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1. 发明授权

US6133279A Therapeutic agents for renal diseases and organ preservatives 失效
标题翻译：肾脏疾病和器官防腐剂的治疗剂
公开(公告)号：US6133279A
公开(公告)日：2000-10-17
申请号：US202593
申请日：1998-12-17
申请人： Osamu Cynshi , Yoshiaki Takashima , Kunio Tamura , Akira Ishikawa , Yoshiaki Kato
发明人： Osamu Cynshi , Yoshiaki Takashima , Kunio Tamura , Akira Ishikawa , Yoshiaki Kato
IPC分类号： A61K31/08 , A61K31/085 , A61K31/216 , A61K31/34 , A61K31/343 , A61K31/351 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/4525 , C07D307/79 , C07D307/80 , C07D307/81 , C07D307/85 , C07D307/94 , C07D333/54 , C07D333/56 , C07D333/58 , C07D333/60 , C07D407/04 , C07D409/04 , A61K31/22
CPC分类号： C07D307/79 , A61K31/08 , A61K31/085 , A61K31/216 , A61K31/34 , A61K31/343 , A61K31/351 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/4525 , C07D307/80 , C07D307/81 , C07D307/85 , C07D307/94 , C07D333/54 , C07D333/56 , C07D333/58 , C07D333/60 , C07D407/04 , C07D409/04
摘要： Herein disclosed are therapeutic agents for renal diseases and organ preservatives containing a compound represented by the general formula (1): ##STR1## wherein X represents an oxygen atom or a group represented by the general formula (2): ##STR2## where n represents an integer from 0 to 2, R.sub.1 represents a hydrogen atom or an acyl group, R.sub.2 represents a hydrogen atom, a lower alkyl group or a lower alkenyl group, R.sub.3 represents a lower alkyl group, R.sub.4, R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom or an optionally substituted alkyl group, and R.sub.6 further represents a formyl, carboxyl, lower alkoxycarbonyl or optionally substituted carbamoyl group, or R.sub.3 and R.sub.4 may be taken together to form a five-membered ring, or R.sub.5 and R.sub.6 may be taken together to form a cycloalkyl group, provided that when the five-membered ring formed by R.sub.3 and R.sub.4 and the benzene ring form benzofuran or benzo[b]thiophene, R.sub.6 is absent.
摘要翻译： PCT No.PCT / JP97 / 01729 Sec。 371日期1998年12月17日第 102（e）日期1998年12月17日PCT提交1997年5月23日PCT公布。出版物WO97 / 49388 1997年12月31日，日本公开了含有通式（1）表示的化合物的肾脏疾病和器官防腐剂的治疗剂：其中X表示氧原子或由通式（2）表示的基团：其中n表示 0〜2的整数，R1表示氢原子或酰基，R2表示氢原子，低级烷基或低级烯基，R3表示低级烷基，R4，R5，R6表示相同或不同的，各自表示氢原子或任选取代的烷基，R 6还表示甲酰基，羧基，低级烷氧基羰基或任选取代的氨基甲酰基，或者R 3和R 4可以一起形成五元环，或R 5 并且R6可以一起形成环烷基，条件是当由R3和R4形成的五元环和苯环形成苯并呋喃或苯并[b]噻吩时，R6不存在。

