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1. 发明申请

US20140151548A1 MATRIX FOR MALDI MASS SPECTROMETRY AND MALDIMASS SPECTROMETRY METHOD 审中-公开
标题翻译：用于MALDI质谱和MALDIMASS光谱法的MATRIX方法
公开(公告)号：US20140151548A1
公开(公告)日：2014-06-05
申请号：US14130136
申请日：2012-07-05
申请人： Mitsuru Shindo , Hiroyuki Wariishi , Daisuke Miura , Yoshinori Fujimura
发明人： Mitsuru Shindo , Hiroyuki Wariishi , Daisuke Miura , Yoshinori Fujimura
IPC分类号： H01J49/16
CPC分类号： H01J49/164 , C07D215/42 , C07D215/44 , C07D219/10
摘要： Provided is a matrix for MALDI mass spectrometry that has a high ability of ionizing low-molecular-weight compounds, and makes it possible to make measurement in a negative ion mode. The matrix is a matrix for mass spectrometry that contains one or more compounds selected from the group consisting of compounds each represented by the following general formula (I), (II) or (III), and their salts thereof. In the formulae (I), (II) and (III), X and Z are each C or N; R1 and R5 are each selected from the group consisting of H, an alkyl group, a (substituted) aryl group, a (substituted) arylalkyl group, and a (substituted) heteroaryl group; R2 and R6 are each selected from the group consisting of H, an alkyl group, an alkoxyl group, an amino group, a halogen atom, a nitro group, an allyl group, a (substituted) aryl group, and a (substituted) heteroaryl group; and R7 and R8 are each selected from the group consisting of H and an amino group provided that a case where R1=R2=H, and a case where R7=R8=an amino group are excluded.
摘要翻译：本发明提供了一种具有高电离低分子量化合物的能力的MALDI质谱法的基质，能够以负离子模式进行测定。该基质是含有一种或多种选自下列通式（I），（II）或（III）表示的化合物及其盐的化合物的质谱用基质。在式（I），（II）和（III）中，X和Z各自为C或N; R 1和R 5各自选自H，烷基，（取代的）芳基，（取代的）芳基烷基和（取代的）杂芳基; R2和R6各自选自H，烷基，烷氧基，氨基，卤素原子，硝基，烯丙基，（取代的）芳基和（取代的）杂芳基组; 并且R 7和R 8各自选自H和氨基，条件是R1 = R2 = H的情况和R7 = R8 =氨基的情况被排除。

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