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    • 1. 发明授权
    • Dry gel composition
    • 干凝胶组成
    • US5556640A
    • 1996-09-17
    • US464559
    • 1995-06-05
    • Yoji ItoYasuo Hirai
    • Yoji ItoYasuo Hirai
    • A61K9/00A61K9/14A61K9/16A61K9/20A61K47/36
    • A61K9/0056A61K47/36A61K9/205A61K9/2054A61K9/2059Y10S514/944
    • There is provided a dry gel composition comprising 40% by weight or below of a medicine which can be orally administered, 3% by weight or above of a gelling agent and 5% by weight or below of a binder, which composition is capable of forming a gruel-like aqueous gel composition upon mixing with 2 to 15 parts weight of water per part by weight of the composition at a temperature of 40.degree. C. or below. The gelling agent usable herein is, for example, pregelatinized starch having a concentration of 50% by weight or above. The medicine which can be orally administered is, for example, cinnarizine. Upon mixing with a predetermined quantity of water, the dry gel composition forms a homogeneous aqueous gel composition having a viscosity of about 100 to 500 cp, which is preferably thixotropic. Even aged people having a weak swallowing function can easily swallow the aqueous gel composition, without causing improper sucking into their tracheas. Thus, the dry gel composition of the present invention is very useful in their medical care. The aqueous gel composition can be prepared in a short time by an extremely simple operation at the time of use.
    • 提供一种干凝胶组合物,其包含40重量%以下的可以口服的药物,3重量%以上的胶凝剂和5重量%以下的粘合剂,所述组合物能够形成 在40℃或更低的温度下,每份重量份的组合物与2至15份重量的水混合时,是一种稀有的水性凝胶组合物。 可用于本发明的胶凝剂是例如浓度为50重量%以上的预胶化淀粉。 可以口服的药物是例如cinnarizine。 当与预定量的水混合时,干凝胶组合物形成粘度为约100至500cp的均匀的水性凝胶组合物,其优选为触变性的。 即使具有弱吞咽功能的老年人也可以容易地吞咽水凝胶组合物,而不会引起不适当的吸入气管。 因此,本发明的干凝胶组合物在其医疗保健中非常有用。 水性凝胶组合物可以在使用时通过非常简单的操作在短时间内制备。
    • 4. 发明授权
    • Dry gel composition
    • 干凝胶组成
    • US5496563A
    • 1996-03-05
    • US196070
    • 1994-02-28
    • Yoji ItoYasuo Hirai
    • Yoji ItoYasuo Hirai
    • A61K9/00A61K9/14A61K9/16A61K9/20A61K47/36
    • A61K9/0056A61K47/36A61K9/205A61K9/2054A61K9/2059Y10S514/944
    • There is provided a dry gel composition comprising 40% by weight or below of a medicine which can be orally administered, 3% by weight or above of a gelling agent and 5% by weight or below of a binder, which composition is capable of forming a gruel-like aqueous gel composition upon mixing with 2 to 15 parts by weight of water per part by weight of the composition at a temperature of 40.degree. C. or below. The gelling agent usable herein is, for example, pregelatinized starch having a concentration of 50% by weight or above. The medicine which can be orally administered is, for example, cinnarizine. Upon mixing with a predetermined quantity of water, the dry gel composition forms a homogeneous aqueous gel composition having a viscosity of about 100 to 500 cp, which is preferably thixotropic. Even aged people having a weak swallowing function can easily swallow the aqueous gel composition, without causing improper sucking into their tracheas. Thus, the dry gel composition of the present invention is very useful in their medical care. The aqueous gel composition can be prepared in a short time by an extremely simple operation at the time of use.
    • PCT No.PCT / JP92 / 01097 Sec。 371日期1994年2月28日 102(e)1994年2月28日PCT PCT 1992年8月28日PCT公布。 出版物WO93 / 04670 日本公开1993年3月18日。提供一种干凝胶组合物,其包含40重量%以下的可以口服的药物,3重量%以上的胶凝剂和5重量%以下的粘合剂 在40℃或更低的温度下,该组合物能够在每份重量份组合物与2至15重量份的水混合时形成稀的水性凝胶组合物。 可用于本发明的胶凝剂是例如浓度为50重量%以上的预胶化淀粉。 可以口服的药物是例如cinnarizine。 当与预定量的水混合时,干凝胶组合物形成粘度为约100至500cp的均匀的水性凝胶组合物,其优选为触变性的。 即使具有弱吞咽功能的老年人也可以容易地吞咽水凝胶组合物,而不会引起不适当的吸入气管。 因此,本发明的干凝胶组合物在其医疗保健中非常有用。 水性凝胶组合物可以在使用时通过非常简单的操作在短时间内制备。