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1. 发明授权

US5366866A Method of diagnosing ovarian and endometrial cancer with monoclonal antibodies OXA and OXB 失效
标题翻译：用单克隆抗体OXA和OXB诊断卵巢和子宫内膜癌的方法
公开(公告)号：US5366866A
公开(公告)日：1994-11-22
申请号：US879860
申请日：1992-05-06
申请人： Fengi J. Xu , Yinhua Yu , Robert C. Bast, Jr.
发明人： Fengi J. Xu , Yinhua Yu , Robert C. Bast, Jr.
IPC分类号： C07K16/00 , C07K14/435 , C07K14/705 , C07K16/30 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/531 , G01N33/574 , G01N33/577 , G01N33/53 , G01N33/567
CPC分类号： C07K16/3015 , C07K14/705 , C07K16/30 , G01N33/57415 , G01N33/57442 , G01N33/57449 , Y10S436/813
摘要： A method for detecting the presence of cancer employs monoclonal antibody OXA or OXB, antibodies which bind to the antigen bound by monoclonal antibody OXA or OXB, or fragments of the foregoing which bind to the antigen bound by monoclonal antibody OXA or OXB. The method comprises contacting a sample of a biological fluid from a subject with the antibody under conditions permitting the antibody to form a reaction product, and then detecting the presence or absence of the reaction product. The method is particularly useful for monitoring the progression of treatment in a patient previously diagnosed as having ovarian cancer. The method is also useful for detecting and monitoring endometrial cancer.
摘要翻译：用于检测癌症存在的方法使用单克隆抗体OXA或OXB，结合由单克隆抗体OXA或OXB结合的抗原的抗体或与由单克隆抗体OXA或OXB结合的抗原结合的前述的片段的抗体。该方法包括在允许抗体形成反应产物的条件下将来自受试者的生物流体样品与抗体接触，然后检测反应产物的存在或不存在。该方法对于监测先前诊断为患有卵巢癌的患者的治疗进展是特别有用的。该方法也可用于检测和监测子宫内膜癌。

2. 发明授权

US07183401B1 NOEY2 gene compositions and methods of use 失效
标题翻译： NOEY2基因组成及使用方法
公开(公告)号：US07183401B1
公开(公告)日：2007-02-27
申请号：US10166325
申请日：1998-03-20
申请人： Yinhua Yu , Fengji Xu , Robert C. Bast, Jr.
发明人： Yinhua Yu , Fengji Xu , Robert C. Bast, Jr.
IPC分类号： C07H21/04 , C12N15/00 , C12N5/00
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N2799/021
摘要： Disclosed are compositions and methods comprising a novel tumor suppressor gene, designated NOEY2, that is expressed in normal ovarian and breast surface epithelial cells but consistently absent or down-regulated in ovarian and breast cancer cells. Disclosed are polynucleotide compositions comprising a NOEY2 gene from mammalian sources, and polypeptides encoded by these nucleic acid sequences. Also disclosed are methods for preparing NOEY2 polypeptides, transformed host cells, and antibodies reactive with NOEY2 polypeptides. In certain embodiments, the invention describes methods for diagnosing and treating cancers, as well as methods for identifying NOEY2-related polynucleotide and polypeptide compositions.
摘要翻译：公开了包括在正常卵巢和乳腺表面上皮细胞中表达但在卵巢和乳腺癌细胞中一贯缺失或下调的称为NOEY2的新型肿瘤抑制基因的组合物和方法。公开了包含来自哺乳动物来源的NOEY2基因的多核苷酸组合物和由这些核酸序列编码的多肽。还公开了制备NOEY2多肽，转化的宿主细胞和与NOEY2多肽反应的抗体的方法。在某些实施方案中，本发明描述了用于诊断和治疗癌症的方法，以及用于鉴定NOEY2相关多核苷酸和多肽组合物的方法。

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