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1. 发明申请

US20080160541A1 Methods of Screening Compounds Inhibiting Signal Transduction Through Inflammatory Cytokines 失效
标题翻译：筛选化合物抑制信号转导通过炎症细胞因子的方法
公开(公告)号：US20080160541A1
公开(公告)日：2008-07-03
申请号：US12026932
申请日：2008-02-06
申请人： Masayuki Tsuchiya , Toshihiko Ohtomo , Yasuhiro Sugamata , Kunihiro Matsumoto
发明人： Masayuki Tsuchiya , Toshihiko Ohtomo , Yasuhiro Sugamata , Kunihiro Matsumoto
IPC分类号： G01N33/53
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/47 , C12Q1/48 , G01N33/573 , G01N2500/02
摘要： Revealed are that the actions of inflammatory cytokine and the production of inflammatory cytokines such as IL-1 and TNF induced by an inflammatory stimulus as well as the production of other inflammatory cytokines such as IL-6 induced by the former class of inflammatory cytokines are all suppressed by inhibiting the signal transduction through TAK1.
摘要翻译：显示炎症细胞因子的作用以及由炎症刺激诱导的炎性细胞因子如IL-1和TNF的产生，以及由前一类炎性细胞因子诱导的其它炎性细胞因子如IL-6的产生都是通过抑制通过TAK1的信号转导来抑制。

2. 发明授权

US09052320B2 Method for analysis of hepatitis B virus s antigen 有权
标题翻译：乙型肝炎病毒抗原分析方法
公开(公告)号：US09052320B2
公开(公告)日：2015-06-09
申请号：US12447806
申请日：2007-10-30
申请人： Naoko Matsubara , Yasuhiro Sugamata , Osamu Kusano , Noriko Shirata
发明人： Naoko Matsubara , Yasuhiro Sugamata , Osamu Kusano , Noriko Shirata
IPC分类号： G01N33/545 , C12Q1/70 , G01N33/576 , C07K16/08
CPC分类号： G01N33/5764 , C07K16/082
摘要： An object of the present invention is to enable to accurately quantify HBs antigen in the samples for which measured values are low or false-negative results by the conventional assaying method of HBs antigen. In the method of assaying HBs antigen according to the present invention, at least one inner capture probe that binds to a first inner region peptide consisting of 26th to 80th amino acid residues of HBs antigen and at least one outer capture probe that binds to a second outer region peptide consisting of 98th to 156th amino acid residues of HBs antigen are used as capture probes; and at least one inner detection probe which binds to the first inner region and at least one outer detection probe which binds to the second outer region are used as detection probes.
摘要翻译：本发明的目的是能够通过HBs抗原的常规测定方法准确地定量测量值低的假手段或假阴性的样品中的HBs抗原。在根据本发明的测定HBs抗原的方法中，至少一种内部捕获探针，其结合由HBs抗原的第二十六至第八十八个氨基酸残基组成的第一内部区域肽和至少一个与第二个结合的外部捕获探针使用由HBs抗原的第98个至第156个氨基酸残基组成的外部区域肽作为捕获探针; 并且使用与第一内部区域结合的至少一个内部检测探针和与第二外部区域结合的至少一个外部检测探针作为检测探针。

3. 发明授权

US08105799B2 Methods of screening compounds inhibiting signal transduction through inflammatory cytokines 失效
标题翻译：筛选通过炎性细胞因子抑制信号转导的化合物的方法
公开(公告)号：US08105799B2
公开(公告)日：2012-01-31
申请号：US12026932
申请日：2008-02-06
申请人： Masayuki Tsuchiya , Toshihiko Ohtomo , Yasuhiro Sugamata , Kunihiro Matsumoto
发明人： Masayuki Tsuchiya , Toshihiko Ohtomo , Yasuhiro Sugamata , Kunihiro Matsumoto
IPC分类号： C12Q1/48 , G01N33/53 , C12P21/04 , C12N15/00 , C12N1/20 , C07H21/04 , C07K1/00
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/47 , C12Q1/48 , G01N33/573 , G01N2500/02
摘要： Revealed are that the actions of inflammatory cytokine and the production of inflammatory cytokines such as IL-1 and TNF induced by an inflammatory stimulus as well as the production of other inflammatory cytokines such as IL-6 induced by the former class of inflammatory cytokines are all suppressed by inhibiting the signal transduction through TAK1.
摘要翻译：显示炎症细胞因子的作用以及由炎症刺激诱导的炎性细胞因子如IL-1和TNF的产生，以及由前一类炎性细胞因子诱导的其它炎性细胞因子如IL-6的产生都是通过抑制通过TAK1的信号转导来抑制。

