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1. 发明授权

US07960373B2 2-alkoxy-3,4,5-trihydroxyalkylamide-benzothiazepines preparation thereof, compositions containing them and use thereof 失效
标题翻译： 2-烷氧基-3,4,5-三羟基烷基酰胺 - 苯并硫氮杂制剂，含有它们的组合物及其用途
公开(公告)号：US07960373B2
公开(公告)日：2011-06-14
申请号：US12267691
申请日：2008-11-10
申请人： Jidong Zhang , Yannick Benedetti , Frederico Nardi , Alain Commerçon
发明人： Jidong Zhang , Yannick Benedetti , Frederico Nardi , Alain Commerçon
IPC分类号： C07D223/12 , A61K31/55
CPC分类号： C07D281/10 , C07D307/33
摘要： The present invention relates to 2-alkoxy-3,4,5-trihydroxyalkylamide benzothiazepine compounds, to pharmaceutical compositions comprising such compounds, to methods of treatment comprising administering such compounds, to processes for the preparation of such compounds and to intermediate precursors to such compounds.
摘要翻译：本发明涉及2-烷氧基-3,4,5-三羟基烷基酰胺苯并硫氮杂化合物，包含这些化合物的药物组合物，涉及治疗方法，包括给予这些化合物，制备这些化合物的方法和这种化合物的中间体前体。

2. 发明授权

US5444051A Erythromycin compounds 失效
标题翻译：红霉素化合物
公开(公告)号：US5444051A
公开(公告)日：1995-08-22
申请号：US83636
申请日：1993-06-28
申请人： Constantin Agouridas , Yannick Benedetti , Jean-Francois Chantot , Alexis Denis , Claude Fromentin , Odile Le Martret
发明人： Constantin Agouridas , Yannick Benedetti , Jean-Francois Chantot , Alexis Denis , Claude Fromentin , Odile Le Martret
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61P31/00 , A61P31/04 , A61P31/12 , C07H20060101 , C07H17/00 , C07H17/08
CPC分类号： C07H17/08
摘要： Compounds of the formula ##STR1## wherein X and X' form C.dbd.O or C.dbd.NOR, R is selected from the group consisting of hydrogen, heterocycle, alkyl, alkenyl, alkynyl, all optionally substituted,or X is ##STR2## R.sub.a and R.sub.b are hydrogen or a hydrocarbon group or form together with the nitrogen a heterocycle, or with A forms a 9-N, 11-O ring, and X' is hydrogen, --Y and Y' have the same definition as X and X', B is hydrogen or OR.sub.4, R.sub.4 is hydrogen or forms together with A a carbonate or a carbamate, A forms with C a double bond or A is OR'.sub.4, R'.sub.4 is hydrogen or forms together with B a carbonate or ##STR3## R.sub.2 is alkyl or --CONH.sub.2, --CONHCOR.sub.11 or --CONHSO.sub.2 R.sub.11, R.sub.11 is a hydrocarbon up to 18 carbon atoms, R.sub.3 is hydrogen, ##STR4## and Z is hydrogen or a carboxylic acid remainder and their non-toxic, pharmaceutically acceptable acid addition salts, their preparation and intermediates useful as antibiotics.
摘要翻译：式I的化合物其中X和X'形成C = O或C = NOR，R选自氢，杂环，烷基，烯基，炔基，全部被取代，或X是< R a和R b是氢或烃基或与氮一起形成杂环或与A一起形成9-N，11-O环，X'是氢，-Y和Y'具有与X相同的定义， X'，B是氢或OR 4，R 4是氢或与A一起形成碳酸酯或氨基甲酸酯，A形式与C是双键或A是OR'4，R'4是氢或与B一起形成碳酸酯或 R 2是烷基或-CONH 2，-CONHCOR 11或-CONHSO 2 R 11，R 11是至多18个碳原子的烃，R 3是氢，Z是氢或羧酸残基，它们是无毒的，药学上可接受的酸加成盐，它们的制备和中间体可用作抗生素。