2. 发明授权

US06403639B1 2,3-dihydrobenzofuran derivatives 失效
标题翻译： 2,3-二氢苯并呋喃衍生物
公开(公告)号：US06403639B1
公开(公告)日：2002-06-11
申请号：US09424456
申请日：1999-11-23
申请人： Akira Ishikawa , Yoshiaki Kato , Kunio Tamura , Yoshiaki Takashima , Osamu Cynshi
发明人： Akira Ishikawa , Yoshiaki Kato , Kunio Tamura , Yoshiaki Takashima , Osamu Cynshi
IPC分类号： A61K31343
CPC分类号： C07D307/79 , A61K31/343 , C07D307/94
摘要： 2,3-Dihydrobenzofuran derivatives of general formula (1): wherein R1 represents a hydrogen atom or an acyl group; R2, R3 and R4 represent a hydrogen atom, a lower alkyl group or a lower alkenyl group; R5 and R6 represent a hydrogen atom or an optionally substituted alkyl group, or R5 and R6 combine to form a cycloalkyl group or a saturated heterocyclic group containing one or more oxygen atoms or alkyl-substituted nitrogen atoms, provided that R2 and R3 can not simultaneously represent a t-butyl group, or optically active isomers or pharmaceutically acceptable salts thereof are useful as therapeutic or prophylactic agents for various renal diseases and as organ preservatives.
摘要翻译：通式（1）的2,3-二氢苯并呋喃衍生物：其中R1表示氢原子或酰基; R2，R3和R4表示氢原子，低级烷基或低级烯基; R 5和R 6表示氢原子或任选取代的烷基，或者R 5和R 6结合形成环烷基或含有一个或多个氧原子或烷基取代的氮原子的饱和杂环基，条件是R 2和R 3不能同时代表叔丁基，或其光学活性异构体或其药学上可接受的盐可用作各种肾脏疾病的治疗剂或预防剂和作为器官防腐剂。

3. 发明授权

US5726564A Temperature-compensating method for a resistance bridge circuit, resistance bridge circuit with temperature-compensating circuit, and acceleration sensor using the same 失效
标题翻译：用于电阻桥式电路的温度补偿方法，带温度补偿电路的电阻桥式电路，以及使用该电路的加速度传感器
公开(公告)号：US5726564A
公开(公告)日：1998-03-10
申请号：US431958
申请日：1995-05-01
申请人： Yoshiaki Takashima
发明人： Yoshiaki Takashima
IPC分类号： G01L1/22 , G01P1/00 , G01P15/12 , G01R17/10 , H03H1/00
CPC分类号： G01P15/123 , G01L1/2281 , G01P1/006 , G01R17/105 , Y10S323/907
摘要： A temperature-compensating method of a resistance bridge circuit constructed of a plurality of resistance devices, comprises: a first step of adjusting in direction and in curvature a temperature characteristic curve of an output signal issued from the resistance bridge circuit in which a resistor for temperature compensation is connected in parallel with one of a pair of the resistance devices, the pair being disposed in adjacent arms of the resistance bridge circuit; and a second step of applying an additional signal to the output signal of the resistance bridge circuit so as to offset the temperature variation of the output signal of the resistance bridge circuit.
摘要翻译：由多个电阻器件构成的电阻桥接电路的温度补偿方法包括：第一步骤，在方向和曲率上调整从电阻电桥电路发出的输出信号的温度特性曲线，其中温度电阻器补偿与一对电阻装置中的一个并联连接，该对设置在电阻桥电路的相邻臂中; 以及向电阻桥式电路的输出信号施加附加信号以抵消电阻桥式电路的输出信号的温度变化的第二步骤。

4. 发明申请

US20100103576A1 GLOW PLUG DRIVER 审中-公开
公开(公告)号：US20100103576A1
公开(公告)日：2010-04-29
申请号：US12530016
申请日：2008-03-03
申请人： Hitoshi Sugimoto , Yoshiaki Takashima , Yutaka Tanaka
发明人： Hitoshi Sugimoto , Yoshiaki Takashima , Yutaka Tanaka
IPC分类号： H02H3/00
CPC分类号： F02P19/027 , F02P11/00 , H02J7/0034 , H03K17/0822
摘要： In the case where a battery is reversely connected, unnecessary current-carrying to a glow plug is avoided.Power MOS type field effect transistors 1-1 to 1-n are provided according to a number of glow plugs 5-1 to 5-n to be connected in series between a vehicle battery and the glow plugs 5-1 to 5-n and can be controlled in conduction or non-conduction by a glow-plug control part 51, while a MOS type field effect transistor 2 for protection against reverse connection is provided in series connection between a battery-power joining terminal 3, to which a positive voltage of a vehicle battery is applied, and the ground to cause a reverse current to flow to a fuse 4 through the MOS type field effect transistor 2 at the time of reverse connection of a battery to melt the fuse 4 early whereby current-carrying to the glow plugs 5-1 to 5-n can be avoided.
摘要翻译：在电池反向连接的情况下，避免了对电热塞的不必要的载流。功率MOS型场效应晶体管1-1至1-n根据要在车辆电池和电热塞5-1至5-n之间串联连接的电热塞5-1至5-n的数量提供，以及可以通过电热塞控制部分51进行导通或非导通控制，而用于防止反向连接的MOS型场效应晶体管2串联连接在电池连接端子3之间，并且在电池反向连接时通过MOS型场效应晶体管2引起反向电流流向保险丝4的接地，以提早熔化保险丝4，从而将电流传送到可以避免电热塞5-1至5-n。

