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1. 发明申请

US20080306152A1 COMPOSITIONS CONTAINING PRODRUGS OF FLORFENICOL AND METHODS OF USE 审中-公开
标题翻译：含有氟虫腈的组合物及其使用方法
公开(公告)号：US20080306152A1
公开(公告)日：2008-12-11
申请号：US12143097
申请日：2008-07-28
申请人： Yerramilli V.S.N. Murthy , Robert H. Suva
发明人： Yerramilli V.S.N. Murthy , Robert H. Suva
IPC分类号： A61K31/22 , A61P31/04
CPC分类号： A61K31/222 , A61K9/0019 , A61K9/0024 , A61K31/205 , A61K31/23 , A61K49/0004 , C07C317/32 , A61K2300/00
摘要： The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.
摘要翻译：本发明提供了用于向哺乳动物施用氟苯尼考的组合物和方法。组合物在药学上可接受的载体中含有氟苯尼考的前药。在一个实施方案中，前药是氟苯尼考的酯化形式。合适的前药的实例包括以下的一种或组合的一种或其组合：氟苯尼考乙酸酯，氟苯尼考丙酸酯，氟苯尼考丁酸酯，氟苯尼考戊酸酯，氟苯尼考己酸酯，氟苯尼考辛酸酯，氟苯尼考辛酸酯，氟苯尼考羧酸酯，氟苯尼考十一酸酯，氟苯尼考十二酸酯和氟苯尼考邻苯二甲酸酯。在另一个实施方案中，前体药物通过一种或多种内源性酯酶的作用在体内转化成氟苯尼考。本发明还提供新的化合物，含有这些化合物的药物组合物及其给药方法。

2. 发明申请

US20100035274A1 Methods for Detecting Symmetrical Dimethylarginine 有权
标题翻译：检测对称二甲基精氨酸的方法
公开(公告)号：US20100035274A1
公开(公告)日：2010-02-11
申请号：US12512479
申请日：2009-07-30
申请人： Yerramilli V.S.N. Murthy , Mahalakshmi Padmanabhan , Michael Atkinson , Kwok Kam Yeung
发明人： Yerramilli V.S.N. Murthy , Mahalakshmi Padmanabhan , Michael Atkinson , Kwok Kam Yeung
IPC分类号： G01N33/53 , C07C237/06 , C07K16/00 , C12M1/34
CPC分类号： G01N33/53 , C07C279/12 , C07K16/44 , G01N33/54366 , G01N33/6812
摘要： Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
摘要翻译：检测生物样品中对称二甲基精氨酸（SDMA）的方法。 SDMA类似物用于产生与不对称的二甲基精氨酸，精氨酸和单甲基精氨酸几乎没有或没有交叉反应性的抗SDMA抗体。类似物具有受保护或游离的硫醇（-SH）基团或羟基（-OH）基团，其允许它们连接到合适的缀合靶标，其可以是例如含蛋白质的标记分子。抗SDMA抗体可用于诊断免疫测定以诊断SDMA相关疾病和/或疾病。

3. 发明授权

US07404964B2 Injectable compositions for the controlled delivery of pharmacologically active compound 有权
标题翻译：用于控制递送药理学活性化合物的可注射组合物
公开(公告)号：US07404964B2
公开(公告)日：2008-07-29
申请号：US11088922
申请日：2005-03-25
申请人： Yerramilli V.S.N. Murthy , Robert H. Suva
发明人： Yerramilli V.S.N. Murthy , Robert H. Suva
IPC分类号： A61K9/00
CPC分类号： A61K31/00 , A61K9/0019 , A61K9/0024 , A61K31/24 , A61K31/496 , A61K31/65 , A61K31/7034 , A61K31/7048 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmaceutically acceptable water soluble solvent combined together to form an injectable composition. The lipophilic counterion may be a saturated or unsaturated C8-C22 fatty acid, and preferably may be a saturated or unsaturated C10-C18 fatty acid. When injected into a mammal, at least a portion of the composition precipitates and releases the active compound over time. Thus, the composition forms a slowly releasing drug depot of the active compound in the mammal. Therefore, the present invention enables one to provide a controlled dose administration of the active compound for a periods of up to 15 days or even longer. Many compounds can be administered according to the present invention including, but not limited to, tilmicosin, oxytetracycline, metoprolol, fluoxetine, roxithromycin, and turbinafine.
摘要翻译：本发明提供用于延长释放时间并降低药理活性化合物的毒性的组合物和方法。化合物包含药理活性化合物的盐与亲脂性抗衡离子和药学上可接受的水溶性溶剂组合在一起形成可注射组合物。亲油抗衡离子可以是饱和或不饱和的C 12 -C 22脂肪酸，优选可以是饱和或不饱和的C 10 -C 18 脂肪酸。当注射到哺乳动物中时，组合物的至少一部分随时间沉淀并释放活性化合物。因此，组合物在哺乳动物中形成缓慢释放活性化合物的药物贮库。因此，本发明使得能够提供活性化合物的受控剂量给药长达15天甚至更长时间。根据本发明可以施用许多化合物，包括但不限于替米考星，土霉素，美托洛尔，氟西汀，罗红霉素和头孢噻吩。

