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1. 发明申请

US20050172343A1 Astrocyte modulated genes and uses thereof 有权
标题翻译：星形胶质细胞调节基因及其用途
公开(公告)号：US20050172343A1
公开(公告)日：2005-08-04
申请号：US10975280
申请日：2004-10-27
申请人： Paul Fisher , Zhao-zhong Su , Dong-chul Kang
发明人： Paul Fisher , Zhao-zhong Su , Dong-chul Kang
IPC分类号： A01K67/027 , C07H21/04 , C07K14/47 , C12N5/06 , C12N7/00 , C12N15/12 , C12Q1/70
CPC分类号： C07K14/47
摘要： The present invention relates to Astrocyte Modulated Genes (AMGs). AMGs are genes whose expression are modulated in human astrocytes grown in primary cell culture following the exposure of these cells to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120. AMGs comprise both Astrocyte Enhanced Genes (AEGs) and Astrocyte Suppressed Genes (ASGs). Thus, the present invention further relates to Astrocyte Enhanced Genes (AEGs), the expression of which are up-regulated in human astrocytes grown in primary cell culture that are exposed to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120, and to Astrocyte Suppressed Genes (ASGs), the expression of which are downregulated in human astrocytes grown in primary cell culture that are exposed to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120. Because they may play a role in HIV-associated dementia (“HAD”), AMGs may be used as markers in methods for screening for drugs that treat or prevent HAD.
摘要翻译：本发明涉及星形胶质细胞调节基因（AMG）。 AMG是在将这些细胞暴露于人免疫缺陷病毒HIV-1或HIV-1蛋白gp120后在原代细胞培养物中生长的人星形胶质细胞中表达的基因。 AMGs包括星形胶质细胞增强基因（AEG）和星形胶质细胞抑制基因（ASGs）。因此，本发明还涉及星形胶质细胞增强型基因（AEG），其表达在暴露于人类免疫缺陷病毒HIV-1或HIV-1蛋白的原代细胞培养物中生长的人星形胶质细胞中上调 gp120，以及星形胶质细胞抑制基因（ASG），其表达在暴露于人体免疫缺陷病毒HIV-1或HIV-1蛋白gp120的原代细胞培养物中生长的人星形胶质细胞中下调。因为它们可能在HIV相关性痴呆（“HAD”）中发挥作用，AMGs可用作筛选治疗或预防HAD的药物的方法中的标记。

2. 发明申请

US20090203885A1 Astrocyte Modulated Genes And Uses Thereof 审中-公开
标题翻译：星形胶质细胞调控基因及其用途
公开(公告)号：US20090203885A1
公开(公告)日：2009-08-13
申请号：US12422882
申请日：2009-04-13
申请人： Paul B. Fisher , Zhao-zhong Su , Dong-chul Kang
发明人： Paul B. Fisher , Zhao-zhong Su , Dong-chul Kang
IPC分类号： C07K14/16
CPC分类号： C07K14/47
摘要： The present invention relates to Astrocyte Modulated Genes (AMGs). AMGs are genes whose expression are modulated in human astrocytes grown in primary cell culture following the exposure of these cells to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120. AMGs comprise both Astrocyte Enhanced Genes (AEGs) and Astrocyte Suppressed Genes (ASGs). Thus, the present invention further relates to Astrocyte Enhanced Genes (AEGs), the expression of which are up-regulated in human astrocytes grown in primary cell culture that are exposed to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120, and to Astrocyte Suppressed Genes (ASGs), the expression of which are downregulated in human astrocytes grown in primary cell culture that are exposed to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120. Because they may play a role in HIV-associated dementia (“HAD”), AMGs may be used as markers in methods for screening for drugs that treat or prevent HAD.
摘要翻译：本发明涉及星形胶质细胞调节基因（AMG）。 AMG是在将这些细胞暴露于人免疫缺陷病毒HIV-1或HIV-1蛋白gp120后在原代细胞培养物中生长的人星形胶质细胞中表达的基因。 AMGs包括星形胶质细胞增强基因（AEG）和星形胶质细胞抑制基因（ASGs）。因此，本发明还涉及星形胶质细胞增强型基因（AEG），其表达在暴露于人类免疫缺陷病毒HIV-1或HIV-1蛋白的原代细胞培养物中生长的人星形胶质细胞中上调 gp120，以及星形胶质细胞抑制基因（ASG），其表达在暴露于人类免疫缺陷病毒HIV-1或HIV-1蛋白gp120的原代细胞培养物中生长的人星形胶质细胞中下调。因为它们可能在HIV相关性痴呆（“HAD”）中发挥作用，AMGs可用作筛选治疗或预防HAD的药物的方法中的标记。

