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1. 发明授权

US06723544B2 Biotin biosynthetic genes 失效
公开(公告)号：US06723544B2
公开(公告)日：2004-04-20
申请号：US10033078
申请日：2001-12-27
申请人： Yasuhiro Furuichi , Tatsuo Hoshino , Hitoshi Kimura , Tatsuya Kiyasu , Yoshie Nagahashi
发明人： Yasuhiro Furuichi , Tatsuo Hoshino , Hitoshi Kimura , Tatsuya Kiyasu , Yoshie Nagahashi
IPC分类号： C12N910
CPC分类号： C12N15/52 , A23L33/15 , A23V2002/00 , C12P17/185 , A23V2250/70
摘要： The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.

2. 发明授权

US06365388B1 Biotin biosynthetic genes 失效
公开(公告)号：US06365388B1
公开(公告)日：2002-04-02
申请号：US09594185
申请日：2000-06-14
申请人： Yasuhiro Furuichi , Tatsuo Hoshino , Hitoshi Kimura , Tatsuya Kiyasu , Yoshie Nagahashi
发明人： Yasuhiro Furuichi , Tatsuo Hoshino , Hitoshi Kimura , Tatsuya Kiyasu , Yoshie Nagahashi
IPC分类号： C12N910
CPC分类号： C12N15/52 , A23L33/15 , A23V2002/00 , C12P17/185 , A23V2250/70
摘要： The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.

3. 发明授权

US06361978B1 Production of biotin 失效
标题翻译：生物素生产
公开(公告)号：US06361978B1
公开(公告)日：2002-03-26
申请号：US08840059
申请日：1997-04-24
申请人： Tatsuo Hoshino , Akira Asakura , Tatsuya Kiyasu , Yoshie Nagahashi
发明人： Tatsuo Hoshino , Akira Asakura , Tatsuya Kiyasu , Yoshie Nagahashi
IPC分类号： C12P1718
CPC分类号： C12N9/93 , C12N9/13 , C12P17/186
摘要： The present invention provides processes for making biotin from desthiobiotin by either contacting desthiobiotin with an enzyme reaction mixture containing bioB gene product and nifU gene product and/or nifS gene product and isolating the biotin or cultivating a microorganism transformed with DNA encoding the bioB gene product, nifU gene product and nifS gene product and isolating the biotin.
摘要翻译：本发明提供通过将脱硫生物素与含有bioB基因产物和nifU基因产物和/或nifS基因产物的酶反应混合物接触来生产脱氧生物素的生物素的方法，并分离生物素或培养用编码bioB基因产物的DNA转化的微生物， nifU基因产物和nifS基因产物，并分离生物素。

4. 发明申请

US20060127992A1 Microorganism and process for preparing vitamin b6 审中-公开
标题翻译：微生物和维生素B6的制备方法
公开(公告)号：US20060127992A1
公开(公告)日：2006-06-15
申请号：US10528881
申请日：2003-09-16
申请人： Tatsuo Hoshino , Keiko Ichikawa , Yoshie Nagahashi , Masaaki Tazoe
发明人： Tatsuo Hoshino , Keiko Ichikawa , Yoshie Nagahashi , Masaaki Tazoe
IPC分类号： C12P17/12 , C12N1/21
CPC分类号： C12N9/0008 , C12N9/93 , C12P17/12
摘要： Disclosed is a recombinant microorganism of the genus Sinorhizobium which is transformed with a vector containing pyridoxol 5′-phophate synthase gene and D-erythrose 4-phosphate dehydrogenase gene, and being capable of producing vitamin B6.
摘要翻译：公开了用含有吡哆醇5'-磷酸合酶基因和D-赤藓糖-4-磷酸脱氢酶基因的载体转化的Sinorhizobium属的重组微生物，并且能够产生维生素B6。