4. 发明申请

US20090023678A1 Amino Acid Vitamin Ester Compositions for Controlled Delivery of Pharmaceutically Active Compounds 有权
标题翻译：用于控制药物活性化合物递送的氨基酸维生素酯组合物
公开(公告)号：US20090023678A1
公开(公告)日：2009-01-22
申请号：US12171353
申请日：2008-07-11
申请人： Yerramilli V.S.N. Murthy , Michael Atkinson
发明人： Yerramilli V.S.N. Murthy , Michael Atkinson
IPC分类号： A61K31/7076 , A61K47/16 , A61K31/44 , A61K31/713 , A61K47/12 , A61K31/7052
CPC分类号： A61K45/06 , A61K8/67 , A61K31/198 , A61K31/223 , A61K31/59 , A61K31/7088 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal. When the pharmaceutical compositions are administered to an animal by injection, they form a drug depot that releases the pharmaceutically active compound over time. The pharmaceutical compositions can also be administered orally.
摘要翻译：本发明涉及通过向动物施用药物组合物来提供药物活性化合物的持续释放的药物组合物和治疗或预防动物病症的方法。当通过注射将药物组合物施用于动物时，它们形成随时间释放药物活性化合物的药物贮库。药物组合物也可以口服给药。

5. 发明申请

US20090012072A1 FLUOROQUINOLONE COMPOSITIONS 有权
标题翻译：氟代喹诺酮组合物
公开(公告)号：US20090012072A1
公开(公告)日：2009-01-08
申请号：US12210566
申请日：2008-09-15
申请人： Yerramilli V.S.N. MURTHY
发明人： Yerramilli V.S.N. MURTHY
IPC分类号： A61K31/5383 , A61K31/496 , A61P31/04
CPC分类号： A61K31/4709 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K31/496 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/40
摘要： The invention relates to pharmaceutical compositions comprising (i) a fluoroquinolone, (ii) a salt formed between a carboxylate anion and a divalent metal cation, (iii) a liquid comprising an organic solvent selected from the group consisting of glycerol, propylene glycol, glycerol formal, and (iv) optionally water. The invention further relates to methods of treating or preventing a condition in an animal comprising administering to the animal in need thereof a pharmaceutical composition of the invention.
摘要翻译：本发明涉及药物组合物，其包含（i）氟喹诺酮，（ii）在羧酸根阴离子和二价金属阳离子之间形成的盐，（iii）包含选自甘油，丙二醇，甘油（iv）任选的水。本发明还涉及治疗或预防动物病症的方法，其包括向有需要的动物施用本发明的药物组合物。

6. 发明申请

US20090005326A1 SINGLE DOSE ROXITHROMYCIN 审中-公开
标题翻译：单剂量ROXITHROMYCIN
公开(公告)号：US20090005326A1
公开(公告)日：2009-01-01
申请号：US12143270
申请日：2008-06-20
申请人： Yerramilli V.S.N. Murthy , Edward Obare
发明人： Yerramilli V.S.N. Murthy , Edward Obare
IPC分类号： A61K31/7048 , A61P31/04
CPC分类号： A61K31/7048
摘要： The invention relates to a method of treating a bacterial infection in an animal by administering a single dose of roxithromycin.
摘要翻译：本发明涉及通过施用单剂量的罗红霉素来治疗动物细菌感染的方法。

