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1. 发明申请

US20100227311A1 TISSUE CULTURE SYSTEM FOR PRODUCTION OF HEPATITIS C VIRUS 有权
标题翻译：用于生产乙型肝炎病毒的组织培养系统
公开(公告)号：US20100227311A1
公开(公告)日：2010-09-09
申请号：US12310309
申请日：2007-08-22
申请人： Jang Han , Qui-Lim Choo , Michael Houghton , Taewoo Kwon , Hyun Chul Song , Yifei Zhu
发明人： Jang Han , Qui-Lim Choo , Michael Houghton , Taewoo Kwon , Hyun Chul Song , Yifei Zhu
IPC分类号： C12Q1/70 , C12N15/74 , C12N5/10 , C12N7/00 , G01N33/567
CPC分类号： C12N7/00 , A61K2039/525 , C07K14/005 , C07K2319/61 , C12N2760/16022 , C12N2770/24243 , G01N2333/186 , G01N2500/10
摘要： A tissue culture system for production of infectious hepatitis C virus is described. In particular, the invention provides recombinant monocistronic and bicistronic genomic constructs for production of virus, including constructs for production of wild-type HCV type 2a strain JFH1 and constructs for production of chimeric viruses comprising HCV proteins from strain JFH1 and a second HCV isolate. Constructs of the invention also include a reporter gene to facilitate measurement of RNA replication and viral infectivity in cultures. The cell culture system may also include various factors that improve viral replication or infectivity. In addition, a neutralization assay using HCV grown in cell culture is described.
摘要翻译：描述了用于生产感染性丙型肝炎病毒的组织培养系统。特别地，本发明提供了用于产生病毒的重组单顺反子和双顺反子基因组构建体，包括用于产生野生型HCV 2a型菌株JFH1的构建体和用于产生包含来自菌株JFH1的HCV蛋白质和第二HCV分离物的嵌合病毒的构建体。本发明的构建体还包括有利于测量培养物中RNA复制和病毒感染性的报告基因。细胞培养系统还可以包括改善病毒复制或感染性的各种因素。此外，描述了使用在细胞培养物中生长的HCV的中和测定。

2. 发明授权

US08481050B2 Tissue culture system for production of hepatitis C virus 有权
标题翻译：组织培养系统用于生产丙型肝炎病毒
公开(公告)号：US08481050B2
公开(公告)日：2013-07-09
申请号：US12310309
申请日：2007-08-22
申请人： Qui-Lim Choo , Jang Han , Michael Houghton , Taewoo Kwon , Hyun Chul Song , Yifei Zhu
发明人： Qui-Lim Choo , Jang Han , Michael Houghton , Taewoo Kwon , Hyun Chul Song , Yifei Zhu
IPC分类号： A61K48/00 , A61K50/00
CPC分类号： C12N7/00 , A61K2039/525 , C07K14/005 , C07K2319/61 , C12N2760/16022 , C12N2770/24243 , G01N2333/186 , G01N2500/10
摘要： A tissue culture system for production of infectious hepatitis C virus is described. In particular, the invention provides recombinant monocistronic and bicistronic genomic constructs for production of virus, including constructs for production of wild-type HCV type 2a strain JFH1 and constructs for production of chimeric viruses comprising HCV proteins from strain JFH1 and a second HCV isolate. Constructs of the invention also include a reporter gene to facilitate measurement of RNA replication and viral infectivity in cultures. The cell culture system may also include various factors that improve viral replication or infectivity. In addition, a neutralization assay using HCV grown in cell culture is described.
摘要翻译：描述了用于生产感染性丙型肝炎病毒的组织培养系统。特别地，本发明提供了用于产生病毒的重组单顺反子和双顺反子基因组构建体，包括用于产生野生型HCV 2a型菌株JFH1的构建体和用于产生包含来自菌株JFH1的HCV蛋白质和第二HCV分离物的嵌合病毒的构建体。本发明的构建体还包括有利于测量培养物中RNA复制和病毒感染性的报告基因。细胞培养系统还可以包括改善病毒复制或感染性的各种因素。此外，描述了使用在细胞培养物中生长的HCV的中和测定。

3. 发明授权

US07428490B2 Method for spectral subtraction in speech enhancement 有权
标题翻译：语音增强中频谱减法的方法
公开(公告)号：US07428490B2
公开(公告)日：2008-09-23
申请号：US10673570
申请日：2003-09-30
申请人： Bo Xu , Liang He , YiFei Zhu
发明人： Bo Xu , Liang He , YiFei Zhu
IPC分类号： G10L21/02
CPC分类号： G10L21/0208
摘要： A method and system is provided for enhancing an audio signal based on spectral subtraction. The noise power spectrum for each frame of an audio signal is dynamically estimated based on a plurality of signal power spectrum values computed from a corresponding plurality of adjacent frames. An over-subtraction factor is then dynamically computed for each frame based on the noise power spectrum estimated for the frame. The signal power spectrum of the audio signal at each frame is then reduced in accordance with the over-subtraction factor computed for the corresponding frame.
摘要翻译：提供了一种基于频谱减法来增强音频信号的方法和系统。基于从相应的多个相邻帧计算的多个信号功率谱值来动态地估计音频信号的每个帧的噪声功率谱。然后，基于针对帧估计的噪声功率谱，针对每个帧动态地计算过减去因子。然后根据为相应的帧计算出的过减去因子，减少每个帧处的音频信号的信号功率谱。

4. 发明申请

US20050071156A1 Method for spectral subtraction in speech enhancement 有权
标题翻译：语音增强中频谱减法的方法
公开(公告)号：US20050071156A1
公开(公告)日：2005-03-31
申请号：US10673570
申请日：2003-09-30
申请人： Bo Xu , Liang He , YiFei Zhu
发明人： Bo Xu , Liang He , YiFei Zhu
IPC分类号： G10L21/02 , G10L21/00
CPC分类号： G10L21/0208
摘要： A method and system is provided for enhancing an audio signal based on spectral subtraction. The noise power spectrum for each frame of an audio signal is dynamically estimated based on a plurality of signal power spectrum values computed from a corresponding plurality of adjacent frames. An over-subtraction factor is then dynamically computed for each frame based on the noise power spectrum estimated for the frame. The signal power spectrum of the audio signal at each frame is then reduced in accordance with the over-subtraction factor computed for the corresponding frame.
摘要翻译：提供了一种基于频谱减法来增强音频信号的方法和系统。基于从相应的多个相邻帧计算的多个信号功率谱值来动态地估计音频信号的每个帧的噪声功率谱。然后，基于针对帧估计的噪声功率谱，针对每个帧动态地计算过减去因子。然后根据为相应的帧计算出的过减去因子，减少每个帧处的音频信号的信号功率谱。

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