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1. 发明申请

US20160058896A1 METHOD AND COMPOUND FOR TREATMENT OF CANCER USING PHOSPHOROUS-32 LABELED DNA 审中-公开
标题翻译：使用磷酸32标记的DNA治疗癌症的方法和化合物
公开(公告)号：US20160058896A1
公开(公告)日：2016-03-03
申请号：US14822841
申请日：2015-08-10
申请人： Yanping Kong , Jinhong Liu
发明人： Yanping Kong , Jinhong Liu
IPC分类号： A61K51/04
CPC分类号： A61K51/0491 , C12N15/113 , C12N2310/315 , C12N2310/3517
摘要： This invention provides a combination of a DNA strand/fragment and isotope therapy that is applied to a cancerous tissue to selectively kill cancer cells with minimal negative effects on surrounding non-cancerous cells. The mechanism of cancer cells uptake of large DNA fragment (larger than 30 bp) is endocytosis which does not occur in normal organ cells. We are the first to identify this difference and use the selectivity to deliver isotope P-32 to treat cancer. The DNA fragments with labeled isotope are able to be absorbed by the tumor cells and bind the tumor cell's DNA through recombination, and then the isotope kills the tumor cells. Illustratively, a gene or a DNA fragment is employed as a carrier to deliver the P-32 which can kill cancer cells through radioactive emission. Appropriate doses are provided to patients as part of a medical treatment method.
摘要翻译：本发明提供了应用于癌组织的DNA链/片段和同位素治疗的组合，以选择性地杀死癌细胞，对周围的非癌细胞具有最小的负面影响。癌细胞摄取大DNA片段（大于30bp）的机制是在正常器官细胞中不发生的内吞作用。我们是第一个确定这种差异，并使用选择性提供同位素P-32来治疗癌症。具有标记同位素的DNA片段能够被肿瘤细胞吸收并通过重组结合肿瘤细胞的DNA，然后同位素杀死肿瘤细胞。说明性地，使用基因或DNA片段作为载体来递送可通过放射性发射杀死癌细胞的P-32。作为治疗方法的一部分，向患者提供适当的剂量。

2. 发明授权

US08642007B2 Method and compound for treatment of cancer using phosphorous-32 labeled DNA 有权
标题翻译：使用磷32标记的DNA治疗癌症的方法和化合物
公开(公告)号：US08642007B2
公开(公告)日：2014-02-04
申请号：US12886127
申请日：2010-09-20
申请人： Yanping Kong , Jinhong Liu
发明人： Yanping Kong , Jinhong Liu
IPC分类号： A61K51/00 , C07H21/04 , A61P35/00
CPC分类号： A61K51/0491
摘要： This invention provides a combination of a gene and isotope therapy that is applied to a cancerous tissue to selectively kill that associated cancer cells with minimal negative effects on surrounding non-cancerous cells. Functionally, the specific DNA fragments with labeled isotope are able to bind the tumor cells DNA through recombination, and then the isotope kills the tumor cells. A gene is employed as a carrier to deliver the P-32 which can kill cancer cells through radioactive emission. Unlike traditional gene therapy, which employs a gene to express a protein, which can suppress the cancer cell growth or increase the sensitivity for radiation therapy or chemotherapy, the illustrative embodiment actually binds the radioactive substance via a gene. The illustrative embodiment produces the compound/agent containing a gene (DNA fragment) and P-32 through use of conventional P-32 labeling techniques such as those employed in molecular biology experiments (for example experiments used to test gene expression and gene amplification potency). In the illustrative embodiment, however, the same P-32 labeled DNA is employed directly for cancer treatment through a novel medical treatment method. Appropriate doses are provided to patients as part of a medical treatment method.
摘要翻译：本发明提供了应用于癌组织的基因和同位素治疗的组合，以选择性地杀死相关的癌细胞，对周围的非癌细胞具有最小的负面影响。功能上，具有标记同位素的特异性DNA片段能够通过重组结合肿瘤细胞DNA，然后同位素杀死肿瘤细胞。使用基因作为载体来递送可通过放射性发射杀死癌细胞的P-32。与使用基因表达蛋白质的传统基因治疗不同，传统的基因治疗可以抑制癌细胞生长或增加放射治疗或化疗的敏感性，但是说明性实施方案实际上通过基因结合放射性物质。说明性实施方案通过使用常规P-32标记技术（例如用于分子生物学实验的实验（例如用于测试基因表达和基因扩增效力的实验））产生含有基因（DNA片段）和P-32的化合物/试剂，。然而，在说明性实施方案中，通过新颖的治疗方法将相同的P-32标记的DNA直接用于癌症治疗。作为治疗方法的一部分，向患者提供适当的剂量。

