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1. 发明授权

US5972889A Method for inhibiting the proliferation of epithelial lens cells and implantable lens therefor 失效
标题翻译：抑制上皮镜片细胞及其可植入镜片增殖的方法
公开(公告)号：US5972889A
公开(公告)日：1999-10-26
申请号：US979129
申请日：1997-11-26
申请人： Yves Courtois
发明人： Yves Courtois
IPC分类号： A61K47/48 , A61K38/00 , A61F13/00 , C07K1/00
CPC分类号： A61K47/48261 , Y10S514/912 , Y10S530/849
摘要： A conjugate of a polypeptide reactive with a fibroblast growth factor receptor and a cytotoxic agent is used for inhibiting the proliferation of epithelial lens cells, especially following extracapsular cataract surgery.
摘要翻译：与成纤维细胞生长因子受体和细胞毒性剂反应的多肽的缀合物用于抑制上皮镜片细胞的增殖，特别是在囊外白内障手术后。

2. 发明申请

US20180036383A1 TREATMENT OF A DISEASE ASSOCIATED WITH RETINAL DEGENERATIVE DISORDER 审中-公开
公开(公告)号：US20180036383A1
公开(公告)日：2018-02-08
申请号：US15784424
申请日：2017-10-16
申请人： Yves Courtois , Jean-Claude Jeanny , Emilie Picard , Francine Behar-Cohen
发明人： Yves Courtois , Jean-Claude Jeanny , Emilie Picard , Francine Behar-Cohen
IPC分类号： A61K38/40
CPC分类号： A61K38/40
摘要： Treatment of a disease associated with retinal degenerative disorder. The present invention relates to human Transferrin or an active fragment thereof for use in the treatment of a disease associated with retinal degenerative disorder.

3. 发明授权

US4533635A Process for stimulating the growth of epidermal cells 失效
标题翻译：刺激表皮细胞生长的过程
公开(公告)号：US4533635A
公开(公告)日：1985-08-06
申请号：US237153
申请日：1981-02-18
申请人： Isabelle Guedon born Saglier , Denis Barritault , Yves Courtois , Cristina Arruti , Michel Prunieras
发明人： Isabelle Guedon born Saglier , Denis Barritault , Yves Courtois , Cristina Arruti , Michel Prunieras
IPC分类号： A61K8/00 , A61K8/98 , A61K35/36 , A61K35/44 , A61L26/00 , A61L27/60 , A61Q5/00 , A61Q19/00 , C12N5/071 , G01N33/48 , C12N5/00
CPC分类号： A61Q19/00 , A61K35/36 , A61K35/44 , A61K8/981 , A61L27/60 , A61Q5/00 , C12N5/0629 , G01N33/48 , A61Q19/08 , C12N2500/84 , Y10S514/859 , Y10S514/861 , Y10S514/863
摘要： A process for stimulating the growth of human epidermal cells, applications of said process and products applying the said process.A process for stimulating the growth of epidermis cells.The epidermis cells are contacted with an aqueous saline extract (RE) of ocular tissues. The process is especially applied for human epidermis cells.Application to the study of chromosomes of the human epidermis cell, particularly for the detection of natural or induced chromosome anomalies, and to the production of grafts, and especially autografts, usable on man, for example in the treatment of burns, cosmetic and diagnostic products.
摘要翻译： PCT No.PCT / FR80 / 00118 Sec。 371日期1981年2月18日 102（e）日期1981年2月18日PCT提交1980年7月10日PCT公布。公开号WO81 / 00260 日期：1981年2月5日。一种刺激人表皮细胞生长的方法，所述方法的应用和应用所述方法的产品。刺激表皮生长的过程。将表皮细胞与眼组织的盐水提取物（RE）接触。该方法特别适用于人类表皮细胞。适用于研究人类表皮细胞的染色体，特别是用于检测天然或诱导的染色体异常，以及生产可用于人的移植物，特别是自体移植物，例如用于治疗烧伤，化妆品和诊断产品。

