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1. 发明授权

US5376533A Methods and compositions for the detection of Addison's disease 失效
标题翻译：用于检测艾迪生病的方法和组合物
公开(公告)号：US5376533A
公开(公告)日：1994-12-27
申请号：US066281
申请日：1993-05-24
申请人： Noel K. Maclaren , Yao H. Song
发明人： Noel K. Maclaren , Yao H. Song
IPC分类号： G01N33/564 , G01N33/573
CPC分类号： G01N33/564 , G01N33/573 , Y10S436/811
摘要： An epitope of 21-hydroxylase has been identified which specifically reacts with autoantibodies to 21-hydroxylase. This epitope immunoreacts with anti-adrenocortical autoantibodies characteristically present in patients having autoimmune Addison's disease. The peptide can be used in a specific, sensitive immunoassay for the detection of these autoantibodies in the diagnosis of Addison's disease. The immunoassay permits the diagnosis of autoimmune Addison's disease and has considerable value in the screening of persons at risk. Persons in the early phases or at clinical onset of any kind of adrenocortical disease can also be screened to exclude Addison's disease as a cause.
摘要翻译：已经鉴定了21-羟化酶的表位，其与21-羟化酶的自身抗体特异性反应。与具有自身免疫性艾迪生氏病的患者相比，该表位与抗肾上腺皮质自身抗体具有特异性的免疫反应。该肽可用于特异性，敏感的免疫测定中，用于检测这些自身抗体以诊断艾迪生病。免疫测定允许诊断自身免疫性艾迪生病，并且在筛查处于危险中的人中具有相当的价值。任何类型的肾上腺皮质疾病的早期阶段或临床发作的人员也可以筛选出排除艾迪生病的原因。

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