3. 发明申请

US20090156910A1 Noninvasive glucose monitor and method 审中-公开
标题翻译：无创葡萄糖监测仪及方法
公开(公告)号：US20090156910A1
公开(公告)日：2009-06-18
申请号：US12002263
申请日：2007-12-17
申请人： Yanping Kong , Youchun Kong
发明人： Yanping Kong , Youchun Kong
IPC分类号： A61B5/00 , A61B8/00
CPC分类号： A61B5/0531 , A61B5/14532 , A61B5/681
摘要： An instrument and method for determining the current blood glucose level of an individual by noninvasive measurement of the current electrical capacitance of the outer surface of the skin of such individual and comparing that current capacitance level to stored data of previously determined capacitance levels of the skin and their associated blood glucose levels of that individual for determining the blood glucose level associated with the currently determined capacitance level.
摘要翻译：一种用于通过无创测量这些个体的皮肤的外表面的当前电容来确定个体的当前血糖水平的仪器和方法，并将该电流电容水平与先前确定的皮肤电容水平的存储数据进行比较，以及其个体的相关联的血糖水平用于确定与当前确定的电容水平相关联的血糖水平。

4. 发明授权

US11617729B2 Uses of guanidine hydrochloride as a drug for treating cancers/tumors 有权
公开(公告)号：US11617729B2
公开(公告)日：2023-04-04
申请号：US16925260
申请日：2020-07-09
申请人： Yanping Kong , Jinhong Liu
发明人： Yanping Kong , Jinhong Liu
IPC分类号： A61K31/155 , A61P35/00
摘要： The uses of guanidine hydrochloride as a drug for treating cancers/tumors. Guanidine hydrochloride can destroy the formation of hydrogen bonds by polar molecules on the surface of cancer cells and the macromolecules taken up, thereby demonstrating that guanidine hydrochloride can inhibit the uptake by cancer cells. The present invention provides new uses of guanidine hydrochloride in the treatment of subjects suffering from cancers/tumors and prevention of recurrence after cancer operation. The dose of guanidine hydrochloride administration is 10-35 mg/kg a day. The hydrochloride dose of the guanidine has a significant inhibitory effect on the uptake of DNA by cancer cells, which in turn can effectively inhibit the proliferation of cancer cells; besides, the inhibition rate of liver cancer tumors 9 days after the injection of guanidine hydrochloride drugs can reach 42%, and the inhibition rate of lung cancer tumors 7 days after the injection of guanidine hydrochloride drugs reach 56.8%.

5. 发明申请

US20210154159A1 USES OF GUANIDINE HYDROCHLORIDE AS A DRUG FOR TREATING CANCERS/TUMORS 有权
公开(公告)号：US20210154159A1
公开(公告)日：2021-05-27
申请号：US16925260
申请日：2020-07-09
申请人： Yanping KONG , Jinhong LIU
发明人： Yanping KONG , Jinhong LIU
IPC分类号： A61K31/155 , A61P35/00
摘要： The uses of guanidine hydrochloride as a drug for treating cancers/tumors. Guanidine hydrochloride can destroy the formation of hydrogen bonds by polar molecules on the surface of cancer cells and the macromolecules taken up, thereby demonstrating that guanidine hydrochloride can inhibit the uptake by cancer cells. The present invention provides new uses of guanidine hydrochloride in the treatment of subjects suffering from cancers/tumors and prevention of recurrence after cancer operation. The dose of guanidine hydrochloride administration is 10-35 mg/kg a day. The hydrochloride dose of the guanidine has a significant inhibitory effect on the uptake of DNA by cancer cells, which in turn can effectively inhibit the proliferation of cancer cells; besides, the inhibition rate of liver cancer tumors 9 days after the injection of guanidine hydrochloride drugs can reach 42%, and the inhibition rate of lung cancer tumors 7 days after the injection of guanidine hydrochloride drugs reach 56.8%.