3. 发明授权

US5439889A Erythromycin derivatives 失效
标题翻译：红霉素衍生物
公开(公告)号：US5439889A
公开(公告)日：1995-08-08
申请号：US207355
申请日：1994-03-07
申请人： Constantin Agouridas , Yannick Benedetti , Jean-Francois Chantot , Alexis Denis
发明人： Constantin Agouridas , Yannick Benedetti , Jean-Francois Chantot , Alexis Denis
IPC分类号： A61K31/445 , A61K31/443 , A61K31/4523 , A61P31/04 , C07D405/14 , C07H17/08 , A61K31/70
CPC分类号： C07H17/08
摘要： All possible stereoisomeric forms and mixtures thereof of a compound of the formula ##STR1## wherein the substituents are as defined in the specification and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.
摘要翻译：式I化合物的所有可能的立体异构形式及其混合物，其中取代基如说明书中所定义，及其无毒的药学上可接受的具有抗生素性质的酸加成盐。

4. 发明授权

US6022965A Method for isomerising the 10-methyl radical of erythromycin derivatives 有权
标题翻译：红霉素衍生物的10-甲基异构化方法
公开(公告)号：US6022965A
公开(公告)日：2000-02-08
申请号：US180641
申请日：1998-11-11
申请人： Yannick Benedetti , Jacques Lagouardat , Jacques Scholl
发明人： Yannick Benedetti , Jacques Lagouardat , Jacques Scholl
IPC分类号： A61K31/70 , C07H17/08 , C07H1/00
CPC分类号： C07H17/08
摘要： An isomerization method wherein a compound of formula ##STR1## wherein X and y together form a 3-oxo radical, or X is a hydrogen atom and Y is either a radical a ##STR2## where R.sub.2 is OH or O-acyl, or an O-alkyl or NH.sub.2 radical; R.sub.1 is a hydrogen atom or a methyl radical; Z is hydrogen or an acyl radical; and R is a hydrogen atom, an NH.sub.2 radical or a (CH.sub.2).sub.n Ar, NH(CH.sub.2).sub.n Ar or N.dbd.CH(CH.sub.2).sub.n Ar radical, in the form of a 10.alpha. isomer or a mixture of 10.alpha. and 10.beta. isomers, is exposed to a basic agent to give the corresponding compound of formula I in which the 10-methyl radical is in the .beta. position.
摘要翻译： PCT No.PCT / FR97 / 00840 Sec。 371日期：1998年11月11日 102（e）1998年11月11日PCT PCT 1997年5月13日PCT公布。出版物WO97 / 43297 日期：1997年11月20日一种异构化方法，其中其中X和Y一起形成3-氧代基，或X是氢原子，Y是其中R2是OH或O-酰基的基团，或O - 烷基或NH 2基; R1是氢原子或甲基; Z是氢或酰基; 和R是氢原子，NH 2基团或（CH 2）n Ar，NH（CH 2）n Ar或N = CH（CH 2）n Ar基，其为10α异构体或10α和10β异构体的混合物暴露于碱性试剂中，得到相应的10-甲基在β位的式I化合物。

5. 发明授权

US5770579A Erythromycin compounds 失效
标题翻译：红霉素化合物
公开(公告)号：US5770579A
公开(公告)日：1998-06-23
申请号：US378186
申请日：1995-01-25
申请人： Constantin Agouridas , Yannick Benedetti , Jean-Fran.cedilla.ois Chantot , Alexis Denis , Claude Fromentin , Odile Le Martret
发明人： Constantin Agouridas , Yannick Benedetti , Jean-Fran.cedilla.ois Chantot , Alexis Denis , Claude Fromentin , Odile Le Martret
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61P31/00 , A61P31/04 , A61P31/12 , C07H20060101 , C07H17/00 , C07H17/08
CPC分类号： C07H17/08
摘要： Compounds of the formula ##STR1## wherein X and X' form C.dbd.O or C.dbd.NOR, R is selected from the group consisting of hydrogen, heterocycle, alkyl, alkenyl, alkynyl, all optionally substituted, ##STR2## R.sub.a and R.sub.b are hydrogen or a hydrocarbon group or form together with the nitrogen a heterocycle, or with A forms a 9-N, 11-O ring, and X' is hydrogen, --Y and Y' have the same definition as X and X', b is hydrogen or OR.sub.4, R.sub.4 is hydrogen or forms together with A a carbonate or a carbamate, A forms with C a double bond or A is OR'.sub.4, R'.sub.4 is hydrogen or forms together with B a carbonate or ##STR3## R.sub.2 is alkyl or --CONH.sub.2, --CONHCOR.sub.11 or --CONHSO.sub.2 R.sub.11, R.sub.11 is a hydrocarbon up to 18 carbon atoms, R.sub.3 is hydrogen, ##STR4## and Z is hydrogen or a carboxylic acid remainder and their non-toxic, pharmaceutically acceptable acid addition salts, their preparation and intermediates useful as antibiotics.
摘要翻译：式I的化合物其中X和X'形成C = O或C = NOR，R选自氢，杂环，烷基，烯基，炔基，全部被取代，R a和R b 是氢或烃基或与氮杂环的形式，或与A一起形成9-N，11-O环，X'为氢，-Y和Y'具有与X和X'相同的定义， b是氢或OR 4，R 4是氢或与A一起形成碳酸酯或氨基甲酸酯，A形式与C是双键或A是OR'4，R'4是氢或与B一起形成碳酸酯或 R 2是烷基或-CONH 2，-CONHCOR 11或-CONHSO 2 R 11，R 11是至多18个碳原子的烃，R 3是氢，Z是氢或羧酸残基及其无毒的药学上可接受的酸加成盐，它们的制备和中间体可用作抗生素。

