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1. 发明申请

US20210325322A1 METHOD FOR EXAMINING BIOLOGICAL FLUID 有权
公开(公告)号：US20210325322A1
公开(公告)日：2021-10-21
申请号：US17273155
申请日：2019-08-22
申请人： Yoshitane KOJIMA
发明人： Yoshitane KOJIMA
IPC分类号： G01N23/223 , G01N33/84
摘要： A method for examining a biological fluid whereby quantitative examinations of various minerals and methionine, one of essential amino acids, contained in a biological fluid can be conducted simply, accurately, and at a low price is provided, wherein using an X-ray fluorescence analysis device, content ratios of minerals contained in a biological fluid of a subject which can be taken by the subject to sulfur originating in methionine contained therein are measured, contents of the sulfur and the minerals contained therein are calculated using the measured content ratios and calibration curves previously prepared by X-ray fluorescence analysis of standard solutions of the sulfur and the minerals, and a content of the methionine contained therein is calculated on the basis of the calculated content of the sulfur.

2. 发明申请

US20070155656A1 Hypoglycemic agent 审中-公开
标题翻译：降血糖药
公开(公告)号：US20070155656A1
公开(公告)日：2007-07-05
申请号：US11633870
申请日：2006-12-04
申请人： Yoshitane Kojima , Hiromu Sakurai , Yutaka Yoshikawa
发明人： Yoshitane Kojima , Hiromu Sakurai , Yutaka Yoshikawa
IPC分类号： A61K31/555 , A61K31/315
CPC分类号： C07K5/1002 , A61K31/315 , A61K31/341 , A61K31/555 , A61K38/00 , C07C51/412 , C07C229/76 , C07D307/58 , C07K5/06008 , C07K5/08 , C07K5/0802 , C07C59/08
摘要： A zinc(II) complex which is lowly toxic, has high insulin-like activity, and is effectively usable as a hypoglycemic agent for the prevention or treatment of diabetes; a hypoglycemic agent containing the complex; a medicinal preparation which contains the complex and is useful as a preventive/remedy for diabetes; and a food containing the complex, such as a health food or supplementary health food. The hypoglycemic agent contains an organic zinc(II) complex having as a ligand a compound selected among aminoalkylpyridines, bis-optically active amino acids, bisaminoalkylcarboxylic acids, oligopeptides, oligopseudopeptides, di-substituted aminocarboxylic acids, α- and β-hydroxycarboxylic acids, vitamins, glutamine derivatives, etc.
摘要翻译：低毒性的锌（II）络合物具有高胰岛素样活性，可有效用作预防或治疗糖尿病的降血糖药; 含有复合物的降血糖剂; 含有该复合物并可用作糖尿病预防/补救剂的药物制剂; 以及含有复合物的食物，例如保健食品或辅助保健食品。降血糖剂含有作为配位体的有机锌（II）配合物，其选自氨基烷基吡啶类，双旋光活性氨基酸类，双氨基烷基羧酸类，寡肽类，寡假型肽类，二取代氨基羧酸类，α-羟基羧酸类，β-羟基羧酸类，维生素类，谷氨酰胺衍生物等

3. 发明申请

US20070155655A1 Hypoglycemic agent 审中-公开
公开(公告)号：US20070155655A1
公开(公告)日：2007-07-05
申请号：US11607223
申请日：2006-12-01
申请人： Yoshitane Kojima , Hiromu Sakurai , Yutaka Yoshikawa
发明人： Yoshitane Kojima , Hiromu Sakurai , Yutaka Yoshikawa
IPC分类号： A61K31/555 , A61K31/315
CPC分类号： C07K5/1002 , A61K31/315 , A61K31/341 , A61K31/555 , A61K38/00 , C07C51/412 , C07C229/76 , C07D307/58 , C07K5/06008 , C07K5/08 , C07K5/0802 , C07C59/08
摘要： A zinc(II) complex which is lowly toxic, has high insulin-like activity, and is effectively usable as a hypoglycemic agent for the prevention or treatment of diabetes; a hypoglycemic agent containing the complex; a medicinal preparation which contains the complex and is useful as a preventive/remedy for diabetes; and a food containing the complex, such as a health food or supplementary health food. The hypoglycemic agent contains an organic zinc(II) complex having as a ligand a compound selected among aminoalkylpyridines, bis-optically active amino acids, bisaminoalkylcarboxylic acids, oligopeptides, oligopseudopeptides, di-substituted aminocarboxylic acids, α- and β-hydroxycarboxylic acids, vitamins, glutamine derivatives, etc.

