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1. 发明申请

US20080269345A1 Quarternary Ammonium Compound, Process for Producing the Same, Therapeutic Agent for Cerebrovascular Disorder, and Therapeutic Agent for Heart Disease 失效
标题翻译：四季铵化合物，其制备方法，脑血管障碍治疗剂和心脏病治疗剂
公开(公告)号：US20080269345A1
公开(公告)日：2008-10-30
申请号：US10594545
申请日：2005-03-29
申请人： Hidetsugu Takagaki , Yoshiyuki Sano , Yasuyuki Katakami , Masanori Miyamoto
发明人： Hidetsugu Takagaki , Yoshiyuki Sano , Yasuyuki Katakami , Masanori Miyamoto
IPC分类号： A61K31/14 , C07C217/54 , A61P7/00 , A61P9/00
CPC分类号： C07C217/22 , A61K31/205 , C07C309/42
摘要： A quaternary ammonium compound of the present invention is a quaternary ammonium compound represented by general formula (I) or (I′) (wherein, A represents a linear alkyl group having 1 to 4 carbon atoms, a branched alkyl group having 2 to 4 carbon atoms, a linear alkyl group having 1 to 4 carbon atoms and a hydroxyl group, or a branched alkyl group having 2 to 4 carbon atoms and a hydroxyl group, R1 to R3 may be the same or different and represent a linear or branched alkyl group having 1 to 12 carbon atoms, one of R4 to R8 represents CO2− or SO3−, while no more than three of the remaining R4 to R8 represent a group selected from the group consisting of a hydroxyl group and an alkoxy group having 1 to 4 carbon atoms, and other R4 to R8 represent a hydrogen atom, one of R′4 to R′8 represents CO2H or SO3H, no more than three of the remaining R′4 to R′8 represent a group selected from a protected hydroxyl group and an alkoxy group having 1 to 4 carbon atoms, while other R′4 to R′8 represent a hydrogen atom, and X− represents an anion capable of forming a salt with a quaternary ammonium group).
摘要翻译：本发明的季铵化合物是通式（I）或（I'）表示的季铵化合物（其中，A表示碳原子数1〜4的直链烷基，碳原子数2〜4的支链烷基原子，具有1至4个碳原子和羟基的直链烷基或具有2至4个碳原子和羟基的支链烷基，R 1至R 3， SUB>可以相同或不同，表示具有1至12个碳原子的直链或支链烷基，R 4至R 8中的一个表示CO 2 ^{- 或SO 3 ^{- ，而不超过三个剩余的R 4至R 8表示选自羟基和碳原子数1〜4的烷氧基的基团，以及其它R 4〜R 8， SUB>表示氢原子，R'4'至R'8之一表示CO 2 H或SO 3}}

2. 发明授权

US07687546B2 Quaternary ammonium compound, process for producing the same, therapeutic agent for cerebrovascular disorder, and therapeutic agent for heart disease 失效
标题翻译：第四季铵化合物，其制备方法，脑血管障碍治疗剂和心脏病治疗剂
公开(公告)号：US07687546B2
公开(公告)日：2010-03-30
申请号：US10594545
申请日：2005-03-29
申请人： Hidetsugu Takagaki , Yoshiyuki Sano , Yasuyuki Katakami , Masanori Miyamoto
发明人： Hidetsugu Takagaki , Yoshiyuki Sano , Yasuyuki Katakami , Masanori Miyamoto
IPC分类号： A01N33/12 , A61K31/14
CPC分类号： C07C217/22 , A61K31/205 , C07C309/42
摘要： A quaternary ammonium compound of the present invention is a quaternary ammonium compound represented by general formula (I) or (I′) (wherein, A represents a linear alkyl group having 1 to 4 carbon atoms, a branched alkyl group having 2 to 4 carbon atoms, a linear alkyl group having 1 to 4 carbon atoms and a hydroxyl group, or a branched alkyl group having 2 to 4 carbon atoms and a hydroxyl group, R1 to R3 may be the same or different and represent a linear or branched alkyl group having 1 to 12 carbon atoms, one of R4 to R8 represents CO2− or SO3−, while no more than three of the remaining R4 to R8 represent a group selected from the group consisting of a hydroxyl group and an alkoxy group having 1 to 4 carbon atoms, and other R4 to R8 represent a hydrogen atom, one of R′4 to R′8 represents CO2H or SO3H, no more than three of the remaining R′4 to R′8 represent a group selected from a protected hydroxyl group and an alkoxy group having 1 to 4 carbon atoms, while other R′4 to R′8 represent a hydrogen atom, and X− represents an anion capable of forming a salt with a quaternary ammonium group).
摘要翻译：本发明的季铵化合物是由通式（I）或（I'）（表示的季铵化合物，其中，A表示具有1至4个碳原子，具有2-4个碳支链烷基的直链烷基原子，碳原子数为1〜4的直链烷基和羟基的基团，或具有2至4个碳原子和羟基基团的支链烷基，R1至R3可以相同或不同，表示直链或支链的烷基具有1至12个碳原子，R4中的一个来R8表示CO 2 - 或SO 3 - ，而不超过三个剩余的R 4至R 8中的表示选自羟基的基团和具有1至4的烷氧基中的基团碳原子，并且另一个R 4至R 8表示氢原子，R'4中的一个来表示R 18 CO 2 H或SO 3 H，不超过三个剩余的R'4至R'8的表示从受保护的羟基中的基团和具有1至4个碳原子的烷氧基，而其它R 4至R'8表示氢原子，X - 表示能够形成与季铵基团的盐）的阴离子。

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