5. 发明申请

US20110098477A1 Method Of Producing Compound Having Anti-Hcv Activity 审中-公开
标题翻译：生产具有抗Hcv活性的化合物的方法
公开(公告)号：US20110098477A1
公开(公告)日：2011-04-28
申请号：US11988003
申请日：2006-06-27
申请人： Masahiro Aoki , Yoshie Nagahashi , Hideyuki Kato , Tatsuya Ito , Miyako Masubuchi , Toru Okuda
发明人： Masahiro Aoki , Yoshie Nagahashi , Hideyuki Kato , Tatsuya Ito , Miyako Masubuchi , Toru Okuda
IPC分类号： C07D213/55 , C07C229/36 , C12P13/04
CPC分类号： C07C229/36 , C07C231/14 , C12P13/02 , C07C235/76
摘要： There is provided a convenient and inexpensive method of producing a compound which has a high activity of inhibiting replication of hepatitis C virus (HCV) and is useful for preventing and treating a liver disease caused by HCV infection.It is a method of biologically producing a compound represented by the formula (1): [wherein A represents a hydrogen atom, a straight or branched alkyl group having 1 to 8 carbon atoms, or the like], or a pharmaceutically acceptable salt thereof, a method comprising adding an amino acid derivative represented by the formula (3): [wherein A has the same meaning as defined for the compound of the above formula (1); and R represents a hydrogen atom, a straight or branched alkyl group having 1 to 8 carbon atoms, or the like], or a salt thereof into the fungal mycelium or the culture medium/culture broth of a filamentous fungal strain having an ability to produce the compound represented by the formula (2): to thereby cause the fungal strain to directly produce the compound of the formula (1).
摘要翻译：提供了一种方便且廉价的生产具有抑制丙型肝炎病毒（HCV）复制活性的化合物的方法，并且可用于预防和治疗由HCV感染引起的肝脏疾病。生物地制造式（1）表示的化合物或其药学上可接受的盐的方法：[其中A表示氢原子，碳原子数1〜8的直链或支链烷基等] 包括加入由式（3）表示的氨基酸衍生物的方法：[其中A具有与上述式（1）的化合物相同的含义; R表示氢原子，碳原子数为1〜8的直链或支链烷基等，或其盐形成具有生产能力的丝状真菌菌株的真菌菌丝体或培养液/培养液由式（2）表示的化合物：由此使真菌菌株直接生成式（1）的化合物。

6. 发明授权

US06955906B2 Biotin biosynthetic genes having biotin synthase activity 失效
标题翻译：具有生物素合成酶活性的生物素生物合成基因
公开(公告)号：US06955906B2
公开(公告)日：2005-10-18
申请号：US10763933
申请日：2004-01-23
申请人： Yasuhiro Furuichi , Tatsuo Hoshino , Hitoshi Kimura , Tatsuya Kiyasu , Yoshie Nagahashi
发明人： Yasuhiro Furuichi , Tatsuo Hoshino , Hitoshi Kimura , Tatsuya Kiyasu , Yoshie Nagahashi
IPC分类号： A23K1/16 , A23L33/15 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/52 , C12P17/18 , C12R1/01 , C12R1/19 , C12N9/10 , C07H21/04 , C12N1/20 , C12N9/00
CPC分类号： C12N15/52 , A23L33/15 , A23V2002/00 , C12P17/185 , A23V2250/70
摘要： The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.
摘要翻译：本发明涉及使用遗传工程微生物的发酵生物素的生产方法，以及用于该方法的DNA序列和载体。

