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1. 发明授权

US09265409B2 Capsule medical device and capsule medical system 有权
标题翻译：胶囊医疗器械和胶囊医疗系统
公开(公告)号：US09265409B2
公开(公告)日：2016-02-23
申请号：US12599737
申请日：2008-05-20
申请人： Yasushige Ishihara
发明人： Yasushige Ishihara
IPC分类号： A61B1/04 , A61B1/00 , A61B5/00 , A61B5/07 , A61B5/06
CPC分类号： A61B1/041 , A61B1/00004 , A61B1/00036 , A61B1/043 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/065 , A61B5/073 , H04N5/347 , H04N2005/2255
摘要： Radiation is captured without fail, and a sharp image of a region where radiation is generated is acquired. A capsule medical device (3) includes an excitation light source (7) that generates excitation light for irradiating an inner wall (4) of a body cavity, a CCD (9), having variable sensitivity, that captures fluorescence generated at the inner wall (4) of the body cavity by the excitation light emitted from the excitation light source (7) to acquire a two-dimensional fluorescence image, and a control unit (35) that performs control so as to reduce the sensitivity of the CCD (9) when the fluorescence intensity in at least part of the fluorescence image acquired by the CCD (9) exceeds a predetermined threshold.
摘要翻译：捕获辐射，并且获取产生辐射的区域的清晰图像。胶囊型医疗装置（3）具有产生用于照射体腔内壁（4）的激发光的激发光源（7），具有灵敏度不同的CCD（9），其捕获在内壁产生的荧光通过由激发光源（7）发射的激发光来获得二维荧光图像的控制单元（35），以及控制单元（35），以降低CCD（9）的灵敏度）当由CCD（9）获取的至少部分荧光图像中的荧光强度超过预定阈值时。

2. 发明授权

US09119553B2 Fluorescence endoscope device 有权
标题翻译：荧光内窥镜装置
公开(公告)号：US09119553B2
公开(公告)日：2015-09-01
申请号：US13599372
申请日：2012-08-30
申请人： Yasushige Ishihara
发明人： Yasushige Ishihara
IPC分类号： A61B1/04 , A61B1/06 , A61B1/00 , A61B5/00 , G06T5/00 , G06T5/50
CPC分类号： A61B1/0638 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/0646 , A61B5/0071 , A61B5/0084 , G06T5/009 , G06T5/50
摘要： Provided is a fluorescence endoscope device including a light source that irradiates with excitation light and white light; an image generator that acquires a fluorescence image by capturing fluorescence generated in a subject irradiated with the excitation light and that acquires a white-light image by capturing return light from the subject irradiated with the white light; an image corrector that corrects the fluorescence image by using the white-light image so as to generate a corrected fluorescence image; a threshold-value setting unit that sets a threshold value on the basis of an average value of gradation values of pixels in the corrected fluorescence image; an image adjuster that increases the contrast in the corrected fluorescence image between an area having gradation values larger than the threshold value, and an area having gradation values smaller than the threshold value; and a monitor that displays the corrected fluorescence image whose contrast is increased.
摘要翻译：本发明提供一种荧光内窥镜装置，其包括用激发光和白光照射的光源; 一种图像发生器，其通过捕获在被激发光照射的被摄体中产生的荧光来获取荧光图像，并且通过捕获来自被照射的白光的被摄体的返回光获取白光图像; 图像校正器，其通过使用白光图像校正荧光图像，以产生校正的荧光图像; 阈值设定单元，其基于校正后的荧光图像中的像素的灰度值的平均值来设定阈值; 图像调整器，其增加校正的荧光图像中的灰度值大于阈值的区域与具有小于阈值的灰度值的区域之间的对比度; 以及显示校正的荧光图像的显示器，其对比度增加。