3. 发明申请

US20060127980A1 Human excitatory amino acid transporter-2 gene promoter and uses thereof 审中-公开
标题翻译：人兴奋性氨基酸转运蛋白-2基因启动子及其用途
公开(公告)号：US20060127980A1
公开(公告)日：2006-06-15
申请号：US11197226
申请日：2005-08-04
申请人： Paul Fisher , Zhao-zhong Su
发明人： Paul Fisher , Zhao-zhong Su
IPC分类号： A61K38/17 , C07K14/705 , C07H21/04 , C12N5/08 , C12P21/06
CPC分类号： C07K14/705
摘要： The nucleic acid sequence of the human Excitatory Amino Acid Transporter-2 Gene (hEAAT2) promoter, a nucleic acid sequence that hybridizes to the hEAAT2 promoter nucleic acid sequence under stringent hybridization conditions, and a nucleic acid sequence that is functionally equivalent to the hEAAT2 promoter sequence are provided, as are vectors containing these nucleic acid sequences. In addition, methods for the use of these nucleic acids to achieve tissue- or cell-specific gene expression are provided, as are methods for the use of these hEAAT2 promoter nucleic acids to identify agents that can modulate glutamate transport or the activity of the glutamate promoter. Such agents may be useful in the prevention, palliation or treatment of neurodegenerative and/or cerebrovascular diseases.
摘要翻译：人激动性氨基酸转运蛋白-2基因（hEAAT2）启动子的核酸序列，在严格杂交条件下与hEAAT2启动子核酸序列杂交的核酸序列以及在功能上等同于hEAAT2启动子的核酸序列提供了序列，以及含有这些核酸序列的载体。此外，提供了使用这些核酸实现组织或细胞特异性基因表达的方法，以及使用这些hEAAT2启动子核酸鉴定可调节谷氨酸转运或谷氨酸活性的试剂的方法启动子。这样的药剂可用于预防，缓解或治疗神经变性和/或脑血管疾病。

4. 发明授权

US07517973B2 Astrocyte modulated genes and uses thereof 有权
标题翻译：星形胶质细胞调节基因及其用途
公开(公告)号：US07517973B2
公开(公告)日：2009-04-14
申请号：US10975280
申请日：2004-10-27
申请人： Paul B Fisher , Zhao-zhong Su , Dong-chul Kang
发明人： Paul B Fisher , Zhao-zhong Su , Dong-chul Kang
IPC分类号： C12N15/00 , C07H21/00
CPC分类号： C07K14/47
摘要： The present invention relates to Astrocyte Enhanced Genes (AEGs), the expression of which is upregulated in human astrocytes grown in primary cell cultures that are exposed to either the human immunodeficiency virus (HIV-1) or to the HIV-1 glycoprotein gp120.
摘要翻译：本发明涉及星形胶质细胞增强型基因（AEG），其表达在暴露于人类免疫缺陷病毒（HIV-1）或HIV-1糖蛋白gp120的原代细胞培养物中生长的人星形胶质细胞中上调。

5. 发明申请

US20080108067A1 Cloning of the retinoic acid inducible gene-1 promoter and uses thereof 审中-公开
标题翻译：视黄酸诱导型基因-1启动子的克隆及其用途
公开(公告)号：US20080108067A1
公开(公告)日：2008-05-08
申请号：US11788093
申请日：2007-04-19
申请人： Paul B. Fisher , Zhao-zhong Su
发明人： Paul B. Fisher , Zhao-zhong Su
IPC分类号： C12Q1/68 , C12N15/11 , C12N15/00 , C07H21/04 , C12N5/06 , A01K67/00
CPC分类号： C07K14/47
摘要： The present invention relates to the human Retinoic Acid Inducible Gene-1 (hereafter, “RIG-1”) promoter. The present invention provides for the promoter itself which is inducible by interferon, virus infection, retinoic acid and double-stranded RNA. A further embodiment includes expression constructs comprising the RIG-1 promoter operatively linked to a gene of interest, which may be a reporter gene or a therapeutic gene. It also provides for cells and non-human transgenic animals comprising such expression constructs. In addition, the present invention provides for methods of screening agents for anti-viral activity using RIG-1 promoter activation or inhibition as the basis of the screening system.
摘要翻译：本发明涉及人视黄酸诱导基因-1（以下称为“RIG-1”）启动子。本发明提供可由干扰素，病毒感染，视黄酸和双链RNA诱导的启动子本身。另一个实施方案包括包含可操作地连接到目的基因的RIG-1启动子的表达构建体，其可以是报道基因或治疗基因。它还提供包含这种表达构建体的细胞和非人转基因动物。此外，本发明提供了使用RIG-1启动子活化或抑制作为筛选系统的基础筛选抗病毒活性物质的方法。

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