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1. 发明申请

US20220110970A1 Engineered Extracellular Vesicle Delivery Systems and Uses Thereof 有权
公开(公告)号：US20220110970A1
公开(公告)日：2022-04-14
申请号：US17501759
申请日：2021-10-14
申请人： Yong-Yu Jhan , Corey J. Bishop , Guillermo Palou , Daniel Prasca-Chamorro
发明人： Yong-Yu Jhan , Corey J. Bishop , Guillermo Palou , Daniel Prasca-Chamorro
IPC分类号： A61K35/12 , C12N5/071 , A61K47/54 , A61K45/06
摘要： Provided herein is an engineered extracellular vesicle (eEV) and an extracellular vesicle delivery vehicle. The engineered extracellular vesicle is an isolated extracellular vesicle that has a membrane hybridized with lipids. The extracellular vesicle delivery vehicle is a lipid-hybridized extracellular vesicle with a nucleic acid loaded within the core, a multi-layered polyelectrolyte coating deposited around the lipid-hybridized extracellular vesicle and a therapeutic drug complexed to one of the layer of polyelectrolyte coatings. Also provided are methods for preparing an engineered extracellular vesicle, for preparing an extracellular vesicle delivery vehicle, for treating a pathophysiological condition in a subject, and for co-delivering a nucleic acid and a therapeutic drug to a cell of interest.

2. 发明申请

US20140349938A1 METHODS OF DIAGNOSING AND TREATING AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
标题翻译：方法诊断和治疗左心室狭窄
公开(公告)号：US20140349938A1
公开(公告)日：2014-11-27
申请号：US14123392
申请日：2012-06-01
申请人： Robin Reed , Shi Chen , Yong Yu , Tomohiro Yamazaki
发明人： Robin Reed , Shi Chen , Yong Yu , Tomohiro Yamazaki
IPC分类号： G01N33/68 , G01N33/50
CPC分类号： G01N33/6896 , C12Q1/6883 , C12Q2600/158 , G01N33/5023 , G01N33/6875 , G01N2500/10 , G01N2800/2835 , G01N2800/285 , G01N2800/50 , G01N2800/52
摘要： The invention features methods of diagnosing a subject as having, or at risk of developing ALS by determining the frequency of Gems in cells obtained from the subject. These methods include diagnosing the severity or monitoring the progression of ALS by determining the Gem frequency in a subject. Also, the invention features methods of identifying compounds useful for the treatment of ALS as well as methods for the treatment of ALS.
摘要翻译：本发明的特征在于通过确定从受试者获得的细胞中宝石的频率，将受试者诊断为具有或有发展ALS风险的方法。这些方法包括通过确定受试者的宝石频率来诊断严重程度或监测ALS的进展。此外，本发明的特征在于鉴定可用于治疗ALS的化合物的方法以及用于治疗ALS的方法。

3. 发明申请

US20140066647A1 METHOD FOR SYNTHESIS OF [6,6]-PHENYL-C61-BUTYRIC ACID METHYL ESTER (PCBM) AND FULLERENE DERIVATIVES 有权
标题翻译：合成[6,6] - 苯基-C 1-6 - 丁酸甲酯（PCBM）和全烯衍生物的方法
公开(公告)号：US20140066647A1
公开(公告)日：2014-03-06
申请号：US13601371
申请日：2012-08-31
申请人： Ka Ming NG , Jianle ZHUANG , Nai Wen TSENG , Yong YU
发明人： Ka Ming NG , Jianle ZHUANG , Nai Wen TSENG , Yong YU
IPC分类号： C07C67/30
CPC分类号： C07C67/343 , C07C67/333 , C07C67/347 , C07C69/618 , C07C2604/00
摘要： The present subject matter relates to methods for the synthesis of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) and fullerene derivatives in a yield of at least 40%.
摘要翻译：本主题涉及以至少40％的产率合成[6,6] - 苯基-C61-丁酸甲酯（PCBM）和富勒烯衍生物的方法。

