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1. 发明申请

US20120107293A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症的方法和组合
公开(公告)号：US20120107293A1
公开(公告)日：2012-05-03
申请号：US13282832
申请日：2011-10-27
申请人： Zheng Cui , Mark C. Willingham
发明人： Zheng Cui , Mark C. Willingham
IPC分类号： A61K35/14 , C40B30/06 , A61P35/00 , C12Q1/02
CPC分类号： A61K35/17 , A61K35/15 , A61K2300/00
摘要： A method of treating cancer comprises: (a) providing allogenic or autologous white blood cells from a suitable donor; and then (b) administering the white blood cells to the subject in an amount effective to treat the cancer. Preferably the white blood cells comprise innate immune cells. Preferably the white blood cells comprise less than 10% by number of cytotoxic T lymphocytes. Preferably the white blood cells, or more particularly the innate immune cells, are preselected in vitro to kill cancer cells in vitro (for example, by collecting white blood cells from the patient and determining that the white blood cells kill cancer cells in vitro before and thereby pre-selecting the donor, before collecting a subsequent population of cells from the donor for administration).
摘要翻译：治疗癌症的方法包括：（a）从合适的供体提供同种异体或自体白细胞; 然后（b）以有效治疗癌症的量给受试者施用白细胞。优选地，白细胞包含先天免疫细胞。优选地，白细胞包含少于10个数量的细胞毒性T淋巴细胞。优选地，在体外预先选择白细胞，或更特别是先天免疫细胞，以在体外杀死癌细胞（例如，通过从患者中收集白细胞并确定白细胞在体外杀死癌细胞，从而在从供体施用之前收集随后的细胞群体之前预先选择供体）。

2. 发明申请

US20070113298A1 Genetically determined mouse model of resistance to transplantable cancers 审中-公开
标题翻译：遗传决定的抗移植癌的小鼠模型
公开(公告)号：US20070113298A1
公开(公告)日：2007-05-17
申请号：US11586227
申请日：2006-10-25
申请人： Zheng Cui , Mark Willingham
发明人： Zheng Cui , Mark Willingham
IPC分类号： A01K67/027 , C12N5/06
CPC分类号： A61K49/0008 , A01K67/027 , A01K2227/105 , A01K2267/02 , A01K2267/0331 , A01K2267/0337
摘要： We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately following exposure, cancer cells provoke a massive infiltration of host leukocytes which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy, cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance that may have potential for therapy or prevention of cancer.
摘要翻译：我们建立并研究了一种具有宿主对宿主对移植细胞诱导的腹水和固体癌症的独特性状的小鼠集落。这种特征的一个戏剧性表现是晚期癌症的年龄依赖性自发性消退。这种强大的抗性作为单基因座的主要特征分离，与肿瘤负荷无关，对多种类型癌症的细胞系有效。在自发消退或暴露后立即，癌细胞引起宿主白细胞的大量浸润，其与肿瘤细胞形成聚集体和玫瑰花结。先天性白细胞对癌细胞的细胞溶解破坏是快速且特异的，没有对正常细胞的明显损伤。小鼠健康，无癌症，寿命长。这些观察结果表明，以前无法识别的可能具有治疗或预防癌症潜力的免疫监测机制。

3. 发明申请

US20120276013A1 GENETICALLY DETERMINED MOUSE MODEL OF RESISTANCE TO TRANSPLANTABLE CANCERS 审中-公开
标题翻译：基因确定的可移植癌症耐药模型
公开(公告)号：US20120276013A1
公开(公告)日：2012-11-01
申请号：US13535824
申请日：2012-06-28
申请人： Zheng Cui , Mark c. Willingham
发明人： Zheng Cui , Mark c. Willingham
IPC分类号： A01K67/027 , A61K49/00 , C12N5/09
CPC分类号： A61K49/0008 , A01K67/027 , A01K2227/105 , A01K2267/02 , A01K2267/0331 , A01K2267/0337
摘要： We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately following exposure, cancer cells provoke a massive infiltration of host leukocytes which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy, cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance that may have potential for therapy or prevention of cancer.
摘要翻译：我们建立并研究了一种具有宿主对宿主对移植细胞诱导的腹水和固体癌症的独特性状的小鼠集落。这种特征的一个戏剧性表现是晚期癌症的年龄依赖性自发性消退。这种强大的抗性作为单基因座的主要特征分离，与肿瘤负荷无关，对多种类型癌症的细胞系有效。在自发消退或暴露后立即，癌细胞引起宿主白细胞的大量浸润，其与肿瘤细胞形成聚集体和玫瑰花结。先天性白细胞对癌细胞的细胞溶解破坏是快速且特异的，没有对正常细胞的明显损伤。小鼠健康，无癌症，寿命长。这些观察结果表明，以前无法识别的可能具有治疗或预防癌症潜力的免疫监测机制。