4. 发明申请

US20050130880A1 Hypoglycemic agent 审中-公开
标题翻译：降血糖药
公开(公告)号：US20050130880A1
公开(公告)日：2005-06-16
申请号：US11047206
申请日：2005-01-28
申请人： Yoshitane Kojima , Hiromu Sakurai , Yutaka Yoshikawa
发明人： Yoshitane Kojima , Hiromu Sakurai , Yutaka Yoshikawa
IPC分类号： A23L1/30 , A61K31/315 , A61K31/341 , A61K31/555 , A61K33/30 , A61K38/00 , A61P3/10 , A61P9/12 , C07C51/41 , C07C229/76 , C07D213/36 , C07D307/58 , C07D307/62 , C07F3/06 , C07K5/06 , C07K5/08 , C07K5/10 , A61K38/16 , A61K38/04
CPC分类号： C07K5/1002 , A61K31/315 , A61K31/341 , A61K31/555 , A61K38/00 , C07C51/412 , C07C229/76 , C07D307/58 , C07K5/06008 , C07K5/08 , C07K5/0802 , C07C59/08
摘要： A zinc(II) complex which is lowly toxic, has high insulin-like activity, and is effectively usable as a hypoglycemic agent for the prevention or treatment of diabetes; a hypoglycemic agent containing the complex; a medicinal preparation which contains the complex and is useful as a preventive/remedy for diabetes; and a food containing the complex, such as a health food or supplementary health food. The hypoglycemic agent contains an organic zinc(II) complex having as a ligand a compound selected among aminoalkylpyridines, bis-optically active amino acids, bisaminoalkylcarboxylic acids, oligopeptides, oligopseudopeptides, di-substituted aminocarboxylic acids, α- and β-hydroxycarboxylic acids, vitamins, glutamine derivatives, etc.
摘要翻译：低毒性的锌（II）络合物具有高胰岛素样活性，可有效用作预防或治疗糖尿病的降血糖药; 含有复合物的降血糖剂; 含有该复合物并可用作糖尿病预防/补救剂的药物制剂; 以及含有复合物的食物，例如保健食品或辅助保健食品。降血糖剂含有作为配位体的有机锌（II）配合物，其选自氨基烷基吡啶类，双旋光活性氨基酸类，双氨基烷基羧酸类，寡肽类，寡假型肽类，二取代氨基羧酸类，α-羟基羧酸类，β-羟基羧酸类，维生素类，谷氨酰胺衍生物等

5. 发明申请

US20110248189A1 METHOD FOR PREVENTING DETERIORATION OF EDIBLE OIL OR INDUSTRIAL OIL AND APPARATUS THEREFOR 有权
标题翻译：用于防止可食用油或工业油及其装置的检测的方法
公开(公告)号：US20110248189A1
公开(公告)日：2011-10-13
申请号：US13139771
申请日：2009-12-18
申请人： Shimpei Fukamachi , Tetsuya Ogura , Yoshitane Kojima , Yoshimitsu Tachi
发明人： Shimpei Fukamachi , Tetsuya Ogura , Yoshitane Kojima , Yoshimitsu Tachi
IPC分类号： G21K5/02 , A61L2/08
CPC分类号： C11B3/005 , A47J37/1271 , C10G2400/14
摘要： A fluororesin-coated electric wire cable is wound around a ring-shaped groove defined by an outer periphery of a cylinder and two flange edges immersed in an edible oil in a tank, forming each oscillating unit having a coil part; and the oscillating units are connected to an electromagnetic wave generator through a relay unit. Electromagnetic waves are irradiated from the coil parts based on an alternating current having a single frequency, an alternating current having a plurality of single frequencies different from one another, or an alternating current having a timewise varying frequency, the alternating currents each being within a frequency band of 4 kHz to 25 kHz, and a treatment based on a far-infrared heater or far-infrared ceramic is used combinedly therewith, to prevent deterioration of an edible oil or industrial oil.
摘要翻译：氟树脂涂覆的电线电缆缠绕在由圆筒的外周限定的环形槽和浸在罐中的食用油中的两个凸缘边缘，形成具有线圈部分的每个振荡单元; 并且振荡单元通过中继单元连接到电磁波发生器。基于具有单个频率的交流电，具有多个彼此不同的单个频率的交流电或具有时间上变化的频率的交流电，电磁波从线圈部分照射，每个交流电流在频率范围内 4kHz至25kHz的波段，并且组合使用基于远红外加热器或远红外线陶瓷的处理，以防止食用油或工业油的劣化。