4. 发明申请

US20090088721A1 Enhanced retinal delivery of a nucleic acid through iontophoresis 审中-公开
标题翻译：通过离子电渗法增强核酸的视网膜递送
公开(公告)号：US20090088721A1
公开(公告)日：2009-04-02
申请号：US11999638
申请日：2007-12-05
申请人： Therese de Bizemont , Florian Sennlaub , Francine Behar-Cohen , Yves Courtois , Andrieu Charlotte
发明人： Therese de Bizemont , Florian Sennlaub , Francine Behar-Cohen , Yves Courtois , Andrieu Charlotte
IPC分类号： A61K31/7088 , A61N1/30
CPC分类号： A61K48/0083 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3517 , C12Y301/04035 , C12N2310/3521
摘要： The present invention provides a device and a method for the enhanced retinal delivery of nucleic acid therapeutics utilizing iontophoresis to evoke a transient elongation of the Müller Cells of a mammalian eye. The enhanced retinal deposition can be achieved by either a topical application, subconjunctival, or an intravitreal injection of the nucleic acid composition followed by, preceded by, or administered simultaneously with the iontophoretic application. The present invention thus provides a particularly advantageous method for the treatment of ocular diseases comprising the in vivo administration of a nucleic acid capable of alleviating the symptoms of a disease, the delivery of the nucleic acid being enhanced by using iontophoresis. This method can be applied particularly to the diseases of the retina resulting from an alteration of a gene expression and/or the over-expression of particular growth factors. The diseases include, but are not limited to, human ocular retinopathies including, neovascular diseases (Age-Related Macular Edema, Diabetic Retinopathies, Diabetic Macular Edema, etc.) and inherited retinopathies such as retinitis pigmentosa.
摘要翻译：本发明提供了利用离子电渗疗法增强视网膜递送的装置和方法，以引起哺乳动物眼睛的Müller细胞的瞬时延长。增强的视网膜沉积可以通过局部应用，结膜下或玻璃体内注射的核酸组合物，之后，之后，或与离子电渗疗法同时施用来实现。因此，本发明提供了一种治疗眼部疾病的特别有利的方法，其包括体内施用能够减轻疾病症状的核酸，通过使用离子电渗法提高核酸的递送。该方法可以特别适用于由于基因表达的改变和/或特定生长因子的过表达导致的视网膜疾病。这些疾病包括但不限于人眼视网膜病变，包括新生血管疾病（年龄相关性黄斑水肿，糖尿病性视网膜病，糖尿病性黄斑水肿等）和遗传性视网膜病变如色素性视网膜炎。

5. 发明授权

US4670257A Cosmetic compositions containing retinal extracts for increasing epidermal cell growth 失效
标题翻译：包含视网膜提取物以增加表皮细胞生长的化妆品组合物
公开(公告)号：US4670257A
公开(公告)日：1987-06-02
申请号：US702879
申请日：1985-02-19
申请人： Isabelle Guedon born Saglier , Denis Barritault , Yves Courtois , Cristina Arruti , Michel Prunieras
发明人： Isabelle Guedon born Saglier , Denis Barritault , Yves Courtois , Cristina Arruti , Michel Prunieras
IPC分类号： A61K8/00 , A61K8/98 , A61K35/36 , A61K35/44 , A61L26/00 , A61L27/60 , A61Q5/00 , A61Q19/00 , C12N5/071 , G01N33/48
CPC分类号： A61Q19/00 , A61K35/36 , A61K35/44 , A61K8/981 , A61L27/60 , A61Q5/00 , C12N5/0629 , G01N33/48 , A61Q19/08 , C12N2500/84 , Y10S514/859 , Y10S514/861 , Y10S514/863
摘要： A process for stimulating the growth of epidermis cells.The epidermis cells are contacted with an aqueous saline extract (RE) of ocular tissues. The process is especially applied for human epidermis cells.Application to the study of chromosomes of the human epidermis cell, particularly for the detection of natural or induced chromosome anomalies, and to the production of grafts, and especially autografts, usable on man, for example in the treatment of burns, cosmetic and diagnostic products.

6. 发明申请

US20130150304A1 TREATMENT OF A DISEASE ASSOCIATED WITH RETINAL DEGENERATIVE DISORDER 审中-公开
标题翻译：治疗与退行性疾病相关的疾病
公开(公告)号：US20130150304A1
公开(公告)日：2013-06-13
申请号：US13808976
申请日：2011-07-11
申请人： Yves Courtois , Jean-Claude Jeanny , Emilie Picard , Francine Behar-Cohen
发明人： Yves Courtois , Jean-Claude Jeanny , Emilie Picard , Francine Behar-Cohen
IPC分类号： A61K38/40
CPC分类号： A61K38/40
摘要： Treatment of a disease associated with retinal degenerative disorder. The present invention relates to human Transferrin or an active fragment thereof for use in the treatment of a disease associated with retinal degenerative disorder.
摘要翻译：治疗与视网膜退行性疾病相关的疾病。本发明涉及用于治疗与视网膜退行性疾病相关的疾病的人转铁蛋白或其活性片段。

