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1. 发明申请

US20080214584A1 Method for treating cancer 失效
标题翻译：癌症治疗方法
公开(公告)号：US20080214584A1
公开(公告)日：2008-09-04
申请号：US12005883
申请日：2007-12-27
申请人： Yoshikazu Ohta , Shinji Takagi
发明人： Yoshikazu Ohta , Shinji Takagi
IPC分类号： A61K31/517 , A61K31/519 , G01N33/574 , A61P35/00
CPC分类号： G01N33/57484 , A61K31/517 , A61K31/519
摘要： The present invention provides a method for treating cancer, which includes selecting a patient coexpressing HER2 and HER3, and administering an effective amount of a HER2 inhibitor to the patient.
摘要翻译：本发明提供一种治疗癌症的方法，其包括选择共同表达HER2和HER3的患者，以及向患者施用有效量的HER2抑制剂。

2. 发明申请

US20060009327A1 Starting clutch control device 失效
标题翻译：启动离合器控制装置
公开(公告)号：US20060009327A1
公开(公告)日：2006-01-12
申请号：US11154954
申请日：2005-06-17
申请人： Yoshikazu Ohta
发明人： Yoshikazu Ohta
IPC分类号： B60K41/12
CPC分类号： F16D48/066 , F16D2500/10412 , F16D2500/1088 , F16D2500/3061 , F16D2500/50224 , F16D2500/70252 , F16D2500/70426 , Y10T477/6403 , Y10T477/6418 , Y10T477/753 , Y10T477/78
摘要： A starting clutch control device includes a starting clutch disposed between an engine and a transmission installed to a vehicle. A torque coefficient setting section sets a torque coefficient based on a clutch speed ratio of the starting clutch and a throttle opening of the engine. A torque coefficient correction section increases the torque coefficient by a torque coefficient correction amount, increasing the torque coefficient by a progressively larger torque coefficient correction amount as the throttle opening increases, in order to increase the torque coefficient within a region of smaller clutch speed ratios (e.g., clutch speed ratios less than approximately 0.5). A hydraulic pressure control section controls hydraulic pressure supplied to the starting clutch based on the torque coefficient and the rotational speed of the engine.
摘要翻译：起动离合器控制装置包括设置在发动机和安装到车辆的变速器之间的起动离合器。扭矩系数设定部基于起动离合器的离合器速度比和发动机的节气门开度来设定转矩系数。转矩系数校正部通过转矩系数修正量来增大转矩系数，从而随着节气门开度的上升，通过逐渐变大的转矩系数校正量来增大转矩系数，以便在较小的离合器转速比的区域内增加转矩系数（例如，离合器速度比小于约0.5）。液压控制部基于转矩系数和发动机的转速来控制供给到起动离合器的液压。

3. 发明授权

US07825127B2 Method for treating cancer 失效
标题翻译：癌症治疗方法
公开(公告)号：US07825127B2
公开(公告)日：2010-11-02
申请号：US12005883
申请日：2007-12-27
申请人： Yoshikazu Ohta , Shinji Takagi
发明人： Yoshikazu Ohta , Shinji Takagi
IPC分类号： A61K31/519
CPC分类号： G01N33/57484 , A61K31/517 , A61K31/519
摘要： The present invention provides a method for treating cancer, which includes selecting a patient coexpressing HER2 and HER3, and administering an effective amount of a HER2 inhibitor to the patient.
摘要翻译：本发明提供一种治疗癌症的方法，其包括选择共同表达HER2和HER3的患者，以及向患者施用有效量的HER2抑制剂。

4. 发明申请

US20060145558A1 Alternator for a vehicle 审中-公开
标题翻译：交通工具车辆
公开(公告)号：US20060145558A1
公开(公告)日：2006-07-06
申请号：US10560244
申请日：2004-05-28
申请人： Toshiaki Kashihara , Kazunori Tanaka , Yukiyoshi Ohnishi , Syuichi Tamura , Yoshikazu Ohta
发明人： Toshiaki Kashihara , Kazunori Tanaka , Yukiyoshi Ohnishi , Syuichi Tamura , Yoshikazu Ohta
IPC分类号： H02K1/00 , H02K23/26 , H02K15/14
CPC分类号： H02K3/12 , H02K3/34 , H02K3/345 , H02K3/38 , H02K3/44 , Y10T29/49009 , Y10T29/49073
摘要： An ac generator for a vehicle is constituted so that the thickness in insulation layers of conductors in the slot-in portions located in the slot is smaller than the other to permit a metal portion of conductors to be much larger and to increase a density of conductors in the slots, causing heating from electrical conductors to efficiently conduct to a laminated core and a housing. On the contrary, the thickness in insulating layers of the cross-over portions is larger than the other to assure insulation capability among the coils and to prevent conductors of the cross-over portion axially exposed from the core to air from water immersion to improve an electrolytic corrosion resistibility without disposing unnecessary space among coils.
摘要翻译：构成车辆用交流发电机，使得位于槽内的槽口部分中的导体的绝缘层的厚度小于另一个，以允许导体的金属部分大得多并且增加导体的密度在槽中，导致从电导体的加热，以有效地传导到层压芯和壳体。相反，交叉部分的绝缘层中的厚度大于另一个，以确保线圈之间的绝缘能力，并且防止交叉部分的导体从芯部到水中浸入空气中轴向暴露以改善电解腐蚀电阻，不会在线圈之间留出不必要的空间。

