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1. 发明授权

US08293365B2 Liquid crystal display panel and conductive adhesive, conductive particles and method of manufacturing thereof 有权
标题翻译：液晶显示面板和导电胶，导电颗粒及其制造方法
公开(公告)号：US08293365B2
公开(公告)日：2012-10-23
申请号：US12109898
申请日：2008-04-25
申请人： Yuhua Li
发明人： Yuhua Li
IPC分类号： B32B5/16
CPC分类号： H01B1/24 , H05K3/321 , Y10T428/1059 , Y10T428/249924 , Y10T428/254 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998
摘要： The present invention relates to a conductive particle, a conductive adhesive with the conductive particles, a LCD panel with the conductive adhesive, a method of manufacturing of the conductive particle and a method of manufacturing of the conductive adhesive. The conductive particle comprising an outer coating layer of graphite and an inner core of an organic resin enclosed by the outer coating layer, and therefore the conductive particles can have good conductivity as well as good strength and elasticity.
摘要翻译：本发明涉及导电性粒子，导电性粒子的导电性粘合剂，导电性粘合剂的液晶显示面板，导电性粒子的制造方法以及导电性粘合剂的制造方法。导电性粒子包含石墨的外涂层和由外涂层包围的有机树脂的内芯，因此导电性粒子具有良好的导电性以及良好的强度和弹性。

2. 发明授权

US08206735B2 Pharmaceutical compositions for sustained release delivery of peptides 有权
标题翻译：用于肽缓释递送的药物组合物
公开(公告)号：US08206735B2
公开(公告)日：2012-06-26
申请号：US11827260
申请日：2007-07-11
申请人： Yuhua Li , Benjamin Chien
发明人： Yuhua Li , Benjamin Chien
IPC分类号： A61K47/48
CPC分类号： A61K38/1808 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K38/2278 , A61K38/25 , A61K38/26 , A61K38/29 , A61K38/47 , A61K47/542 , A61K47/543 , A61K47/60
摘要： The present invention provides methods of forming a solid, biodegradable implant in-situ in a body by administering a liquid pharmaceutical composition comprising an effective amount of a biocompatible, water-insoluble, biodegradable polymer and an effective amount of a therapeutic peptide covalently modified with one or more lipophilic or amphiphilic moieties, which are dissolved or dispersed in a biocompatible, water-soluble organic solvent. This invention also provides related compositions and methods.
摘要翻译：本发明提供了通过施用包含有效量的生物相容性，水不溶性，可生物降解的聚合物和有效量的与一种共价修饰的治疗肽的液体药物组合物在体内原位形成固体，可生物降解的植入物的方法或更多亲脂性或两亲性部分，其被溶解或分散在生物相容的水溶性有机溶剂中。本发明还提供相关的组合物和方法。

3. 发明申请

US20100034801A1 Non-Polymeric Compositions for Controlled Drug Delivery 失效
标题翻译：用于控制药物递送的非聚合物组合物
公开(公告)号：US20100034801A1
公开(公告)日：2010-02-11
申请号：US12366402
申请日：2009-02-05
申请人： Yuhua Li , Andrew Guarino , Benjamin Chien
发明人： Yuhua Li , Andrew Guarino , Benjamin Chien
IPC分类号： A61K38/12 , A61K38/08 , A61K31/704 , A61K31/426 , A61K31/7036 , A61K38/47 , A61K31/485 , A61P25/00
CPC分类号： A61K38/31 , A61K9/0024 , A61K31/428 , A61K31/485 , A61K31/7036 , A61K31/704 , A61K38/09 , A61K38/26 , A61K47/541
摘要： The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.
摘要翻译：本发明提供了一种适用于原位形成贮库系统以便以受控方式递送生物活性物质的新型液体组合物。本发明的组合物包括：（a）疏水性非聚合物载体材料; （b）溶解疏水性非聚合物材料的水混溶性生物相容性有机溶剂; （c）在两亲性分子和具有中性pH在水中的净电荷的生物活性物质之间形成的离子络合物。本发明还提供了其组合物的制造和使用方法。