4. 发明授权

US08329051B2 Method for forming stair-step structures 有权
标题翻译：形成阶梯结构的方法
公开(公告)号：US08329051B2
公开(公告)日：2012-12-11
申请号：US12968210
申请日：2010-12-14
申请人： Qian Fu , Hyun-Yong Yu
发明人： Qian Fu , Hyun-Yong Yu
IPC分类号： B44C1/22 , H01L21/302
CPC分类号： H01L21/3086 , H01L21/02164 , H01L21/02274 , H01L21/3065 , H01L21/3081 , H01L21/31116 , H01L21/31144 , H01L21/32139 , H01L21/67069 , H01L27/11551 , H01L27/11556
摘要： A method for forming a stair-step structure in a substrate is provided. An organic mask is formed over the substrate. A hardmask with a top layer and sidewall layer is formed over the organic mask. The sidewall layer of the hard mask is removed while leaving the top layer of the hardmask. The organic mask is trimmed. The substrate is etched. The forming the hardmask, removing the sidewall layer, trimming the organic mask, and etching the substrate are repeated a plurality of times.
摘要翻译：提供了一种在基板中形成台阶结构的方法。在衬底上形成有机掩模。在有机掩模上形成具有顶层和侧壁层的硬掩模。去除硬掩模的侧壁层，同时留下硬掩模的顶层。有机面罩被修剪。衬底被蚀刻。重复多次形成硬掩模，去除侧壁层，修整有机掩模和蚀刻基板。

5. 发明申请

US20120237964A1 LUMINOGEN COMPOUNDS AND THE USE OF THE SAME FOR BIOSENSING AND CELLULAR IMAGING 有权
标题翻译：发光化合物及其使用与生物传感和细胞成像相同
公开(公告)号：US20120237964A1
公开(公告)日：2012-09-20
申请号：US13422374
申请日：2012-03-16
申请人： Benzhong TANG , Yang Liu , Wing Yip Lam , Yong Yu
发明人： Benzhong TANG , Yang Liu , Wing Yip Lam , Yong Yu
IPC分类号： G01N21/64 , C09B62/343 , C07D207/448
CPC分类号： C07D207/444 , C07D207/448 , C09B57/00 , C09B69/008 , Y10T436/182
摘要： Provided herein are a luminogen compound of formula (I) including a AIE luminophore moiety conjugated with a maleimide moiety and a use of the same for detecting thiol groups in biomolecules. Also provided is a dye molecule, a biosensor or a bioprobe comprising the luminogen compound of formula (I) in use for detecting thiol groups in biomolecules. The detection method of the present subject matter not only has high thio-selectivity and sensitivity, but also is rapid, convenient and handy.
摘要翻译：本文提供式（I）的发光剂化合物，其包含与马来酰亚胺部分缀合的AIE发光体部分，以及用于检测生物分子中的硫醇基团的用途。还提供了染料分子，生物传感器或生物探针，其包含用于检测生物分子中硫醇基团的式（I）的发光剂化合物。本发明的检测方法不仅具有高硫选择性和灵敏度，而且快速，方便，方便。

6. 发明申请

US20120149201A1 METHOD FOR FORMING STAIR-STEP STRUCTURES 有权
标题翻译：形成平台结构的方法
公开(公告)号：US20120149201A1
公开(公告)日：2012-06-14
申请号：US12968210
申请日：2010-12-14
申请人： Qian Fu , Hyun-Yong Yu
发明人： Qian Fu , Hyun-Yong Yu
IPC分类号： H01L21/3065
CPC分类号： H01L21/3086 , H01L21/02164 , H01L21/02274 , H01L21/3065 , H01L21/3081 , H01L21/31116 , H01L21/31144 , H01L21/32139 , H01L21/67069 , H01L27/11551 , H01L27/11556
摘要： A method for forming a stair-step structure in a substrate is provided. An organic mask is formed over the substrate. A hardmask with a top layer and sidewall layer is formed over the organic mask. The sidewall layer of the hard mask is removed while leaving the top layer of the hardmask. The organic mask is trimmed. The substrate is etched. The forming the hardmask, removing the sidewall layer, trimming the organic mask, and etching the substrate are repeated a plurality of times.
摘要翻译：提供了一种在基板中形成阶梯结构的方法。在衬底上形成有机掩模。在有机掩模上形成具有顶层和侧壁层的硬掩模。去除硬掩模的侧壁层，同时留下硬掩模的顶层。有机面罩被修剪。衬底被蚀刻。重复多次形成硬掩模，去除侧壁层，修整有机掩模和蚀刻基板。

