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1. 发明申请

US20090061295A1 Battery tray, electronic apparatus, and vertical grip device 失效
标题翻译：电池托盘，电子设备和垂直握把装置
公开(公告)号：US20090061295A1
公开(公告)日：2009-03-05
申请号：US12219567
申请日：2008-07-24
申请人： Yukari Matsumoto , Yoshio Kajino , Shinjiro Komatani , Michihiro Iwata
发明人： Yukari Matsumoto , Yoshio Kajino , Shinjiro Komatani , Michihiro Iwata
IPC分类号： H01M2/10
CPC分类号： H01M2/1066
摘要： A battery tray in which two batteries each having a thin and long shape are accommodated includes two thin and long shaped battery accommodation spaces in which the two batteries are accommodated in a state where the batteries are arranged such that the longitudinal direction of the batteries extends on the same straight line.
摘要翻译：其中容纳两个具有薄且长形状的电池的电池托盘包括两个细长形电池容纳空间，其中两个电池被容纳在电池布置成使得电池的纵向方向延伸的状态同样的直线。

2. 发明授权

US07354925B2 Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists 失效
标题翻译： α芳基或杂芳基甲基β-哌啶子基丙酰胺化合物作为ORL1受体拮抗剂
公开(公告)号：US07354925B2
公开(公告)日：2008-04-08
申请号：US10599473
申请日：2005-03-16
申请人： Yoshinobu Hashizume , Masako Hirota , Sachiko Mihara , Hisoshi Nakamura , Hiroki Koike , Yukari Matsumoto
发明人： Yoshinobu Hashizume , Masako Hirota , Sachiko Mihara , Hisoshi Nakamura , Hiroki Koike , Yukari Matsumoto
IPC分类号： A61K31/438 , C07D491/107
CPC分类号： C07D221/20 , C07D401/06 , C07D471/06 , C07D471/10 , C07D491/10 , C07D513/10
摘要： This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently represent a hydrogen atom or the like; R3 represents a hydrogen atom, or the like; R4 represents a hydrogen atom or the like; represents one of the following or the like; R5 represents an aryl group having from 6 to 10 ring atoms or the like; X represents an oxygen atom, or the like; Y represents an oxygen atom or the like and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的酯或其药学上可接受的盐，其中R 1和R 2独立地表示氢原子等; R 3表示氢原子等; R 4表示氢原子等; 代表以下之一或类似物; R 5表示具有6至10个环原子等的芳基; X表示氧原子等; Y表示氧原子等，n表示0,1或2的整数。这些化合物具有ORL1-受体拮抗剂活性; 因此，可用于治疗诸如疼痛，各种CNS疾病等疾病或病症。

3. 发明申请

US20050250818A1 Ortho substituted aryl or heteroaryl amide compounds 审中-公开
标题翻译：正构取代的芳基或杂芳基酰胺化合物
公开(公告)号：US20050250818A1
公开(公告)日：2005-11-10
申请号：US11118646
申请日：2005-04-29
申请人： Hiroki Koike , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人： Hiroki Koike , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号： A61K31/195 , A61K31/4415 , C07C235/60 , C07C255/54 , C07D213/61 , C07D213/82 , C07D213/89 , C07D261/08 , C07D307/12 , C07D307/42 , C07D309/06
CPC分类号： C07D261/08 , C07C235/60 , C07C255/54 , C07C2601/04 , C07C2601/14 , C07D213/61 , C07D213/82 , C07D213/89 , C07D307/12 , C07D307/42 , C07D309/06 , C07D405/12
摘要： This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: Z represents a hydrogen atom or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中X表示碳原子等：Y表示亚氨基等; Z表示氢原子等：R 1表示具有1至6个碳原子的烷基等：R 2和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

4. 发明申请

US20080200490A1 Alpha-(Aryl-or Heteroaryl-Methyl)-Beta-Piperidino Propanamide Compounds as Orl-1-Receptor Antagonists 审中-公开
标题翻译： α-（芳基或杂芳基 - 甲基） - 哌啶子基丙酰胺化合物作为Orl-1受体拮抗剂
公开(公告)号：US20080200490A1
公开(公告)日：2008-08-21
申请号：US11917218
申请日：2006-06-09
申请人： Yoshinobu Hashizume , Masako Hirota , Sachiko Mihara , Hiroshi Nakamura , Hiroki Koike , Yukari Matsumoto
发明人： Yoshinobu Hashizume , Masako Hirota , Sachiko Mihara , Hiroshi Nakamura , Hiroki Koike , Yukari Matsumoto
IPC分类号： A61K31/438 , C07D491/20 , A61P35/04
CPC分类号： C07D451/06
摘要： This invention provides the compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently represent hydrogen or the like; R3 and R4 independently represents hydrogen or the like; R5 represents aryl or the like; —X—Y— represents —CH2O— or the like; and n represents 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中R 1和R 2独立代表氢或类似物; R 3和R 4独立地表示氢等; R 5表示芳基等; -X-Y-表示-CH 2 O-等; 并且n表示0,1或2.这些化合物具有ORL1受体拮抗剂活性; 因此，可用于治疗诸如疼痛，各种CNS疾病等疾病或病症。