7. 发明申请

US20080262083A1 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：US20080262083A1
公开(公告)日：2008-10-23
申请号：US12144243
申请日：2008-06-23
申请人： Yerramilli V.S.N. MURTHY
发明人： Yerramilli V.S.N. MURTHY
IPC分类号： A61K31/222 , A61K31/16 , C07C233/01 , C07C69/00
CPC分类号： C07C317/32 , C07B2200/07 , C07C233/18 , C07C235/08 , C07C311/37 , C07C311/46
摘要： D-(threo)-1-aryl-2-disubstitutedacylamido-3-fluoro-1-propanol compounds compounds and analogues thereof (“Fenicol Compounds”), compositions comprising an effective amount of a Fenicol Compound, and methods for treating or preventing a bacterial infection in an animal comprising administering to an animal in need thereof an effective amount of a Fenicol Compound are disclosed.
摘要翻译： D-（苏式）-1-芳基-2-二取代的酰基氨基-3-氟-1-丙醇化合物及其类似物（“Fenicol Compounds”），包含有效量的Fenicol化合物的组合物，以及治疗或预防包括向有需要的动物施用有效量的Fenicol化合物的动物中的细菌感染。

8. 发明授权

US08828960B2 Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds 有权
标题翻译：用于控制递送药物活性化合物的氨基酸维生素酯组合物
公开(公告)号：US08828960B2
公开(公告)日：2014-09-09
申请号：US12171353
申请日：2008-07-11
申请人： Yerramilli V.S.N. Murthy , Michael Atkinson
发明人： Yerramilli V.S.N. Murthy , Michael Atkinson
IPC分类号： A61K31/7088 , A61K31/223 , A61K31/67 , A61K45/06 , A61K31/198 , A61K31/59 , A61K8/67
CPC分类号： A61K45/06 , A61K8/67 , A61K31/198 , A61K31/223 , A61K31/59 , A61K31/7088 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal. When the pharmaceutical compositions are administered to an animal by injection, they form a drug depot that releases the pharmaceutically active compound over time. The pharmaceutical compositions can also be administered orally.
摘要翻译：本发明涉及通过向动物施用药物组合物来提供药物活性化合物的持续释放的药物组合物和治疗或预防动物病症的方法。当通过注射将药物组合物施用于动物时，它们形成随时间释放药物活性化合物的药物贮库。药物组合物也可以口服给药。

9. 发明申请

US20100204303A1 Pharmaceutical Compositions for Administering Oligonucleotides 审中-公开
标题翻译：用于管理寡核苷酸的药物组合物
公开(公告)号：US20100204303A1
公开(公告)日：2010-08-12
申请号：US12678776
申请日：2008-09-24
申请人： Yerramilli V.S.N. Murthy , Michael Atkinson
发明人： Yerramilli V.S.N. Murthy , Michael Atkinson
IPC分类号： A61K31/7088
CPC分类号： A61K31/7088 , A61K9/0019 , A61K9/5123
摘要： The invention relates to pharmaceutical compositions useful for administering an oligonucleotide to an animal in need thereof. The pharmaceutical compositions include nano-particles or micro-particles of (i) a protonated oligonucleotide and (ii) a pharmaceutically acceptable organic base or include nano-particles or micro-particles of (i) an oligonucleotide and (ii) a divalent metal ion.
摘要翻译：本发明涉及可用于向有需要的动物施用寡核苷酸的药物组合物。药物组合物包括（i）质子化寡核苷酸和（ii）药学上可接受的有机碱的纳米颗粒或微粒，或包括（i）寡核苷酸和（ii）二价金属离子的纳米颗粒或微粒。

10. 发明申请

US20090105337A1 Esters of Florfenicol 失效
标题翻译：氟苯尼考酯
公开(公告)号：US20090105337A1
公开(公告)日：2009-04-23
申请号：US12250238
申请日：2008-10-13
申请人： Yerramilli V.S.N. Murthy
发明人： Yerramilli V.S.N. Murthy
IPC分类号： A61K31/222 , C07C229/34 , A61P31/04
CPC分类号： C07C317/40
摘要： The invention relates to compounds of formula (I): wherein R is —C(O)CH2OCH2CH2OCH3 or —C(O)CH2N(CH3)2. The invention also relates to pharmaceutical compositions comprising a compound formula (I) and methods of treating or preventing a condition in an animal comprising administering to an animal in need thereof a compound of formula (I).
摘要翻译：本发明涉及式（I）化合物：其中R是-C（O）CH 2 OCH 2 CH 2 OCH 3或-C（O）CH 2 N（CH 3）2。本发明还涉及包含化合物式（I）的药物组合物和治疗或预防动物病症的方法，其包括向有需要的动物施用式（I）化合物。

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