5. 发明申请

US20100183604A1 PREVENTIVE/REMEDY FOR CANCER 审中-公开
标题翻译：预防/救治癌症
公开(公告)号：US20100183604A1
公开(公告)日：2010-07-22
申请号：US12665631
申请日：2008-06-19
申请人： Yoshikazu Ohta , Akira Hayashi
发明人： Yoshikazu Ohta , Akira Hayashi
IPC分类号： A61K39/395 , A61K31/517 , A61K31/519 , A61K31/55 , A61K31/5383 , A61K31/551 , C07D487/04 , A61P35/00 , G01N33/68 , C12Q1/48
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/7105 , A61K31/713 , A61K39/395 , A61K45/06 , C07K16/32 , C12N2310/14 , A61K2300/00
摘要： The present invention provides an agent for preventing or treating a trastuzumab-resistant cancer, which contains one or more medicaments selected from a cofilin inhibitor, a PAK1 inhibitor, a LIMK inhibitor, a RHO inhibitor, a ROCK1 inhibitor and a ROCK2 inhibitor.
摘要翻译：本发明提供了用于预防或治疗曲妥单抗耐药性癌症的药剂，其含有选自由cofilin抑制剂，PAK1抑制剂，LIMK抑制剂，RHO抑制剂，ROCK1抑制剂和ROCK2抑制剂的一种或多种药物。

6. 发明申请

US20100008912A1 COMBINATION DRUG 审中-公开
标题翻译：组合药物
公开(公告)号：US20100008912A1
公开(公告)日：2010-01-14
申请号：US12444309
申请日：2007-10-05
申请人： Yoshikazu Ohta , Toshiya Tamura , Shinji Takagi
发明人： Yoshikazu Ohta , Toshiya Tamura , Shinji Takagi
IPC分类号： A61K39/395 , A61K31/519 , A61K38/16 , A61K31/535 , A61K31/56
CPC分类号： A61K31/337 , A61K31/395 , A61K31/4745 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/565 , A61K31/704 , A61K2300/00
摘要： The present invention provides a pharmaceutical agent containing an HER2 inhibitor and a hormonal therapeutic agent or anti-cancer agent in combination. The present invention provides a pharmaceutical agent containing (1) an HER2 inhibitor having a pyrrolopyrimidine skeleton or pyrazolopyrimidine skeleton, and (2) a hormonal therapeutic agent or an anti-cancer agent in combination.
摘要翻译：本发明提供组合含有HER2抑制剂和激素治疗剂或抗癌剂的药剂。本发明提供含有（1）具有吡咯并嘧啶骨架或吡唑并嘧啶骨架的HER2抑制剂的药剂，和（2）组合的激素治疗剂或抗癌剂。

7. 发明申请

US20110003805A1 CONCOMITANT DRUG 审中-公开
标题翻译：可持续药物
公开(公告)号：US20110003805A1
公开(公告)日：2011-01-06
申请号：US12920566
申请日：2009-03-02
申请人： Yoshikazu Ohta , Shinji Takagi , Masahiro Yaguchi
发明人： Yoshikazu Ohta , Shinji Takagi , Masahiro Yaguchi
IPC分类号： A61K31/519 , A61K31/5377 , C07D487/04 , A61P35/00
CPC分类号： C07D471/04 , A61K31/436 , A61K31/4545 , A61K31/519 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： Provided is a combination drug. The present invention provides a pharmaceutical agent comprising (1) a HER2 inhibitor having a pyrrolopyrimidine skeleton or pyrazolopyrimidine skeleton, and (2) not less than one pharmaceutical agent selected from an mTOR inhibitor, a PI3 kinase inhibitor and a cMet inhibitor in combination.
摘要翻译：提供组合药物。本发明提供了包含（1）具有吡咯并嘧啶骨架或吡唑并嘧啶骨架的HER2抑制剂的药剂，和（2）从mTOR抑制剂，PI3激酶抑制剂和cMet抑制剂组合而成的不少于1种药剂。

