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1. 发明申请

US20090156829A1 5,5'- POSITION LINKED 1,1'- BIPHENYL AXIAL CHIRAL LIGAND AND METHOD FOR PREPARING THE SAME 失效
标题翻译： 5,5'-位置连接1,1'-二苯乙烯轴向配对配体及其制备方法
公开(公告)号：US20090156829A1
公开(公告)日：2009-06-18
申请号：US12159440
申请日：2006-12-29
申请人： Wanbin Zhang , Yongjian Zhang , Feijun Wang
发明人： Wanbin Zhang , Yongjian Zhang , Feijun Wang
IPC分类号： C07D413/10
CPC分类号： C07D263/12
摘要： The present invention relates to a 5,5′-position linked 1,1′-biphenyl axis chiral ligand in chemical industry field. The present invention incorporates both the central chirality of oxazoline and the axial chirality of diphenyls. Such ligand can be used in various asymmetric reactions catalyzed by metal with high reactivity and stereoselectivity, and thus represents a good application outlook.The ligand of the present invention has the formula of: wherein: n=5, 6, 7, 8, 9, 10, 11 or 12; R1=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R2=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R3=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R4=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl.
摘要翻译：本发明涉及化学工业领域中5,5'-位连接的1,1'-联苯轴线手性配体。本发明既包括恶唑啉的中心手性和二苯基的轴向手性。这种配体可用于具有高反应性和立体选择性的金属催化的各种不对称反应中，因此代表了良好的应用前景。本发明的配体具有下式：其中：n = 5,6,7,8,9,10,11或12; R1 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R2 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R3 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R4 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基。

2. 发明授权

US07767825B2 2,2′,6,6′-tetraoxazolinyl biphenyl ligand and method for preparing the same 失效
标题翻译： 2,2'，6,6'-四恶唑啉基联苯基配体及其制备方法
公开(公告)号：US07767825B2
公开(公告)日：2010-08-03
申请号：US12159322
申请日：2006-12-29
申请人： Wanbin Zhang , Yongjian Zhang , Feijun Wang
发明人： Wanbin Zhang , Yongjian Zhang , Feijun Wang
IPC分类号： C07D263/08
CPC分类号： C07D263/14
摘要： The present invention relates to a method for preparing 2,2′,6,6′-tetraoxazolinyl biphenyl ligand in chemical industry field. In the present invention, compound (III) is reacted with an activator that can activate the hydroxyl group selected from the group consisting of alkyl halosulfonium compound, aryl halosulfonium compound, phosphoryl chloride, phosphorus pentachloride, thionyl chloride and triphenyl phosphine, in the presence of alkali(s), to give the target product (IV), 2,2′,6,6′-tetraoxazolinyl biphenyl ligand. The ligand of the present invention can be used in various asymmetric reactions catalyzed by metals, with high reactivity and stereoselectivity, and thus represents a good application outlook. The 2,2′,6,6′-tetraoxazolinyl biphenyl ligand has the formula of: wherein, R1=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R2=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R3=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R4=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl.
摘要翻译：本发明涉及化学工业领域中2,2'，6,6'-四恶唑啉基联苯配体的制备方法。在本发明中，化合物（III）与可活化选自烷基卤锍化合物，芳基卤锍化合物，磷酰氯，五氯化磷，亚硫酰氯和三苯基膦的羟基的活化剂在存在下反应得到目标产物（IV），2,2'，6,6'-四恶唑啉基联苯基配体。本发明的配体可用于金属催化的各种不对称反应中，具有高反应性和立体选择性，因此代表了良好的应用前景。 2,2'，6,6'-四恶唑啉基联苯配体具有下式：其中，R1 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R2 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R3 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R4 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基。

3. 发明授权

US07754891B2 5,5′-Position linked 1,1′-biphenyl axial chiral ligand and method for preparing the same 失效
标题翻译： 5,5'-位连接的1,1'-联苯轴向手性配体及其制备方法
公开(公告)号：US07754891B2
公开(公告)日：2010-07-13
申请号：US12159440
申请日：2006-12-29
申请人： Wanbin Zhang , Yongjian Zhang , Feijun Wang
发明人： Wanbin Zhang , Yongjian Zhang , Feijun Wang
IPC分类号： C07D413/10
CPC分类号： C07D263/12
摘要： The present invention relates to a 5,5′-position linked 1,1′-biphenyl axis chiral ligand in chemical industry field. The present invention incorporates both the central chirality of oxazoline and the axial chirality of diphenyls. Such ligand can be used in various asymmetric reactions catalyzed by metal with high reactivity and stereoselectivity, and thus represents a good application outlook. The ligand of the present invention has the formula of: wherein: n=5, 6, 7, 8, 9, 10, 11 or 12; R1=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R2=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R3=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R4=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl.
摘要翻译：本发明涉及化学工业领域中5,5'-位连接的1,1'-联苯轴线手性配体。本发明既包括恶唑啉的中心手性和二苯基的轴向手性。这种配体可用于具有高反应性和立体选择性的金属催化的各种不对称反应中，因此代表了良好的应用前景。本发明的配体具有下式：其中：n = 5,6,7,8,9,10,11或12; R1 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R2 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R3 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R4 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基。

4. 发明申请

US20090043104A1 2,2',6,6' - TETRAOXAZOLINYL BIPHENYL LIGAND AND METHOD FOR PREPARING THE SAME 失效
标题翻译： 2,2'，6,6' - 四羟甲基苯乙烯联苯系列及其制备方法
公开(公告)号：US20090043104A1
公开(公告)日：2009-02-12
申请号：US12159322
申请日：2006-12-29
申请人： Wanbin Zhang , Yongjian Zhang , Feijun Wang
发明人： Wanbin Zhang , Yongjian Zhang , Feijun Wang
IPC分类号： C07D413/14
CPC分类号： C07D263/14
摘要： The present invention relates to a method for preparing 2,2′,6,6′-tetraoxazolinyl biphenyl ligand in chemical industry field. In the present invention, compound (III) is reacted with an activator that can activate the hydroxyl group selected from the group consisting of alkyl halosulfonium compound, aryl halosulfonium compound, phosphoryl chloride, phosphorus pentachloride, thionyl chloride and triphenyl phosphine, in the presence of alkali(s), to give the target product (IV), 2,2′,6,6′-tetraoxazolinyl biphenyl ligand. The ligand of the present invention can be used in various asymmetric reactions catalyzed by metals, with high reactivity and stereoselectivity, and thus represents a good application outlook. The 2,2′,6,6′-tetraoxazolinyl biphenyl ligand has the formula of: wherein, R1=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R2=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R3=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl; R4=hydrogen, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl.
摘要翻译：本发明涉及化学工业领域中2,2'，6,6'-四恶唑啉基联苯配体的制备方法。在本发明中，化合物（III）与可活化选自烷基卤锍化合物，芳基卤锍化合物，磷酰氯，五氯化磷，亚硫酰氯和三苯基膦的羟基的活化剂在存在下反应得到目标产物（IV），2,2'，6,6'-四恶唑啉基联苯基配体。本发明的配体可用于金属催化的各种不对称反应中，具有高反应性和立体选择性，因此代表了良好的应用前景。 2,2'，6,6'-四恶唑啉基联苯配体具有下式：其中，R1 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R2 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R3 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基; R4 =氢，烷基，取代或未取代的芳基，取代或未取代的苄基。

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