3. 发明申请

US20120302893A1 FLUORESCENCE ENDOSCOPE DEVICE 有权
标题翻译：荧光内窥镜装置
公开(公告)号：US20120302893A1
公开(公告)日：2012-11-29
申请号：US13565440
申请日：2012-08-02
申请人： Yasushige ISHIHARA
发明人： Yasushige ISHIHARA
IPC分类号： A61B1/07 , A61B6/00
CPC分类号： A61B1/00186 , A61B1/00009 , A61B1/043 , A61B1/05 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084 , G01N21/6456
摘要： Provided is a fluorescence endoscope device that includes a light source; an image generating portion that captures an image of fluorescence generated at a subject due to irradiation with excitation light to obtain a fluorescence image and that captures an image of return light returning from the subject due to irradiation with white light to obtain a white-light image; a dividing portion that divides the fluorescence image by the white-light image to generate a divided fluorescence image; a coordinate extracting portion that extracts a second region of the divided fluorescence image having a gradation value higher than a second threshold; a fluorescence-image correcting portion that extracts a first region having a gradation value higher than a first threshold in the fluorescence image and generates a corrected fluorescence image in which an overlap region that overlaps the second region is extracted; and a monitor that displays the corrected fluorescence image.
摘要翻译：提供一种荧光内窥镜装置，其包括光源; 图像生成部，其捕获由于激发光照射而在被检体处产生的荧光的图像，以获得荧光图像，并且捕获由于被白色光照射而从被检体返回的返回光的图像，以获得白光图像 ; 分割部，其将荧光图像除以白光图像，生成分割荧光图像; 提取具有高于第二阈值的灰度值的分割荧光图像的第二区域的坐标提取部分; 荧光图像校正部，其在所述荧光图像中提取具有高于第一阈值的灰度值的第一区域，并生成其中提取与所述第二区域重叠的重叠区域的校正荧光图像; 以及显示校正的荧光图像的监视器。

4. 发明授权

US08193517B2 Fluoroscopy system, fluoroscopy apparatus, and fluoroscopy method 有权
标题翻译：荧光透视系统，荧光透视仪和荧光透视法
公开(公告)号：US08193517B2
公开(公告)日：2012-06-05
申请号：US13237170
申请日：2011-09-20
申请人： Yasushige Ishihara
发明人： Yasushige Ishihara
IPC分类号： G01N21/64
CPC分类号： A61B1/0638 , A61B1/00057 , A61B1/043 , A61B1/0646 , A61B5/0071 , A61B5/0084 , A61B2560/0233 , G01N21/274 , G01N21/6456 , G01N2021/6419 , G01N2021/6423 , G01N2021/6484
摘要： Observation is performed with a fluorescence image having high quantitativeness by satisfactorily eliminating dependencies on distance and angle that remain in an image subjected to division. Provided is a fluoroscopy system 1 including a fluoroscopy apparatus (100); a calibration device (101) equipped with a standard specimen (30) and an observation-state setting mechanism (31), (32) that sets, in a variable manner, an observation distance D and an observation angle θ of the fluoroscopy apparatus (100) relative to the standard specimen (30); and an observation-conditions adjusting portion (10) that adjusts observation conditions on the basis of the set observation distance D and observation angle θ and a reference image G1 and a fluorescence image G2 acquired by capturing the standard specimen (30) with the fluoroscopy apparatus (100).
摘要翻译：通过满意地消除残留在分割图像中的距离和角度的依赖性，通过具有高定量度的荧光图像进行观察。提供一种荧光透视系统1，其包括荧光透视装置（100）; 配备有标准样本（30）和观察状态设定机构（31）的校准装置（101），（32）以可变的方式设定观察距离D和观察角度; 的所述荧光透视装置（100）相对于所述标准样品（30）; 以及根据设定的观察距离D和观察角度θ来调整观察条件的观察条件调整部（10）。以及通过用荧光透视装置（100）捕获标准样本（30）而获取的参考图像G1和荧光图像G2。

