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1. 发明申请

US20060252068A1 Markers for prenatal diagnosis and monitoring 有权
标题翻译：产前诊断和监测的标记
公开(公告)号：US20060252068A1
公开(公告)日：2006-11-09
申请号：US11378598
申请日：2006-03-17
申请人： Yuk-Ming Lo , Rossa Wai Chiu , Stephen Siu Chim , Nancy Bo Tsui
发明人： Yuk-Ming Lo , Rossa Wai Chiu , Stephen Siu Chim , Nancy Bo Tsui
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a set of genetic loci and comparing the amount of the RNA species with a standard control.
摘要翻译：提供了方法和试剂盒，用于诊断，监测或预测孕妇，18岁的三体性和胎儿中的21三体，以及通过在母亲血液中定量测量一个或多个胎儿的数量，在胎儿中检测怀孕。衍生自一组遗传基因座的RNA物种，并将RNA物质的量与标准对照进行比较。

2. 发明申请

US20080081338A1 Diagnostic Method 有权
标题翻译：诊断方法
公开(公告)号：US20080081338A1
公开(公告)日：2008-04-03
申请号：US11861809
申请日：2007-09-26
申请人： Yuk Ming LO , Kwan Chee Chan , Chunming Ding
发明人： Yuk Ming LO , Kwan Chee Chan , Chunming Ding
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/154
摘要： The present invention concerns a method for the detection or monitoring of cancer using a biological sample selected from blood, plasma, serum, saliva, urine from an individual, said method comprising: (a) obtaining DNA from the said biological sample; (b) digesting the DNA sample with one or more methylation-sensitive restriction enzymes; (c) quantifying or detecting a DNA sequence of interest after step (b), wherein the target sequence of interest contains at least two methylation-sensitive restriction enzyme recognition sites; and (d) comparing the level of the DNA sequence from the individual to a normal standard, to detect, prognosticate or monitor cancer.
摘要翻译：本发明涉及使用选自血液，血浆，血清，唾液，个体尿液的生物样品检测或监测癌症的方法，所述方法包括：（a）从所述生物样品中获得DNA; （b）用一种或多种甲基化敏感性限制酶消化DNA样品; （c）在步骤（b）之后量化或检测目标DNA序列，其中所述靶序列含有至少两个甲基化敏感性限制酶识别位点; 和（d）将来自个体的DNA序列的水平与正常标准进行比较，以检测，预测或监测癌症。

3. 发明申请

US20060252071A1 Method for the detection of chromosomal aneuploidies 有权
标题翻译：染色体非整倍体检测方法
公开(公告)号：US20060252071A1
公开(公告)日：2006-11-09
申请号：US11384128
申请日：2006-03-17
申请人： Yuk-Ming Lo , Rossa Chiu , Bo Tsui , Chunming Ding , Charles Cantor
发明人： Yuk-Ming Lo , Rossa Chiu , Bo Tsui , Chunming Ding , Charles Cantor
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6851 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2545/101
摘要： The non-invasive detection of fetal chromosomal aneuploidies is demonstrated. Alleles of fetal RNA-SNPs present in a biological sample (e.g. maternal blood) containing fetal RNA are detected and quantified in order to determine the ratio of the alleles. This ratio is compared to a standard control consisting of euploid fetuses. Deviation of allele ratio indicates the presence of chromosomal aneuploidy.
摘要翻译：证明了胎儿染色体非整倍体的非侵入性检测。检测并定量存在于含有胎儿RNA的生物样品（例如母体血液）中的胎儿RNA-SNP的等位基因，以确定等位基因的比例。将该比率与由整倍体胎儿组成的标准对照进行比较。等位基因比率的偏差表明存在染色体非整倍体。

