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1. 发明授权

US08135203B2 Cell image processor and cell image processing method 有权
标题翻译：细胞图像处理器和细胞图像处理方法
公开(公告)号：US08135203B2
公开(公告)日：2012-03-13
申请号：US12439778
申请日：2007-08-24
申请人： Kosuke Takagi , Yuichiro Matsuo , Yoshihiro Shimada
发明人： Kosuke Takagi , Yuichiro Matsuo , Yoshihiro Shimada
IPC分类号： G06K9/00
CPC分类号： G01N15/1463 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： Cells showing specific characters can be separated from noise, extracted, and analyzed, through processing of a cell image. It is intended to provide a cell image processor (1) comprising: a characteristic quantity measuring section (11) which processes a cell image obtained by photographing cells to measure characteristic quantities of respective cells in the cell image; a characteristic quantity distribution forming section (12) which forms the distribution of the thus measured characteristic quantities; a group forming section (13) which divides cells having continuously distributed characteristic quantities into groups in the thus formed characteristic quantity distribution; and a specific cell extracting section (14) which extracts cells having characteristic quantities falling within a predetermined range at both ends of a characteristic quantity distribution in each group, as specific cells.
摘要翻译：显示特定字符的单元可以通过处理单元图像与噪声分离，提取和分析。旨在提供一种单元图像处理器（1），包括：特征量测量部分（11），处理通过拍摄单元而获得的单元图像，以测量单元图像中各个单元的特征量; 特征量分布形成部（12），其形成如此测定的特征量的分布; 在这样形成的特征量分布中将具有连续分布的特征量的单元分成组的组形成部分（13）; 以及特征单元提取部（14），作为特定单元，提取具有落入各组的特征量分布的两端的特征量在特定量范围内的单元的单元。

2. 发明申请

US20110121199A1 IMAGING APPARATUS FOR LOW-LIGHT SAMPLE 审中-公开
标题翻译：低照度成像装置
公开(公告)号：US20110121199A1
公开(公告)日：2011-05-26
申请号：US12952387
申请日：2010-11-23
申请人： Yoshihisa TANIKAWA , Masahiro Oba , Yoshihiro Shimada
发明人： Yoshihisa TANIKAWA , Masahiro Oba , Yoshihiro Shimada
IPC分类号： G01J1/58
CPC分类号： G01J3/02 , G01J3/0208 , G01J3/4406 , G01N21/6456 , G01N21/763 , G02B13/22 , G02B21/16
摘要： An imaging apparatus for low-light sample comprises: an image-forming optical system which includes an objective lens and an image-forming lens and forms the sample image of an sample having a point light source, where the point light source emits weak light including fluorescence; an illumination optical system which radiates light from an illumination light source to the sample to make the sample emit fluorescence; and an image capturing means which includes a plurality of pixels and captures the image corresponding to the sample image. The illumination optical system radiates light from the illumination light source to the sample with the light not traveling via the objective lens, the image-forming optical system is approximately telecentric and is provided with a filter which is arranged between the objective lens and the image forming lens and wavelength-selectively extracts fluorescence from the sample, and the image-forming optical system is formed in such a way that the image-forming optical system collects weak light from the point light source to form airy disks the sizes of which are is approximately the same as or smaller than the sizes of the pixels.
摘要翻译：一种用于低光样本的成像装置，包括：成像光学系统，其包括物镜和图像形成透镜，并形成具有点光源的样本的样本图像，其中点光源发射弱光，包括荧光; 照明光学系统，其将来自照明光源的光辐射到样品以使样品发射荧光; 以及包括多个像素并且捕获与样本图像相对应的图像的图像捕获装置。照明光学系统以不经由物镜行进的光将照明光源的光照射到样品，图像形成光学系统近似为远心，并且设置有设置在物镜和图像形成之间的滤光器透镜和波长选择性地从样品中提取荧光，并且成像光学系统以这样的方式形成，使得成像光学系统收集来自点光源的弱光，以形成其大小近似的通风盘与像素的尺寸相同或小于像素的尺寸。