7. 发明授权

US07598066B2 Gene encoding vitamin b6 phosphate phosphatase and use thereof 有权
标题翻译：编码维生素B6磷酸磷酸酶的基因及其用途
公开(公告)号：US07598066B2
公开(公告)日：2009-10-06
申请号：US10528845
申请日：2003-09-23
申请人： Tatsuo Hoshino , Yoshie Nagahashi , Masaaki Tazoe
发明人： Tatsuo Hoshino , Yoshie Nagahashi , Masaaki Tazoe
IPC分类号： C12N9/16 , C12N15/70 , C12N1/21 , C12N1/16 , C12P21/06 , C12P17/00 , C12P17/12 , C07H21/04
CPC分类号： C12N9/16 , C12P17/12
摘要： Disclosed is an isolated DNA encoding vitamin B6 phosphate phosphatase selected from the group consisting of: (a) a DNA sequence represented in SEQ ID NO:9; (b) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and hybridizes under standard conditions to the DNA sequence defined in (a) or a fragment of thereof; (c) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity, wherein said polypeptide is at least 70% identical to the amino acid sequence represented in SEQ ID NO:10; (d) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and is at least 70% identical to the DNA sequence represented in SEQ ID NO:9; (e) a degenerate DNA sequence of any one of (a) to (c).
摘要翻译：公开了编码选自以下的维生素B6磷酸磷酸酶的分离DNA：（a）SEQ ID NO：9所示的DNA序列; （b）编码具有维生素B6磷酸酯酶活性的多肽的DNA序列，并在标准条件下与（a）中定义的DNA序列或其片段杂交; （c）编码具有维生素B6磷酸酯酶活性的多肽的DNA序列，其中所述多肽与SEQ ID NO：10所示氨基酸序列至少70％相同; （d）编码具有维生素B6磷酸酯酶活性并与SEQ ID NO：9所示DNA序列至少70％相同的多肽的DNA序列; （e）（a）至（c）中任一项的简并DNA序列。

8. 发明申请

US20060263862A1 Gene encoding vitamin b6 phosphate phosphatase and use thereof 有权
标题翻译：编码维生素B6磷酸磷酸酶的基因及其用途
公开(公告)号：US20060263862A1
公开(公告)日：2006-11-23
申请号：US10528845
申请日：2003-09-23
申请人： Tatsuo Hoshino , Yoshie Nagahashi , Masaaki Tazoe
发明人： Tatsuo Hoshino , Yoshie Nagahashi , Masaaki Tazoe
IPC分类号： C12P17/00 , C12N9/16 , C12N15/74 , C12N1/21
CPC分类号： C12N9/16 , C12P17/12
摘要： Disclosed is an isolated DNA encoding vitamin B6 phosphate phosphatase selected from the group consisting of: (a) a DNA sequence represented in SEQ ID NO:9; (b) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and hybridizes under standard conditions to the DNA sequence defined in (a) or a fragment of thereof; (c) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity, wherein said polypeptide is at least 70% identical to the amino acid sequence represented in SEQ ID NO: 10; (d) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and is at least 70% identical to the DNA sequence represented in SEQ ID NO:9; (e) a degenerate DNA sequence of any one of (a) to (c).
摘要翻译：公开了编码选自以下的维生素B 6磷酸磷酸酶的分离DNA：（a）SEQ ID NO：9所示的DNA序列; （b）编码具有维生素B 6磷酸磷酸酶活性的多肽的DNA序列，并在标准条件下与（a）中定义的DNA序列或其片段杂交; （c）编码具有维生素B 6磷酸磷酸酶活性的多肽的DNA序列，其中所述多肽与SEQ ID NO：10所示氨基酸序列至少70％相同; （d）编码具有维生素B 6磷酸磷酸酶活性的多肽的DNA序列，与SEQ ID NO：9所示的DNA序列至少70％相同; （e）（a）至（c）中任一项的简并DNA序列。

9. 发明授权

US6117669A Biotin biosynthetic genes 失效
公开(公告)号：US6117669A
公开(公告)日：2000-09-12
申请号：US935263
申请日：1997-09-22
申请人： Yasuhiro Furuichi , Tatsuo Hoshino , Hitoshi Kimura , Tatsuya Kiyasu , Yoshie Nagahashi
发明人： Yasuhiro Furuichi , Tatsuo Hoshino , Hitoshi Kimura , Tatsuya Kiyasu , Yoshie Nagahashi
IPC分类号： A23K1/16 , A23L33/15 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/52 , C12P17/18 , C12R1/01 , C12R1/19 , C12N1/22 , C07H21/02
CPC分类号： C12N15/52 , A23L33/15 , C12P17/185 , A23V2002/00
摘要： The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.

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