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    • 2. 发明申请
    • Nozel azalide and azalactam derivatives and method for producing the same
    • 诺贝尔氮杂和吖内酰胺衍生物及其制备方法
    • US20070042974A1
    • 2007-02-22
    • US10569063
    • 2004-08-20
    • Tomoaki MiuraKenichi KanemotoSatomi NatsumeNaoto OhkuraYumiko FujihiraTakashi WatanabeHideki FushimiKunio AtsumiKeiichi Ajito
    • Tomoaki MiuraKenichi KanemotoSatomi NatsumeNaoto OhkuraYumiko FujihiraTakashi WatanabeHideki FushimiKunio AtsumiKeiichi Ajito
    • A61K31/7052C07H17/08
    • A61K31/7052C07H15/04C07H17/00
    • A compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, which is useful for a prophylactic and/or therapeutic treatment of a microbial infectious disease. [R1 is hydrogen atom, or a linear C1-6 alkylcarbonyl group; R2 is hydrogen atom, or a C1-6 alkylcarbonyl group; R3 is hydrogen atom, a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C1-6 alkenyl group, a C2-6 alkenylcarbonyl group, a C2-6 alkynyl group, or an Ar—B— group (Ar represents an aryl group, or a heterocyclic group, and B is a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C2-6 alkenyl group, a C2-6 alkenylcarbonyl group, or a C2-6 alkynyl group); R5, R6, R7, and R8 represent hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or an Ar—B′— group (B′ is a C1-6 alkyl group, a C2-6 alkenyl group, or a C2-6 alkynyl group); X is oxygen atom, or an —NR4— group (R4 is hydrogen atom, a C1-6 alkyl group, or a C1-6 alkyl group which may be substituted with an Ar group); and R4′ is hydrogen atom, or a group represented by the aforementioned formula (a) (R3″ and R4″ represent hydrogen atom, or a linear or branched C1-6 alkylcarbonyl group)]
    • 由以下通式(1)表示的化合物或其药学上可接受的盐,其可用于预防和/或治疗微生物感染性疾病。 R 1是氢原子或直链C 1-6烷基羰基; R 2是氢原子或C 1-6烷基羰基; R 3是氢原子,C 1-6烷基,C 1-6烷基羰基,C 1-6烯基,C 2-6烯基羰基,C 2-6炔基或 Ar-B-基(Ar表示芳基或杂环基,B为C1-6烷基,C1-6烷基羰基,C2-6烯基,C2-6链烯基羰基或 C 2-6炔基); R 5,R 6,R 7和R 8表示氢原子,C 1-6烷基 ,C2-6烯基,C2-6炔基或Ar-B'-基(B'是C1-6烷基,C2-6链烯基或C2-6炔基); X是氧原子或-NR 4 - 基团(R 4)是氢原子,C 1-6烷基或可以是C 1-6烷基的C 1-6烷基 被Ar基团取代); 和R 4'是氢原子,或由上述式(a)表示的基团(R 3'和R 4“ 代表氢原子,或直链或支链C 1-6烷基羰基)]