3. 发明申请

US20100202679A1 AUTOMATIC CELL ANALYZER AND AUTOMATIC CELL ANALYZING METHOD 有权
标题翻译：自动细胞分析仪和自动细胞分析方法
公开(公告)号：US20100202679A1
公开(公告)日：2010-08-12
申请号：US12377324
申请日：2007-08-10
申请人： Kosuke Takagi , Yuichiro Matsuo , Yoshihiro Shimada
发明人： Kosuke Takagi , Yuichiro Matsuo , Yoshihiro Shimada
IPC分类号： G06K9/62
CPC分类号： G01N21/6486 , G01N21/6458 , G01N2021/6482
摘要： A sharp image showing a thin projecting part is acquired without using a complex dyeing method, and the analysis accuracy is improved. An automatic cell analyzer (1) comprises: an imaging unit (4) for capturing fluorescence emitted from a cell (S) and acquiring a cell image; an exposure changing section (5) for changing the exposure condition when the imaging unit (4) captures cell images; and a processing section (5) for analyzing the cell (S) on the basis of a plurality of cell images respectively captured under the changed exposure conditions.
摘要翻译：在不使用复杂染色方法的情况下获取显示薄的突出部分的清晰图像，并且提高分析精度。一种自动细胞分析仪（1）包括：用于捕获从细胞（S）发射的荧光并获取细胞图像的成像单元（4）用于当所述成像单元（4）捕获细胞图像时改变所述曝光条件的曝光改变部分（5）; 以及用于基于在改变的曝光条件下分别捕获的多个单元图像来分析单元（S）的处理部分（5）。

4. 发明授权

US07602494B2 Method of imaging fluorescence and fluorescence imaging apparatus 有权
标题翻译：荧光和荧光成像设备成像方法
公开(公告)号：US07602494B2
公开(公告)日：2009-10-13
申请号：US11950712
申请日：2007-12-05
申请人： Mitsuo Harada , Yoshihiro Shimada
发明人： Mitsuo Harada , Yoshihiro Shimada
IPC分类号： G01N21/64
CPC分类号： G02B21/16 , G02B21/0088 , G02B21/33 , G02B21/367
摘要： A method of imaging fluorescence, in which an inverted fluorescence imaging apparatus provided with an immersion objective is used to image an observation phosphor for a constant term, includes an imaging position locating step of locating a vessel incorporating the observation phosphor at an imaging position of the fluorescence imaging apparatus; a liquid pouring step of pouring a preset amount of liquid between a top portion of the immersion objective in the fluorescence imaging apparatus and the vessel to bring about a charged state; an imaging step of imaging the observation phosphor in the vessel in a state where a space between the top portion of the immersion objective and the vessel is charged with the liquid; and a repeated control step of repeating a series of operations including the liquid pouring step of a single operation and the imaging step of a preset number of times of operations performed after the liquid pouring step of the single operation, at preset time intervals.
摘要翻译：一种成像荧光的方法，其中使用设置有浸没物镜的反相荧光成像设备来使观察荧光体成像一个常数项，其包括成像位置定位步骤，将包含观察荧光体的容器定位在荧光成像装置; 在所述荧光成像装置中的所述浸没物体的顶部与所述容器之间倾倒预定量的液体以引起充电状态的液体倾倒步骤; 成像步骤，在浸没物体的顶部与容器之间的空间被充满液体的状态下对容器中的观察荧光体进行成像; 以及重复控制步骤，重复包括单次操作的液体注入步骤和在单次操作的液体注入步骤之后执行的预定次数的操作的成像步骤的预定时间间隔的一系列操作。

5. 发明申请

US20090195866A1 MICROSCOPE 有权
标题翻译：显微镜
公开(公告)号：US20090195866A1
公开(公告)日：2009-08-06
申请号：US12090763
申请日：2007-10-19
申请人： Kenji Kawaski , Yoshihiro Shimada
发明人： Kenji Kawaski , Yoshihiro Shimada
IPC分类号： G02B21/06 , G02B21/04
CPC分类号： G01N21/6458 , G02B13/0095 , G02B21/0032 , G02B21/0076 , G02B21/082 , G02B21/16 , G02B21/361 , G02B21/367
摘要： A microscope has an objective lens, an imaging lens projecting light passing through the objective lens to form an image of a specimen, an image sensor located at an imaging position where the image of the specimen is formed by the imaging lens, an illumination light source, and a reflecting fluorescence illumination optical system including a dichroic mirror introducing light from the illumination light source into an optical path on the objective lens side, illuminating the specimen with the light. In this case, the microscope further has a relay optical system in which an intermediate image of the specimen is formed between the objective lens and the imaging lens and is relayed to the imaging lens, and the dichroic mirror of the reflecting fluorescence illumination optical system is located between a pupil position conjugate with a pupil position of the objective lens, formed between the relay optical system and the imaging lens, and the relay optical system.
摘要翻译：显微镜具有物镜，成像透镜，投影透过物镜的光以形成样本的图像，位于成像位置处的图像传感器，其中通过成像透镜形成样本的图像;照明光源以及反射荧光照明光学系统，其包括将来自照明光源的光引入物镜侧的光路的二向色镜，用光照射样本。在这种情况下，显微镜还具有中继光学系统，其中样品的中间图像形成在物镜和成像透镜之间并被中继到成像透镜，反射荧光照明光学系统的分色镜是位于与中继光学系统和成像透镜之间形成的物镜的光瞳位置的光瞳位置和中继光学系统之间。