4. 发明申请

US20140218637A1 CONDUCTIVE FILM, MANUFACTURING METHOD THEREOF, AND TOUCH SCREEN INCLUDING THE CONDUCTING FILM 审中-公开
标题翻译：导电膜及其制造方法，以及包括导电膜的触摸屏
公开(公告)号：US20140218637A1
公开(公告)日：2014-08-07
申请号：US14000526
申请日：2013-07-06
申请人： Yulong Gao , Zheng Cui , Chao Sun
发明人： Yulong Gao , Zheng Cui , Chao Sun
IPC分类号： H05K1/02 , H05K3/46
CPC分类号： H05K3/1258 , G06F3/044 , G06F2203/04103 , H05K2201/0108 , H05K2203/0108 , Y10T428/2495
摘要： A conductive film includes a substrate, a first conductive layer, a matrix layer, and a second conductive layer. The substrate includes a first surface and an oppositely arranged second surface. The first conductive layer is embedded in the substrate. The matrix layer is set on the first surface of the substrate. The matrix layer is formed by solidified jelly coating. The second conductive layer embedded in the matrix layer. The second conductive layer is insulated from the first conductive layer. Due to the capacitor formed between the first conductive layer and the second conductive layer, it just needs to attach the conductive film to a glass panel when the conductive film is adopted to manufacture a touch screen, without bonding two pieces of conductive films. In addition, the matrix layer, formed by solidifying the jelly painted on the substrate, is with a much smaller thickness than the substrate. Therefore, the touch screen using the conductive film has a smaller thickness. In addition, a method of manufacturing the conductive film and a touch screen including the conductive film are also provided by the present disclosure.
摘要翻译：导电膜包括衬底，第一导电层，矩阵层和第二导电层。基板包括第一表面和相对布置的第二表面。第一导电层嵌入衬底中。基质层设置在基底的第一表面上。基质层由固化的果冻涂层形成。第二导电层嵌入矩阵层。第二导电层与第一导电层绝缘。由于在第一导电层和第二导电层之间形成的电容器，当导电膜被采用来制造触摸屏而不粘合两片导电膜时，仅需要将导电膜附着到玻璃面板上。此外，通过固化涂布在基材上的果冻形成的基质层的厚度比基材小得多。因此，使用导电膜的触摸屏具有较小的厚度。此外，本公开也提供了制造导电膜的方法和包括导电膜的触摸屏。

5. 发明申请

US20080089875A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症的方法和组合
公开(公告)号：US20080089875A1
公开(公告)日：2008-04-17
申请号：US11870768
申请日：2007-10-11
申请人： Zheng Cui , Mark Willingham
发明人： Zheng Cui , Mark Willingham
IPC分类号： A61K35/00 , A61P43/00
CPC分类号： A61K35/17 , A61K35/15 , A61K2300/00
摘要： A method of treating cancer comprises: (a) providing allogenic or autologous white blood cells from a suitable donor; and then (b) administering the white blood cells to the subject in an amount effective to treat the cancer. Preferably the white blood cells comprise innate immune cells. Preferably the white blood cells comprise less than 10% by number of cytotoxic T lymphocytes. Preferably the white blood cells, or more particularly the innate immune cells, are preselected in vitro to kill cancer cells in vitro (for example, by collecting white blood cells from the patient and determining that the white blood cells kill cancer cells in vitro before and thereby pre-selecting the donor, before collecting a subsequent population of cells from the donor for administration).
摘要翻译：治疗癌症的方法包括：（a）从合适的供体提供同种异体或自体白细胞; 然后（b）以有效治疗癌症的量给受试者施用白细胞。优选地，白细胞包含先天免疫细胞。优选地，白细胞包含少于10个数量的细胞毒性T淋巴细胞。优选地，在体外预先选择白细胞，或更特别是先天免疫细胞，以在体外杀死癌细胞（例如，通过从患者中收集白细胞并确定白细胞在体外杀死癌细胞，从而在从供体施用之前收集随后的细胞群体之前预先选择供体）。

6. 发明申请

US20050022258A1 Genetically determined mouse model of resistance to transplantable cancers 审中-公开
标题翻译：遗传决定的抗移植癌的小鼠模型
公开(公告)号：US20050022258A1
公开(公告)日：2005-01-27
申请号：US10827654
申请日：2004-04-19
申请人： Zheng Cui , Mark Willingham
发明人： Zheng Cui , Mark Willingham
IPC分类号： A01K67/027 , A61K49/00 , C12N5/06
CPC分类号： A61K49/0008 , A01K67/027 , A01K2227/105 , A01K2267/02 , A01K2267/0331 , A01K2267/0337
摘要： We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately following exposure, cancer cells provoke a massive infiltration of host leukocytes which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy, cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance that may have potential for therapy or prevention of cancer.
摘要翻译：我们建立并研究了一种具有宿主对宿主对移植细胞诱导的腹水和固体癌症的独特性状的小鼠集落。这种特征的一个戏剧性表现是晚期癌症的年龄依赖性自发性消退。这种强大的抗性作为单基因座的主要特征分离，与肿瘤负荷无关，对多种类型癌症的细胞系有效。在自发消退或暴露后立即，癌细胞引起宿主白细胞的大量浸润，其与肿瘤细胞形成聚集体和玫瑰花结。先天性白细胞对癌细胞的细胞溶解破坏是快速且特异的，没有对正常细胞的明显损伤。小鼠健康，无癌症，寿命长。这些观察结果表明，以前无法识别的可能具有治疗或预防癌症潜力的免疫监测机制。

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