5. 发明申请

US20100245619A1 FLUOROSCOPY APPARATUS 有权
标题翻译：荧光设备
公开(公告)号：US20100245619A1
公开(公告)日：2010-09-30
申请号：US12726549
申请日：2010-03-18
申请人： Toshiaki WATANABE , Yasushige ISHIHARA
发明人： Toshiaki WATANABE , Yasushige ISHIHARA
IPC分类号： H04N9/73
CPC分类号： A61B5/0071 , A61B1/00009 , A61B1/043 , A61B1/051 , A61B5/0084 , G06T5/50 , G06T2207/10064 , G06T2207/10068 , G06T2207/20192 , G06T2207/20224 , G06T2207/30101 , H04N5/325
摘要： A fluoroscopy apparatus includes an illumination portion irradiating an observation target with illumination light; a fluorescence image acquisition device acquires fluorescence emitted from an observation target to acquire a fluorescence image; a fluorescence image-acquisition optical system forms an image of the observation target using the fluorescence; a reference-light image acquisition device acquires returning light from the observation region to acquire a reference image; a reference-light image-acquisition optical system forms an image using the returning light; and an image correction section corrects the fluorescence image by the reference image, wherein the product of an pixel density of the reference-light image acquisition device and the image-forming magnification of the reference-light image-acquisition optical system is less than the product of the pixel density of the fluorescence image acquisition device and the image-forming magnification of the fluorescence image-acquisition optical system.
摘要翻译：荧光透视设备包括：用照明光照射观察目标的照明部分; 荧光图像获取装置获取从观察对象发出的荧光以获取荧光图像; 荧光图像采集光学系统使用荧光形成观察目标的图像; 参考光图像获取装置获取来自观察区域的返回光以获取参考图像; 参考光图像采集光学系统使用返回光形成图像; 并且图像校正部分通过参考图像校正荧光图像，其中参考光图像获取装置的像素密度与参考光图像采集光学系统的图像形成倍率的乘积小于产品的荧光图像获取装置的像素密度和荧光图像采集光学系统的成像放大率。

6. 发明申请

US20100134607A1 ENDOSCOPIC OBSERVATION APPARATUS AND ENDOSCOPIC OBSERVATION METHOD 审中-公开
标题翻译：内窥镜观察装置和内窥镜观察方法
公开(公告)号：US20100134607A1
公开(公告)日：2010-06-03
申请号：US12531163
申请日：2008-03-14
申请人： Yasushige Ishihara
发明人： Yasushige Ishihara
IPC分类号： H04N7/18
CPC分类号： A61B5/1076 , A61B1/00096 , A61B1/00177 , A61B1/00183 , A61B1/05 , A61B1/0615 , A61B1/07 , A61B8/12 , A61B8/4461
摘要： A quantitative image of a subject is obtained without being influenced by the distance from the subject by accurately measuring the absolute distance between the subject and the tip of a phototransmitter that radiates light onto the subject. There is provided an endoscopic observation apparatus (1) that includes, at the tip of an inserted member (6) to be disposed in a body cavity, a phototransmitter (12) that radiates light onto a subject opposing the tip and a photoreceptor (12) that receives observation light returning from the subject, an ultrasonic sensor (13) that measures the absolute distance between the inserted member (6) and the subject using oscillation of ultrasonic waves, a correcting unit (32) that corrects the luminance information of the observation light on the basis of the absolute-distance information obtained by the ultrasonic sensor (13), and an image generating unit (32) that generates an image of the subject on the basis of the luminance information of the observation light, corrected by the correcting unit (32).
摘要翻译：通过精确地测量被摄体和将光照射到被摄体上的光发射体的末端之间的绝对距离，不受受试者的距离的影响而获得被摄体的定量图像。提供了一种内窥镜观察装置（1），其在设置在体腔内的插入构件（6）的前端包括将光照射到与尖端相对的被检体上的光发射体（12）和感光体（12）），其接收从被检体返回的观察光，超声波传感器（13），其利用超声波的振荡来测量插入部件（6）与被检体之间的绝对距离;校正部（32），其对基于由超声波传感器（13）获得的绝对距离信息的观察光，以及根据观察光的亮度信息生成被摄体的图像的图像生成单元（32），该图像生成单元校正单元（32）。