5. 发明申请

US20050159476A1 Pharmaceutical composition for preventing or treating respiratory disease 审中-公开
标题翻译：用于预防或治疗呼吸系统疾病的药物组合物
公开(公告)号：US20050159476A1
公开(公告)日：2005-07-21
申请号：US10508604
申请日：2003-03-28
申请人： John Efthimiou , Toshihiko Komori , Mikio Sakai , Osamu Cynshi , Yoshiaki Takashima , Yoshiki Kawabe
发明人： John Efthimiou , Toshihiko Komori , Mikio Sakai , Osamu Cynshi , Yoshiaki Takashima , Yoshiki Kawabe
IPC分类号： C07D333/54 , A61K31/343 , A61K31/35 , A61K31/381 , A61K31/382 , A61P7/06 , A61P11/00 , A61P11/06 , C07D307/79 , C07D307/81 , C07D307/85 , C07D493/10 , C07D495/10
CPC分类号： A61K31/382 , A61K31/343 , A61K31/35 , A61K31/381 , Y02A50/478
摘要： An object of the present invention is to provide a pharmaceutical composition and a method for preventing or treating a respiratory disease. The pharmaceutical composition comprises a compound represented by formula (1): or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明的目的是提供一种用于预防或治疗呼吸系统疾病的药物组合物和方法。药物组合物包含由式（1）表示的化合物或其药学上可接受的盐作为活性成分。

6. 发明授权

US06686389B2 2,3-dihydrobenzofuran derivatives 失效
标题翻译： 2,3-二氢苯并呋喃衍生物
公开(公告)号：US06686389B2
公开(公告)日：2004-02-03
申请号：US10121663
申请日：2002-04-15
申请人： Akira Ishikawa , Yoshiaki Kato , Kunio Tamura , Yoshiaki Takashima , Osamu Cynshi
发明人： Akira Ishikawa , Yoshiaki Kato , Kunio Tamura , Yoshiaki Takashima , Osamu Cynshi
IPC分类号： A61K31335
CPC分类号： C07D307/79 , A61K31/343 , C07D307/94
摘要： 2,3-Dihydrobenzofuran derivatives of general formula (1): wherein R1 represents a hydrogen atom or an acyl group; R2, R3 and R4 represent a hydrogen atom, a lower alkyl group or a lower alkenyl group; R5 and R6 combine to form a cycloalkyl group or a saturated heterocyclic group containing one or more oxygen atoms or sulfur atoms, provided that R2 and R3 can not simultaneously represent a t-butyl group, or optically active isomers or pharmaceutically acceptable salts thereof are useful as therapeutic or prophylactic agents for various renal diseases and as organ preservatives.
摘要翻译：通式（1）的2,3-二氢苯并呋喃衍生物：其中R1表示氢原子或酰基; R2，R3和R4表示氢原子，低级烷基或低级烯基; R 5和R 6结合形成含有一个或多个氧原子或硫原子的环烷基或饱和杂环基，条件是R 2和R 3不能同时代表叔丁基，或其光学活性异构体或药学上可接受的盐是有用的作为各种肾脏疾病的治疗剂或预防剂和作为器官防腐剂。

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