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    • 1. 发明授权
    • Composition for inducing migration of neural stem cells containing periostin as effective ingredient
    • 用于诱导含有骨膜素的神经干细胞迁移的组合物作为有效成分
    • US09028810B2
    • 2015-05-12
    • US13165322
    • 2011-06-21
    • Myung Ae LeeJeong Yong Jeon
    • Myung Ae LeeJeong Yong Jeon
    • A61P35/00A61K35/12A61P25/00C12N5/0797A61K38/17A61P25/28C07K14/47C12N5/0793
    • C07K14/47A61K38/1709C12N5/0619C12N5/0623C12N2501/998
    • A novel use of periostin, and more particularly a composition for inducing the migration of neural stem cells, which contains periostin or a periostin-secreting cell as an active ingredient, based on the discovery of a novel function of periostin that induces the migration of neural stem cells. Periostin induces the migration of neural stem cells, and thus the composition for inducing the migration of neural stem cells, which contains periostin or periostin-secreting cells as an active ingredient, can be used in various applications based on neural stem cells. A pharmaceutical composition containing suicide gene-expressing neural stem cells and periostin allows the neural stem cells to effectively migrate to tumor tissues, and thus can be used as a cell therapeutic agent for treating cancer. Also, the pharmaceutical composition containing neural stem cells and periostin has improved effects on the stimulation of regeneration of nerve cells and the treatment of neural diseases.
    • 基于发现骨诱导神经元迁移的骨膜素的新功能,尤其是用于诱导神经干细胞迁移的组合物,其包含骨膜素或分泌骨膜素分泌细胞作为活性成分的新用途 干细胞。 骨钙素诱导神经干细胞的迁移,因此用于诱导神经干细胞迁移的组合物可以用于基于神经干细胞的各种应用中,所述神经干细胞含有骨膜素或分泌骨膜素的细胞作为活性成分。 含有表达自杀基因的神经干细胞和骨膜素的药物组合物可使神经干细胞有效迁移至肿瘤组织,从而可用作治疗癌症的细胞治疗剂。 此外,含神经干细胞和骨膜素的药物组合物对刺激神经细胞的再生和神经疾病的治疗有改善的作用。