4. 发明申请

US20070196416A1 Pharmaceutical compositions with enhanced stability 审中-公开
标题翻译：具有增强稳定性的药物组合物
公开(公告)号：US20070196416A1
公开(公告)日：2007-08-23
申请号：US11653636
申请日：2007-01-16
申请人： Yuhua Li , Benjamin Chien
发明人： Yuhua Li , Benjamin Chien
IPC分类号： A61K38/22 , A61K38/18
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0024 , A61K9/0031 , A61K9/0034 , A61K9/0073 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/146 , A61K9/5031 , A61K38/09 , A61K38/2292 , A61K47/14 , A61K47/22
摘要： The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a peptide agent formed with a strong acid that minimizes or prevents the interaction/reaction between the peptide agent and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
摘要翻译：本发明提供了可用作肽剂的控制释放递送系统的稳定的可生物降解的聚合物组合物。本发明的组合物包含a）由强酸形成的肽剂的有益盐，其使有机溶液中肽剂和聚合物之间的相互作用/反应最小化或防止; b）可生物降解的聚合物; c）药学上可接受的有机溶剂; 和d）任选的一种或多种赋形剂。本发明还涉及一种制造方法及其使用方法。

5. 发明授权

US07224863B1 All optical regeneration 有权
标题翻译：所有光学再生
公开(公告)号：US07224863B1
公开(公告)日：2007-05-29
申请号：US10661184
申请日：2003-09-12
申请人： Yuhua Li , Guifang Li
发明人： Yuhua Li , Guifang Li
IPC分类号： G02B6/26
CPC分类号： H04B10/299 , G02B6/02028
摘要： All optical regeneration methods and systems can be realized through an exponential amplifier and a limiting amplifier, which could be two independent devices (one piece of fiber with parametric amplification and a semiconductor optical amplifier operating at saturation state) or one single device (one piece of fiber). The signal quality and the extinction ratio after regeneration are significantly improved compared with the degraded incoming data using a parametric amplifier with the data signal to be regenerated as the pump. The regenerated data has an extinction ratio as high as 14 dB, an extinction ratio enhancement of approximately 5 dB and an approximately 5 dB negative power penalty. This regeneration schemes are format transparent (RZ and NRZ), and provide noise reduction both for bit 1's and bit 0's of the data sequence. The regeneration method and apparatus that just utilizes fibers has the additional capability of ultrafast response speed (several femtoseconds due to the Kerr effect).
摘要翻译：所有光学再生方法和系统都可以通过指数放大器和限幅放大器来实现，该放大器可以是两个独立的器件（一个具有参数放大的光纤和在饱和状态下工作的半导体光放大器）或一个单一器件纤维）。再生后的信号质量和消光比与使用参数放大器的劣化输入数据相比显着提高，数据信号作为泵再生。再生数据具有高达14dB的消光比，大约5dB的消光比增强和大约5dB的负功率损耗。这种再生方案是格式透明的（RZ和NRZ），并且为数据序列的位1和位0提供降噪。刚刚利用光纤的再生方法和装置具有超快速响应速度（由于克尔效应而产生的几个飞秒）的附加能力。

6. 发明公开

US20240277670A1 SAFE USE OF MMP-12 INHIBITOR 审中-公开
公开(公告)号：US20240277670A1
公开(公告)日：2024-08-22
申请号：US18568043
申请日：2022-06-07
申请人： Yuhua LI , Foresee Pharmaceuticals Co., Ltd.
发明人： Yuhua LI , Benjamin CHIEN
IPC分类号： A61K31/4178 , A61K9/16 , A61K9/48
CPC分类号： A61K31/4178 , A61K9/1652 , A61K9/4808
摘要： Methods of safely administrating a matrix metalloproteinase 12 (MMP-12) inhibitor by oral administration are described. Also described are methods for providing clinically proven safe treatment of asthma, chronic obstructive pulmonary disease (COPD), or pulmonary fibrosis, by oral administration of an MMP-12 inhibitor.