5. 发明授权

US07279486B2 Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as ORL1-receptor antagonists 失效
标题翻译： α芳基或杂芳基甲基β-哌啶子基丙酸化合物作为ORL1-受体拮抗剂
公开(公告)号：US07279486B2
公开(公告)日：2007-10-09
申请号：US11092503
申请日：2005-03-29
申请人： Yoshinobu Hashizume , Masako Hirota , Sachiko Mihara , Hiroshi Nakamura , Hiroki Koike , Yukari Matsumoto
发明人： Yoshinobu Hashizume , Masako Hirota , Sachiko Mihara , Hiroshi Nakamura , Hiroki Koike , Yukari Matsumoto
IPC分类号： A61K31/438 , C07D491/107
CPC分类号： C07D221/20 , C07D401/06 , C07D471/06 , C07D471/10 , C07D491/10 , C07D513/10
摘要： This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently represent a hydrogen atom or the like; R3 represents an aryl group having from 6 to 10 ring atoms or the like; X represents an oxygen atom, or the like; Y represents an oxygen atom or the like; and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的酯或其药学上可接受的盐，其中R 1和R 2独立地表示氢原子等; R 3表示具有6至10个环原子等的芳基; X表示氧原子等; Y表示氧原子等; 并且n表示整数0,1或2.这些化合物具有ORL1-受体拮抗剂活性; 因此，可用于治疗诸如疼痛，各种CNS疾病等疾病或病症。

6. 发明授权

US08084476B2 Substituted methyl aryl or heteroaryl amide compounds 有权
标题翻译：取代的甲基芳基或杂芳基酰胺化合物
公开(公告)号：US08084476B2
公开(公告)日：2011-12-27
申请号：US12368778
申请日：2009-02-10
申请人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号： A61K31/44 , C07D211/72
CPC分类号： C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要： This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中X表示碳原子等：Y表示亚氨基等：R 1表示具有1至6个碳原子的烷基等：R 2和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

7. 发明申请

US20090163558A1 Substituted Methyl Aryl or Heteroaryl Amide Compounds 有权
标题翻译：取代的甲基芳基或杂芳基酰胺化合物
公开(公告)号：US20090163558A1
公开(公告)日：2009-06-25
申请号：US12368778
申请日：2009-02-10
申请人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号： A61K31/44 , C07D213/56
CPC分类号： C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要： This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中X表示碳原子等：Y表示亚氨基等：R 1表示具有1至6个碳原子的烷基等：R 2和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

8. 发明授权

US07534914B2 Substituted methyl aryl or heteroaryl amide compounds 失效
标题翻译：取代的甲基芳基或杂芳基酰胺化合物
公开(公告)号：US07534914B2
公开(公告)日：2009-05-19
申请号：US11118497
申请日：2005-04-29
申请人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号： C07C229/00
CPC分类号： C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要： This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中X表示碳原子等：Y表示亚氨基等：R 1表示具有1至6个碳原子的烷基等：R 2和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

9. 发明申请

US20070219237A1 Chromane Derivatives 审中-公开
标题翻译：色原衍生物
公开(公告)号：US20070219237A1
公开(公告)日：2007-09-20
申请号：US11687781
申请日：2007-03-19
申请人： Yukari Matsumoto , Hirohisa Shimokawa , Tatsuya Yamagishi
发明人： Yukari Matsumoto , Hirohisa Shimokawa , Tatsuya Yamagishi
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, cancer, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8， A和B各自如本文所述或其药学上可接受的盐，以及含有这些化合物的组合物及其治疗和使用方法，其包含用于治疗由酸泵拮抗活性介导的病症的化合物，所述活性例如但不限于，胃肠疾病，胃食管疾病，胃食管反流病（GERD），咽喉反流病，消化性溃疡，胃溃疡，十二指肠溃疡，NSAID诱发的溃疡，胃炎，幽门螺杆菌感染，消化不良，功能性消化不良，佐林格 - 埃里森综合征，非侵蚀性反流病（NERD），内脏痛，癌症，胃灼热，恶心，食管炎，吞咽困难，过度激活，气道障碍或哮喘。

10. 发明申请

US20070197500A1 Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonists 失效
标题翻译： α芳基或杂芳基甲基β-哌啶子基丙酰胺化合物作为or1受体拮抗剂
公开(公告)号：US20070197500A1
公开(公告)日：2007-08-23
申请号：US10599473
申请日：2005-03-19
申请人： Yoshinobu Hashizume , Masako Hirota , Sachiko Mihara , Hisoshi Nakamura , Hiroki Koike , Yukari Matsumoto
发明人： Yoshinobu Hashizume , Masako Hirota , Sachiko Mihara , Hisoshi Nakamura , Hiroki Koike , Yukari Matsumoto
IPC分类号： A61K31/4747 , C07D498/10 , C07D491/10
CPC分类号： C07D221/20 , C07D401/06 , C07D471/06 , C07D471/10 , C07D491/10 , C07D513/10
摘要： This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently represent a hydrogen atom or the like; R3 represents a hydrogen atom, or the like; R4 represents a hydrogen atom or the like; (formula II) represents one of the following or the like; R5 represents an aryl group having from 6 to 10 ring atoms or the like; X represents an oxygen atom, or the like; Y represents an oxygen atom or the like and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的酯或其药学上可接受的盐，其中R 1和R 2独立地表示氢原子等; R 3表示氢原子等; R 4表示氢原子等; （式II）表示以下等中的一种; R 5表示具有6至10个环原子等的芳基; X表示氧原子等; Y表示氧原子等，n表示0,1或2的整数。这些化合物具有ORL1-受体拮抗剂活性; 因此，可用于治疗诸如疼痛，各种CNS疾病等疾病或病症。

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