6. 发明申请

US20090311370A1 Highly water-soluble agave inulin, agave inulin-containing product, agave inulin-origin product, by-product and method for producing the same 审中-公开
标题翻译：高水溶性龙舌兰菊糖，龙舌兰含菊粉的产品，龙舌兰菊糖来源的产品，副产物及其制备方法
公开(公告)号：US20090311370A1
公开(公告)日：2009-12-17
申请号：US12227997
申请日：2007-06-07
申请人： Tetsuya Ogura , Celia Beltran , Yoshitane Kojima
发明人： Tetsuya Ogura , Celia Beltran , Yoshitane Kojima
IPC分类号： C12G3/00 , C13D1/00 , A23K1/14 , A23L1/09
CPC分类号： A61K36/88 , A23K10/37 , A23K20/163 , A23L2/385 , A23L29/244 , A61K31/733 , C08B37/0054 , Y02P60/877
摘要： Inulin, which is contained at a high concentration in agave plants growing in arid areas, has been utilized hitherto exclusively in producing alcoholic drinks as tequila. It is intended to produce highly water-soluble inulin having a high added value from these plants. It is also intended to produce an agave syrup, tequila, an alcoholic drink or highly water-soluble inulin from the squeezed residue. Agave plant bulbs (several tens kg) having been employed in producing tequila called pina are cut into small pieces and enzymes therein are inactivated and the texture is softened either at room temperature or under heating. Next, the pieces are squeezed to give a liquid extract which is then refined by using an adsorbent resin. The refined product is employed either as such as a concentrate or after drying to give a powder.
摘要翻译：在干旱地区生长的龙舌兰植物中以高浓度含有的菊粉已经被用于生产酒精饮料作为龙舌兰酒。用于从这些植物生产高附加值的高度水溶性的菊粉。它也用于从挤压的残渣中生产龙舌兰糖浆，龙舌兰酒，酒精饮料或高度水溶性的菊粉。在龙舌兰酒生产中使用的龙舌兰植物鳞茎（几十公斤）被称为豌豆，被切成小块，其中的酶被灭活，并且在室温或加热下使织构软化。接下来，将该片挤压，得到液体提取物，然后用吸附树脂进行精制。精制产物可以如浓缩物或干燥后得到粉末。

7. 发明授权

US07226935B2 Hypoglycemic agent 失效
公开(公告)号：US07226935B2
公开(公告)日：2007-06-05
申请号：US10470786
申请日：2002-01-25
申请人： Yoshitane Kojima , Hiromu Sakurai , Yutaka Yoshikawa
发明人： Yoshitane Kojima , Hiromu Sakurai , Yutaka Yoshikawa
IPC分类号： A61K31/44 , C07D211/70
CPC分类号： C07K5/1002 , A61K31/315 , A61K31/341 , A61K31/555 , A61K38/00 , C07C51/412 , C07C229/76 , C07D307/58 , C07K5/06008 , C07K5/08 , C07K5/0802 , C07C59/08
摘要： A zinc(II) complex which is lowly toxic, has high insulin-like activity, and is effectively usable as a hypoglycemic agent for the prevention or treatment of diabetes; a hypoglycemic agent containing the complex; a medicinal preparation which contains the complex and is useful as a preventive/remedy for diabetes; and a food containing the complex, such as a health food or supplementary health food. The hypoglycemic agent contains an organic zinc(II) complex having as a ligand a compound selected among aminoalkylpyridines, bis-optically active amino acids, bisaminoalkylcarboxylic acids, oligopeptides, oligopseudopeptides, di-substituted aminocarboxylic acids, α- and β-hydroxycarboxylic acids, vitamins, glutamine derivatives, etc.

8. 发明申请

US20060153897A1 Zinc-containing foods 审中-公开
标题翻译：含锌食品
公开(公告)号：US20060153897A1
公开(公告)日：2006-07-13
申请号：US11371971
申请日：2006-03-08
申请人： Yoshitane Kojima , Hiromu Sakurai , Yutaka Yoshikawa
发明人： Yoshitane Kojima , Hiromu Sakurai , Yutaka Yoshikawa
IPC分类号： A61K47/00 , A61K33/32 , A61K38/05 , A61K38/04
CPC分类号： A21D2/245 , A21D2/02 , A23L33/165 , A23V2002/00 , A23V2250/1642
摘要： It is intended to provide foods such as health (supplementary) foods, nutrition (supplementary) foods and foods with health claims (foods for specified health uses and foods with nutrient function claims) containing zinc compositions which are less toxic and have a high insulin-like activity. Foods containing organic compounds capable of forming a complex with zinc and zinc sources. More specifically, foods such as health foods, health supplementary foods, nutrition foods nutrition supplementary foods and foods with health claims (foods for specified health uses and foods with nutrient function claims) containing organic compounds such as picolinic acid, L-amino acids, oligopeptides, niacin, maltol, etc. and organic zinc complexes or mineral acid salts of zinc containing these compounds as a ligand and having an effect of lowering blood glucose level.
摘要翻译：旨在提供食品，如健康（补充）食品，营养（补充）食品和具有健康要求的食品（具体健康用途的食品和营养功能要求的食品），其含有毒性较小且具有高胰岛素的锌组合物，喜欢活动含有能与锌和锌源形成复合物的有机化合物的食品。更具体地说，包括保健食品，健康补充食品，营养食品营养补充食品和具有健康要求的食品（具体的健康用途的食品和具有营养功能要求的食品）的食品包含有机化合物如吡啶甲酸，L-氨基酸，寡肽，烟酸，麦芽醇等，以及含有这些化合物作为配体并且具有降低血糖水平的作用的锌的有机锌络合物或无机酸盐。

