：2010-04-12
申请人： Michael R. Bialas , David P. Strauss , Robert Barbier , Duane M. DeMore , Alan Gene Tahran , Zhicheng Lin , Sophia Wong
发明人： Michael R. Bialas , David P. Strauss , Robert Barbier , Duane M. DeMore , Alan Gene Tahran , Zhicheng Lin , Sophia Wong
IPC分类号： C25F3/16 , C25F7/00
CPC分类号： C25F3/16 , C25F7/00
摘要： A system and method is described for electropolising tubular metallic prostheses. In one aspect, the system provides a continuously changing set of points of contact between anode and prosthesis. In another aspect, the cathode is given a conical shape to correct for current concentrations that would otherwise exist and unevenly affect the amount of electropolishing over the length of the prosthesis.
摘要翻译：描述了用于电解汞管状金属假体的系统和方法。在一个方面，系统提供阳极和假体之间连续变化的接触点组。在另一方面，阴极被给予圆锥形形状以校正否则将存在的电流浓度并且不均匀地影响假体长度上的电解抛光量。

10. 发明申请

US20100331951A1 STENT DELIVERY CATHETER SYSTEM AND METHOD OF IMPLANTING A SELF-EXPANDING STENT WITH EMBOLIC PROTECTION 有权
标题翻译： STENT传送导管系统及其自动伸展手柄的嵌入式保护方法
公开(公告)号：US20100331951A1
公开(公告)日：2010-12-30
申请号：US12857467
申请日：2010-08-16
申请人： Nianjiong Joan Bei , Keif Fitzgerald , Patrick C. Saxton , Zhicheng Lin , Steven A. Tyler , Joanna Lubas
发明人： Nianjiong Joan Bei , Keif Fitzgerald , Patrick C. Saxton , Zhicheng Lin , Steven A. Tyler , Joanna Lubas
IPC分类号： A61F2/82 , A61M29/00
CPC分类号： A61F2/958 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2002/9583 , A61F2230/0006 , A61F2230/008
摘要： A catheter system and method for implanting an endoprosthesis such as a stent at a treatment site in a patient's body lumen. The catheter provides a complete system for stent delivery, dilatation, and delivery and/or recovery of an expandable device, such as an embolic protection device, adjacent to the treatment site in the body lumen.
摘要翻译：用于在患者体腔内的治疗部位植入诸如支架的内假体的导管系统和方法。该导管提供了用于支架输送，扩张，以及邻近体腔内治疗部位的可扩张装置（例如栓塞保护装置）的递送和/或回收的完整系统。

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