6. 发明授权

US5561118A Erythromycin compounds 失效
标题翻译：红霉素化合物
公开(公告)号：US5561118A
公开(公告)日：1996-10-01
申请号：US220484
申请日：1994-03-31
申请人： Constantin Agouridas , Yannick Benedetti , Jean-Francois Chantot , Alexis Denis , Claude Fromentin , Odile Le Martret
发明人： Constantin Agouridas , Yannick Benedetti , Jean-Francois Chantot , Alexis Denis , Claude Fromentin , Odile Le Martret
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61P31/00 , A61P31/04 , A61P31/12 , C07H20060101 , C07H17/00 , C07H17/08
CPC分类号： C07H17/08
摘要： Compounds of the formula ##STR1## wherein X and X' form C.dbd.O or C.dbd.NOR, R is selected from the group consisting of hydrogen, heterocycle, alkyl, alkenyl, alkynyl, all optionally substituted, or X is ##STR2## R.sub.a and R.sub.b are hydrogen or a hydrocarbon group or form together with the nitrogen a heterocycle, or with A forms a 9-N, 11-0 ring, and X' is hydrogen, --Y and Y' have the same definition as X and X', B is hydrogen or OR.sub.4, R.sub.4 is hydrogen or forms together with A a carbonate or a carbamate, A forms with C a double bond or A is OR'.sub.4, R'.sub.4 is hydrogen or forms together with B a carbonate or A is ##STR3## R.sub.2 is alkyl or --CONH.sub.2, --CONHCOR.sub.11 or --CONHSO.sub.2 R.sub.11, R.sub.11 is a hydrocarbon up to 18 carbon atoms, R.sub.3 is hydrogen, ##STR4## and Z is hydrogen or a carboxylic acid remainder and their non-toxic, pharmaceutically acceptable acid addition salts, their preparation and intermediates useful as antibiotics.
摘要翻译：式I的化合物其中X和X'形成C = O或C = NOR，R选自氢，杂环，烷基，烯基，炔基，全部被取代，或X是< R a和R b是氢或烃基或与氮一起形成杂环或与A一起形成9-N，11-0环，X'是氢，-Y和Y'具有与X相同的定义， X'，B是氢或OR 4，R 4是氢或与A一起形成碳酸酯或氨基甲酸酯，A形式与C是双键或A是OR'4，R'4是氢或与B一起形成碳酸酯或 A是R 2是烷基或-CONH 2，-CONHCOR 11或-CONHSO 2 R 11，R 11是至多18个碳原子的烃，R 3是氢，Z是氢或羧酸残基，它们是无毒的，药学上可接受的酸加成盐，它们的制剂和用作抗生素的中间体。

7. 发明申请

US20080096891A1 TRIAZINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATION THEREOF 失效
标题翻译： TRIAZINE衍生物，其制备和治疗应用
公开(公告)号：US20080096891A1
公开(公告)日：2008-04-24
申请号：US11869260
申请日：2007-10-09
申请人： Yannick BENEDETTI , Andrees BOHME , Arielle GENEVOIS-BORELLA , Gaetan TOUYER , Jidong ZHANG
发明人： Yannick BENEDETTI , Andrees BOHME , Arielle GENEVOIS-BORELLA , Gaetan TOUYER , Jidong ZHANG
IPC分类号： A61K31/53 , A61P25/00 , C07D253/06
CPC分类号： C07D403/04 , C07D253/075 , C07D405/04 , C07D409/04 , C07D453/02
摘要： The invention relates to triazine derivatives of general formula (I): Wherein R1, R2 and R3 are as defined herein. The invention also relates to a method for preparing these triazine derivatives and to the therapeutic application thereof.
摘要翻译：本发明涉及通式（I）的三嗪衍生物：其中R 1，R 2和R 3 3如本文所定义。本发明还涉及这些三嗪衍生物的制备方法及其治疗应用。

