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1. 发明申请

US20110033430A1 METHODS FOR THE INDUCTION OF A CELL TO ENTER THE ISLET 1+ LINEAGE AND A METHOD FOR THE EXPANSION THEREOF 审中-公开
标题翻译：用于诱导细胞进入ISLET 1+线的方法及其扩展方法
公开(公告)号：US20110033430A1
公开(公告)日：2011-02-10
申请号：US12526447
申请日：2008-02-08
申请人： Kenneth R Chien , Yibing Qyang , Silvia Martin-Puig
发明人： Kenneth R Chien , Yibing Qyang , Silvia Martin-Puig
IPC分类号： A61K35/12 , C12N5/071 , C12N5/10 , A61P9/00
CPC分类号： C12N5/0668 , C12N2501/415 , C12N2502/02 , C12N2502/1329
摘要： The present invention relates to methods for the induction and a cell to enter the Islet 1+ (Isl1+) lineage and methods for expansion of cells of islet 1+ lineage. One aspect of the present invention relates to methods to induce a cell to enter the islet 1+ lineage, and more particularly to a method to induce a cell to enter a the Isl1+ lineage to become an Isl1+ progenitor that is capable of differentiating along multiple different lineages such as a endothelial lineage, a smooth muscle lineage or a cardiac lineage. In particular, one embodiment present invention relates to methods to induce a cell to enter the Isl1+ lineage by inhibiting a wnt signalling pathway in the cell. Another aspect of the present invention relates to methods to expand a cell of the Isl1+ lineage, such as a Isl1+ progenitor by activating a wnt signalling pathway in the Isl1+ progenitor. Another aspect of the present invention relates to use of cells of the isl1+ lineage in subjects for therapeutic and preventative treatment of cardiovascular diseases.
摘要翻译：本发明涉及诱导和细胞进入胰岛1+（Isl1 +）谱系的方法和用于扩增胰岛1+谱系细胞的方法。本发明的一个方面涉及诱导细胞进入胰岛1+谱系的方法，更具体地涉及诱导细胞进入Isl1 +谱系以成为可以沿着多个不同的区分的Isl1 +祖细胞的方法谱系，如内皮谱系，平滑肌谱系或心脏谱系。特别地，本发明的一个实施方案涉及通过抑制细胞中的wnt信号通路来诱导细胞进入Isl1 +谱系的方法。本发明的另一方面涉及通过激活Isl1 +祖细胞中的wnt信号通路来扩展Isl1 +谱系的细胞的方法，例如Isl1 +祖细胞。本发明的另一方面涉及isl1 +谱系的细胞在受试者中用于治疗和预防性治疗心血管疾病的用途。

2. 发明申请

US20100261196A1 METHODS OF IDENTIFYING SMALL MOLECULES FOR RENEWALS, SURVIVAL AND MIGRATION OF CARDIAC PROGENITORS 有权
标题翻译：鉴定小分子的方法，用于重建，存活和移植心脏病患者
公开(公告)号：US20100261196A1
公开(公告)日：2010-10-14
申请号：US12770597
申请日：2010-04-29
申请人： Sylvia Evans , Ju Chen , Lizhu Lin , Ken Chien , Yibing Qyang , Alessandra Moretti , Karl Laugwitz
发明人： Sylvia Evans , Ju Chen , Lizhu Lin , Ken Chien , Yibing Qyang , Alessandra Moretti , Karl Laugwitz
IPC分类号： C12N5/00 , G01N33/53
CPC分类号： C07K14/4702 , A01K67/0275 , A01K2217/052 , A01K2217/072 , A01K2217/203 , A01K2217/206 , A01K2227/105 , A01K2267/0375 , C12N5/0657 , C12N5/0662 , C12N2501/155 , C12N2501/415 , C12N2502/99 , C12N2800/30 , C12N2840/203 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5073 , G01N33/56966
摘要： The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3β inhibitor.
摘要翻译：本发明涉及由可检测标记的心脏祖细胞组成的小分子高通量筛选测定。本发明还描述了一种从影响心脏发生和/或调节心脏祖细胞发育的高通量测定中鉴定小分子的方法。还描述了使用GSK-3和bgr刺激心脏祖细胞成熟的方法; 抑制剂。

3. 发明授权

US08323909B2 Methods of identifying small molecules for renewals, survival and migration of cardiac progenitors 有权
标题翻译：识别小分子进行心脏祖细胞的更新，存活和迁移的方法
公开(公告)号：US08323909B2
公开(公告)日：2012-12-04
申请号：US12770597
申请日：2010-04-29
申请人： Sylvia Evans , Ju Chen , Lizhu Lin , Ken Chien , Yibing Qyang , Alessandra Moretti , Karl Laugwitz
发明人： Sylvia Evans , Ju Chen , Lizhu Lin , Ken Chien , Yibing Qyang , Alessandra Moretti , Karl Laugwitz
IPC分类号： C12N5/00 , G01N33/53
CPC分类号： C07K14/4702 , A01K67/0275 , A01K2217/052 , A01K2217/072 , A01K2217/203 , A01K2217/206 , A01K2227/105 , A01K2267/0375 , C12N5/0657 , C12N5/0662 , C12N2501/155 , C12N2501/415 , C12N2502/99 , C12N2800/30 , C12N2840/203 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5073 , G01N33/56966
摘要： The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3β inhibitor.
摘要翻译：本发明涉及由可检测标记的心脏祖细胞组成的小分子高通量筛选测定。本发明还描述了一种从影响心脏发生和/或调节心脏祖细胞发育的高通量测定中鉴定小分子的方法。还描述了使用GSK-3和bgr刺激心脏祖细胞成熟的方法; 抑制剂。

4. 发明申请

US20080108090A1 Methods of identifying small molecules for renewal, survival and migration of cardiac progenitors 审中-公开
标题翻译：识别小分子用于心脏祖细胞的更新，存活和迁移的方法
公开(公告)号：US20080108090A1
公开(公告)日：2008-05-08
申请号：US11799839
申请日：2007-05-02
申请人： Sylvia Evans , Ju Chen , Lizhu Lin , Ken Chien , Yibing Qyang , Alessandra Moretti , Karl Laugwitz
发明人： Sylvia Evans , Ju Chen , Lizhu Lin , Ken Chien , Yibing Qyang , Alessandra Moretti , Karl Laugwitz
IPC分类号： G01N33/53
CPC分类号： C07K14/4702 , A01K67/0275 , A01K2217/052 , A01K2217/072 , A01K2217/203 , A01K2217/206 , A01K2227/105 , A01K2267/0375 , C12N5/0657 , C12N5/0662 , C12N2501/155 , C12N2501/415 , C12N2502/99 , C12N2800/30 , C12N2840/203 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5073 , G01N33/56966
摘要： The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3β inhibitor.
摘要翻译：本发明涉及由可检测标记的心脏祖细胞组成的小分子高通量筛选测定。本发明还描述了一种从影响心脏发生和/或调节心脏祖细胞发育的高通量测定中鉴定小分子的方法。还描述了使用GSK-3β抑制剂刺激心脏祖细胞成熟的方法。

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