6. 发明申请

US20090185268A1 BOX-TYPE MICROSCOPE APPARATUS 有权
标题翻译： BOX型微型计算机
公开(公告)号：US20090185268A1
公开(公告)日：2009-07-23
申请号：US12141371
申请日：2008-06-18
申请人： Mitsuo HARADA , Yoshihiro SHIMADA
发明人： Mitsuo HARADA , Yoshihiro SHIMADA
IPC分类号： G02B21/06 , G02B21/26
CPC分类号： G01N21/6458 , G02B21/0088 , G02B21/24 , G02B21/362
摘要： A box-type microscope apparatus includes a stage, a microscope, and a housing, which has a fixed housing and a moving housing provided to be openable, closable, and movable with respect to the fixed housing. The box-type microscope apparatus further includes a specimen vessel positioning device for fixing the specimen vessel placed on the stage at a constant position. of the stage and a positioning release device for actuating the specimen vessel positioning means when the moving housing is moved toward a position of a closed state to release a positioning of the specimen vessel performed by the specimen vessel positioning device with respect to the stage when the moving housing is opened.
摘要翻译：盒式显微镜装置包括台架，显微镜和壳体，其具有设置成可相对于固定壳体可开启，关闭和移动的固定壳体和移动壳体。盒型显微镜装置还包括用于将放置在台架上的标本容器固定在恒定位置的检体容器定位装置。以及定位释放装置，用于当移动壳体朝向关闭状态的位置移动时致动样本容器定位装置，以释放由样本容器定位装置执行的样本容器相对于该阶段的定位移动房屋开放。

7. 发明授权

US07187493B2 Laser microscope 有权
标题翻译：激光显微镜
公开(公告)号：US07187493B2
公开(公告)日：2007-03-06
申请号：US10006373
申请日：2001-10-29
申请人： Hiroshi Sasaki , Yoshihiro Shimada
发明人： Hiroshi Sasaki , Yoshihiro Shimada
IPC分类号： G02B21/00
CPC分类号： G02B21/16 , G02B21/002
摘要： A laser microscope is provided in which a beam splitter extracts a part of a laser light of two wavelengths λ1=488 nm and λ2=514.5 nm, a prism spectrally resolves the laser light of the two wavelengths λ1 and λ2, a two-split photodiode detects intensities of two lines spectrally resolved in this manner, and a controller controls an acousto-optical tunable filter (AOTF) fixed to an output end of an argon laser based on a detection signal outputted from the two-split photodiode so that respective light intensities of both lines of wavelengths λ1 and λ2 become constant.
摘要翻译：提供了一种激光显微镜，其中分束器提取两个波长λ1 = 488nm和λ2 = 514.5nm的激光的一部分，棱镜分光解析两个波长λ1和λ2的激光，a 双分辨光电二极管以这种方式检测两束光谱解析的强度，并且控制器基于从二分离光电二极管输出的检测信号来控制固定到氩激光器的输出端的声光可调谐滤波器（AOTF）两条波长λ1和λ2的各自的光强度变得恒定。