9. 发明申请

US20060068046A1 Zinc (ii)-rich natural materials using plant 审中-公开
标题翻译：锌（ii）丰富的天然材料使用植物
公开(公告)号：US20060068046A1
公开(公告)日：2006-03-30
申请号：US10537706
申请日：2003-11-25
申请人： Junichi Arita , Yoshitane Kojima , Yutaka Yoshikawa , Munekazu Gemba , Yoshiko Kawai , Yuka Koda
发明人： Junichi Arita , Yoshitane Kojima , Yutaka Yoshikawa , Munekazu Gemba , Yoshiko Kawai , Yuka Koda
IPC分类号： A61K36/185
CPC分类号： A23L33/16 , A23L19/01 , A23L33/105 , A23V2002/00 , A23V2250/1642
摘要： To relieve symptoms caused by mineral deficiency such as taste abnormality and skin damage due to zinc deficiency, anemia due to iron deficiency and decreased bone mineral content due to calcium deficiency to thereby improve quality of life (QOL). Namely, foods such as foods for specific health uses and foods with nutrient function claims containing 0.1% or marc, based on gram of a dry natural plant material comprising a papaya powder etc., of zinc which are prepared by nonproliferatively stirring and/or shaking the natural plant material in a state of being suspended in a solution containing 100 ppm or greater of zinc.
摘要翻译：缓解因锌缺乏引起的异味，皮肤损伤，铁缺乏引起的贫血，钙缺乏导致的骨矿物质含量降低，从而提高生活质量（QOL）。也就是说，基于革兰氏木瓜粉等的干燥天然植物材料，通过非吸收性搅拌和/或摇动来制备的锌的食品，例如特定健康用食品和营养功能要求的食品含有0.1％或马克悬浮在含有100ppm以上锌的溶液中的天然植物材料。

10. 发明申请

US20060057254A1 Zinc-rich foods having effect of preventing diabetes 审中-公开
标题翻译：富含锌的食物具有预防糖尿病的作用
公开(公告)号：US20060057254A1
公开(公告)日：2006-03-16
申请号：US10538693
申请日：2003-10-03
申请人： Yoshitane Kojima , Yutaka Yoshikawa , Naemi Kajiwara , Hiroko Anzai , Hiroshi Taniguchi
发明人： Yoshitane Kojima , Yutaka Yoshikawa , Naemi Kajiwara , Hiroko Anzai , Hiroshi Taniguchi
IPC分类号： A23L1/30
CPC分类号： A61K45/06 , A23L33/105 , A23L33/16 , A23V2002/00 , A61K33/00 , A61K33/30 , A61K36/064 , A61K36/16 , A61K36/185 , A61K36/31 , A61K2300/00 , A23V2250/1642
摘要： Zinc (II) ions (zinc sulfate, zinc acetate and the like) originated in inorganic salts making it difficult for such ions to pass through biological membranes, thus being difficult to be incorporated in a human body. For overcoming such problems, it is necessary to develop food products with a prophylactic effect against diabetes, which contain zinc sources and have a lower toxicity than zinc (II) ions, a good stability and good fat-solubility. The present invention provides food products which have a prophylactic effect against diabetes using specified health foods, nutritional (functional) foods or the like containing natural substances that contain zinc in high concentrations (plants such as papaya, maca and the like, and yeasts such as baker's yeast, brewer's yeast and the like).
摘要翻译：锌（II）离子（硫酸锌，乙酸锌等）起源于无机盐，使得这些离子难以通过生物膜，因此难以掺入人体内。为了克服这些问题，有必要开发具有预防糖尿病的食品，其含有锌源，毒性低于锌（II）离子，具有良好的稳定性和良好的脂溶性。本发明提供了使用特定保健食品，营养（功能性）食品等含有高浓度锌的天然物质（植物如番木瓜，马卡类等）和酵母菌等的具有预防糖尿病作用的食品面包师酵母，啤酒酵母等）。

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