8. 发明授权

US07255664B2 Starting clutch control device 失效
标题翻译：启动离合器控制装置
公开(公告)号：US07255664B2
公开(公告)日：2007-08-14
申请号：US11154954
申请日：2005-06-17
申请人： Yoshikazu Ohta
发明人： Yoshikazu Ohta
IPC分类号： B60W10/02
CPC分类号： F16D48/066 , F16D2500/10412 , F16D2500/1088 , F16D2500/3061 , F16D2500/50224 , F16D2500/70252 , F16D2500/70426 , Y10T477/6403 , Y10T477/6418 , Y10T477/753 , Y10T477/78
摘要： A starting clutch control device includes a starting clutch disposed between an engine and a transmission installed to a vehicle. A torque coefficient setting section sets a torque coefficient based on a clutch speed ratio of the starting clutch and a throttle opening of the engine. A torque coefficient correction section increases the torque coefficient by a torque coefficient correction amount, increasing the torque coefficient by a progressively larger torque coefficient correction amount as the throttle opening increases, in order to increase the torque coefficient within a region of smaller clutch speed ratios (e.g., clutch speed ratios less than approximately 0.5). A hydraulic pressure control section controls hydraulic pressure supplied to the starting clutch based on the torque coefficient and the rotational speed of the engine.
摘要翻译：起动离合器控制装置包括设置在发动机和安装到车辆的变速器之间的起动离合器。扭矩系数设定部基于起动离合器的离合器速度比和发动机的节气门开度来设定转矩系数。转矩系数校正部通过转矩系数修正量来增加转矩系数，从而随着节气门开度的上升，随着转矩系数的逐渐增大而增加转矩系数，以便在较小的离合器转速比的区域内增加转矩系数（例如，离合器速度比小于约0.5）。液压控制部基于转矩系数和发动机的转速来控制供给到起动离合器的液压。

9. 发明授权

US6004954A Condensed thiazine derivatives, their production and use thereof 失效
标题翻译：缩合噻嗪衍生物，其生产和使用
公开(公告)号：US6004954A
公开(公告)日：1999-12-21
申请号：US813986
申请日：1997-03-10
申请人： Shuichi Furuya , Seiichi Tanida , Yoshikazu Ohta
发明人： Shuichi Furuya , Seiichi Tanida , Yoshikazu Ohta
IPC分类号： C07D513/04 , A61K31/54
CPC分类号： C07D513/04
摘要： This invention relates to a compound of the following formula or a salt thereof, their production and use. ##STR1## wherein R.sup.1 and R.sup.2 independently represent hydrogen, a group bonding through a carbon atom, a group bonding through a nitrogen atom, a group bonding through an oxygen atom, or a group bonding through a sulfur atom; R.sup.3 represents hydrogen, halogen, a group bonding through a carbon atom, a group bonding through a nitrogen atom, a group bonding through an oxygen atom, or a group bonding through a sulfur atom; W represents an oxygen atom or sulfur atom; A represents a group forming a nitrogen-containing condensed ring at the 3,4- of a 1,4-thiazine ring; R.sup.1 and R.sup.2 may be combined to form a bivalent hydrocarbon group interrupted by one or more hetero atoms or an alkylene group. The above compound or a salt thereof not only has Th1 and Th2 cell function modulating activity but has splenocyte proliferation response, interleukin-5 production, and interferon-gamma production inhibitory activity and finds application as an effective therapeutic and/or prophylactic agent for allergic or autoimmune diseases or as an effective therapeutic and/or prophylactic agent for graft rejection or graft-vs-host disease.
摘要翻译：本发明涉及下式的化合物或其盐，其制备和用途。其中R1和R2独立地表示氢，通过碳原子键合的基团，通过氮原子键合的基团，通过氧原子键合的基团，或通过硫原子键合的基团; R3表示氢，卤素，通过碳原子键合的基团，通过氮原子键合的基团，通过氧原子键合的基团，或通过硫原子键合的基团; W表示氧原子或硫原子; A表示在1,4-噻嗪环的3,4-中形成含氮缩合环的基团; R1和R2可以组合形成被一个或多个杂原子或亚烷基间隔的二价烃基。上述化合物或其盐不仅具有Th1和Th2细胞功能调节活性，而且具有脾细胞增殖反应，白细胞介素-5产生和干扰素-γ产生抑制活性，并且被用作有效的治疗和/或预防药物用于过敏或自身免疫疾病或作为移植排斥或移植物抗宿主病的有效治疗和/或预防剂。

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