4. 发明申请

US20100248211A1 METHOD FOR ANALYSIS OF HEPATITIS B VIRUS S ANTIGEN 有权
标题翻译：乙型肝炎病毒抗原分析方法
公开(公告)号：US20100248211A1
公开(公告)日：2010-09-30
申请号：US12447806
申请日：2007-10-30
申请人： Naoko Matsubara , Yasuhiro Sugamata , Osamu Kusano , Noriko Shirata
发明人： Naoko Matsubara , Yasuhiro Sugamata , Osamu Kusano , Noriko Shirata
IPC分类号： C12Q1/70 , C07K16/08 , C12N5/18
CPC分类号： G01N33/5764 , C07K16/082
摘要： An object of the present invention is to enable to accurately quantify HBs antigen in the samples for which measured values are low or false-negative results by the conventional assaying method of HBs antigen. In the method of assaying HBs antigen according to the present invention, at least one inner capture probe that binds to a first inner region peptide consisting of 26th to 80th amino acid residues of HBs antigen and at least one outer capture probe that binds to a second outer region peptide consisting of 98th to 156th amino acid residues of HBs antigen are used as capture probes; and at least one inner detection probe which binds to the first inner region and at least one outer detection probe which binds to the second outer region are used as detection probes.
摘要翻译：本发明的目的是能够通过HBs抗原的常规测定方法准确地定量测量值低的假手段或假阴性的样品中的HBs抗原。在根据本发明的测定HBs抗原的方法中，至少一种内部捕获探针，其结合由HBs抗原的第二十六至第八十八个氨基酸残基组成的第一内部区域肽和至少一个与第二个结合的外部捕获探针使用由HBs抗原的第98个至第156个氨基酸残基组成的外部区域肽作为捕获探针; 并且使用与第一内部区域结合的至少一个内部检测探针和与第二外部区域结合的至少一个外部检测探针作为检测探针。

5. 发明申请

US20060040316A1 Method for screening compounds inhibiting signal transduction through inflammatory cytokines 审中-公开
标题翻译：筛选通过炎性细胞因子抑制信号转导的化合物的方法
公开(公告)号：US20060040316A1
公开(公告)日：2006-02-23
申请号：US11261346
申请日：2005-10-27
申请人： Masayuki Tsuchiya , Toshihiko Ohtomo , Yasuhiro Sugamata , Kunihiro Matsumoto
发明人： Masayuki Tsuchiya , Toshihiko Ohtomo , Yasuhiro Sugamata , Kunihiro Matsumoto
IPC分类号： C12Q1/68 , G01N33/542 , G01N33/53
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/47 , C12Q1/48 , G01N33/573 , G01N2500/02
摘要： Revealed are that the actions of inflammatory cytokine and the production of inflammatory cytokines such as IL-1 and TNF induced by an inflammatory stimulus as well as the production of other inflammatory cytokines such as IL-6 induced by the former class of inflammatory cytokines are all suppressed by inhibiting the signal transduction through TAK1.
摘要翻译：显示炎症细胞因子的作用以及由炎症刺激诱导的炎性细胞因子如IL-1和TNF的产生，以及由前一类炎性细胞因子诱导的其它炎性细胞因子如IL-6的产生都是通过抑制通过TAK1的信号转导来抑制。

6. 发明授权

US06989244B1 Method for screening compounds inhibiting signal transduction through inflammatory cytokines 失效
标题翻译：筛选通过炎性细胞因子抑制信号转导的化合物的方法
公开(公告)号：US06989244B1
公开(公告)日：2006-01-24
申请号：US09830144
申请日：1999-10-21
申请人： Masayuki Tsuchiya , Toshihiko Ohtomo , Yasuhiro Sugamata , Kunihiro Matsumoto
发明人： Masayuki Tsuchiya , Toshihiko Ohtomo , Yasuhiro Sugamata , Kunihiro Matsumoto
IPC分类号： C12Q1/48 , C07K1/00 , C07H21/04 , G01N33/53
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/47 , C12Q1/48 , G01N33/573 , G01N2500/02
摘要： The present invention relates to methods of screening for compounds that inhibit signal transduction by inflammatory cytokines. The methods include providing a sample that contains a TAK1 and a TAB1; contacting the sample with a compound; detecting binding between the TAK1 and the TAB1; and selecting the compound if binding between the TAK1 and TAB1 is inhibited in the sample compared to a control.
摘要翻译：本发明涉及筛选抑制炎性细胞因子信号转导的化合物的方法。所述方法包括提供含有TAK1和TAB1的样品; 使样品与化合物接触; 检测TAK1和TAB1之间的结合; 并且如果与对照相比，在样品中抑制TAK1和TAB1之间的结合，则选择该化合物。

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