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1. 发明申请

US20140288063A1 Heterocyclic Substituted Pyrimidine Compound 有权
标题翻译：杂环取代的嘧啶化合物
公开(公告)号：US20140288063A1
公开(公告)日：2014-09-25
申请号：US14233823
申请日：2012-07-19
申请人： Yongqian Wu , Aichen Wang
发明人： Yongqian Wu , Aichen Wang
IPC分类号： C07D498/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
CPC分类号： C07D498/08 , A61K31/506 , A61K31/5377 , A61K31/5386 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： The present invention pertains to the field of medical technology, and particularly relates to a heterocyclic substituted pyrimidine compound represented by General Formula (I) and its pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description, the present invention also relates to a preparation method of the compound, a pharmaceutical composition containing the compound, and a use of the compound and the pharmaceutical composition in preparation of a medicine for enhancing a cGMP signal transduction function or a medicine for treating or preventing sexual dysfunction and diseases with lower urinary tract symptoms.
摘要翻译：本发明涉及医疗技术领域，特别涉及由通式（I）表示的杂环取代的嘧啶化合物及其药学上可接受的盐，其中R1，R2，R3，R4和R5如说明书中所定义本发明还涉及该化合物的制备方法，含有该化合物的药物组合物，以及该化合物和药物组合物在制备用于增强cGMP信号转导功能的药物或用于治疗或预防的药物中的用途性功能障碍和尿路症状较低的疾病。

2. 发明授权

US08764241B2 Ring light source system for interferometer with adjustable ring radius and ring radial width 有权
标题翻译：用于干涉仪的环形光源系统，具有可调环形半径和环形径向宽度
公开(公告)号：US08764241B2
公开(公告)日：2014-07-01
申请号：US13558572
申请日：2012-07-26
申请人： Yan Xu , Yongjian Wan , Yongqian Wu
发明人： Yan Xu , Yongjian Wan , Yongqian Wu
IPC分类号： F21S8/00
CPC分类号： G01B9/02001 , G02B27/0944
摘要： A ring light source system for an interferometer with adjustable ring radius and ring radial width may comprise a laser light source, an expander and collimator optical system, an adjustable aperture, a binary phase grating, a variable-focus optical system, and a spatial filter. The expander and collimator optical system is configured to convert a light beam from the light source into a parallel light beam. The adjustable aperture is configured to adjust a diameter of the parallel light beam. The light beam with the diameter adjusted by the adjustable aperture is incident perpendicularly onto the binary phase grating, followed by the variable-focus optical system. The filter is positioned on a back focal plane of the variable-focus optical system, and is configured to receive a ring light source. The ring radius and radial width of the light source are adjustable by adjusting a focus length f1 of the variable-focus optical system.
摘要翻译：用于具有可调节环半径和环径向宽度的干涉仪的环形光源系统可以包括激光源，扩展器和准直器光学系统，可调节孔径，二进制相位光栅，可变焦距光学系统和空间滤波器。扩展器和准直器光学系统被配置为将来自光源的光束转换成平行光束。可调整孔径被配置为调节平行光束的直径。具有由可调孔径调节的直径的光束垂直入射到二进制相位光栅上，随后是可变焦光学系统。滤光器位于可变焦光学系统的后焦平面上，并且被配置为接收环形光源。通过调整可变焦光学系统的焦距f1可以调节光源的环半径和径向宽度。

3. 发明授权

US08980904B2 Heterocyclic substituted pyrimidine compound 有权
标题翻译：杂环取代的嘧啶化合物
公开(公告)号：US08980904B2
公开(公告)日：2015-03-17
申请号：US14233823
申请日：2012-07-19
申请人： Yongqian Wu , Aichen Wang
发明人： Yongqian Wu , Aichen Wang
IPC分类号： A01N43/54 , A61K31/505 , C07D498/08 , C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , A61K31/506
CPC分类号： C07D498/08 , A61K31/506 , A61K31/5377 , A61K31/5386 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： The present invention pertains to the field of medical technology, and particularly relates to a heterocyclic substituted pyrimidine compound represented by General Formula (I) and its pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description, the present invention also relates to a preparation method of the compound, a pharmaceutical composition containing the compound, and a use of the compound and the pharmaceutical composition in preparation of a medicine for enhancing a cGMP signal transduction function or a medicine for treating or preventing sexual dysfunction and diseases with lower urinary tract symptoms.
摘要翻译：本发明涉及医疗技术领域，特别涉及由通式（I）表示的杂环取代的嘧啶化合物及其药学上可接受的盐，其中R1，R2，R3，R4和R5如说明书中所定义本发明还涉及该化合物的制备方法，含有该化合物的药物组合物，以及该化合物和药物组合物在制备用于增强cGMP信号转导功能的药物或用于治疗或预防的药物中的用途性功能障碍和尿路症状较低的疾病。

4. 发明申请

US20130027942A1 RING LIGHT SOURCE SYSTEM FOR INTERFEROMETER WITH ADJUSTABLE RING RADIUS AND RING RADIAL WIDTH 有权
标题翻译：具有可调节环的干涉仪的环形光源系统RADIUS和环径向宽度
公开(公告)号：US20130027942A1
公开(公告)日：2013-01-31
申请号：US13558572
申请日：2012-07-26
申请人： Yan Xu , Yongjian Wan , Yongqian Wu
发明人： Yan Xu , Yongjian Wan , Yongqian Wu
IPC分类号： F21V5/04
CPC分类号： G01B9/02001 , G02B27/0944
摘要： A ring light source system for an interferometer with adjustable ring radius and ring radial width may comprise a laser light source, an expander and collimator optical system, an adjustable aperture, a binary phase grating, a variable-focus optical system, and a spatial filter. The expander and collimator optical system is configured to convert a light beam from the light source into a parallel light beam. The adjustable aperture is configured to adjust a diameter of the parallel light beam. The light beam with the diameter adjusted by the adjustable aperture is incident perpendicularly onto the binary phase grating, followed by the variable-focus optical system. The filter is positioned on a back focal plane of the variable-focus optical system, and is configured to receive a ring light source. The ring radius and radial width of the light source are adjustable by adjusting a focus length f1 of the variable-focus optical system.
摘要翻译：用于具有可调节环半径和环径向宽度的干涉仪的环形光源系统可以包括激光源，扩展器和准直器光学系统，可调节孔径，二进制相位光栅，可变焦距光学系统和空间滤波器。扩展器和准直器光学系统被配置为将来自光源的光束转换成平行光束。可调整孔径被配置为调节平行光束的直径。具有由可调孔径调节的直径的光束垂直入射到二进制相位光栅上，随后是可变焦光学系统。滤光器位于可变焦光学系统的后焦平面上，并且被配置为接收环形光源。通过调整可变焦光学系统的焦距f1可以调节光源的环半径和径向宽度。

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