8. 发明申请

US20070093488A1 Novel Benzothiazoles And The Use Thereof As Medicaments 失效
标题翻译：新型苯并噻唑及其作为药物的用途
公开(公告)号：US20070093488A1
公开(公告)日：2007-04-26
申请号：US11536757
申请日：2006-09-29
申请人： Stephanie Deprets , Anke Steinmetz , Odile Angouillant-Boniface , Daniel Bezard , Jidong Zhang , Yannick Benedetti , Francois Clerc
发明人： Stephanie Deprets , Anke Steinmetz , Odile Angouillant-Boniface , Daniel Bezard , Jidong Zhang , Yannick Benedetti , Francois Clerc
IPC分类号： A61K31/53 , A61K31/517 , A61K31/506 , A61K31/4745 , A61K31/4439 , A61K31/4709 , A61K31/428 , C07D417/02
CPC分类号： C07D417/12 , C07D277/82 , C07D417/14
摘要： The invention especially relates to novel chemical compounds, especially novel benzothiazole derivatives, to compositions containing said compounds, and to the use thereof as medicaments.
摘要翻译：本发明特别涉及新型化合物，特别是新颖的苯并噻唑衍生物，含有所述化合物的组合物及其作为药物的用途。

9. 发明授权

US5656607A Erythromycin derivatives 失效
标题翻译：红霉素衍生物
公开(公告)号：US5656607A
公开(公告)日：1997-08-12
申请号：US414503
申请日：1995-03-31
申请人： Constantin Agouridas , Yannick Benedetti , Jean-Francois Chantot , Alexis Denis , Odile Le Martret
发明人： Constantin Agouridas , Yannick Benedetti , Jean-Francois Chantot , Alexis Denis , Odile Le Martret
IPC分类号： C07H17/08 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P31/04 , C07H17/00
CPC分类号： C07H17/08 , C07H17/00
摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form ##STR2## and R'.sub.1 and R'.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 23 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and optionally having at least one functional group, Z is hydrogen or acyl of an organic carboxylic acid of 1 to 18 carbon atoms and the wavy line indicates the 10-methyl may have R or S configuration or a mixture of R+S and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.
摘要翻译：选自下式的化合物的化合物其中R 1和R 2分别选自氢和至多24个碳原子的任选不饱和烃，任选地被至少一个选自以下的杂原子间隔的杂原子由氧，硫和氮组成并且任选地具有至少一个官能团或一起形成的基团组成，并且R'1和R'2分别选自氢和任选不饱和的烃，最多达23个碳原子任选地被至少一个选自氮，氧和硫并且任选具有至少一个官能团的杂原子中断，Z是氢或具有1至18个碳原子的有机羧酸的酰基，波浪线表示该10-甲基可具有R或S构型或R + S与其无毒的药学上可接受的具有抗生素的酸加成盐的混合物 tic属性。

10. 发明授权

US07632952B2 Benzothiazoles and the use thereof as medicaments 失效
标题翻译：苯并噻唑及其作为药物的用途
公开(公告)号：US07632952B2
公开(公告)日：2009-12-15
申请号：US11536757
申请日：2006-09-29
申请人： Stéphanie Deprets , Anke Steinmetz , Odile Angouillant-Boniface , Daniel Bezard , Jidong Zhang , Yannick Benedetti , François Clerc
发明人： Stéphanie Deprets , Anke Steinmetz , Odile Angouillant-Boniface , Daniel Bezard , Jidong Zhang , Yannick Benedetti , François Clerc
IPC分类号： A61K31/428 , C07D277/82
CPC分类号： C07D417/12 , C07D277/82 , C07D417/14
摘要： The invention especially relates to novel chemical compounds, especially novel benzothiazole derivatives, to compositions containing said compounds, and to the use thereof as medicaments.
摘要翻译：本发明特别涉及新型化合物，特别是新颖的苯并噻唑衍生物，含有所述化合物的组合物及其作为药物的用途。

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