6. 发明申请

US20140219916A1 METHOD AND COMPOUND FOR TREATMENT OF CANCER USING PHOSPHOROUS-32 LABELED DNA 审中-公开
标题翻译：使用磷酸32标记的DNA治疗癌症的方法和化合物
公开(公告)号：US20140219916A1
公开(公告)日：2014-08-07
申请号：US14172819
申请日：2014-02-04
申请人： Yanping Kong , Jinhong Liu
发明人： Yanping Kong , Jinhong Liu
IPC分类号： A61K51/04
CPC分类号： A61K51/0491
摘要： This invention provides a combination of a DNA strand/fragment and isotope therapy that is applied to a cancerous tissue to selectively kill cancer cells with minimal negative effects on surrounding non-cancerous cells. Linear DNA fragments with labeled isotope are able to be absorbed by the tumor cells and bind the tumor cell's DNA through recombination, and then the isotope kills the tumor cells. Illustratively, a gene or a DNA fragment is employed as a carrier to deliver the P-32 which can kill cancer cells through radioactive emission. The illustrative embodiment produces the compound/agent containing a DNA fragment and P-32 through use of conventional P-32 labeling techniques such as those employed in molecular biology experiments (for example experiments used to test gene expression and gene amplification potency). The same P-32 labeled DNA can be employed directly for cancer treatment through a novel medical treatment method. Appropriate doses are provided to patients as part of a medical treatment method.
摘要翻译：本发明提供了应用于癌组织的DNA链/片段和同位素治疗的组合，以选择性地杀死癌细胞，对周围的非癌细胞具有最小的负面影响。具有标记同位素的线性DNA片段能够被肿瘤细胞吸收并通过重组结合肿瘤细胞的DNA，然后同位素杀死肿瘤细胞。说明性地，使用基因或DNA片段作为载体来递送可通过放射性发射杀死癌细胞的P-32。说明性实施例通过使用常规P-32标记技术（例如用于分子生物学实验的实验（例如用于测试基因表达和基因扩增效力的实验））产生含有DNA片段和P-32的化合物/试剂。相同的P-32标记的DNA可以直接用于通过新的治疗方法进行癌症治疗。作为治疗方法的一部分，向患者提供适当的剂量。

7. 发明公开

US20240099992A1 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
公开(公告)号：US20240099992A1
公开(公告)日：2024-03-28
申请号：US18272939
申请日：2022-01-28
申请人： Yanping KONG
发明人： Yanping Kong , Jinhong Liu
IPC分类号： A61K31/132 , A61K45/06 , A61P35/00
CPC分类号： A61K31/132 , A61K45/06 , A61P35/00
摘要： The invention provides pharmaceutical compositions of methylenediamine and methods thereof for treating various types of cancer (e.g., lung cancer, liver cancer, skin cancer, ovarian cancer, prostate cancer, breast cancer and blood cancer).

8. 发明申请

US20120070373A1 METHOD AND COMPOUND FOR TREATMENT OF CANCER USING PHOSPHOROUS-32 LABELED DNA 有权
标题翻译：使用磷酸32标记的DNA治疗癌症的方法和化合物
公开(公告)号：US20120070373A1
公开(公告)日：2012-03-22
申请号：US12886127
申请日：2010-09-20
申请人： Yanping Kong , Jinhong Liu
发明人： Yanping Kong , Jinhong Liu
IPC分类号： A61K51/00 , A61P35/00 , C07H21/04
CPC分类号： A61K51/0491
摘要： This invention provides a combination of a gene and isotope therapy that is applied to a cancerous tissue to selectively kill that associated cancer cells with minimal negative effects on surrounding non-cancerous cells. Functionally, the specific DNA fragments with labeled isotope are able to bind the tumor cells DNA through recombination, and then the isotope kills the tumor cells. A gene is employed as a carrier to deliver the P-32 which can kill cancer cells through radioactive emission. Unlike traditional gene therapy, which employs a gene to express a protein, which can suppress the cancer cell growth or increase the sensitivity for radiation therapy or chemotherapy, the illustrative embodiment actually binds the radioactive substance via a gene. The illustrative embodiment produces the compound/agent containing a gene (DNA fragment) and P-32 through use of conventional P-32 labeling techniques such as those employed in molecular biology experiments (for example experiments used to test gene expression and gene amplification potency). In the illustrative embodiment, however, the same P-32 labeled DNA is employed directly for cancer treatment through a novel medical treatment method. Appropriate doses are provided to patients as part of a medical treatment method.
摘要翻译：本发明提供了应用于癌组织的基因和同位素治疗的组合，以选择性地杀死相关的癌细胞，对周围的非癌细胞具有最小的负面影响。功能上，具有标记同位素的特异性DNA片段能够通过重组结合肿瘤细胞DNA，然后同位素杀死肿瘤细胞。使用基因作为载体来递送可通过放射性发射杀死癌细胞的P-32。与使用基因表达蛋白质的传统基因治疗不同，传统的基因治疗可以抑制癌细胞生长或增加放射治疗或化疗的敏感性，但是说明性实施方案实际上通过基因结合放射性物质。说明性实施方案通过使用常规P-32标记技术（例如用于分子生物学实验的实验（例如用于测试基因表达和基因扩增效力的实验））产生含有基因（DNA片段）和P-32的化合物/试剂，。然而，在说明性实施方案中，通过新颖的治疗方法将相同的P-32标记的DNA直接用于癌症治疗。作为治疗方法的一部分，向患者提供适当的剂量。

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