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1. 发明授权

US08071650B2 Thiourea derivatives and the pharmaceutical compositions containing the same 有权
标题翻译：硫脲衍生物和含有它们的药物组合物
公开(公告)号：US08071650B2
公开(公告)日：2011-12-06
申请号：US11727413
申请日：2007-03-26
申请人： Young Ger Suh , Uh Taek Oh , Hee Doo Kim , Jee Woo Lee , Hyeung Geun Park , Ok Hui Park , Yong Sil Lee , Young Ho Park , Yung Hyup Joo , Jin Kyu Choi , Kyung Min Lim , Sun Young Kim , Jin Kwan Kim , Hyun Ju Koh , Joo Hyun Moh , Yeon Su Jeong , Jung Bum Yi , Young Im Oh
发明人： Young Ger Suh , Uh Taek Oh , Hee Doo Kim , Jee Woo Lee , Hyeung Geun Park , Ok Hui Park , Yong Sil Lee , Young Ho Park , Yung Hyup Joo , Jin Kyu Choi , Kyung Min Lim , Sun Young Kim , Jin Kwan Kim , Hyun Ju Koh , Joo Hyun Moh , Yeon Su Jeong , Jung Bum Yi , Young Im Oh
IPC分类号： A61K31/24 , A61K31/17 , A61K31/16 , C07C335/20 , C07C279/28 , C07C311/13
CPC分类号： C07D333/42 , C07C311/08 , C07C311/47 , C07C333/20 , C07C335/12 , C07C335/14 , C07C335/20 , C07C335/26 , C07C2601/14 , C07C2602/10 , C07D207/323 , C07D207/416 , C07D207/42 , C07D209/08 , C07D209/14 , C07D213/40 , C07D213/61 , C07D213/76 , C07D217/06 , C07D231/14 , C07D231/56 , C07D233/64 , C07D235/14 , C07D239/42 , C07D241/12 , C07D241/24 , C07D277/28 , C07D295/13 , C07D295/215 , C07D295/32 , C07D307/52 , C07D311/58 , C07D317/58 , C07D333/20
摘要： The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.
摘要翻译：本发明涉及作为香草素受体（VR）的调节剂的新型硫脲衍生物以及含有它们的药物组合物。作为与香草素受体活动有关的疾病，疼痛急性疼痛，慢性疼痛，神经性疼痛，手术后疼痛，偏头痛，关节痛，神经病变，神经损伤，糖尿病性神经病变，神经变性，神经性皮肤病，中风，膀胱过敏反应，易怒肠综合征，哮喘或慢性阻塞性肺疾病等呼吸系统疾病，皮肤，眼睛或粘膜的刺激，发热，胃十二指肠溃疡，炎性肠病和炎症性疾病。本发明提供了用于预防或治疗这些疾病的药物组合物。

2. 发明授权

US5338725A Anti-aggregatory agents for platelets 失效
公开(公告)号：US5338725A
公开(公告)日：1994-08-16
申请号：US906525
申请日：1992-06-30
申请人： Iwao Ojima , Masakatsu Eguchi , Young-Im Oh , Barry S. Coller
发明人： Iwao Ojima , Masakatsu Eguchi , Young-Im Oh , Barry S. Coller
IPC分类号： A61K38/00 , C07K7/02 , C07K14/75 , A61K37/02 , C07K7/06 , C07K7/08
CPC分类号： C07K14/75 , C07K7/02 , A61K38/00
摘要： The present invention provides synthetic antiaggregatory agents for preventing inhibition of fibrinogen-platelet binding. These anti-aggregatory agents have the general formulas (1)-(5).H--[--(AA.sub.i).sub.i --R--G--D--(AA.sub.j).sub.j --].sub.n --Cx (1)[Ri--C(O)--R--G--D--(AA.sub.j).sub.j --].sub.n --CX (2)Cy--[--AA.sub.i).sub.i --R--G--D--(AA.sub.j).sub.i --].sub.n --Z (3)H--[--(AA.sub.i).sub.i --R--G--D--(AA.sub.j).sub.j --].sub.n --CZ--[--(AA.sub.k).sub.k --R--G--D--(AA.sub.l).sub.l --].sub.m --Z (4)[R.sub.1 --C(O)--R--G--D--(AA.sub.i).sub.i --].sub.n --CZ[--(AA.sub.j).sub.j ]--R--G--D--(AA.sub.k).sub.k --].sub.m --Z (5)in which: R=Arg; G=Gly; D=Asp; AA.sub.i, AA.sub.j, AA.sub.k and AA.sub.l = alpha-, beta- and omega-amino acid residues; (AA.sub.i).sub.i (AA.sub.j).sub.j =peptide chains having the same or different amino acid residues; (AA.sub.k).sub.k =peptide chains having the same or different amino acid residues; (AA.sub.l).sub.l =peptide chains having the same or different amino acid residues; i and j =integers 0-20; m =an integer 1-10; n=an integer 2-10; Cx =a conjugator bearing at least two amine residues in a molecule having 1-30 carbon atoms, i.e, diamines, triamines, tetramines, and polyamines, which can have other functional groups in the molecule; Cy =a conjugator bearing at least two carboxyl residues in a molecule having 1-30 carbon atoms, i.e., aliphatic, aromatic, heteroaromatic, cycloalkyl dicarboxylic acid, tricarboxylic acid, and polycarboxylic acid residues, which can have other functional groups in the molecule; Cz .sup.= a conjugator bearing at least one amine residue and one carboxyl residue in an aromatic or a cycloalkyl skeleton, having 1-30 carbon atoms, i.e., aromatic, heteroaromatic and cycloalkyl amino carboxylic acid, diamino carboxylic acid, diamino dicarboxylic acid, and ployamino polycarboxylic acid residues; R.sub.1 =an alkyl, aromatic, heteroaromatic, or cycloalkyl group having 1-30 carbons, which can have other functional groups in the molecule; and Z=carboxyl, amide, N-substituted amide, hydrazide, N-substituted hydrazide, or ester group.

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