7. 发明申请

US20100059690A1 FLUOROSCOPIC DEVICE AND FLUOROSCOPIC METHOD 有权
标题翻译：荧光装置和荧光方法
公开(公告)号：US20100059690A1
公开(公告)日：2010-03-11
申请号：US12522601
申请日：2008-01-17
申请人： Yasushige Ishihara
发明人： Yasushige Ishihara
IPC分类号： G01J1/58 , G01N21/64
CPC分类号： A61B5/489 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084
摘要： A lesion can be made distinctive in an acquired fluorescence image so as to allow for accurate diagnosis. There is provided a fluoroscopic device (1) including a light source unit (2) that emits illumination light, which is in a wavelength range to be absorbed by a blood vessel, and excitation light, which generates agent fluorescence by exciting a fluorochrome accumulated specifically in a lesion, to an examination site (S); an image acquisition unit (15, 16) that acquires an image by irradiating the same examination site (S) with the illumination light and the excitation light and photographing the respective reflected light and fluorescence obtained; and an image processing unit (4) that acquires a reference image by smoothing the luminance of the reflected-light image acquired by the image acquisition unit (15, 16) and corrects the fluorescence image on the basis of the acquired reference image.
摘要翻译：在获得的荧光图像中可以使损伤变得显着，以便准确地诊断。提供了一种荧光检查装置（1），其包括发射波长范围被血管吸收的照明光的光源单元（2），以及激发光，其通过激发特定的荧光染料而产生试剂荧光在病变中，到检查点（S）; 图像获取单元，通过用照明光和激发光照射相同的检查部位（S）并拍摄各自的反射光和获得的荧光来获取图像; 以及图像处理单元（4），其通过平滑由图像获取单元（15,16）获取的反射光图像的亮度来获取参考图像，并且基于获取的参考图像来校正荧光图像。

8. 发明申请

US20100049058A1 FLUORESCENCE ENDOSCOPE AND FLUOROMETRY METHOD 有权
标题翻译：荧光内窥镜和荧光法
公开(公告)号：US20100049058A1
公开(公告)日：2010-02-25
申请号：US12520932
申请日：2007-12-25
申请人： Yasushige Ishihara
发明人： Yasushige Ishihara
IPC分类号： A61B1/06 , A61B6/00
CPC分类号： A61B5/0071 , A61B1/043 , A61B1/05 , A61B1/07 , A61B5/0084 , A61B5/7257
摘要： Provided are a fluorescence endoscope and a fluorometry method that allow distinguishing between normal and affected areas in a simple manner by reducing the effect of the distance from a subject. Provided are a light source (7) that emits light for irradiation of a subject, fluorescence image-acquiring section (23) for acquiring an image of fluorescence contained in return light originating from the subject (3), fluorescence-image generating section (37) for generating fluorescence image data based on fluorescence-related data acquired by the fluorescence image-acquiring section (23), region-of-concern defining section (39) for defining a region of concern with a higher fluorescence intensity than a surrounding region based on the fluorescence image data, neighboring-region defining section (41) for defining a neighboring region near the region of concern, and image-operation section (43) for generating corrected image data based on the ratio of a grayscale level related to fluorescence intensity in the region of concern to a grayscale level related to fluorescence intensity in the neighboring region.
摘要翻译：提供了通过减少与被摄体的距离的影响，能够以简单的方式区分正常区域和受影响区域的荧光内窥镜和荧光测定方法。设置有用于照射被检体的光源（7），用于获取源自被检体（3）的返回光中含有的荧光的图像的荧光图像获取部（23），荧光图像生成部（37）），用于基于由荧光图像获取部（23）获取的荧光相关数据产生荧光图像数据，所述关注区域定义部（39）用于定义比周围区域更高的荧光强度的关注区域在荧光图像数据上，用于限定关注区域附近的相邻区域的相邻区域限定部（41），以及用于基于与荧光强度相关的灰度级的比例来生成校正图像数据的图像操作部（43）在与相邻区域的荧光强度相关的灰度级的关注区域。