7. 发明授权

US5843893A Method for inhibiting the proliferation of epithelial lens cells and implantable lens therefor 失效
标题翻译：抑制上皮镜片细胞及其可植入镜片增殖的方法
公开(公告)号：US5843893A
公开(公告)日：1998-12-01
申请号：US290788
申请日：1994-10-12
申请人： Yves Courtois
发明人： Yves Courtois
IPC分类号： A61K47/48 , A61K38/00 , A61F13/00 , C07K1/00
CPC分类号： A61K47/48261 , Y10S514/912 , Y10S530/849
摘要： A conjugate of a polypeptide reactive with a fibroblast growth factor receptor and a cytotoxic agent is used for inhibiting the proliferation of epithelial lens cells, especially following extracapsular cataract surgery.
摘要翻译： PCT No.PCT / EP93 / 00389 371日期：1994年10月12日 102（e）日期1994年10月12日PCT 1993年2月18日提交PCT公布。公开号WO93 / 16734 日期1993年9月2日，与成纤维细胞生长因子受体和细胞毒性剂反应的多肽的缀合物用于抑制上皮镜片细胞的增殖，特别是在囊外白内障手术后。

8. 发明授权

US4872108A Device having multiplexer for enabling priority and non-priority common circuit 失效
标题翻译：具有用于使能优先级和非优先级公共电路的多路复用器的装置
公开(公告)号：US4872108A
公开(公告)日：1989-10-03
申请号：US159817
申请日：1988-02-24
申请人： Andre Bussonniere , Yves Courtois
发明人： Andre Bussonniere , Yves Courtois
IPC分类号： G06F15/16 , G06F9/52 , G06F13/18 , G06F15/177
CPC分类号： G06F13/18
摘要： A priority processor (1) and a non-priority processor (20) cooperatively access a common memory (30) by means of an address multiplexer (40) which memory and multiplexer are controlled by a control unit (60). The priority processor issues data strobe (DSSN), clock (CLK) and write control (WSN) signals to the control unit to which the non-polarity processor also issues various memory access request signals. By forming a preparation signal (DSSN=0), the priority processor, through the control unit, claims the memory for a memory access cycle if a prior memory access request by the non-priority processor occurred less than about a clock cycle earlier.
摘要翻译：优先处理器（1）和非优先处理器（20）通过地址多路复用器（40）协同地访问公共存储器（30），所述存储器和多路复用器由控制单元（60）控制。优先处理器向非极性处理器也发出各种存储器访问请求信号的控制单元发出数据选通（DSSN），时钟（CLK）和写入控制（WSN）信号。通过形成准备信号（DSSN = 0），如果非优先处理器的先前存储器访问请求发生时间小于大约一个时钟周期，则通过控制单元的优先处理器要求存储器进行存储器访问周期。

9. 发明授权

US4477435A Method for regenerating corneal epithelium 失效
标题翻译：再生角膜上皮的方法
公开(公告)号：US4477435A
公开(公告)日：1984-10-16
申请号：US429798
申请日：1982-09-30
申请人： Yves Courtois , Denis Barritault , Yves Pouliquen
发明人： Yves Courtois , Denis Barritault , Yves Pouliquen
IPC分类号： A61K35/44 , A61K35/12
CPC分类号： A61K35/44
摘要： A composition and a method for regenerating wounded or damaged corneal epelium are described. The composition comprises an aqueous solution containing an effective amount of ocular extract RE. The RE is extracted from eye tissues, such as choroid, iris and vitreous as well as aqueous humor. The active extract is obtained by the treatment of bovine ocular tissues with a buffered aqueous saline solution at pH of about 7.2. For ophthalmological use, the RE extract is purified by precipitation with acetic acid and dialyzed against physiologic saline NaCl solution. Such a composition is shown to increase significantly the rate of healing of wounded corneal epithelium.
摘要翻译：描述了用于再生受伤或损伤的角膜上皮的组合物和方法。该组合物包含含有有效量的眼提取物RE的水溶液。 RE从眼组织提取，如脉络膜，虹膜和玻璃体以及房水。通过用pH为约7.2的缓冲盐水溶液处理牛眼组织获得活性提取物。对于眼科用途，RE提取物通过用乙酸沉淀来纯化，并对生理盐水NaCl溶液进行透析。显示这种组合物显着增加受伤的角膜上皮的愈合速率。

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