7. 发明授权

US07986157B1 High speed probing apparatus for semiconductor devices and probe stage for the same 有权
标题翻译：用于半导体器件和探针台的高速探测装置相同
公开(公告)号：US07986157B1
公开(公告)日：2011-07-26
申请号：US12874563
申请日：2010-09-02
申请人： Yong Yu Liu
发明人： Yong Yu Liu
IPC分类号： G01R31/20
CPC分类号： G01R1/07392 , G01R31/2891
摘要： A probing apparatus for semiconductor devices includes a housing configured to define a testing chamber, a device holder positioned in the housing and configured to receive at least one device under test, and at least one probe stage positioned in the housing. In one embodiment of the present disclosure, the probe stage includes a base, a retaining arm pivotally coupled with the base and having a retaining portion configured to retain at least one probe, and a stepper positioned on the base. In one embodiment of the present disclosure, the stepper is configured in response to an electric signal to move the probe downward through the retaining arm to contact a device under test and to move the probe upward through the retaining arm to separate from the device under test such that the up-and-down movement of the probe can be performed at relatively high frequency of typically greater than six cycles per second. In one embodiment of the present disclosure, the stepper further equipped with a contact sensor configured to sense the contact of the probe to the device under test.
摘要翻译：用于半导体器件的探测装置包括被配置为限定测试室的壳体，位于壳体中并且被配置为容纳至少一个待测器件的器件保持器，以及定位在壳体中的至少一个探针台。在本公开的一个实施例中，探针台包括基座，保持臂与基座枢转地联接并具有被配置为保持至少一个探针的保持部分和位于基座上的步进器。在本公开的一个实施例中，步进器被配置为响应于电信号将探针向下移动通过保持臂以接触待测设备并且将探针向上移动通过保持臂以与被测器件分离使得探针的上下移动可以以通常大于每秒六个周期的相对高的频率执行。在本公开的一个实施例中，步进器还配备有接触传感器，该接触传感器被配置为感测探针与被测器件的接触。

8. 发明申请

US20070212727A1 Microorganisms for therapy 失效
标题翻译：微生物治疗
公开(公告)号：US20070212727A1
公开(公告)日：2007-09-13
申请号：US11796027
申请日：2007-04-25
申请人： Aladar Szalay , Tatyana Timiryasova , Yong Yu , Qian Zhang
发明人： Aladar Szalay , Tatyana Timiryasova , Yong Yu , Qian Zhang
IPC分类号： C12Q1/68 , C12N5/06 , C12N5/16
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要翻译：提供了治疗方法和微生物。与其他组织，细胞和器官相比，微生物被设计为在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有相对低的毒性。微生物也被设计或修饰以导致其中积聚的细胞的泄漏的细胞膜，导致产生对蛋白质和其他细胞产物具有反应性的抗体，并且还允许开发促进增殖的组织，特别是肿瘤以产生选定的蛋白质等产品。提供含有微生物的疫苗。还提供了微生物和抗癌剂的组合及其用于治疗癌症的用途。

9. 发明申请

US20070025981A1 Microorganisms for therapy 有权
公开(公告)号：US20070025981A1
公开(公告)日：2007-02-01
申请号：US11529662
申请日：2006-09-27
申请人： Aladar Szalay , Tatyana Timiryasova , Yong Yu , Qian Zhang
发明人： Aladar Szalay , Tatyana Timiryasova , Yong Yu , Qian Zhang
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

10. 发明申请

US20050259182A1 System and method for scaling multiple channel and interlaced images with different offsets between channels 失效
标题翻译：用于缩放通道间不同偏移量的多通道和隔行扫描图像的系统和方法
公开(公告)号：US20050259182A1
公开(公告)日：2005-11-24
申请号：US11112632
申请日：2005-04-22
申请人： Yong Yu
发明人： Yong Yu
IPC分类号： G06T3/40 , H04N5/44 , H04N5/765 , H04N5/775 , H04N5/91 , H04N9/64
CPC分类号： H04N7/012 , G06T3/40 , H04N5/765 , H04N5/775 , H04N9/64
摘要： A system and method that scale a first image to a second image. The scaling factor between the first image and the second image may be used to determine the number of pixels from the first image to be used to produce a pixel of the second image. The number of pixels from the first image may be utilized to pre-compute coefficients of a filter to be applied to the pixels from the first image. The location of the pixels from the first image relative to the pixels of the second image may be utilized to compute the filter coefficients. The coefficients may be computed using a Sinc function. The predetermined coefficients may be organized according to the order in which the pixels from the first image are to be processed to produce the second image.
摘要翻译：将第一图像缩放到第二图像的系统和方法。可以使用第一图像和第二图像之间的缩放因子来确定要用于产生第二图像的像素的第一图像的像素数。可以利用来自第一图像的像素的数量来预先计算要从第一图像应用于像素的滤波器的系数。可以利用来自第一图像的像素相对于第二图像的像素的位置来计算滤波器系数。可以使用Sinc函数来计算系数。预定系数可以根据来自第一图像的像素被处理以产生第二图像的顺序被组织。

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