9. 发明申请

US20100020163A1 FLUORESCENCE ENDOSCOPE 审中-公开
标题翻译：荧光内窥镜
公开(公告)号：US20100020163A1
公开(公告)日：2010-01-28
申请号：US12518377
申请日：2007-12-07
申请人： Toshiaki Watanabe , Atsushi Okawa , Yasushige Ishihara , Ryo Karasawa
发明人： Toshiaki Watanabe , Atsushi Okawa , Yasushige Ishihara , Ryo Karasawa
IPC分类号： H04N7/18
CPC分类号： A61B5/0071 , A61B1/00165 , A61B1/043 , A61B5/0084 , A61B2560/0223
摘要： A fluorescence endoscope is provided that can easily judge whether body-cavity tissue is benign or malignant when fluorescence generated at the entire inner circumferential face of the body cavity serving as a subject is observed. The fluorescence endoscope includes: an insertion portion (5) be inserted into a body cavity (3); a balloon (15) brought into contact with an inner wall of the body cavity (3) located in radial directions of the insertion portion (5), thereby positioning the insertion portion (5) with respect to the body cavity (3) in the radial directions of the insertion portion (5); a light emitting and introducing unit (17, 19) emits excitation light for irradiating the inner wall, outward in the radial directions of the insertion portion (5), and introduces fluorescence generated at the inner wall to the inside of the insertion portion (5) from a plurality of different radial directions of the insertion portion (5); an image-acquisition unit (21) acquires an image with the fluorescence introduced by the light emitting and introducing unit (17, 19); a correction-signal calculating unit (57) calculates a correction signal for correcting an image-acquisition signal output from the image-acquisition unit (21), based on a distance between the insertion portion (5) and a contact surface of the balloon (15) that is brought into contact with the inner wall; and a signal processing unit (57) corrects the intensity of the image-acquisition signal based on the correction signal and generates an image signal from the corrected image-acquisition signal.
摘要翻译：提供了一种荧光内窥镜，其可以容易地判断当观察到在用作对象的体腔的整个内周面处产生的荧光时，体腔组织是良性还是恶性。荧光内窥镜包括：插入部（5）插入体腔（3）中; 与所述体腔（3）的位于所述插入部（5）的径向方向的内壁接触的气囊（15），从而将所述插入部（5）相对于所述体腔（3）定位在所述插入部插入部分（5）的径向方向; 发光引入单元（17,19）发射用于照射插入部（5）的径向外侧的内壁的激发光，并且将在内壁产生的荧光引入到插入部（5）的内部）从所述插入部（5）的多个不同的径向方向移动; 图像获取单元（21）获取由发光和导入单元（17,19）引入的荧光的图像。校正信号计算单元（57）基于插入部分（5）和气球的接触表面之间的距离来计算用于校正从图像获取单元（21）输出的图像采集信号的校正信号 15）与内壁接触; 并且信号处理单元（57）基于校正信号校正图像采集信号的强度，并从校正后的图像采集信号生成图像信号。

10. 发明申请

US20070197874A1 Endoscope observation device, observation device and observation method using endoscope 有权
标题翻译：内窥镜观察装置，观察装置及使用内窥镜的观察方法
公开(公告)号：US20070197874A1
公开(公告)日：2007-08-23
申请号：US11707204
申请日：2007-02-15
申请人： Yasushige Ishihara
发明人： Yasushige Ishihara
IPC分类号： A61B1/06 , A61B1/00
CPC分类号： A61B5/1076 , A61B1/00165 , A61B1/00183 , A61B1/043 , A61B1/045 , A61B1/0638 , A61B1/07 , A61B5/0062 , A61B5/0066 , A61B5/0071 , A61B5/0084
摘要： A high accurate image of a specimen is obtained by accurately measuring a distance between the specimen and a tip of a light emitting portion that irradiates a light to the specimen. An endoscope observation device includes the light emitting portion that irradiates the light to the specimen and a light receiving portion that receives an observation light returning from the specimen so as to form an image of the observation light received by the light receiving portion. The endoscope observation device is equipped with a distance measurement unit that measures an absolute distance between the tip of the insertion portion and the specimen through an interference of the low coherence light, a correction unit that corrects the brightness information of the observation light based on the absolute distance measured by the distance measurement unit, and an image forming unit that forms the image of the specimen based on the brightness information of the observation light corrected by the correction unit.
摘要翻译：通过精确测量样品与向样品照射光的发光部分的末端之间的距离，可以获得样品的高精度图像。内窥镜观察装置包括对样本照射光的发光部和接受从样本返回的观察光以形成由受光部接收的观察光的图像的受光部。内窥镜观察装置配备有距离测量单元，该距离测量单元通过低相干光的干涉来测量插入部分的尖端与样本之间的绝对距离;校正单元，其基于该相干光校正观察光的亮度信息由距离测量单元测量的绝对距离，以及基于由校正单元校正的观察光的亮度信息形成样本图像的图像形成单元。

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