7. 发明申请

US20180050108A1 Methods of Making Pharmaceutical Compositions with Enhanced Stability 审中-公开
公开(公告)号：US20180050108A1
公开(公告)日：2018-02-22
申请号：US15661066
申请日：2017-07-27
申请人： Yuhua Li , Benjamin Chien
发明人： Yuhua Li , Benjamin Chien
IPC分类号： A61K47/34 , A61K38/09 , A61K9/00
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0024 , A61K9/0031 , A61K9/0034 , A61K9/0073 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/146 , A61K9/5031 , A61K38/09 , A61K38/2292 , A61K47/14 , A61K47/22
摘要： The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analogue formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.

8. 发明授权

US09453062B2 Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof 有权
标题翻译：葡萄糖依赖性促胰岛素多肽类似物，药物组合物及其用途
公开(公告)号：US09453062B2
公开(公告)日：2016-09-27
申请号：US14125061
申请日：2012-06-08
申请人： Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
发明人： Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
IPC分类号： A61K38/22 , A61K38/00 , A61K38/28 , A61K38/26 , A61K38/16 , A61P3/04 , A61P3/10 , A61P7/12 , A61P19/10 , C07K14/605 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K14/575 , C07K14/00
CPC分类号： C07K14/575 , A61K38/00 , A61K38/16 , A61K38/22 , C07K14/00 , C07K14/605
摘要： The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
摘要翻译：本发明提供衍生自GIP（1-29，SEQ ID NO：1）的GIP类似物具有GLP-1激动剂活性和GIPR刺激活性，并且包含由下式I表示的氨基酸序列： Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp- Leu- A27-A28-A29-Y。本发明还提供了包含GIP类似物及其用途的药物组合物。

9. 发明申请

US20140162945A1 GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE ANALOGS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF 有权
标题翻译：葡萄糖依赖性胰岛素多肽类似物，药物组合物及其用途
公开(公告)号：US20140162945A1
公开(公告)日：2014-06-12
申请号：US14125061
申请日：2012-06-08
申请人： Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
发明人： Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , A61K38/16 , A61K38/22 , C07K14/00 , C07K14/605
摘要： The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu-A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
摘要翻译：本发明提供衍生自GIP（1-29，SEQ ID NO：1）的GIP类似物具有GLP-1激动剂活性和GIPR刺激活性，并且包含由下式I表示的氨基酸序列： Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp- Leu-A27-A28-A29-Y。本发明还提供了包含GIP类似物及其用途的药物组合物。

10. 发明授权

US08586103B2 Non-polymeric compositions for controlled drug delivery 失效
标题翻译：用于受控药物递送的非聚合物组合物
公开(公告)号：US08586103B2
公开(公告)日：2013-11-19
申请号：US12366402
申请日：2009-02-05
申请人： Yuhua Li , Andrew Guarino , Benjamin Chien
发明人： Yuhua Li , Andrew Guarino , Benjamin Chien
IPC分类号： A01N65/00
CPC分类号： A61K38/31 , A61K9/0024 , A61K31/428 , A61K31/485 , A61K31/7036 , A61K31/704 , A61K38/09 , A61K38/26 , A61K47/541
摘要： The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.
摘要翻译：本发明提供了一种适用于原位形成贮库系统以便以受控方式递送生物活性物质的新型液体组合物。本发明的组合物包括：（a）疏水性非聚合物载体材料; （b）溶解疏水性非聚合物材料的水混溶性生物相容性有机溶剂; （c）在两亲性分子和具有中性pH在水中的净电荷的生物活性物质之间形成的离子络合物。本发明还提供了其组合物的制造和使用方法。

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