4. 发明申请

US20060019278A1 Marker for prenatal diagnosis and monitoring 有权
标题翻译：产前诊断和监测的标记
公开(公告)号：US20060019278A1
公开(公告)日：2006-01-26
申请号：US11144951
申请日：2005-06-03
申请人： Yuk Ming Lo , Rossa Chiu , Stephen Chim , Yu-kwan Tong , Chunming Ding
发明人： Yuk Ming Lo , Rossa Chiu , Stephen Chim , Yu-kwan Tong , Chunming Ding
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/154 , C12Q2600/156 , C12Q2521/331
摘要： The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
摘要翻译：本发明涉及通过分析存在于母亲血液中的胎儿DNA来诊断妊娠相关疾病的新方法。更具体地说，本发明依赖于maspin基因在胎儿DNA和母体DNA中差异甲基化的发现，并提供了这些新的诊断方法，其将胎儿DNA与母体DNA区分开，并根据胎儿DNA水平和甲基化异常检测产前疾病状态。

5. 发明申请

US20050095618A1 Compositions and methods for diagnosing and treating severe acute respiratory syndrome (SARS) 有权
标题翻译：诊断和治疗严重急性呼吸综合征（SARS）的组合和方法
公开(公告)号：US20050095618A1
公开(公告)日：2005-05-05
申请号：US10901744
申请日：2004-07-28
申请人： Kwok Tsui , Kwok Fung , Mary Miu Waye , Yuk Ming Lo , Siu Chung Chim , Wai Kwun Chiu , Siu Lun Tam , Kay Sheung Chan
发明人： Kwok Tsui , Kwok Fung , Mary Miu Waye , Yuk Ming Lo , Siu Chung Chim , Wai Kwun Chiu , Siu Lun Tam , Kay Sheung Chan
IPC分类号： A61K39/00 , C07K14/165 , C12Q1/68 , A61K48/00 , C07H21/02 , C07H21/04 , C07K14/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C12N2770/20022
摘要： The present invention relates to the fields of immunochemistry and pharmacology. Methods and compositions are described for the diagnosis and treatment of SARS CoV infection. More specifically, the application discloses nucleic acids and peptides of the spike glycoprotein of SARS CoV that provide prognostic and therapeutic compositions in treatment of individuals contracting, or in danger of contracting SARS CoV. The peptides of the invention are also useful in producing antibodies against the SARS CoV glycoprotein.
摘要翻译：本发明涉及免疫化学和药理学领域。描述了SARS CoV感染的诊断和治疗方法和组成。更具体地，该申请公开了SARS CoV的尖峰糖蛋白的核酸和肽，其提供治疗个体的预后和治疗组合物，这些个体承受或承受SARS CoV的危险。本发明的肽也可用于产生针对SARS CoV糖蛋白的抗体。

6. 发明申请

US20050112558A1 Prognostic PCR assay for severe acute respiratory syndrome (SARS) 审中-公开
标题翻译：严重急性呼吸综合征（SARS）的预后PCR检测
公开(公告)号：US20050112558A1
公开(公告)日：2005-05-26
申请号：US10948915
申请日：2004-09-23
申请人： Yuk Ming Lo , Kai Ng , Kwan Chee Chan , Wai Kwun Chiu , Siu Lun Tam , Chi Wan Hung , Siu Chung Chim , Yu Tong
发明人： Yuk Ming Lo , Kai Ng , Kwan Chee Chan , Wai Kwun Chiu , Siu Lun Tam , Chi Wan Hung , Siu Chung Chim , Yu Tong
IPC分类号： C07H21/04 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/701 , C07H21/04
摘要： Disclosed are nucleic acid primers, probes and standard target sequences that allow for the quantitative assessment of the SARS-CoV viral titer found in a biological specimen from a patient. Quantifying the viral titer in the patient sample allows the practitioner to make a prognostic determination of the severity of the SARS-CoV infection and the necessary treatment regime.
摘要翻译：公开了核酸引物，探针和标准靶序列，其允许定量评估来自患者的生物标本中发现的SARS-CoV病毒滴度。量化患者样品中的病毒滴度允许从业者对SARS-CoV感染的严重程度和必要的治疗方案进行预后测定。

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