8. 再颁专利

USRE38860E1 Scanning optical microscope 有权
标题翻译：扫描光学显微镜
公开(公告)号：USRE38860E1
公开(公告)日：2005-11-01
申请号：US10613664
申请日：2003-07-02
申请人： Yoshihiro Shimada
发明人： Yoshihiro Shimada
IPC分类号： G01B11/24 , G01J3/28 , G01N21/64 , G02B21/00 , G02B21/06 , G02B21/16 , G02B21/18
CPC分类号： G02B21/16 , G01J3/021 , G01J3/14 , G01J3/4406 , G01N21/64 , G01N21/6458 , G02B21/0076
摘要： A scanning optical microscope comprising a laser source, a scan optical system for scanning a sample with a laser beam from the laser source, a spectral resolving optical system for resolving spectra of fluorescent rays from the sample, a wavelength splitting optical system for splitting the fluorescent rays that have passed the spectral resolving optical system into rays of a plurality of different wavelengths and guiding the split rays to optical paths of the plurality of different wavelengths, a plurality of image forming optical systems, respectively provided in the optical paths of the plurality of different wavelengths, for forming images of the fluorescent rays from the sample, a plurality of confocal apertures respectively provided in the optical paths at focal points of the image forming optical systems, and a plurality of photosensors, respectively provided in the optical paths, for sensing the fluorescent rays from the sample that have passed the respective confocal apertures.
摘要翻译：一种扫描光学显微镜，包括激光源，用于从激光源激光束扫描样品的扫描光学系统，用于分辨来自样品的荧光的光谱的光谱分辨光学系统，用于分离荧光的波长分裂光学系统已经通过光谱分辨光学系统的光线成为多个不同波长的光线并且将分裂光线引导到多个不同波长的光路;分别设置在多个不同波长的光路中的多个成像光学系统用于形成来自样品的荧光的图像，分别设置在图像形成光学系统的焦点处的光路中的多个共焦孔，以及分别设置在光路中的多个光电传感器，用于感测来自样品的已经通过各个共焦孔的荧光 s。

9. 发明授权

US06934020B2 Laser microscope 有权
标题翻译：激光显微镜
公开(公告)号：US06934020B2
公开(公告)日：2005-08-23
申请号：US10186573
申请日：2002-07-01
申请人： Yoshihiro Shimada
发明人： Yoshihiro Shimada
IPC分类号： G01N21/65 , G02B21/00 , G02B21/06 , G01J3/44
CPC分类号： G02B21/002
摘要： A laser microscope includes a laser light emitting system which emits a pump beam and a Stokes beam having different frequencies, and a common optical fiber having one end and the other end. The pump beam and the Stokes beam emitted from the laser light emitting system are incident on the one end thereof and emitted from the other end thereof. A beam irradiating mechanism condenses and irradiates the pump beam and the Stokes beam emitted from the other end of the optical fiber, onto a sample via the objective lens, thereby making an anti-Stokes beam be emitted from the sample. A photo detector detects the anti-Stokes beam emitted from the sample. A beam selecting mechanism allows only the anti-Stokes beam of the pump beam, the Stokes beam and the anti-Stokes beam to be received on the photo detector.
摘要翻译：激光显微镜包括发射泵浦光束的激光发射系统和具有不同频率的斯托克斯光束，以及具有一端和另一端的公共光纤。从激光发射系统发射的泵浦光束和斯托克斯光束入射到其一端并从其另一端射出。光束照射机构将从光纤的另一端发射的泵浦光束和斯托克斯光束经由物镜冷凝并照射到样品上，从而从样品发射反斯托克斯光束。光电检测器检测从样品发射的反斯托克斯光束。光束选择机构仅允许泵光束的反斯托克斯光束，斯托克斯光束和反斯托克斯光束被接收在光检测器上。

10. 发明授权

US06693945B1 Scanning type laser microscope 有权
标题翻译：扫描型激光显微镜
公开(公告)号：US06693945B1
公开(公告)日：2004-02-17
申请号：US09663631
申请日：2000-09-18
申请人： Yoshihiro Shimada
发明人： Yoshihiro Shimada
IPC分类号： H01S308
CPC分类号： G02B21/002 , G02B21/16 , H01S3/0941
摘要： This invention provides a laser scanning microscope in which a harmonic generator for modulating a laser beam Q having passed through an optical fiber into a laser beam Qb having a wavelength different from that of the laser beam Q, and sending the laser beam Qb to a scanning type optical microscope main body is integrally attached to the scanning type optical microscope main body.
摘要翻译：本发明提供一种激光扫描显微镜，其中用于将已经通过光纤的激光束Q调制成具有与激光束Q的波长不同的波长的激光束Qb的谐波发生器，并将激光束Qb发送到扫描光学显微镜主体一体地安装在扫描型光学显微镜主体上。

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